scholarly journals Ostropest plamisty (Silybum marianum [L .] Gaertn.) – fitochemia i efekty terapeutyczne

2018 ◽  
Vol 28 (4) ◽  
pp. 15-32
Author(s):  
RENATA NURZYŃSKA-WIERDAK ◽  
JAN DYDUCH ◽  
AGNIESZKA SAWICKA ◽  
HELENA ŁABUDA ◽  
HALINA BUCZKOWSKA
Keyword(s):  
Silybum Marianum ◽  
Rna I

Ostropest plamisty (Silybum marianum (L.) Gaertn.) jest obecnie jednym z ważniejszych gatunków roślin leczniczych uprawianym na plantacjach zielarskich. Surowcem zielarskim ostropestu jest owoc (Silybi mariani fructus) zawierający kompleks flawonolignanów określanych jako sylimaryna. Sylimaryna wykazuje działanie ochronne i regenerujące względem uszkodzonych komórek wątroby. Działanie ochronne sylimaryny wiąże się z jej aktywnością antyoksydacyjną, przeciwzapalną, przeciwwirusową, a także odtruwającą. Związek ten wpływa również na syntezę RNA i DNA. Sylimaryna jest obecnie szeroko stosowana jako środek terapeutyczny w leczeniu wielu ostrych i przewlekłych chorób wątroby. Ostatnie badania dowodzą, że sylimaryna jest skutecznym lekiem przeciwwirusowym w przypadku wirusa zapalenia wątroby typu C (HCV). Wskazywana jest także jako obiecujący środek przeciwnowotworowy, przeciwcukrzycowy i nefroochronny. W lecznictwie i kosmetologii zastosowanie ma także olej z nasion ostropestu, bogaty w cenne kwasy tłuszczowe, fosfolipidy i witaminę E.

Elicitor-enhanced Silymarin production in hairy root cultures of Silybum marianum L. Gaertn

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
T Hasanloo ◽  
H Rahnama ◽  
R Sepehrifar ◽  
MR Shams
Keyword(s):  
Hairy Root ◽  
Hairy Root Cultures ◽  
Root Cultures ◽  
Silybum Marianum

Silymarin from Silybum marianum – new approaches to separation and derivatization

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
D Biedermann ◽  
A Křenková ◽  
K Valentová ◽  
V Křen
Keyword(s):  
Silybum Marianum ◽  
New Approaches

The pathogen of Milk Thistle (Silybum marianum (L.) Gaertn.) in the Czech Republic

2015 ◽  
Vol 5 (1) ◽  
pp. 538-544
Author(s):  
Ivana Safrankova ◽  
Kolackova P ◽  
Rutivckova G
Keyword(s):  
Czech Republic ◽  
Environmental Factors ◽  
Active Compound ◽  
Fungal Species ◽  
Medicinal Herb ◽  
Milk Thistle ◽  
Silybum Marianum ◽  
The Czech Republic

Milk thistle is grown in the Czech Republic as a medicinal herb; silymarin is isolated from its achenes and used for the production of liver and gallbladder medicine. The quality and content of the active compound is influenced not only by environmental factors, but also by pests and pathogens. The occurrence of pests of milk thistle variety Silyb was observed in two localities during the years 2011 2013. In the year 2011 the mycoflora of seeds of four milk thistle varieties was determined. Representatives of 15 species were isolated from the seeds, most of them saprophytic. 21 fungal species were isolated and identified from milk thistle plants during the vegetation; Septoria silybi among the most important ones. Possibilities of protection of milt thistle against pathogens are discussed.

Protective Effect of Silybum marianum and Nigella sativa Oil Extracts against Cisplatin Induced Nephrotoxicity in Mice

2018 ◽  
Vol 18 (2) ◽  
pp. 171-175
Author(s):  
Ashraf A. ◽  
Hassan F. ◽  
Batool S. ◽  
Nadeem M. ◽  
Irshad M. ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Petroleum Ether ◽  
Nigella Sativa ◽  
Histological Study ◽  
The Body ◽  
Cellular Damage ◽  
Elevated Blood ◽  
Silybum Marianum ◽  
Elevated Blood Glucose

The objective of present study was to analyze and compare the nephroprotective effects of petroleum ether extracts of seeds of Nigella sativa and Silybum marianum in Swiss albino mice. Petroleum ether extracts of seeds of Nigella sativa and Silybum marianum were administered (200 mg kg–1) orally for 14 days following one dose of cisplatin injection (16 mg kg–1 i.p.) on 4th day. Cisplatin toxicity was identified in mice by loss of body weight, reduced triglycerides levels, elevated blood glucose, blood urea nitrogen and creatinine levels (P < 0.05). Silybum marianum and Nigella sativa significantly enhanced the body weight (9%) of diabetic rats. Silybum marianum had significantly reduced the elevated blood glucose (–106%), and BUN levels (–9%) as compared to the Nigella sativa administration. Silybum marianum extract also significantly elevated the levels of triglycerides (257%) which were much reduced after the cisplatin injection. Histological study showed that the cisplatin treated group demonstrated the necrosis signs in the glomerulus of Bowman’s capsule, hyalinization and severe cellular damage. The animals administered with extracts showed nearly normal kidney architecture, however, the kidney tissues of Silybum marianum-treated animals showed some improvement with slight signs of cellular damages.

Sign in / Sign up

Export Citation Format

Share Document