scholarly journals Optimized treatment of patients with alcoholic steatohepatitis taking into account comorbid anaemic conditions and H.pylori contamination

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 3-11
Author(s):  
T. Antofiichuk ◽  
O. Khukhlina ◽  
M. Antofiichuk
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Control Group ◽  
Control Groups ◽  
Alcoholic Steatohepatitis ◽  
Clinical Syndromes ◽  
B12 Deficiency ◽  
H Pylori ◽  
Optimized Treatment ◽  
And Control

The prospective study of patients with alcoholic steatohepatitis (ASH) showed that 40 % of patients with ASH were diagnosed with anaemic conditions (AC), among which vitamin B12-deficiency anaemia was registered - in 17.5% of cases, anaemia of chronic disease (ACD) – in 10.0% of cases and hemolytic anemia (HA) - in 12.5% of cases. In patients with SH of mixed (including alcoholic) etiology AC was found in 32.0%: vitamin B12 - deficient - in 16.0%, ACD - in 8.0% and hemolytic - in 8.0 % of patients. In patients with ASH, H. pylori contamination was present in 32 (80.0%) individuals, including 100% of patients with B12-deficient anaemia. Among patients with SH of mixed (including alcoholic) etiology, H. pylori was detected in 100.0% of people with AS. The use of Hepadif in the complex therapy of ASH contributed to the elimination or reduction of the intensity of the main clinical syndromes (astheno-vegetative, dyspeptic, cholestatic, hepato-, splenomegaly, hepatic steatosis) and biochemical syndromes (mesenchymal-inflammatory cholestasis, hepatocellular insufficiency), in the range of 1.3-4.3 times (p <0.05), as well as higher efficiency of treatment of patients with ASH with anaemic syndrome in 6.0 times (p <0.05). The efficiency of eradication of H. pylori in the main and control groups accompanied by the use of the 3-component programme of the first line according to the stool test was the same (85.7% and 84.2% (p> 0.05), respectively), but in 57.9 % of patients in the control group, the symptoms of dyspepsia increased or appeared on the background of antibacterial therapy, while no side effects of the drug were found during the study in the main group.

Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study

2011 ◽  
Vol 93 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Angel F. Remacha ◽  
Joan Carles Souto ◽  
José Luis Piñana ◽  
María Pilar Sardà ◽  
Josep Maria Queraltó ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
And Control ◽  
Control Study

Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: preliminary study

2007 ◽  
Vol 122 (1) ◽  
pp. 61-64 ◽  
Author(s):  
İ Aladag ◽  
Y Bulut ◽  
M Guven ◽  
A Eyibilen ◽  
K Yelken
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Control Groups ◽  
Chi Square ◽  
Control Subjects ◽  
The Difference ◽  
H Pylori ◽  
And Control

AbstractBackground and objectives:Chronic nonspecific pharyngitis is a chronic inflammation of the pharynx. It is found worldwide, and treatment is difficult. The underlying aetiopathogenesis is still controversial. The aim of this study was to investigate Helicobacter pylori seroprevalence in chronic nonspecific pharyngitis patients without other possible causative factors for chronic pharyngeal irritation and without H pylori gastric mucosal infection.Materials and methods:Forty-one patients with symptoms of chronic nonspecific pharyngitis and 30 healthy control subjects were enrolled in this prospective, controlled, clinical study. In both study and control groups, selected patients were shown to have gastric mucosa uninfected by H pylori, as demonstrated by the 14C-urea breath test. Comprehensive otorhinolaryngological examination did not elicit any factor contributing to the chronic pharyngeal complaint. Serum H pylori immunoglobulin G antibody titres were assayed using serum enzyme-linked immunosorbent assay. The difference between the study and control groups was analysed by the chi-square test (the likelihood ratio was used).Results:Thirty-two of the 41 patients (78 per cent) and 14 of the 30 control subjects (46.7 per cent) were found to be H pylori positive. Patients with chronic nonspecific pharyngitis were found to have a significantly higher rate of H pylori seropositivity than the control group (p = 0.016).Conclusion:These data may be important in developing future treatment strategies for chronic nonspecific pharyngitis.

scholarly journals Low vitamin B12 diet increases liver homocysteine levels and leads to liver steatosis in rats

2019 ◽  
Vol 38 (3) ◽  
pp. 194
Author(s):  
Imelda Rosalyn Sianipar ◽  
Irena Ujianti ◽  
Sophie Yolanda ◽  
Ahmad Aulia Jusuf ◽  
Neng Tine Kartinah ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin B12 ◽  
Insulin Signaling ◽  
Liver Steatosis ◽  
Vitamin B12 Deficiency ◽  
Dietary Vitamin ◽  
Control Group ◽  
Treatment Groups ◽  
Treatment Standard ◽  
B12 Deficiency

Background <br />Nonalcoholic fatty liver disease (NAFLD) is one of the most widespread chronic liver diseases, caused by the development of insulin resistance. One of the mechanisms involved is a disturbance in insulin signaling by certain toxic substances that interact with one of the proteins responsible for the insulin signaling pathway. Increased homocysteine level, upon disruption of the methionine pathway, is associated with insulin resistance. The aim of this study was to evaluate the effect of hyperhomocysteinemia and insulin resistance (HOMA-IR level) induced by dietary vitamin B12 restriction on liver steatosis. <br /><br />Methods <br />A study of laboratory experimental design was conducted involving 18 male Sprague Dawley rats (age 36-40 weeks, BW 300-350 g), that were randomly divided into 3 groups: control, 8-week treatment, and 16-week treatment. Standard AIN-93 diet was administered to the control group, whereas rats in the treatment groups were fed vitamin B12 deficiency-AIN-93M. At the end of treatment, liver homocysteine levels were determined by ELISA, HOMA-IR values were calculated, and steatosis degree of the liver was determined histologically. Statistical analysis was performed using independent t-test. <br /><br />Results <br />A significant increase in liver homocysteine levels was found between the control and both the 8- and 16-week treatment groups (p&lt;0.001). HOMA-IR levels were significantly higher in both treatment groups compared to controls (p&lt;0.001). The area of liver steatosis in both treatment groups was significantly larger than that of the control group (p&lt;0.001). <br /><br />Conclusion <br />Increased homocysteine levels due to dietary vitamin B12 deficiency induces liver steatosis due to insulin resistance in rats.

scholarly journals Genetic Bases of VitaminB12 Deficiency: Impact of MTHFR, TCN-II and GIF Polymorphisms on Vitamin B12 Level

2022 ◽  
Vol 19 ◽  
pp. 10-13
Author(s):  
Mazhar Salim Al Zoubi
Keyword(s):  
Vitamin B12 ◽  
Neurological Disorders ◽  
Molecular Basis ◽  
Vitamin B12 Deficiency ◽  
Mthfr Gene ◽  
Control Group ◽  
Mthfr Polymorphisms ◽  
Jordanian Population ◽  
B12 Deficiency ◽  
The Impact

Vitamin B12 deficiency is associated with serious health problems such as neurological disorders. In Jordan, few studies have evaluated the level of vitamin B21 in the Jordanian population with different prevalence. Genetic predisposition, lifestyle, environment, socioeconomic status, and geographic have been linked to vitamin B12 deficiency. Polymorphisms in the GIF, MTHFR, and Transcobalamins, have been proposed to be associated with the level of vitamin B12. The aim of the current study was to evaluate the impact of certain polymorphisms in MTHFR, TCN-II and GIF genes on the level of vitamin B12 in the Jordanian population. Polymorphic sites of the MTHFR (c.677 C>T, rs1801133 and c.1286A>C, rs1801131), TCN2-776C>G (Arg259Pro) (rs1801198) and GIF-68 A>G (Q5R) genes were analyzed by RFLP and DNA sequencing in a group of vitamin B12 deficient individuals (n = 100). The control group included 100 matching individuals with a normal level of vitamin B12 (>200 ng/mL). Our results showed a significant association between the homologous variant of the TCN2 gene (G776G) and MTHFR c.677C>T genes and vitamin B12 deficiency. On the other hand, The MTHFR c.1286A>C variant and GIF variants did not show significant association with vitamin B12 deficiency. This study expounds the association of TCN2 and MTHFR polymorphisms with cobalamin levels in a Jordanian population and highlights the necessity of further studies to elucidate the molecular basis and impact of TCN2, GIF, and MTHFR gene polymorphisms on vitamin B12 deficiency and associated disorders.

scholarly journals H. pyloriMay Not Be Associated with Iron Deficiency Anemia in Patients with Normal Gastrointestinal Tract Endoscopy Results

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Tayyibe Saler ◽  
Şakir Özgür Keşkek ◽  
Sibel Kırk ◽  
Süleyman Ahbab ◽  
Gülay Ortoğlu
Keyword(s):  
Gastrointestinal Tract ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Male Patients ◽  
H Pylori ◽  
And Control

Background. The aim of this study was to investigate the association between iron deficiency anemia andH. pyloriin patients with normal gastrointestinal tract endoscopy results.Materials and Methods. A total of 117 male patients with normal gastrointestinal tract endoscopy results were included in this retrospective study. The study and control groups included 69 and 48 patients with and without iron deficiency anemia, respectively. The prevalence ofH. pylori, the number of RBCs, and the levels of HGB, HTC, MCV, iron, and ferritin were calculated and compared.Results. There was no statistically significant difference found between the groups according to the prevalence ofH. pylori(65.2% versus 64.6%,P=0.896). Additionally, the levels of RBCs, HGB, HTC, MCV, iron, and ferritin in the patients in the study group were lower than those in the control group (P<0.05). Finally, there was no association between iron deficiency anemia andH. pylori(OR 1.02, Cl 95% 0.47–2.22, andP=0.943).Conclusion.H. pyloriis not associated with iron deficiency anemia in male patients with normal gastrointestinal tract endoscopy results.

Prevalence of Levodopa-Induced Peripheral Neuropathy in Patients with Parkinson’s Disease and Vitamin B12 Deficiency

2021 ◽  
Vol 10 ◽  
pp. 1837
Author(s):  
Mohammad Yazdchi Marandi ◽  
Hormoz Ayromlou ◽  
Safa Najmi ◽  
Seyyed-Reza Sadat-Ebrahimi ◽  
Zakaria Pezeshki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Term Treatment ◽  
Control Group ◽  
Long Term Treatment ◽  
B12 Deficiency

Background: Parkinson’s disease (PD) is one of the widespread neurodegenerative diseases. Recently, a few studies have suggested that treatment with levodopa and vitamin B12 deficiency may have some role in developing peripheral neuropathy (PN) among PD patients. Hence, the aim of this study was to evaluate PN in patients suffering from PD under long-term treatment with levodopa and also vitamin B12 deficiency in these patients. Materials and Methods: Thirty PD patients who received levodopa for at least two years, 30 levodopa-naïve PD patients, and 30 age-matched controls individuals were included. The participants were subjected to electrodiagnostic tests and the level of vitamin B12 was measured. The prevalence of neuropathy was determined according to electrodiagnostic criteria and compared among the three groups. Results: Overall, 23.3% of cases in levodopa receivers, 3.3% in the levodopa-naïve group, and 3.3% in control group had PN (odds ratio=8.8, 95% confidence interval=1.7-45.6). Levodopa group had significantly lower serum vitamin B12 than the other two groups (P=0.006). Vitamin B12 insufficiency was detected in 36.6% of patients in the levodopa group, which was significantly higher than other groups (23.3% in the levodopa-naïve and 6.6% in the control groups, P=0.02). A significantly negative correlation was noticed between the duration of levodopa exposure and serum level of vitamin B12 (r=-0.31, P=0.016). Conclusion: Our study demonstrated a significantly higher prevalence of vitamin B12 insufficiency and PN in PD patients under treatment with levodopa. Also, our results advocate the role of levodopa in PN development through the vitamin B12 derangement. [GMJ.2021;10:e1837]

scholarly journals Screening of vitamin B12 in children diagnosed as Autism Spectrum Disorder

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M Metyas ◽  
A S Abdelhakim ◽  
H H Ghandour
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin B12 ◽  
Rating Scale ◽  
Megaloblastic Anemia ◽  
Vitamin B12 Deficiency ◽  
Normal Subjects ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Control Group ◽  
B12 Deficiency

Abstract Background Vitamin B12 deficiency causes megaloblastic anemia and disorders of the nervous system. In Autism spectrum disorder intestinal problems in absorption of some minerals like Vitamin B12 which lead to Vitamin B12 deficiency. Aim of the Work to investigate level of vitamin B12 in autistic children in an attempt to reach such etiological factor and to be incorporated in management if proved. Patients and Methods a Case control study. The subjects of this study comprised a convenient sample of 15 children diagnosed as ASD and other 15 children not diagnosed as ASD as control group with age range between 3 years 8 months. Modified Arabic preschool language scale (PLS-4) Test, Stanford Binet intelligence scales, fifth edition were done for all children and Child autism rating scale (CARS) was done for children of 2 groups. Results Vitamin B12 level in ASD is significantly deficiency compared to the Vitamin B12 level of normal subjects. Conclusion Vitamin B12 in ASD was found to be decreased in cases group than the controls group also below the total language level of cases group than the controls group.

scholarly journals Helicobacter pylori infection and vitamin B-12 deficiency- A cross sectional study

2017 ◽  
Vol 8 (4) ◽  
pp. 16-20 ◽  
Author(s):  
K. Ravi ◽  
Jacob Joseph ◽  
David Mathew Thomas
Keyword(s):  
Helicobacter Pylori ◽  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Histopathological Examination ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Helicobacter Pylori Infection ◽  
Blood Levels ◽  
B12 Deficiency ◽  
H Pylori

Background: Vitamin B12 deficiency is a common, often overlooked medical problem in adult  population. Diagnosis of vitamin B12 deficiency is incomplete without the evaluation of underlying cause. In majority of the cases Vitamin B12 deficiency is attributed to malnutrition. H. pylori infection plays an important role in the development of atrophic gastritis and related malabsorption. Hence it is suggested that there may be a relationship between h. pylori infection and vitamin B12 deficiency.Aims and Objective: To evaluate correlation of helicobacter pylori infection and blood levels of vitamin B12.Materials and Methods: A total of 120 patients with deficient serum vitamin B12 levels were evaluated. Upper GI Endoscopy was performed and gastric biopsies were obtained for Histopathological examination and histological evidence of H. pylori infection.Results: Tissue biopsy revealed chronic atrophic gastritis in 65 patients and chronic antral gastritis in 39 patients. H. pylori infection by histology was positive in 68 patients. There was significant correlation between atrophic gastritis and H. pylori as well as between H. pylori and B12 deficiency.Conclusion: H.pylori has an effect on gastric mucosa, which influences the absorption of vitamin B12. Thus individuals with B12 deficiency must be subjected for diagnostic evaluation of H.pylori infection and appropriate therapy must be initiatedAsian Journal of Medical Sciences Vol.8(4) 2017 16-20

scholarly journals Assessment of Vitamin B12 in Patients with Coronary Tortuosity

2016 ◽  
Author(s):  
Levent Cerit ◽  
Hatice Kemal ◽  
Aziz Günsel ◽  
Murat Uncu ◽  
Zeynep Cerit ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Female Gender ◽  
Control Group ◽  
Echocardiographic Parameters ◽  
B12 Deficiency ◽  
Long Term Prognosis ◽  
Coronary Tortuosity

Background: Vitamin B 12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinemia. Coronary tortuosity (CorT) is a common coronary angiography finding. The etiology, clinical implication and long term prognosis are still not well clarified. This study was conducted with the aim to evaluate the relationship between CorT and vitamin B12. Subjects and Method: The medical records of consecutive patients, who underwent coronary angiography, were retrospectively reviewed. The study group consisted of 1624 patients. Taking into consideration the inclusion criteria, 212 patients with CorT and 210 patients with normal coronary angiographies (control group) were included in the study. Vitamin B12, other biochemical parameters, clinical and echocardiographic parameters, and CorT score were evaluated in all patients. CorT is defined as fixed 3 bends during both systole and diastole, with each bend &ge;45 &deg;. Results: Patients with CorT had higher prevalence of older, female gender, hypertension, current smoking. Vitamin B12 was significantly decreased in patient with CorT (134.7&plusmn;47.8 vs 239.6&plusmn;53.8 p&lt;0.001). On multivariate analysis age, female gender, hypertension, diabetes mellitus and vitamin B12 were independent predictors for CorT (OR 1.56; 95% CI: 1.247&ndash;1.962; p &lt; 0.001, OR 1.628; 95% CI: 1.376-2.048; p&lt;0.001, OR 1.865; 95% CI: 1.387-2.695; p&lt;0.001, OR 1.362; 95% CI: 1.184-1.726; p&lt;0.001, OR 1.862; 95% CI: 1.486-2.674; p&lt;0.001, respectively). Conclusion: In our study, we have founded a significant relationship between vitamin B12 deficiency and CorT.

scholarly journals An Additive Effect of Oral N-Acetyl Cysteine on Eradication ofHelicobacter pylori

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Seyed Mohammad-Taghi Hamidian ◽  
Najmeh-sadat Aletaha ◽  
Reza Taslimi ◽  
Mohammad Montazeri
Keyword(s):  
Female Gender ◽  
Drug Regimen ◽  
Additive Effect ◽  
Control Group ◽  
Control Groups ◽  
Acetyl Cysteine ◽  
H Pylori ◽  
Gastric Mucous ◽  
And Control ◽  
Experimental Group

Background. Helicobacter pyloriis highly adapted to the gastric environment where it lives within or beneath the gastric mucous layer. The aim of this study was to evaluate whether the addition of N-acetyl cysteine to the treatment regimen ofH. pyloriinfection would affect eradication rates of the disease.Methods.A total of 79H. pyloripositive patients were randomized to two therapeutic groups. Both groups received a 14-day course of three-drug regimen including amoxicillin/clarithromycin/omeprazole. Experimental group (38 subjects) received NAC, and control group (41 subjects) received placebo, besides three-drug regimen.H. pylorieradication was evaluated by urea breath test at least 4 weeks after the cessation of therapy.Results.The rate ofH. pylorieradication was 72.9% and 60.9% in experimental and control groups, respectively (P=0.005). By logistic regression modeling, female gender (OR 3.68, 95% CI: 1.06–5.79;P=0.040) and treatment including NAC (OR 1.88, 95% CI: 0.68–3.15;P=0.021) were independent factors associated withH. pylorieradication.Conclusion.The results of the present study show that NAC has an additive effect on the eradication rates ofH. pyloriobtained with three-drug regimen and appears to be a promising means of eradicatingH. pyloriinfection.

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