Protective Effect of Silybum marianum and Nigella sativa Oil Extracts against Cisplatin Induced Nephrotoxicity in Mice

2018 ◽  
Vol 18 (2) ◽  
pp. 171-175
Author(s):  
Ashraf A. ◽  
Hassan F. ◽  
Batool S. ◽  
Nadeem M. ◽  
Irshad M. ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Petroleum Ether ◽  
Nigella Sativa ◽  
Histological Study ◽  
The Body ◽  
Cellular Damage ◽  
Elevated Blood ◽  
Silybum Marianum ◽  
Elevated Blood Glucose

The objective of present study was to analyze and compare the nephroprotective effects of petroleum ether extracts of seeds of Nigella sativa and Silybum marianum in Swiss albino mice. Petroleum ether extracts of seeds of Nigella sativa and Silybum marianum were administered (200 mg kg–1) orally for 14 days following one dose of cisplatin injection (16 mg kg–1 i.p.) on 4th day. Cisplatin toxicity was identified in mice by loss of body weight, reduced triglycerides levels, elevated blood glucose, blood urea nitrogen and creatinine levels (P < 0.05). Silybum marianum and Nigella sativa significantly enhanced the body weight (9%) of diabetic rats. Silybum marianum had significantly reduced the elevated blood glucose (–106%), and BUN levels (–9%) as compared to the Nigella sativa administration. Silybum marianum extract also significantly elevated the levels of triglycerides (257%) which were much reduced after the cisplatin injection. Histological study showed that the cisplatin treated group demonstrated the necrosis signs in the glomerulus of Bowman’s capsule, hyalinization and severe cellular damage. The animals administered with extracts showed nearly normal kidney architecture, however, the kidney tissues of Silybum marianum-treated animals showed some improvement with slight signs of cellular damages.

scholarly journals Effect Of The Aqueous Extract Of Nigella Sativa Seeds On Blood Serum Glucose, Cholesterol and Total Protein In · Alloxan-Induced Diabetic Rabbits

2003 ◽  
Vol 27 (1) ◽  
pp. 27-40
Author(s):  
Ekklass H. Al-Assede ◽  
Kahtan A. Almzaien
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Total Protein ◽  
Nigella Sativa ◽  
Serum Glucose ◽  
The Body ◽  
Diabetic Group ◽  
Diabetic Rabbits ◽  
Group D

The effect of five weeks oral administration of the aqueous extract of Nigella Sativa Seeds (320 mg/kg body weight) on body weight, blood glucose, cholesterol and total protein (albumin and globulin) concentrations in alloxan induced diabetic rabbits was studied.  Twenty-four mature male rabbits were randomly assigned into three groups of eight each. Diabetes was induced experimentally by intravenous injection of alloxan monohydrate (100 mg/kg body weight) into two groups; diabetic group (D), diabetic group which was orally administrated aqueous extract of Nigella Sativa seeds (DN) while the third group served as control(C).  The results showed that the aqueous extract of Nigella Sativa seeds significantly reduced (P<0.01) the blood glucose and cholesterol concentrations in group (DN) and significantly increased the concentration of total protein (albumin and globulin), also inhibited the body weight reduction as compared with diabetic group (D) and the control (C). These results revealed the capability of the extract of Nigella Sativa seeds to ameliorate the biochemical changes induced by alloxan in diabetic rabbits.

1439-P: Risk of Dementia and Cognitive Dysfunction in Individuals with Diabetes or Elevated Blood Glucose in Four Large Cohorts

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1439-P
Author(s):  
IDA WIUM-ANDERSEN ◽  
RUNGBY JØRGEN ◽  
MARTIN BALSLEV ◽  
JØ RGENSEN ◽  
MERETE OSLER ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cognitive Dysfunction ◽  
Elevated Blood ◽  
Elevated Blood Glucose

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

Multiple metals exposure, elevated blood glucose and dysglycemia among Chinese occupational workers

2017 ◽  
Vol 31 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Aimin Yang ◽  
Simin Liu ◽  
Ning Cheng ◽  
Hongquan Pu ◽  
Min Dai ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Elevated Blood ◽  
Elevated Blood Glucose ◽  
Metals Exposure

scholarly journals Foods for Specialized Health Use (FOSHU) in Treating Postprandial Elevated Blood Glucose Level

2008 ◽  
Vol 5 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Hirotaka HAYASHI ◽  
Satoshi OHNO ◽  
Takanari ARAI ◽  
Masuo NAKAI ◽  
Yoshio KATO ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Elevated Blood ◽  
Elevated Blood Glucose ◽  
Elevated Blood Glucose Level

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

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