scholarly journals CLEANING THE BRAIN THROUGH TURBULENT GLYMPHATIC FLOW: THE WASHING MACHINE HYPOTHESIS

Lymphology ◽  
2022 ◽  
Vol 54 (3) ◽  
Author(s):  
P.H. Kuo
Keyword(s):  
Fluid Dynamics ◽  
Alzheimer Disease ◽  
Turbulent Flow ◽  
Brain Atrophy ◽  
Thought Experiment ◽  
Washing Machine ◽  
Machine Model ◽  
The Brain

LYMPHSPIRATION: In a thought experiment, a "washing machine" model is proposed based on turbulent flow from complex multi-dimensional forces to characterize fluid dynamics in the brain. The glymphatic system's hypothetical role in this system is illustrated in a series of diagrams. Implications of this model are discussed in terms of normal physiology and a variety of pathologic conditions such as brain atrophy and Alzheimer disease.

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain’s pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain’s disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

scholarly journals The Microbiota–Gut–Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells

2021 ◽  
Vol 10 (11) ◽  
pp. 2358
Author(s):  
Maria Grazia Giovannini ◽  
Daniele Lana ◽  
Chiara Traini ◽  
Maria Giuliana Vannucchi
Keyword(s):  
Alzheimer Disease ◽  
Glial Cells ◽  
Cell Types ◽  
The Past ◽  
The Central Nervous System ◽  
Diseased State ◽  
The Brain ◽  
Alzheimer Disease Pathogenesis ◽  
Brain Homeostasis

The microbiota–gut system can be thought of as a single unit that interacts with the brain via the “two-way” microbiota–gut–brain axis. Through this axis, a constant interplay mediated by the several products originating from the microbiota guarantees the physiological development and shaping of the gut and the brain. In the present review will be described the modalities through which the microbiota and gut control each other, and the main microbiota products conditioning both local and brain homeostasis. Much evidence has accumulated over the past decade in favor of a significant association between dysbiosis, neuroinflammation and neurodegeneration. Presently, the pathogenetic mechanisms triggered by molecules produced by the altered microbiota, also responsible for the onset and evolution of Alzheimer disease, will be described. Our attention will be focused on the role of astrocytes and microglia. Numerous studies have progressively demonstrated how these glial cells are important to ensure an adequate environment for neuronal activity in healthy conditions. Furthermore, it is becoming evident how both cell types can mediate the onset of neuroinflammation and lead to neurodegeneration when subjected to pathological stimuli. Based on this information, the role of the major microbiota products in shifting the activation profiles of astrocytes and microglia from a healthy to a diseased state will be discussed, focusing on Alzheimer disease pathogenesis.

scholarly journals Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. e1002266 ◽  
Author(s):  
Stuart G. Snowden ◽  
Amera A. Ebshiana ◽  
Abdul Hye ◽  
Yang An ◽  
Olga Pletnikova ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Alzheimer Disease ◽  
Cognitive Performance ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
The Brain ◽  
Metabolomic Study

scholarly journals Clearance systems in the brain—implications for Alzheimer disease

2015 ◽  
Vol 11 (8) ◽  
pp. 457-470 ◽  
Author(s):  
Jenna M. Tarasoff-Conway ◽  
Roxana O. Carare ◽  
Ricardo S. Osorio ◽  
Lidia Glodzik ◽  
Tracy Butler ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
The Brain

Computational Fluid Dynamics Techniques for Flows in Lapple Cyclone Separator

2005 ◽  
Vol 498-499 ◽  
pp. 179-185
Author(s):  
A.F. Lacerda ◽  
Luiz Gustavo Martins Vieira ◽  
A.M. Nascimento ◽  
S.D. Nascimento ◽  
João Jorge Ribeiro Damasceno ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Experimental Data ◽  
Computational Fluid Dynamics ◽  
Turbulent Flow ◽  
Reynolds Stress ◽  
Cyclone Separator ◽  
Two Dimensional ◽  
Stress Components ◽  
Computational Fluid Dynamics Cfd

A two-dimensional fluidynamics model for turbulent flow of gas in cyclones is used to evaluate the importance of the anisotropic of the Reynolds stress components. This study presents consisted in to simulate through computational fluid dynamics (CFD) package the operation of the Lapple cyclone. Yields of velocity obtained starting from a model anisotropic of the Reynolds stress are compared with experimental data of the literature, as form of validating the results obtained through the use of the Computational fluid dynamics (Fluent). The experimental data of the axial and swirl velocities validate numeric results obtained by the model.

Novel Multi-Linear Quantitative Brain Volume Formula For Manual Radiological Evaluation Of Brain Atrophy

2020 ◽  
Author(s):  
Richard Erasto Sungura ◽  
Emmanuel Abraham Mpolya ◽  
JM Spitsbergen ◽  
Callen Kwamboka Onyambu ◽  
Elingarami Sauli ◽  
...  
Keyword(s):  
Brain Atrophy ◽  
Quantitative Methods ◽  
Brain Volume ◽  
Northern Tanzania ◽  
Alternative Formula ◽  
Evans Index ◽  
Radiological Measurements ◽  
Technical Simplicity ◽  
Radiological Methods ◽  
The Brain

Abstract Background The brain is a dynamic organ that develops and involutes in volume. The process of volume loss known as brain atrophy commonly occurs in elderly. However, some conditions have been implicated to provoke this paradoxical process in childhood and making it important to have methods and techniques of quantifying brain volume. Automated quantitative methods are very important in brain atrophy assessment but these tools have limited availability in developing countries. The simplified linear radiological methods are poorly reproducible and hence there is a need to develop an alternative formula that is reproducible and applicable at all healthcare levels. Methods The multi-linear diagonal brain fraction formula (DBF) was designed from dimensions of brain relative to skull. To test a developed formula, a total of 347 subjects aged between 0 and 18 years who had brain CT scans performed at the health facilities in Northern Tanzania were recruited and subjected to a systematic measurement of their brains in a diagonal brain fashion. Results Out of 347 patients evaluated, 62 subjects (17.8%) were found to be cases of brain atrophy. The three radiological measurements which included sulcal width (SW), ventricular width (VW) and Evans Index (EI) were concurrently performed. SW and VW showed good age correlation while EI showed no significant correlation with age. Similar tests were extended to diagonal brain fraction (DBF) and skull vertical horizontal ratio (VHR) in which DBF showed significant correlation. Conclusions The DBF formula shows significant ability of differentiating changes of brain volume suggesting that it can be utilized as an alternative brain fraction quantification method bearing technical simplicity in assessing gross brain volume with the ability to classify degrees of brain atrophy into mild, moderate, severe and very severe stages.

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