scholarly journals Ultrasound assisted synthesis and pharmacological evaluation of some (E)-1,2,3-triphenylprop-2-en-1-ones

2020 ◽  
Vol 31 (2) ◽  
pp. 152-157
Author(s):  
Veerendiran Mala ◽  
Inbasekaran Muthuvel ◽  
Ganesamoorthy Thirunarayanan ◽  
Saravanan Palavanivel Sakthinathan ◽  
Ranganathan Arulkumaran ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
Diffusion Method ◽  
Hydrogen Phosphate ◽  
Disodium Hydrogen Phosphate ◽  
Disc Diffusion Method ◽  
Antibacterial And Antifungal Activities ◽  
Ultrasound Assisted ◽  
Data Yield ◽  
Antibacterial And Antifungal ◽  
Micro Analysis

Abstract More than 85% yield of (E)-1,2,3-triphenylprop-2-en-1-ones were synthesized using disodium hydrogen phosphate (Na2HPO4) catalyzed ultrasound assisted aldol condensation of 1,2-diphenylethanone and various substituted benzaldehydes. Synthesized (E)-1,2,3-triphenylprop-2-en-1-ones were examined by their spectroscopic data, yield, micro analysis and physical constants. The effect of solvent on the yield was investigated. The pharmacological effects such as antibacterial and antifungal activities of synthesized enones were evaluated with Bauer-Kirby disc diffusion method.

scholarly journals Manumycin-type Derivatives from a Streptomyces sp. Associated with Meson Bee Osmia cornifrons

2018 ◽  
Vol 13 (6) ◽  
pp. 1934578X1801300
Author(s):  
Zhe Wang ◽  
Ai-Hong Peng ◽  
Dan-Dan Lu ◽  
Ya-Jie Song ◽  
Cheng-Lei Wang ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
2D Nmr ◽  
Diffusion Method ◽  
Minimal Bactericidal Concentration ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Streptomyces Sp ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Mic Minimum Inhibitory Concentration

Two new manumycin-type derivatives named as cornifronin A and cornifronin B, and one known analogue antibiotic SW-B were isolated from the liquid fermentation of Streptomyces sp. OC1401 obtained from body surface of a meson bee Osmia cornifrons. The structures of all isolates were identified by spectroscopic methods (HRESIMS, IR, 1D and 2D NMR) and comparison with literature data. The antibacterial and antifungal activities of these manumycin-type derivatives were evaluated by disc diffusion method and more accurate data on the antibacterial activity were obtained through the MIC (Minimum Inhibitory Concentration) and MBC (Minimal bactericidal concentration) values.

scholarly journals Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes

2019 ◽  
Vol 16 ◽  
pp. 6313-6324
Author(s):  
Hanaa A. El-Boraey ◽  
Aballah El-domiaty
Keyword(s):  
Metal Complexes ◽  
Spectroscopic Characterization ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Magnetic Studies ◽  
Antibacterial And Antifungal Activities ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Four novel Mn(II), Co(II), Cu(II) complexes with nitrogen containing ligand (L) i.e. N,N-((Z)-ethane-1,2-diylidine)bis(2-amino benzo hydrazide) have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), molar conductance and magnetic susceptibility measurements. From the spectroscopic and magnetic studies it has been concluded that all complexes have a six coordinated octahedral geometry. The Schiff base and their metal complexes have also been screened for their antibacterial and antifungal activities by using a modified Kirby-Bauer disc diffusion method.

scholarly journals Chemical composition, antibacterial and antifungal activity of the essential oils of Cotinus coggygria from Serbia

2007 ◽  
Vol 72 (11) ◽  
pp. 1045-1051 ◽  
Author(s):  
Miroslav Novakovic ◽  
Ivan Vuckovic ◽  
Pedja Janackovic ◽  
Marina Sokovic ◽  
Anka Filipovic ◽  
...  
Keyword(s):  
Essential Oils ◽  
Diffusion Method ◽  
Disc Diffusion Method ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Microdilution Method ◽  
Antifungal Potential ◽  
Antibacterial And Antifungal ◽  
Cotinus Coggygria ◽  
Commercial Fungicide

Essential oils from leaves with young branches of Cotinus coggygria Scop. from two localities in Serbia (Deliblatska pescara and Zemun), obtained by hydrodistillation, were analyzed by GC-MS. Thirty-one component were identified from both oils and among them monoterpenic hydrocarbons were the dominant class (87.4 and 93.1 %). The dominant constituent in both essential oils was limonene (47.0 and 39.2 %). Both oils were also tested for antibacterial and antifungal activities. In comparison to streptomycin, both oils showed slightly higher activity (against most Gram-positive bacteria) in the disc diffusion method and slightly lower activity when the microdilution method was employed. They also exhibited antifungal potential higher than that of the commercial fungicide bifonazole.

scholarly journals GC-MS Analysis and Antimicrobial Activity of Essential Oil of Stachys Cretica Subsp. Smyrnaea

2009 ◽  
Vol 4 (1) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Mehmet Öztürk ◽  
Mehmet Emin Duru ◽  
Fatma Aydoğrmuş-Öztürk ◽  
Mansur Harmandar ◽  
Melda Mahlıçlı ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Diffusion Method ◽  
Disc Diffusion Method ◽  
Antibacterial And Antifungal Activities ◽  
Aerial Parts ◽  
Germacrene D ◽  
Total Oil ◽  
Antibacterial And Antifungal ◽  
Standard Disc

The essential oil from the aerial parts of Stachys cretica L. subsp. smyrnaea Rech. fil. (Lamiaceae), endemic to Turkey, was investigated by using GC and GC-MS. Thirty-four of 37 components, represented 99.7% of the total oil, were identified. The major components of the essential oil were trans-β-caryophyllene (51.0%), germacrene-D (32.8%), α-humulene (3.1%), δ-cadinene (2.1%) and δ-elemene (2.1%). The antimicrobial activity of the essential oil, trans-β-caryophyllene and five different extracts of the aerial parts of S. cretica L. subsp. smyrnaea were investigated by the standard disc diffusion method. The essential oil and trans-β-caryophyllene exhibited antibacterial and antifungal activities. The activity increased with increasing concentrations of the essential oil and the extracts. The essential oil showed antimicrobial activity, particularly against Pseudomonas aeruginosa and Bacillus subtilis. The extracts exhibited either moderate or no activity.

scholarly journals Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tanveer MahamadAlli Shaikh ◽  
Habtamu Debebe
Keyword(s):  
Antimicrobial Activities ◽  
New Drugs ◽  
Diffusion Method ◽  
Indole Derivatives ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Standard Drug ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential Oil of Saccocalyx satureioides Coss. et Dur

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Hocine Laouer ◽  
Salah Akkal ◽  
Claire Debarnot ◽  
Bruno Canard ◽  
Uwe J. Meierhenrich ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Hepatitis C ◽  
Chemical Composition ◽  
Essential Oil ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

The chemical composition of the essential oil of Saccocalyx satureioides Coss. et Dur. (Lamiaceae) was analyzed by chiral and achiral GC/MS and 42 components were identified. The main constituents were (+)-α-terpineol (35.9%), thymol (15.6%) and borneol (12.4%). The in vitro antibacterial and antifungal activities of the essential oil were assessed by the disc diffusion method, and were significant on the six microorganisms tested. A moderate inhibitory activity against hepatitis C virus polymerase was also evidenced.

Synthesis of a Series of Novel 2-Amino-5-Substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Antibacterial Agents

2021 ◽  
Vol 17 ◽  
Author(s):  
Em Canh Pham ◽  
Tuyen Ngoc Truong ◽  
Nguyen Hanh Dong ◽  
Duy Duc Vo ◽  
Tuoi Thi Hong Do
Keyword(s):  
Cell Line ◽  
Biological Activities ◽  
Chemical Properties ◽  
Diffusion Method ◽  
Anticancer Activities ◽  
Molecular Docking Study ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Thiadiazole Derivatives ◽  
Antibacterial And Antifungal

Background: Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. Objective: The objective of the present study was the desire to prepare the 5-substituted 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole derivatives and evaluate their potential anticancer, antibacterial and antifungal activities. Methods: Twenty-seven derivatives were synthesized by iodine-mediated cyclization of semicarbazones or thiosemicarbazones obtained from condensation of semicarbazide or thiosemicarbazide and aldehydes. The structures were confirmed by 1H-NMR, 13C-NMR and MS spectra. The antibacterial and antifungal activities were evaluated by diffusion method and the anticancer activities were evaluated by MTT assay. Results: Twenty-seven derivatives have been synthesized in moderate to good yields. A number of derivatives exhibited potential antibacterial, antifungal and anticancer activities. Conclusion: Compounds (1b, 1e and 1g) showed antibacterial activity against Streptococcus faecalis, MSSA and MRSA with MIC ranging between 4 to 64 µg/mL. Compound (2g) showed antifungal activity against Candida albicans (8 µg/mL) and Aspergillus niger (64 µg/mL). Compound (1o) exhibited high cytotoxic activity against HepG2 cell line (IC50 value 8.6 µM), which is comparable to the activity of paclitaxel, and is non-toxic on LLC-PK1 normal cell line. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.

scholarly journals Phytochemical investigation and in vitro antimicrobial activity of Richardia scabra

2016 ◽  
Vol 11 (2) ◽  
pp. 248 ◽  
Author(s):  
Kathirvel Poonkodi ◽  
Subban Ravi
Keyword(s):  
Antimicrobial Activity ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Weed Species ◽  
Antibacterial And Antifungal Activities ◽  
Agar Plug ◽  
Phytochemical Investigation ◽  
Antibacterial And Antifungal ◽  
Simple Sugar

<p class="Abstract">The present study was aimed to evaluate the phytochemical screening and antimicrobial activity of the petroleum ether and methanol extracts from the mature leaves of <em>Richardia scabra</em> from India. Disc diffusion method was used to determine the zone inhibition of the tested samples for antibacterial and agar plug method was used to determine the antifungal activity, while the microtube-dilution technique was used to determine the minimum inhibitory concentration. Both extracts showed significant antibacterial and antifungal activities when tested against 10 bacterial and four fungal strains. The minimum inhibitory concentrations of the methanol extract of<em> R. scabra</em> ranged between 12.5–100 μg/mL for bacterial strains. Alkaloids, steroids, flavonoids, fatty acids, terpenoids and simple sugar were detected as phytoconstituents of extracts. To the best of our knowledge, this is the first report against antimicrobial activity of common weed species <em>R. scabra</em> found in India.</p><p> </p>

scholarly journals Studies on Antibacterial and Antifungal Activities and Minimum Inhibitory Concentrations of Mixed Ligand Transition Metal Complexes of Dibasic Acids as Primary and Heterocyclic Bases as Secondary Ligands

1970 ◽  
Vol 46 (3) ◽  
pp. 365-368 ◽  
Author(s):  
MA Akbor ◽  
MS Islam ◽  
N Akhter ◽  
S Ahmed ◽  
S Siraj
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Diffusion Method ◽  
Antifungal Activities ◽  
Minimum Inhibitory Concentrations ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Mixed ligand (diphenic/ adipic as primary Ligand and quinoline / 8 - hydroxyquinoline as secondary) transition metal complexes of Cobalt (II), Cupper (II), Rhodium (III) and Platinum (IV) ions were synthesized and characterized. Their antibacterial activities against ten bacteria had been evaluated by the disc diffusion method,whilst their antifungal activities against two fungi had been also evaluated by the same method. Minimum inhibitory concentrations (MIC) had been evaluated against six bacteria. The MIC of the complexes against Shigella dysenteriae, Samonella typhi, Streptococcus-β-haemolyticus and Bacillus megaterium were 32 μg/ml; whilst Escherichia coli and Samonella typhi-A the MIC of Co (II) and Pt (IV) were 32μg/ml and those of Cu(II) and Rh(III) complexes were 64 μg/ml. It was found that Cobalt (II), Cupper (II) & Rhodium (III) complexes had pronounced antibacterial and antifungal activities. Platinum (IV) complex had moderate antibacterial and antifungal activity. These values indicate that these are active compounds. Key words: Mixed Ligand; Transition metal; Antimicrobial Activity; Antifungal Activity Minimum Inhibitory Concentrations (MIC) DOI: http://dx.doi.org/10.3329/bjsir.v46i3.9044 BJSIR 2011; 46(3): 365-368

scholarly journals Synthesis, Characterization, and Biological Studies of Binuclear Copper(II) Complexes of (2E)-2-(2-Hydroxy-3-Methoxybenzylidene)-4N-Substituted Hydrazinecarbothioamides

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
P. Murali Krishna ◽  
B. S. Shankara ◽  
N. Shashidhar Reddy
Keyword(s):  
Spectroscopic Characterization ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Moderate Activity ◽  
Binuclear Copper ◽  
Antibacterial And Antifungal Activities ◽  
Agar Disc ◽  
Biological Studies ◽  
Antibacterial And Antifungal ◽  
Ct Dna

Four novel binuclear copper(II) complexes [1–4] of (2E)-2-(2-hydroxy-3-methoxybenzylidene)-4N-substituted hydrazinecarbothioamides, (OH)(OCH3)C6H4CH=NNHC(S)NHR, where R = H (L1), Me (L2), Et (L3), or Ph (L4), have been synthesized and characterized. The FT-IR spectral data suggested the attachment of copper(II) ion to ligand moiety through the azomethine nitrogen, thioketonic sulphur, and phenolic-O. The spectroscopic characterization indicates the dissociation of dimeric complex into mononuclear [Cu(L)Cl] units in polar solvents like DMSO, where L is monoanionic thiosemicarbazone. The DNA binding properties of the complexes with calf thymus (CT) DNA were studied by spectroscopic titration. The complexes show binding affinity to CT DNA with binding constant (Kb) values in the order of 106 M−1. The ligands and their metal complexes were tested for antibacterial and antifungal activities by agar disc diffusion method. Except for complex 4, all complexes showed considerable activity almost equal to the activity of ciprofloxacin. These complexes did not show any effect on Gram-negative bacteria, whereas they showed moderate activity for Gram-positive strains.

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