scholarly journals Metastatic gastric adenocarcinoma associated with hypertrophic gastropathy resembling Ménétrier's disease in an adult Labrador Retriever dog

2021 ◽  
Vol 14 (2) ◽  
pp. 123-128
Author(s):  
Thais Sarandy ◽  
◽  
Carlos Lopes ◽  
Fábio Del Piero ◽  
Roselene Ecco ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Lymphatic Vessels ◽  
Labrador Retriever ◽  
Gastric Body ◽  
Mucous Cells ◽  
Intact Female ◽  
Diagnostic Investigation ◽  
Gastric Glands ◽  
Gross Lesions ◽  
Hypertrophic Gastropathy

We describe a case of hypertrophic gastropathy (Ménétrier’s like disease) with metastatic gastric adenocarcinoma in a seven-year-old intact female Labrador Retriever dog. The animal suddenly presented with emesis and died. Gross lesions included a marked diffuse thickening of the gastric mucosa and an ulcerated transmural neoplastic mass in the gastric body. Gastric body and fundus were affected by foveolar hyperplasia with loss of chief and parietal cells replaced by mucous cells and marked dilatation of gastric glands. An area of gastric adenocarcinoma with submucosal lymphatic vessels invasion was also present and metastases were observed in the gastric lymph nodes, small intestine, pancreas, lung and liver. Due to its similarity with other gastric proliferative disorders, including this condition in the list of differentials is a necessary step in the diagnostic investigation of canine gastropathies.

scholarly journals Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands

2017 ◽  
Vol 23 (38) ◽  
pp. 7047-7053 ◽  
Author(s):  
Shigeo Manabe ◽  
Ken-ichi Mukaisho ◽  
Takayuki Yasuoka ◽  
Fumitaka Usui ◽  
Tatsuzo Matsuyama ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Fundic Gland ◽  
Gastric Glands ◽  
Gland Type

scholarly journals Chemoprevention by celecoxib in reflux-induced gastric adenocarcinoma in Wistar rats that underwent gastrojejunostomy

2009 ◽  
Vol 24 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Frederico Theobaldo Ramos Rocha ◽  
Laercio Gomes Lourenço ◽  
Mário Jorge Jucá ◽  
Valéria Costa ◽  
Antenor Teixeira Leal
Keyword(s):  
Gastric Adenocarcinoma ◽  
Wistar Rats ◽  
Exploratory Laparotomy ◽  
Gastric Body ◽  
Gastrojejunal Anastomosis ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Laparotomy Group ◽  
Group 2 ◽  
Group 1

PURPOSE: To evaluate chemoprevention by celecoxib in cases of reflux-induced gastric adenocarcinoma, in Wistar rats that underwent gastrojejunostomy. METHODS: Sixty male Wistar rats of average age three months underwent surgery and were distributed into three groups: group 1, exploratory laparotomy; group 2, gastrojejunostomy; and group 3, gastrojejunostomy and daily celecoxib administration. After 53 weeks, the animals were sacrificed. Changes in the mucosa of the gastric body of group 1 and in the gastrojejunal anastomosis of groups 2 and 3, observed in histopathological and immunohistochemical examinations, were compared. All statistical analyses were performed using Epi-Info®, version 3.4.3. RESULTS: Comparison between groups 2 and 3 relative to the presence of adenocarcinoma showed a statistically significant difference (p=0.0023). Analysis of the association between groups 2 and 3 relative to COX-2 expression also showed a statistically significant difference (p=0.0018). CONCLUSION: Celecoxib had an inhibiting effect on gastric carcinogenesis induced by enterogastric reflux in an animal model.

Esophageal/gastric adenocarcinoma in a dog

1997 ◽  
Vol 33 (1) ◽  
pp. 42-44 ◽  
Author(s):  
M Takiguchi ◽  
J Yasuda ◽  
A Hashimoto ◽  
K Ochiai ◽  
C Itakura
Keyword(s):  
Weight Loss ◽  
Gastric Adenocarcinoma ◽  
Histopathological Diagnosis ◽  
Intact Female ◽  
Mixed Breed ◽  
History Of ◽  
Contrast Radiography

A nine-year-old, intact female, mixed-breed dog was presented with a history of chronic regurgitation and weight loss. Endoscopy and contrast radiography confirmed the presence of a distal esophageal mass. The dog was euthanized, and histopathological diagnosis of the mass was an esophageal/gastric adenocarcinoma.

Analysis and follow-up of the patients diagnosed with metastatic gastric adenocarcinoma in the Parc Taulí Hospital, Sabadell, between 2010 and 2013.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 169-169
Author(s):  
Marta Ferrer ◽  
Carles Pericay ◽  
Ismael Macias ◽  
Emma Dotor ◽  
Aleydis Pisa ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Clinical Information ◽  
Gastric Body ◽  
Second Line ◽  
First Line ◽  
Kaplan Meier ◽  
Secondary Endpoints ◽  
Third Line ◽  
Line Chemotherapy

169 Background: The primary endpoint of this study was to know the incidence and treatment of gastric carcinoma in our area. Other secondary endpoints were percentage of treated patients, overall survival (OS), survival in subgroups, and more frequent treatments. Methods: Since 2010 to 2013 all the patients diagnosed with metastatic gastric adenocarcinoma and treated at the hospital Parc Taulí from Sabadell were registered. The clinical information was compiled and analyzed. Survivals curves were determined with Kaplan-Meier functions Results: 168 patients were studied, with 79 metastatic (47%). 56% men and median age 67 years. Localizations were gastric body 52%, gastro-esophageal junction 20%, and antrum 25%. OS of the series was 5,05 months (95% CI, 2,99-7,10). 60% of the patients were treated with first line chemotherapy (CT). From them, 42% had a second line and 25% a third line. DFS were respectively 6,62 months (4,06-9,17), 4,29 months (2,28-6,30), and 2,88 months (1,12-4,64) for every line of treatment. OS of the patients that received chemotherapy was 9.7 months (6,40-13,00). CT more used in first line were triplets of fluropyrimidines, platinum and taxanes, in 45% (21 patients). Also just fluoropyrimidines and platinum without taxanes, in 38%. As a second line the predominant CT is also platinum and fluoropyrimidines (37%), and irinotecan (30%). In third line, 50% are combinations based on irinotecan. Conclusions: The OS of the patients who received CT is significantly prolonged respect the ones who didn’t. The data obtained matches the data already published in the literature, even the more frequent chemotherapy.

scholarly journals NHE8 plays important roles in gastric mucosal protection

2013 ◽  
Vol 304 (3) ◽  
pp. G257-G261 ◽  
Author(s):  
Hua Xu ◽  
Jing Li ◽  
Huacong Chen ◽  
Chunhui Wang ◽  
Fayez K. Ghishan
Keyword(s):  
Gastric Ulcer ◽  
Physiological Role ◽  
Mucosal Surface ◽  
Sodium Absorption ◽  
Bicarbonate Secretion ◽  
Mucosal Protection ◽  
Mucous Cells ◽  
Gastric Glands ◽  
Surface Ph ◽  
Gastric Mucosal Protection

Sodium/hydrogen exchanger (NHE) 8 is an apically expressed membrane protein in the intestinal epithelial cells. It plays important roles in sodium absorption and bicarbonate secretion in the intestine. Although NHE8 mRNA has been detected in the stomach, the precise location and physiological role of NHE8 in the gastric glands remain unclear. In the current study, we successfully detected the expression of NHE8 in the glandular region of the stomach by Western blotting and located NHE8 protein at the apical membrane in the surface mucous cells by a confocal microscopic method. We also identified the expression of downregulated-in-adenoma (DRA) in the surface mucous cells in the stomach. Using NHE8−/− mice, we found that NHE8 plays little or no role in basal gastric acid production, yet NHE8−/− mice have reduced gastric mucosal surface pH and higher incidence of developing gastric ulcer. DRA expression was reduced significantly in the stomach in NHE8−/− mice. The propensity for gastric ulcer, reduced mucosal surface pH, and low DRA expression suggest that NHE8 is indirectly involved in gastric bicarbonate secretion and gastric mucosal protection.

scholarly journals Hypertrophic gastropathy associated with gastric sarcoma in a dog

2020 ◽  
Vol 33 (1) ◽  
pp. 112-115
Author(s):  
Mariarita Romanucci ◽  
Paolo E. Crisi ◽  
Maria Veronica Giordano ◽  
Morena Di Tommaso ◽  
Francesco Simeoni ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Neuron Specific Enolase ◽  
Partial Gastrectomy ◽  
Abdominal Ultrasound ◽  
Gastric Body ◽  
Gastric Glands ◽  
Periodic Acid Schiff ◽  
Gastric Lumen

A 14-y-old spayed female Labrador Retriever was presented with an 8-mo history of chronic vomiting. Abdominal ultrasound and gastrointestinal endoscopy revealed a mass protruding into the gastric lumen, with cytologic features suggestive of sarcoma. A partial gastrectomy was performed; the gastric body and antrum were thickened, with a cerebriform appearance of the mucosal surface. Histologic examination revealed a submucosal neoplastic proliferation of fusiform cells variably arranged in irregular bundles and scattered whorls. Fusiform cells strongly reacted to antibodies against vimentin, S100, and neuron-specific enolase; glial fibrillary acidic protein was moderately and multifocally expressed. Pancytokeratin, KIT, α–smooth muscle actin, and desmin were nonreactive. Histologic and immunohistochemical findings suggested a diagnosis of gastric sarcoma with features referable to a non-GIST (gastrointestinal stromal tumor), non–smooth muscle NIMT (non-angiogenic, non-lymphogenic intestinal mesenchymal tumor). The overlying gastric mucosa was thickened by elongated and dilated gastric glands, predominantly lined by intensely periodic acid-Schiff–stained mucous cells. This altered mucosal architecture was suggestive of Ménétrier-like disease. Although this disease has been hypothesized to predispose to gastric adenocarcinoma in dogs, an association with gastric sarcoma has not been documented previously in the veterinary literature, to our knowledge.

Two updates on adenocarcinoma of gastroesophageal junction from the fifth WHO classification of tumors of the digestive system: alteration of gastroesophageal junction definition and the emphasis on HER2 test.

2020 ◽  
Author(s):  
Yunzhu Li ◽  
Jiayu Li ◽  
Manji Li
Keyword(s):  
Gastric Adenocarcinoma ◽  
Who Classification ◽  
Gastroesophageal Junction ◽  
Clinicopathological Features ◽  
Gastric Body ◽  
Clinicopathological Parameters ◽  
Her2 Expression ◽  
Fourth Edition ◽  
Gastric Tumors

Abstract Background: The incidence of gastroesophageal junction (GEJ) adenocarcinoma has increased rapidly but remains controversial over the last decades. There are two crucial updates of the fifth WHO classification including the alteration of GEJ location and the emphasize on human epidermal growth factor receptor 2 (HER2) test.Methods: We retrospectively analyzed the clinicopathological features of 566 patients suffered from gastric adenocarcinoma. We comprehensively compared the clinicopathological features among GEJ and non-GEJ tumors, GEJ and proximal and distal gastric tumors with fourth and fifth edition, respectively. Besides, we discussed the correlation of the HER2 expression with clinicopathological features according to the fifth WHO classification.Results: The results showed that the difference was mainly between GEJ and distal adenocarcinoma in the fourth edition, but some were between proximal and distal adenocarcinoma in the fifth edition. Tumors with longer invasion of the oesophagus were still mainly concentrated in GEJ tumors. The expression of HER2 in GEJ and proximal gastric adenocarcinoma was still higher than that in gastric body and distal site, which was basically consistent with the conclusion of the fourth edition classification.Conclusions: The clinicopathological parameters of the GEJ tumors partly changed with the narrowing scope of the GEJ adenocarcinoma. The proximal gastric tumors rather than GEJ tumors tended to be more invasive. But the GEJ tumors with longer oesophageal invasion required additional management. The HER2-expression of GEJ adenocarcinoma is still higher than that of other gastric sites. The classification of the fifth edition is reasonable and worthy of recommendation.

scholarly journals Hypertrophic gastropathy with gastric adenocarcinoma: Menetrier's disease and lymphocytic gastritis?

Gut ◽  
1991 ◽  
Vol 32 (12) ◽  
pp. 1565-1567 ◽  
Author(s):  
J F Mosnier ◽  
J F Flejou ◽  
G Amouyal ◽  
B Gayet ◽  
G Molas ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Lymphocytic Gastritis ◽  
Menetrier’S Disease ◽  
Ménétrier's Disease ◽  
Hypertrophic Gastropathy ◽  
Menetrier's Disease

scholarly journals Ovariohysterectomy and Partial Vaginectomy for Treatment of Cervicovaginitis in a Dog

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Christian A. Folk ◽  
Cassie N. Lux ◽  
Whitney DeGroot
Keyword(s):  
Postoperative Complications ◽  
Surgical Resection ◽  
Vaginal Discharge ◽  
Clinical Signs ◽  
Labrador Retriever ◽  
Intact Female ◽  
Abdominal Ultrasonography ◽  
Disease Condition

A 1-year-old sexually intact female Labrador Retriever was evaluated for malodorous vaginal discharge, lethargy, and vomiting. A diagnosis of pyometra was suspected based on signalment, clinical signs, and abdominal ultrasonography. The dog underwent an exploratory celiotomy revealing a palpably enlarged cervix and edematous, fluid-filled vagina with an otherwise normal uterus. The ovaries, uterus, cervix, and cranial vagina were surgically resected. Histopathology revealed mild to moderate regionally extensive subacute neutrophilic cervicovaginitis due to an unknown underlying etiology. The dog did not exhibit any postoperative complications or recurrence of clinical signs in 6 months. This case represents an unusual disease condition, which presented in a manner typical for pyometra, yet required more extensive surgical resection.

scholarly journals Differential Cellular Expression of Galectin Family mRNAs in the Epithelial Cells of the Mouse Digestive Tract

2005 ◽  
Vol 53 (11) ◽  
pp. 1323-1334 ◽  
Author(s):  
Junko Nio ◽  
Yasuhiro Kon ◽  
Toshihiko Iwanaga
Keyword(s):  
Small Intestine ◽  
Digestive Tract ◽  
Large Intestine ◽  
Mucous Cells ◽  
Cell Stage ◽  
Gastric Glands ◽  
Specific Expression ◽  
Cellular Expression ◽  
Galectin 3

Galectin is an animal lectin that recognizes β-galactosides of glycoconjugates and is abundant in the gut. This study revealed the cellular expression of galectin subtypes throughout the mouse digestive tract by in situ hybridization. Signals for five subtypes (galectin-2, -3, -4/6, and -7) were detected exclusively in the epithelia. In the glandular stomach, galectin-2 and -4/6 were predominantly expressed from gastric pits to neck of gastric glands, where mucous cells were the main cellular sources. The small intestine exhibited intense, maturation-associated expressions of galectin-2, -3, and -4/6 mRNAs. Galectin-2 was intensely expressed from crypts to the base of villi, whereas transcripts of galectin-3 gathered at villous tips. Signals for galectin-4/6 were most intense at the lower half of villi. Galectin-2 was also expressed in goblet cells of the small intestine but not in those of the large intestine. In the large intestine, galectin-4/6 predominated, and the upper half of crypts simultaneously contained transcripts of galectin-3. Stratified epithelium from the lip to forestomach and anus intensely expressed galectin-7 with weak expressions of galectin-3. Because galectins in the digestive tract may be multi-functional, information on their cell/stage-specific expression contributes to a better understanding of the functions and pathological involvements of galectins.

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