scholarly journals Editorial

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Sara Greco ◽  
Katharina Lobinger

The publication of issue 20(2) of SComS marks an important occasion, namely the 20th anniversary of our journal, which was founded at USI – Università della Svizzera italiana twenty years ago, and consequently published its first issue in early 2001. As you might know, SComS was merged with Medienwissenschaft Schweiz (a publication by the SACM – Swiss Association of Communication and Media Research) in 2007, keeping the name Studies in Communication Sciences. Seizing the occasion of this achievement, we would like to share some important information with you. First, speaking about the history of our journal, we remind you that the early issues of SComS and of Medienwissenschaft Schweiz are fully accessible on our website (section “Archives”), thanks to our collaboration with e-periodica. Second, we are happy to announce that SComS now has an online first publishing policy, meaning that articles are quickly made available online. This policy increases the pace and visibility of articles published in SComS, which is a clear advantage for both our authors and readers. Finally, if you wish to receive regular updates on news, thematic sections and articles published, we encourage you to follow SComS on Twitter (@SComS_Journal). Moving on to discuss the contents of SComS 20(2), we are pleased to announce that this issue contains a variety of topics and perspectives in our field. Alongside a General Section and a Thematic Section, it also contains a Community Section, in which we publish a summary of the PhD thesis that has won the SACM Dissertation Award 2020. Finally, this issue includes a Reviews and Reports Section that comprises two book reviews of recent publications in our field and a report on a scientific workshop held in Zurich.

2021 ◽  
Vol 21 (2) ◽  
Author(s):  
Katharina Lobinger ◽  
Jolanta Drzewiecka ◽  
Mike Meißner

We are pleased to announce several innovations at SComS. In July, SComS was added to the Directory of Open Access Journals (DOAJ). This gives our young open access journal more visibility and connects us even better with the growing community dedicated to developing open access journals and making scientific knowledge accessible. In addition, there are technical innovations on the Submission Platform. Authors can now directly enter their ORCID ID as part of the submission process and link their papers to their unique researcher ID. In case you are not familiar with ORCID, you can find more information on https://orcid.org. Let us now turn our attention from future issues to this issue of SComS. It contains four articles in the General Section, a Thematic Section entitled “Critical perspectives on migration in discourse and communication,” and two book reviews in the Reviews and Reports Section. In addition, the Community Section contains the summary of Sina Blassnig’s dissertation, which was awarded the 2021 Dissertation Prize of the Swiss Association of Communication and Media Research (SACM). On a sad occasion, the issue also contains an obituary of the communication and media scientist Michael Schanne.


Author(s):  
L. M. Besov

Presidents of the Academy of Sciences of Ukraine for 100 years of its existence: Scientific and organizational cont ribution to the progress of fundamental science / VN Gamalia, Yu. K. Duplenko, V. I. Onoprienko, S. P. Ruda, V. S. Savchuk; for ed. V.I. Onoprienko; National Academy of Sciences of Ukraine; State Institution "G. M. Dobrov Institute Research of Scientific-Technical Potential and History of Science". - Kyiv: SE "Inf.-analytical Agency ", 2018. - 215 p.


This issue of the history of universities contains, as usual, an interesting mix of learned articles and book reviews covering topics related to the history of higher education. The volume combines original research and reference material. This issue includes articles on the topics of Alard Palenc; Joseph Belcher and Latin at Harvard; Queens College in Massachusetts; and university reform in Europe. The text includes a review essay as well as the usual book reviews.


2003 ◽  
Vol 37 (2) ◽  
pp. 202-205 ◽  
Author(s):  
Patrick G Clay ◽  
Molly M Adams

OBJECTIVE: To report a case of Parkinson-like symptoms appearing in a patient after introduction of ritonavir to buspirone therapy. CASE SUMMARY: A 54-year-old HIV-positive white man presented to the clinic with a 2-week history of ataxia, shuffling gait, cogwheel rigidity, resting tremor, and sad affect with masked features. This patient had been receiving high-dose buspirone (40 mg every morning and 30 mg every evening) for 2 years prior to the introduction of ritonavir/indinavir combination therapy (400 mg/400 mg twice daily) 6 weeks prior to initiation of the above symptoms. Buspirone was decreased to 15 mg 3 times daily, ritonavir/indinavir was discontinued, and amprenavir 1200 mg twice daily was added. The patient's symptoms began to subside after 1 week, with complete resolution after about 2 weeks. The patient continued to receive buspirone for an additional 12 months without recurrence of symptoms. DISCUSSION: This is the first reported interaction of buspirone and antiretrovirals. Buspirone, extensively metabolized by CYP3A4, was likely at supratherapeutic levels due to the inhibitory effect of ritonavir and, secondarily, indinavir. The Parkinson-like symptoms developed rapidly and severely, impacted this patient's quality of life, and necessitated significant clinic expenditures to identify this drug–drug interaction. CONCLUSIONS: This case demonstrates a severe drug–drug interaction between buspirone and ritonavir and further demonstrates the need for awareness of the metabolic profile for all agents an HIV-infected patient is receiving.


2021 ◽  
Vol 7 (15) ◽  
pp. eabf6780
Author(s):  
Corinde E. Wiers ◽  
Leandro F. Vendruscolo ◽  
Jan-Willem van der Veen ◽  
Peter Manza ◽  
Ehsan Shokri-Kojori ◽  
...  

Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.


Author(s):  
S. Sze ◽  
P. Pellicori ◽  
J. Zhang ◽  
J. Weston ◽  
I. B. Squire ◽  
...  

Abstract Background Frailty is common in patients with chronic heart failure (CHF) and is associated with poor outcomes. The natural history of frail patients with CHF is unknown. Methods Frailty was assessed using the clinical frailty scale (CFS) in 467 consecutive patients with CHF (67% male, median age 76 years, median NT-proBNP 1156 ng/L) attending a routine follow-up visit. Those with CFS > 4 were classified as frail. We investigated the relation between frailty and treatments, hospitalisation and death in patients with CHF. Results 206 patients (44%) were frail. Of 291 patients with HF with reduced ejection fraction (HeFREF), those who were frail (N = 117; 40%) were less likely to receive optimal treatment, with many not receiving a renin–angiotensin–aldosterone system inhibitor (frail: 25% vs. non-frail: 4%), a beta-blocker (16% vs. 8%) or a mineralocorticoid receptor antagonist (50% vs 41%). By 1 year, there were 56 deaths and 322 hospitalisations, of which 25 (45%) and 198 (61%), respectively, were due to non-cardiovascular (non-CV) causes. Most deaths (N = 46, 82%) and hospitalisations (N = 215, 67%) occurred in frail patients. Amongst frail patients, 43% of deaths and 64% of hospitalisations were for non-CV causes; 58% of cardiovascular (CV) deaths were due to advancing HF. Among non-frail patients, 50% of deaths and 57% of hospitalisations were for non-CV causes; all CV deaths were due to advancing HF. Conclusion Frailty in patients with HeFREF is associated with sub-optimal medical treatment. Frail patients are more likely to die or be admitted to hospital, but whether frail or not, many events are non-CV. Graphical abstract


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S681-S681
Author(s):  
Brian R Lee ◽  
Jason Newland ◽  
Jennifer Goldman

Abstract Background Studies have shown that over half of hospitalized children receive an antibiotic during their encounter, of which between 30-50% is considered inappropriate. Antibiotic prescribing is further complicated as approximately 10% of children are labeled beta-lactam allergic, resulting in the use of either broad-spectrum or suboptimal therapy. The purpose of this study was to compare antibiotic prescribing between patients with a documented ADR vs. those without using a nationwide sample of hospitalized children. Methods We performed a point prevalence study among 32 hospitals between July 2016-December 2017 where data were collected via chart review on pediatric patient and antimicrobial characteristics, including the indication for all antimicrobials. In additional, ADR history data were collected on which antimicrobial(s) were documented (e.g., penicillin, cephalosporins). Patients were mutually assigned into either: 1) no documented ADR; 2) penicillin ADR-only; 3) cephalosporin ADR-only; and 4) ADR for both penicillin and cephalosporin. The distribution of antibiotics were compared between the ADR groups, stratified by the indication for treatment. Results A total of 12,250 pediatric patients (17,929 antibiotic orders) who were actively receiving antibiotics were identified. A history of penicillin and cephalosporin ADR was documented in 5.5% and 2.8% of these patients, respectively. When compared to patients with no documented ADR, penicillin ADR patients were more likely to receive a fluoroquinolone for a SSTI infection (odds ratio [OR]: 5.6), surgical prophylaxis (OR: 18.8) or for surgical treatment (OR: 5.2) (see Figure). Conversely, penicillin ADR patients were less likely to receive first-line agents, such as narrow-spectrum penicillin for bacterial LRTI (OR: 0.08) and piperacillin/tazobactam for GI infections (OR: 0.22). Cephalosporin ADR patients exhibited similar patterns with increased use of carbapenems and fluoroquinolones when compared to patients with no ADR. Figure 1: Odds of Receiving Select Antimicrobials Among PCN ADR Patients When Compared to Non-ADR patients, by Indication Conclusion A large, nationwide sample of pediatric patients who were actively prescribed antibiotics helped identify several diagnoses where comprehensive guidelines for appropriate ADR prescribing and increased ADR de-labeling initiatives are needed to ensure optimal treatment. Disclosures Brian R. Lee, MPH, PhD, Merck (Grant/Research Support) Jason Newland, MD, MEd, FPIDS, Merck (Grant/Research Support)Pfizer (Other Financial or Material Support, Industry funded clinical trial)


2020 ◽  
Vol 42 (7-8) ◽  
pp. 1210-1225 ◽  
Author(s):  
Hendrik Storstein Spilker ◽  
Terje Colbjørnsen

Based on research on the development of streaming solutions across media forms and industries, this article traces the dynamics and dimensions of the notion of streaming. It theorizes streaming as an evolving concept, and argues against strict, set and limited definitions such as those suggested by Lotz and Herbert et al. A short substantive and industrial history of streaming is provided, recognizing its many manifestations and variations. Five key dimensions are identified, and trends and traits within each of them discussed: (1) professional versus user-generated streaming, (2) legal versus piracy streaming, (3) on-demand versus live streaming, (4) streaming on dedicated versus multi-feature platforms, and (5) niche versus general-audience streaming. The article concludes by pointing out how streaming is a concept that metaphorically unites media research across industries, practices, and media forms, encouraging more comparative research.


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