scholarly journals The Periodic Table needs negative orbitals in order to eliminate quantum weirdness: a new quantum chemistry mathematics

2020 ◽  
Vol 17 ◽  
pp. 88-125
Author(s):  
Jeffrey H. Boyd

A consensus among quantum experts is that the quantum world is not properly understood. It is a mistake to think we can cure quantum weirdness by tinkering with superficial aspects of quantum mechanics (QM). We propose that nature uses  (–ψ) as its wave function, whereas QM uses (+ψ). We propose therefore that the Periodical Table should be changed to negative orbitals (–ψ). Surprisingly, this change makes almost no difference to chemistry on a practical level. The Born rule takes the absolute square of an amplitude to obtain a probability to test in chemistry lab P=|–ψ|2=|+ψ|2. We propose a new math based on (–ψ) that is the mirror image of quantum mathematics. We call it the Theory of Elementary Waves (TEW). The negative sign is not an electrical charge. It has nothing to do with Coulomb’s law. Valence electrons are unchanged. Ions, covalent bonds, dipoles, metals, hydrogen bonding and the hydrogen 21 cm line are unchanged. The octet rule and rules for drawing dot structures of molecules do not change. Amino acids, sugars and DNA do not change their handedness. We cite abundant experimental evidence showing that TEW is correct and QM is wrong.

2017 ◽  
Vol 26 (03) ◽  
pp. 1730008 ◽  
Author(s):  
Stephen D. H. Hsu

We explain the measure problem (cf. origin of the Born probability rule) in no-collapse quantum mechanics. Everett defined maverick branches of the state vector as those on which the usual Born probability rule fails to hold — these branches exhibit highly improbable behaviors, including possibly the breakdown of decoherence or even the absence of an emergent semi-classical reality. Derivations of the Born rule which originate in decision theory or subjective probability (i.e. the reasoning of individual observers) do not resolve this problem, because they are circular: they assume, a priori, that the observer occupies a non-maverick branch. An ab initio probability measure is sometimes assumed to explain why we do not occupy a maverick branch. This measure is constrained by, e.g. Gleason’s theorem or envariance to be the usual Hilbert measure. However, this ab initio measure ultimately governs the allocation of a self or a consciousness to a particular branch of the wave function, and hence invokes primitives which lie beyond the Everett wave function and beyond what we usually think of as physics. The significance of this leap has been largely overlooked, but requires serious scrutiny.


2021 ◽  
Author(s):  
Irina Gaivoronskaya ◽  
Valenitna Kolpakova

The aim of the work was to optimize the process of obtaining multicomponent protein compositions with high biological value and higher functional properties than the original vegetable protein products. Was realized studies to obtain biocomposites on the base of pea protein-oat protein and pea protein-rice protein. Developed composites were enriched with all limited amino acids. For each of the essential amino acids, the amino acid score was 100% and higher. Protein products used in these compositions are not in major allergen list, which allows to use these compositions in allergen-free products and specialized nutrition. To determine biosynthesis parameters for compositions from pea protein and various protein concentrates with the use of transglutaminase enzyme, was studied effect of concentration and exposition time on the amount of amino nitrogen released during the reaction. Decreasing of amino nitrogen in the medium indicated the occurrence of a protein synthesis reaction with the formation of new covalent bonds. Were determined optimal parameters of reaction: the hydromodule, the exposure time, the concentration of EP of the preparation, were obtained mathematical models. Studies on the functional properties of composites, the physicochemical properties of the proteins that make up their composition, and structural features will make it possible to determine the uses in the manufacture of food products based on their ability to bind fat, water, form foam, gels, and etc.


2019 ◽  
Author(s):  
Miloje M. Rakočević

Searching for the answer to the question why – in the generating of the genetic code – only mirror symmetrical left and not right amino acids (AAs) were selected, in a previous work we showed the existence of a double Boolean "triangle" in mirror symmetry, with superposition of the top vertices: 00 -11-22 / 22-11-00 → 00-11-22-11-00 [0 as 000; 1 as 001; 2 as 010] (Rakočević, 2019a). The resulting sequence, summed with the binary sequence of a 6-bit binary tree, split with a mirror in the middle (101/010) [as in Dirac's positron / electron mirror], results in a sequence of decimal number system: 02-13-24-16-05, where a smaller number (010 = 2) was added three times and a larger number (101 = 5) twice (Survey 1). The mirror image of the obtained decimal sequence (20-31-42-61-50) is 100% consistent with the arrangement of protein AAs, arranged according to strict chemical similarity (Rakočević, 2019a, Table 3). Starting from this result, the paper of which this is a supplement, presents new insights and new examples of mirror symmetry valid for the genetic code, showing that mirror symmetry is also in other respects an essential feature of the genetic code. In this Supplement are given the further new insights.


Author(s):  
Graham Patrick

‘The fundamentals’ investigates why the element carbon is so suited for the generation of so many compounds. Carbon has atomic number six, meaning it has six protons in its nucleus and six electrons around the nucleus, four of which are valence electrons held in the outer shell. Carbon achieves a stable, full outer shell of electrons by sharing electrons with other elements and other carbon atoms to form covalent bonds. The carbon–carbon bonds are one of the principle reasons why so many organic molecules are possible, including linear chains, branched chains, and rings. The naming of compounds and identification of structures is also explained along with stereochemistry, functional groups, and intermolecular and intramolecular interactions.


2019 ◽  
Vol 26 (5) ◽  
pp. 645-651.e3 ◽  
Author(s):  
Joachim Weidmann ◽  
Martina Schnölzer ◽  
Philip E. Dawson ◽  
Jörg D. Hoheisel

1977 ◽  
Vol 32 (8) ◽  
pp. 829-839 ◽  
Author(s):  
Levente Szasz

Abstract An exact pseudopotential theory is presented for atoms and molecules with arbitrary number of valence and core electrons and arbitrary number of nuclei. Using the variation method an equation is derived for the best many-valence-electron wave function which is orthogonalized to the core orbitals. Using this equation the exact equation is derived for the many-valence-electron pseudo-wavefunction which does not have to satisfy any orthogonality conditions. The Hamiltonian of the pseudopotential equation is of surprisingly simple structure and does not depend on the energy and/or on the wave function of the valence electrons. It is shown that the simple model Hamiltonian which is used in many pseudopotential calculations can be derived from the exact equation by two plausible approximations. The theory is elucidated on the example of atoms with two valence electrons.


2018 ◽  
Vol 115 (7) ◽  
pp. 1505-1510 ◽  
Author(s):  
Michael Garton ◽  
Satra Nim ◽  
Tracy A. Stone ◽  
Kyle Ethan Wang ◽  
Charles M. Deber ◽  
...  

Biologics are a rapidly growing class of therapeutics with many advantages over traditional small molecule drugs. A major obstacle to their development is that proteins and peptides are easily destroyed by proteases and, thus, typically have prohibitively short half-lives in human gut, plasma, and cells. One of the most effective ways to prevent degradation is to engineer analogs from dextrorotary (D)-amino acids, with up to 105-fold improvements in potency reported. We here propose a general peptide-engineering platform that overcomes limitations of previous methods. By creating a mirror image of every structure in the Protein Data Bank (PDB), we generate a database of ∼2.8 million D-peptides. To obtain a D-analog of a given peptide, we search the (D)-PDB for similar configurations of its critical—“hotspot”—residues. As a proof of concept, we apply our method to two peptides that are Food and Drug Administration approved as therapeutics for diabetes and osteoporosis, respectively. We obtain D-analogs that activate the GLP1 and PTH1 receptors with the same efficacy as their natural counterparts and show greatly increased half-life.


2021 ◽  
Vol 1 (6) ◽  
Author(s):  
Wardatul Istiqomah ◽  
Sri Rahayu ◽  
M. Muchson

The concept of chemistry must be well understood because the concept of chemistry is hierarchical and sequential. In addition, the concept of chemistry is abstract, which can provoke misconceptions. This study aims to identify misconceptions about the covalent bonding material and to determine the percentage of misconceptions about these materials. The results showed that a misconception was observed in 10 concepts of covalent bonding material with the following percentages: 1) 23 percent of the concepts forming elements of covalent compounds, the covalent compounds must be composed of non-metallic elements with non-metallic elements; 2) 69 percent on the Lewis structure concept, the total number of electrons based on the Lewis structure drawing is the number of valence electrons; 3) 54 percent in the concept of double bonds, the breaking energy of the double bonds is twice that of the energy of the single bonds; 4) 35 percent on the concept of covalent coordination bonds, the covalent coordination bonds are shorter than the covalent bonds; 5) 54 percent on the concept of polar covalent bonds and molecular polarity, the pair of binding electrons is located at the same distance between two bonding atoms; 6) 27 percent in the concept of formal charge, the value of the influences of electronegativity in the determination of the formal charge; 7) on the notion of byte rule and the stability of covalent compounds, 27 percent of the stable Lewis structure does not have a free electron pair (PEB) and respects the byte rule; 62 percent chlorine gas will form the Cl2 molecule because it follows the octet rule; and 54 percent of the covalent bonds store chemical energy; 8) 42 percent on the concept of molecular form, the molecular form of a compound is determined by the repulsion of binding electron pairs; 9) on the concept of intermolecular forces and the properties of covalent compounds, 38 percent of the energy required to boil the table salt is superior because the table salt is an ionic bond; and 81 percent of the strongest interactions are hydrogen bonds; and 10) in the concept of valence bond theory, 23 percent of the most important particles in the formation of covalent bonds are valence electrons; and 27 percent electron sharing means sharing one (1) electron with two atoms, as in the case of sharing an apple for two people. Konsep ilmu kimia perlu dipahami dengan baik, karena konsep ilmu kimia berjenjang dan berurutan. Selain itu, konsep ilmu kimia bersifat abstrak, sehingga dapat menyebabkan miskonsepsi. Penelitian ini bertujuan untuk mengidentifikasi miskonsepsi pada materi ikatan kovalen dan mengetahui persentase miskonsepsi pada materi tersebut. Hasil penelitian menunjukkan bahwa miskonsepsi terjadi pada 10 konsep materi ikatan kovalen dengan persentase sebagai berikut: 1) 23 persen pada konsep unsur-unsur pembentuk senyawa kovalen, senyawa kovalen harus tersusun atas unsur non logam dengan unsur non logam; 2) 69 persen pada konsep struktur Lewis, elektron total berdasarkan gambar struktur Lewis adalah jumlah elektron valensi; 3) 54 persen pada konsep ikatan rangkap, energi pemutusan ikatan rangkap dua kali lipat daripada energi pemutusan ikatan tunggal; 4) 35 persen pada konsep ikatan kovalen koordinasi, ikatan kovalen koordinasi lebih pendek daripada ikatan kovalen; 5) 54 persen pada konsep ikatan kovalen polar dan kepolaran molekul, pasangan elektron ikatan terletak pada jarak yang sama diantara dua atom yang berikatan; 6) 27 persen pada konsep muatan formal, nilai elektronegativitas berpengaruh dalam menentukan muatan formal; 7) pada konsep aturan oktet dan kestabilan senyawa kovalen, 27 persen struktur Lewis yang stabil tidak memiliki Pasangan Elektron Bebas (PEB) dan memenuhi aturan oktet; 62 persen gas klorin akan membentuk molekul Cl2 karena memenuhi aturan oktet; dan 54 persen ikatan kovalen menyimpan energi kimia; 8) 42 persen pada konsep bentuk molekul, bentuk molekul suatu senyawa ditentukan tolakan pasangan elektron ikatan; 9) pada konsep gaya antar molekul dan sifat-sifat senyawa kovalen, 38 persen energi yang dibutuhkan untuk mendidihkan garam dapur lebih besar karena garam dapur merupakan ikatan ionik; dan 81 persen interaksi tarik-menarik yang paling kuat adalah ikatan hidrogen; dan 10) pada konsep teori ikatan valensi, 23 persen partikel paling penting dalam pembentukan ikatan kovalen adalah elektron valensi; dan 27 persen sharing electron berarti pemakaian bersama 1 (satu) elektron oleh dua atom, seperti pada kasus berbagi sebuah apel untuk dua orang.


Blood ◽  
1982 ◽  
Vol 60 (3) ◽  
pp. 558-563
Author(s):  
LA Sherman ◽  
J Lee

Plasma fibronectin (FN) binds fibrin in vitro by both noncovalent and covalent bonds and is decreased in DIC. In rabbits, conventionally purified 125I-FN had a complex blood clearance with a late t1/2 of 71 hr. A large portion was apparently altered, as evinced by rapid clearance and an intravascular/total body ratio (C1) of 0.28–0.51. 3H- labeled FN, made in vivo by injection of 3H amino acids, had a t1/2 of 73 hr. Crosstransfusion of 131I-FN and 3H-FN into a second set of animals gave similar t1/2s and C1s of 0.74–0.82, indicating the altered 125I-FN was biologically screened in the first animals. Other animals were given 125I-fibrinogen and “screened” 131I-FN. Intravenous thrombin (50–60 U/kg/1 hr) caused a 25%-50% decrease in both 125I-fibrinogen and 131I-FN. Ancrod injection reduced fibrinogen by greater than 90% but had no effect on 131I-FN. 131I-FN levels did not change when thrombin was given after ancrod. No cross-linked FN-fibrinogen alpha-chain was found in the plasma, nor was the thrombin-induced fall in FN affected by spermidine blockade. These experiments demonstrate that FN and fibrin bind in vivo during defibrination and are rapidly cleared from the blood. The abnormal fibrin resulting from ancrod either does not bind FN in vivo or does so reversibly.


2017 ◽  
Author(s):  
Po-Yi Huang ◽  
Fanny Wang ◽  
Kamesh Narasimhan ◽  
Kelly Chatman ◽  
John Aach ◽  
...  

To maintain stereospecific biochemistry in cells, living organisms have evolved mechanisms to exclude D-amino acids (DAA) in their protein synthesis machinery, which also limits our exploration of the realm of mirror-image molecules. Here, we show that high affinity between EF-Tu and aminoacyl-tRNA promotes D-amino acid incorporation. More strikingly, Elongation Factor P efficiently resolves peptidyl transferase stalling between two consecutive D-amino acids, and hence enables the translation of D-peptides.


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