scholarly journals FEATURES OF HEMATOLOGICAL INDICES IN PATIENTS WITH IMPAIRED CARDIAC FUNCTION IN UP-TO-DATE CLINICAL PRACTICE

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
V.K. Tashchuk ◽  
R.A. Nesterovska ◽  
V.O. Kalarash
Keyword(s):  
New York ◽  
White Blood Cells ◽  
Heart Association ◽  
Functional Class ◽  
Hematological Indices ◽  
Neutrophil Lymphocyte Ratio ◽  
Versus Group ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Purpose – to investigate the distribution of hematological indices in patients withcardiac insufficiency.Material and methods. Data of 26 case histories with diagnosis of IHD have beenanalyzed. Patients with stable angina pectoris of II-III functional class (FC), Diffusecardiosclerosis, complicated in 17 patients with syndromic manifestations of HF II-IIIFC according to New York Heart Association (NYHA), made up group 1, and 9 patientswithout CH -group 2. Of the group 1 surveyed, there were 8 men and 9 women. Ratioindex of leucocytes and erythrocyte sedimentation rate (ESR): L/ESR=L×ESR/100;Neutrophil-lymphocyte ratio index (N/Li); Lymphocyte to monocyte ratio index (Li / Mo);Lymphocyte to eosinophil index (Li/ E) was used among hematological markers.Results. Analyzing the haemogram data, it was found that group 1 patients, unlike group2 patients, had a significantly higher overall white blood cell count (7,96±1,73) × 109and (4,22 ± 0,24) × 109; p<0,05 due to the number of neutrophils (69,41 ± 6,21) % ascompared to group 2 (51,78±1,79)%; p<0,05 as well as a lower level of lymphocyteswas defined in group 1 (22,06±4,07)% versus group 2 (38,55±1,01)%; p<0,05. In genderstudies, men show elevated levels of eosinophils (4,12±0,83)%, as opposed to women(1,56±0,73) %; p<0,05 and lower level of lymphocytes (18,38±1,69)% versus (25,33±2,24)%; p<0,05 and women had a high level of total white blood cells (9,36±0,66) ×109 thanmen (6,36±0,99)×109; p<0,05, in particular lymphocytes. Analysis of hematologicalindices showed that there was a statistically significant difference in determining theN / Li index, which was increased in group 1 patients (3,28±0,78) у.о versus group 2(1,34±0,05) у.о, p<0,05.Conclusion. In gender comparisons, there is an increase in lymphocytes among womencompared to men, so we can assume that women are less susceptible to systemicinflammation. The increase in the N/Li index ratio is due to severe cardiovascularconsequences among patients with coronary heart disease complicated by heart failure.

scholarly journals Orthosiphon versus Placebo in Nephrolithiasis with Multiple Chronic Complaints: A Randomized Control Trial

2009 ◽  
Vol 6 (4) ◽  
pp. 495-501 ◽  
Author(s):  
Amorn Premgamone ◽  
Pote Sriboonlue ◽  
Srinoi Maskasem ◽  
Wattana Ditsataporncharoen ◽  
Bungornsri Jindawong
Keyword(s):  
Myofascial Pain ◽  
White Blood Cells ◽  
Analog Scale ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Randomized Control ◽  
Group 2 ◽  
Primary Measure ◽  
Group 1

Nephrolithiasis in the communities of Northeast Thailand frequently presents with multiple chronic health complaints, i.e. myofascial pain, back pain, dyspepsia, arthralgia, headache, fatigue, frank paresthesia, dysuria and any of these aggravated by purine-rich food (PRF). We assessed the efficacy of Orthosiphon in treating subjects with at least two active symptoms and negative for urine white blood cells. Subjects were randomly allocated to two groups. Crude extract of Orthosiphon given in a capsule (equivalent to 1.6–1.8 g of dried leaves of Orthosiphon) two times a day to Group 1 (n= 36) and a placebo to Group 2 (n= 40) for 14 days. The medication for each subject was packed and its code kept secret until the data analysis. Both groups were asked not to consume any of 25 purine-rich foods (PRFs) during treatment. The primary measure was the reduced sum of active severity symptoms as recorded using the visual analog scale before and after therapy (i.e. on day 7 and 14). The data on 76 subjects were processed. The mean of the total scores (95% CI) of the symptoms in each group were decreased significantly (P< 0.001); 185.6 (153.3, 218.0) to 94.7 (58.2, 131.2) in the Orthosiphon group and 196.1 (164.4, 227.8) to 89.6 (62.8, 116.5) in the placebo group. When comparing between groups, no statistically significant difference was found. The mean consumption in PRFs was significantly decreased (P< 0.001) in both groups; however, Orthosiphon did not have additional benefit over placebo at 7 and 14 days of treatment during which they reduced these foods.

Comparison of Administration of Two Standard Intravenous Amino Acid Formulas to Severely Brain-Injured Patients

1988 ◽  
Vol 22 (10) ◽  
pp. 763-768 ◽  
Author(s):  
Linda G. Ott ◽  
Jack J. Schmidt ◽  
A. Byron Young ◽  
Diana L. Twyman ◽  
Robert P. Rapp ◽  
...  
Keyword(s):  
Amino Acid ◽  
Patient Group ◽  
Nitrogen Balance ◽  
Nitrogen Excretion ◽  
Versus Group ◽  
Significant Difference ◽  
Brain Injured ◽  
Group 2 ◽  
Injured Patients ◽  
Group 1

Twenty severely brain-injured patients with Glasgow Coma Scale scores of 4–9 were prospectively randomized to receive one of two standard amino acid formulas, starting with the first day of hospital admission up to day 14 postinjury. Formula 2 (patient group 2) had 54 percent more leucine, 53 percent more isoleucine, 74 percent more valine, 28 percent less phenylalanine, 31 percent less methionine, 111 percent more proline, 38 percent less alanine, and 38 percent less glycine than formula 1 (patient group 1). Groups 1 and 2 received statistically equal overall mean parenteral nutrition calories and protein (2173 ± 147 vs. 2059 ± 143 kcal, and 77 ± 12 vs. 83.1 ± 6 g, respectively). There was a significant difference in overall mean urinary urea nitrogen excretion (group 1 = 24.6 ± 1.3 vs. group 2= 18.3 ± 1.1, p = 0.02) and nitrogen balance (group 1 = −8.0 ± 2.1 vs. group 2 = + 1.8 ± 1.2, p = 0.01). Mean overall isoleucine values were significantly higher in group 2 (overall mean 77 μmol/L vs. 62 μmol/L, p = 0.04). Phenylalanine levels were significantly higher in group 1 (107 μmol/L) versus group 2 (82 μmol/L) patients (p = 0.01). Arginine levels were significantly higher in group 1 (78 μmol/L) versus group 2 (49 μmol/L) patients (p = 0.0002). This observation suggests that some standard intravenous amino acid formulas may be more apt to promote positive nitrogen balance than others.

scholarly journals New York Heart Association Functional Class correlated with Depression: Study in Saiful Anwar Hospital

2021 ◽  
Vol 2 (3) ◽  
pp. 25-30
Author(s):  
Yusuf Arifin ◽  
Mohammad Saifur Rohman ◽  
Cholid Tri Tjahjono ◽  
Djanggan Sargowo ◽  
Anna Fuji Rahimah
Keyword(s):  
Heart Failure ◽  
New York ◽  
Marital Status ◽  
Rating Scale ◽  
Nyha Class ◽  
Heart Association ◽  
Functional Class ◽  
Baseline Characteristic ◽  
Significant Difference ◽  
New York Heart Association

Background: Heart Failure prevalence was raising as one of the most Objective: to find the correlation of New York Heart Association Functional Class in heart failure patient with Depression Method: This cross-sectional study recruited 342 patients diagnosed with HF with previously for more than 3 months, at dr. Saiful Anwar General Hospital during December 2016 to March 2021. Each patient was interviewed for their demography data, and their clinical data, and assessed for their depression with Montgomery-Asberg Depression Rating Scale for Indonesian version. We used Spearman coefficients (rs) to evaluate the correlations between variables. Results: Baseline characteristic among depression and non-depression group demonstrated no significant difference (p>0.05), but for marital status. Populations was predominantly male, with ACE-i/ARB and Beta-blockers treatment. Non predominant treatment was MRAs, Diuretics, Digoxin. Baseline age was 22 years old until 87 years old. Baseline LVEF was 50.4±12.9%. (p >0.05). There were significant correlations between NYHA Class and marital status (p < 0.05), while the other baseline was not significantly different. We performed log regression for the confounding. The result was NYHA Class significantly correlated with and effects the depression. Conclusion: In heart failure patients, NYHA Class was significantly correlated with depression.

Evaluating the blood toxicity of functionalized graphene-arginine with anticancer drug ginsenoside Rh2 in balb/c mouse model with breast cancer

2022 ◽  
Author(s):  
Shervin Dokht Farhangfar ◽  
Farzaneh Fesahat ◽  
Sayed Mohsen Miresmaeili ◽  
Hadi Zare-Zardini
Keyword(s):  
Anticancer Drug ◽  
Blood Cells ◽  
White Blood Cells ◽  
Functionalized Graphene ◽  
Ginsenoside Rh2 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1 ◽  
Blood Factors

Background: Gensenoside Rh2 is an anticancer drug with low toxicity and stability in the body. The aim of this study was to evaluate the blood toxicity of functionalized graphene-arginine with anticancer drug ginsenoside Rh2 in balb/c mouse model with breast cancer. Materials and Methods: Graphene-Arginine (G-Arg) and Graphene-Arginine-ginsenoside Rh2 (G-Arg-Rh2) were synthesized using microwave method. For evaluation of blood toxicity, 32 mice with breast tumors were randomly divided into 4 groups: control (3mg/kg 6 mg / kg PBS sterile), group 1 (6 mg / kg ginsenoside), group 2 (3 mg / kg G-Arg), and group 3 (3 mg / kg G-Arg-Rh2). Treatment was done intravenously once every three days for 32 days. Finally, blood factors were also examined by sampling from the heart. Results: Complete functionalization was proven by FTIR and Raman. Examination of blood factors showed that white blood cells had a very small increase. Anova test showed significant difference among four groups in term of WBC count (p=0.016). Pair sample T test showed that there was significant difference between control and group 1(p=0.036) and control and group 2 (p=0.036). There was no significant difference between control and group 3 (p=0.051). Other blood factors had no significant difference among examined groups (p>0.05). Conclusion: Based on results, after treatment with all designed nanostructures, only white blood cells had a very small increase and inflammatory reactions were statistically similar in all groups. This indicates the high efficiency of designed drug.

ASSOCIATION BETWEEN LEUKOCYTES COUNT AND THE SEVERITY OF COVID-19 INFECTION

2021 ◽  
Vol 74 (10) ◽  
pp. 2417-2422
Author(s):  
Ahmed Hamza Ajmi ◽  
Wassan Abdul-Kareem Abbas ◽  
Dalya Basil Hanna ◽  
Maysaa Ali Abdul Khaleq
Keyword(s):  
Clinical Investigation ◽  
White Blood Cells ◽  
Severe Infection ◽  
Laboratory Diagnosis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Lymphocyte To Monocyte Ratio ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

The aim: To find an association of COVID-19 on different types of leukocytes either count increasing or decreasing. Materials and methods: A cross sectional study conducted from October /2020 to January /2021. Eighty patients out of 170 were enrolled in this study, who were attended a private clinic for clinical investigation and a private laboratory for laboratory diagnosis of COVID-19 who were divided into two groups, asymptomatic or mild (group 1), and moderate or severe (group 2). Five milliliter of blood samples were collected from patients with COVD-19 by venipuncture using a syringe for evaluation of different cells. Results: The current study revealed a significant difference in white blood cells count, neutrophils count, monocytes count, basophils count, and neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio between group 1 and group 2. While lymphocytes, and eosinophil showed no significant difference. Conclusion: The current study concluded that COVID-19 may affect the count of some leukocytes in patient with severe infection.

scholarly journals Do neutrophil- lymphocyte, platelet-lymphocyte ratio correlate with pathological outcomes in localized renal tumors?

2019 ◽  
Author(s):  
ahmet camtosun ◽  
Ibrahim Topcu
Keyword(s):  
Blood Cell ◽  
Clear Cell ◽  
Cell Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background: We investigated the association of the blood parameters such as neutrophil, platelet accounts and neutrophil/lymphocyte ratio (NLR) with tumor type, tumor size and Fuhrman grade in nonmetastatic renal cell carcinoma (RCC) cases. Methods: A total of 343 patients with nonmetastatic (T1- 4N0M0) RCC were included into the study. The patients were divided into four groups: clear cell (group-1), papillary (group-2), chromophobes (group-3) and other pathologies (group-4). In each grouping systems, the NLR, white blood cell (WBC), platelet (PLT), mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV) values were compared. Results: There were 222 patients with clear cell (group-1), 62 papillary (group-2), 16 chromophobes (group-3) and 43 patients with other pathologies (group-4). There was a significant difference between the groups in group-1 and group-3 in terms of white blood cell (WBC), platelet (PLT), lymphocyte and neutrophil count. However, there was no significant difference between the groups by the surveys in terms of Neutrophil / Lymphocyte Ratio (NLR) values. There was no significantly difference between survival and NLR either. Conclusion: NLR is a cheap and easy parameter to calculate but is not suitable to predict tumor prognosis and survival yet. NLR cut-off value is the biggest problem for now. But evidences show, we are too close to overcome this problem.

Comparative Analysis of Three-Dimensional Nasal Shape of Casts from Patients With Unilateral Cleft Lip and Palate Treated at Two Institutions Following Rotation Advancement Only (Iowa) or Nasoalveolar Molding and Rotation Advancement in Conjunction With Primary Rhinoplasty (New York)

2018 ◽  
Vol 55 (10) ◽  
pp. 1350-1357 ◽  
Author(s):  
Banafsheh Hosseinian ◽  
Marcie S. Rubin ◽  
Sean A. P. Clouston ◽  
Asma Almaidhan ◽  
Pradip R. Shetye ◽  
...  
Keyword(s):  
New York ◽  
Dome Height ◽  
3 Dimensional ◽  
Alar Base ◽  
Significant Difference ◽  
Group 2 ◽  
Nasoalveolar Molding ◽  
Rotation Advancement ◽  
Base Width ◽  
Group 1

Objectives: To compare 3-dimensional nasal symmetry in patients with UCLP who had either rotation advancement alone or nasoalveolar molding (NAM) followed by rotation advancement in conjunction with primary nasal repair. Design: Pilot retrospective cohort study. Materials and Methods: Nasal casts of 23 patients with UCLP from 2 institutions were analyzed; 12 in the rotation advancement only group (Iowa) and 11 in the NAM, rotation advancement with primary nasal repair group (New York). Casts from patients aged 6 to 18 years were scanned using the 3Shape scanner and 3-dimensional analysis of nasal symmetry performed using 3dMD Vultus software, Version 2507, 3dMD, Atlanta, GA. Cleft and noncleft side columellar height, nasal dome height, alar base width, and nasal projection were linearly measured. Inter- and intragroup analyses were performed using t tests and paired t tests as appropriate. Results: A statistically significant difference in mean-scaled 3-dimensional asymmetry index was found between groups with group 1 having a larger measure of asymmetry (4.69 cm3) than group 2 (2.56 cm3; P = .02). Intergroup analysis performed on the most sensitive linear measure, alar base width, revealed significantly less asymmetry on average in group 2 than in group 1 ( P = .013). Conclusion: This study suggests the NAM followed by rotation advancement in conjunction with primary nasal repair approach may result in less nasal asymmetry compared to rotation advancement alone.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Tuberculosis of the meninges and central nervous system. Experience of clinical diagnostics in St. Petersburg for 50 years

MedAlliance ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 14-24
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Errors ◽  
Clinical Diagnostics ◽  
Lethal Outcome ◽  
Significant Difference ◽  
Group 2 ◽  
Allergic Vasculitis ◽  
Tuberculosis Meningitis ◽  
Group 1

The clinic and diagnostics of tuberculosis meningitis (TM) in 926 patients treated in St. Petersburg hospitals in 1965–1994 (group 1) and in 1995–2018 (group 2) is presented. The TM clinic is demonstrated to be determined by the form of tuberculosis and its characteristic generalization nature in the presence of repeated waves of bacteremia and allergic vasculitis of greater or lesser severity. There is clinical peculiarity of TM in primary pulmonary tuberculosis and its early large-focal and late miliar generalization, as well as in hematogenous tuberculosis. In patients of the 1st and 2nd groups the TM clinic shows in some respects a noticeable similarity, in others — a significant difference. Despite the typical symptoms, early diagnosis of TM took place in less than 20% of patients. Clinical examples illustrating the unusual development of TM, contrasting with its usual course, are given. A number of objective and subjective factors contributing to the adverse evolution of TM and its lethal outcome are discussed. These include the peculiarity of modern tuberculosis, especially when associated with HIV infection, as well as medical errors associated with ignorance of the pathogenesis of tuberculosis and failure to comply with the minimum examination for tuberculosis.

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