Investigation of excipients influence on rheological behaviour of hydrogels with dimethindene maleate and dexpanthenol: conditions of controlled shear rate

Abstract Every year, the number of cases of hypersensitivity to insect bites increases. Thus, particular attention needs to be paid to the treatment of insect allergy in children, as scratching the bites can complicate the healing process and lead to infection. Therefore, a topical issue for modern medicine and pharmacy is the development of a gel of combined anti-allergic, reparative and anti-inflammatory action for the treatment of local manifestations of allergic skin reactions. Rheological studies are one of the stages of pharmaceutical development of soft dosage forms. In this study, we perform rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol made on different carriers of dispersed structures: Carbopol™ Polymers carbomer Ultrez 10 NF, Hydroxypropyl methylcellulose (HPMC) of brand Metolose SR-90SH-100000SR, Ziboxan F200 xanthan gum. The rheological studies were undertaken using a rheometer in controlled shear rate mode CSR. Basic structural and mechanical indices of the dispersed systems were determined. These included: yield stress, structural viscosity, viscosity at infinite shear rate, the hysteresis loop area. Moreover, dynamic liquefaction coefficients have been calculated. Based on the rheological studies of hydrogels containing 0.1% dimethindene maleate and 3.0% dexpanthenol prepared with various carriers, the use of 1.8% and 2.0% HPMC hydrogels, 2.0% and 2.5% xanthan gum hydrogels, 0.5% and 0.75% carbomer gels is recommended for further biopharmaceutical studies. The application of one of these formulations as the final composition, provides adhesion and will not complicate the scaling-up of the process.

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Treatment Peculiarity of the Chronic Trophic Ulcers with Different Pathogenic Mechanism

Acta Balneologica ◽

10.36740/abal202001102 ◽

2020 ◽

Vol 62 (1) ◽

pp. 12-16

Author(s):

Oksana K. Melekhovets ◽

Tetyana O. Kharchenko ◽

Victor F. Orlovskiy ◽

Iuirii V. Melekhovets ◽

Alevtina S. Radko ◽

...

Keyword(s):

Photodynamic Therapy ◽

Healing Process ◽

Modern Medicine ◽

Lower Limbs ◽

Chronic Venous Disease ◽

Venous Disease ◽

Second Stage ◽

Group 2

Introduction: Trophic ulcers of the lower extremities are an unresolved problem of modern medicine. The treatment of this pathology requires new methods that optimize care regimens and improve patients’ quality of life. Aim: The study to improve efficacy of treatment of the patients with trophic ulcers of the lower limbs with consideration to pathogenesis. M aterials and Methods: The study included 32 patients with chronic venous disease C6 (1st group) and 31 with diabetes mellitus type 2, moderate severity, compensation stage with diabetic foot syndrome II stage according to Wagner’s classification (2nd group). In addition to basic therapy in both groups photodynamic therapy was added at the first stage of the study, and at the second stage plasma rich in growth factors was prescribed. Results: At baseline evaluating of the chronic venous disease demonstrates that a total score in patient of the 1st group was 20,9 points on a modified VCSS scale; after two weeks – 15,71 points (improvement by 24.83%), and 6 weeks after–9,72 points (improvement by 53.49%). In patients with DM (2nd group) at the baseline a total score average was 13,91 points according to S(AD)SAD-1 scale; after 2 weeks – 12,29 (improvement by 11,65%), after 6 weeks – 6,39 points (improvement by 54,06%). Conclusions: The inclusion of photodynamic therapy and plasmatherapy in complex therapy in both groups led to a significant improvement of the healing process and helps to reduce the depth and area of the wound surface. However, the wound healing in patients in group 2 was slower.

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DESIGN AND EVALUATION OF INTRAGASTRIC BUOYANT TABLETS OF VENLAFAXINE HYDROCHLORIDE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.16948 ◽

2017 ◽

Vol 10 (5) ◽

pp. 166

Author(s):

Parasuram Rajam Radhika ◽

Nishala N ◽

Kiruthika M ◽

Sree Iswarya S

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Xanthan Gum ◽

Hydroxypropyl Methylcellulose ◽

Methyl Cellulose ◽

In Vitro Drug Release ◽

Weight Variation ◽

Floating Drug Delivery ◽

Venlafaxine Hydrochloride

Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate theintragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulationswere formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration ofdrug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent.Methods: The tablets were prepared by direct compression and evaluated for tablet thickness, weight variation, tablet hardness, friability, in vitrobuoyancy test, in vitro drug release and Fourier transform infrared spectroscopy. Formulations were evaluated by floating time, floating lag time and in vitro drug release. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of drug.Results: It was found that drug release depends on swelling, erosion, and diffusion, thus following the non-Fickian/anomalous type of diffusion.Formulation F8 was considered as an optimized formulation for gastro retentive floating tablet of venlafaxine hydrochloride. The optimizedformulation showed sustained drug release and remained buoyant on the surface of the medium for more than 12 hrs. As the concentration of HPMCK100M increases in the formulation the drug release rate was found to be decreased. The optimized formulation was subjected for the stability studiesand was found to be stable as no significant change was observed in various evaluated parameters of the formulation.Conclusion: It can be concluded that floating drug delivery system of venlafaxine hydrochloride can be successfully formulated as an approach toincrease gastric residence time, thereby improving its bioavailability.Keywords: Venlafaxine hydrochloride, Intragastric buoyant, Floating drug delivery systems, Hydroxypropyl methyl cellulose K100M, Carbopol 934 P,Xanthan gum.

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IgE Levels and Allergic Skin Reactions in Cancer and Non-cancer Patients

International Archives of Allergy and Immunology ◽

10.1159/000230505 ◽

1971 ◽

Vol 41 (1) ◽

pp. 141-143 ◽

Cited By ~ 18

Author(s):

R. Augustin ◽

K.D. Chandradasa

Keyword(s):

Cancer Patients ◽

Skin Reactions ◽

Allergic Skin

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Allergic Skin Reactions to Anticonvulsant Medications in Patients Receiving Cranial Radiation Therapy

Epilepsia ◽

10.1111/j.1528-1157.1999.tb00715.x ◽

1999 ◽

Vol 40 (3) ◽

pp. 341-344 ◽

Cited By ~ 50

Author(s):

Harvey J. Mamon ◽

Patrick Y. Wen ◽

Anne C. Burns ◽

Jay S. Loeffler

Keyword(s):

Radiation Therapy ◽

Skin Reactions ◽

Cranial Radiation ◽

Allergic Skin

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Effects of pH and Electrolytes on Castor Oil Emulsions with Various Stabilisers Using Khaya senegalensis Gum as an Emulsifier

Advances in Pharmacological and Pharmaceutical Sciences ◽

10.1155/2021/7049332 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Deryl Nii Okantey Kuevi ◽

Noble Kuntworbe ◽

Enoch Ayertey

Keyword(s):

Castor Oil ◽

Xanthan Gum ◽

Hydroxypropyl Methylcellulose ◽

Physical Stability ◽

Tween 80 ◽

Volume Data ◽

Emulsifying Property ◽

Khaya Senegalensis ◽

Effects Of Ph ◽

The Stability

Dispersed systems such as emulsions are easily destabilised during processing and storage since they are thermodynamically unstable systems. It is for this reason emulsifiers/stabilisers are frequently employed in pharmaceutical emulsion formulations to increase their short- and long-term kinetic stability. This current study seeks to investigate the potential emulsifying property of gums obtained from Khaya senegalensis (family: Meliaceae) trees. Gums were collected, authenticated, oven-dried, milled, filtered, and purified using 96% ethanol. The microbial quality of the gum was assessed following the BP (2013) specifications. The purified gum was free from some selected pathogenic microorganisms, rendering the gum safe for consumption. The emulsifying property was investigated by formulating emulsions using castor oil and employing the dry gum method. The ratios of oil-to-water-to-gum for the formulation of a stable emulsion were determined. The stability of the emulsion was evaluated, and an effort was made to improve the stability by incorporating Tween 80, hydroxypropyl methylcellulose, and xanthan gum. From the results, it can be inferred that Tween 80 (0.5%) was able to stabilise the emulsion. Addition of xanthan gum worsened the creaming. The effects of pH (4.0, 5.5, 7.2, 9.0, and 11.0) and electrolytes (0.1 M of NaCl, KCl, and CaCl2) on the physical stability of oil-in-water emulsions were studied during 12 weeks of storage. Percentage creaming volume and whether there was phase inversion were the criteria used as the evaluation parameter. From the percentage creaming volume data, emulsions formulated with both gums showed the lowest creaming volumes at pH of 7.2, followed by the acidic regions (pH 4.0, 5.5), with the basic regions (pH 9.0, 11.0) recording the highest creaming volumes. The effects of the various electrolytes at a constant concentration of 0.1 M on the o/w emulsions were found in this order NaCl < KCl < CaCl2. This study proves that Khaya senegalensis gum can successfully be employed as an emulsifying agent in pharmaceutical formulations.

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Dynamics of the Activity of MAP-Kinase Cascades in the Healing Process of Postoperative Musculocutaneous Wounds

Acta biomedica scientifica ◽

10.29413/abs.2019-4.5.9 ◽

2019 ◽

Vol 4 (5) ◽

pp. 55-59

Author(s):

I. A. Shurygina ◽

V. A. Umanets ◽

M. G. Shurygin

Keyword(s):

Map Kinase ◽

Healing Process ◽

Traumatic Injury ◽

Repair Process ◽

Modern Medicine ◽

Peak Activity ◽

Specific Staining ◽

Mapk Cascades ◽

Reparative Process ◽

The Impact

Background. Management of the reparative process is an urgent task of modern medicine. In our opinion, the development of pathogenetically grounded approaches to optimizing the repair process for managing the interrelations of stromal cells is promising. One of the promising areas in this regard is the impact on the MAPK-cascades.Aim: to study the expression of MAP-kinase mechanisms in the regulation of repair by the example of a musculocutaneous wound.Methods. A linear muscular skin wound was modeled using Wistar rats weighing 220–250 g at the age of 9 months (n = 24). Immunofluorescence staining was performed to detect the activity of p38, JNK, and ERK MAPK cascades from 1 to 30 days.Results. It was established that specific staining in the area of connective tissue formation during staining with p38 MAPK and its phosphorylated form was first observed on the 3rd day, and its maximum severity occurred at the same time. On the 7th and 14th day, small zones in the area of scar formation were minimally stained. The phosphorylated part of the JNK-cascade in the zone of traumatic injury was detected starting from the 1st day after the injury. Bright color persisted on the 3rd day. On the 7th day, the color was minimal, and by the 14th day a second wave of expression was observed. ERK-staining was observed from the 1st to the 14th day with a peak activity on the 3rd day.Conclusion. Thus, we revealed the simultaneous involvement of p38, JNK-, and ERK-cascades in the regulation of the reparative process in the conditions of a musculoskeletal wound. At the same time, it is noteworthy that the peak activity of all cascades coincides and falls on the 3rd day.

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Influence of shear rate and concentration ratio on viscous synergism. Application to xanthan—Iocust bean gum— NaCMC mixtures Influencia de la velocidad de cizalla y la relación de concentraciones en la sinergia viscosa. Aplicación a mezclas de xantana-garrofín-CMCNa

Food Science and Technology International ◽

10.1177/108201320000600508 ◽

2000 ◽

Vol 6 (5) ◽

pp. 415-423 ◽

Cited By ~ 8

Author(s):

J. Pellicer ◽

J. Delegido ◽

J. Dolz ◽

M. Dolz ◽

M.J. Hernández ◽

...

Keyword(s):

Shear Rate ◽

Concentration Ratio ◽

Xanthan Gum ◽

Empirical Approach ◽

Exponential Dependence ◽

Locust Bean Gum ◽

Synergistic Interactions ◽

Fixed Proportion ◽

Locust Bean ◽

Definition Of

A method is described that allows the development of an empirical approach to quantify synergistic interactions and their variations with shear rate. The approach is based on the definition of a viscous synergism index, Iv. The method is applied to xanthan-locust bean gum gels, and an equation is developed for relating the synergism index to shear rate, γ, and the locust bean gum/xanthan gum concentration ratio, z. The value of at which that function has a maximum, IMV, is calculated. This value of z provided an estimation of the proportion of gums at which maximum synergism occurs. A decreasing exponential dependence of these IMV on γ is shown. The influence of the addition of a fixed proportion of a third gum (NaCMC) is also analyzed. The results obtained for the higher γ values are analogous to those of other authors.

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LINAGLIPTIN AND GLICLAZIDE DI-LOADED EXTENDED-RELEASE NANOPARTICLES: FORMULATION AND EVALUATION

Wiadomości Lekarskie ◽

10.36740/wlek202109212 ◽

2021 ◽

Vol 74 (9) ◽

pp. 2315-2322

Author(s):

Firas Aziz Rahi ◽

Muath Sheet Mohammed Ameen ◽

Mohammed Shamil Fayyadh

Keyword(s):

Particle Size ◽

Xanthan Gum ◽

Extended Release ◽

Hydroxypropyl Methylcellulose ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Hplc Method ◽

Electronic Microscopy ◽

Vitro Release

The aim: This work aimed to formulate gliclazide and linagliptin extended-release nanoparticles. Materials and methods: A HPLC method was developed and validated to determine gliclazide and linagliptin at the same time without interference. The nanoparticles were prepared by emulsion solvent evaporation using two polymers, namely hydroxypropyl methylcellulose (HPMC) 4000 cps and xanthan gum. Results: Nanoparticles prepared were characterized for drug contents, production yield and entrapment efficiency, zeta potential, particle size, morphology by transmission electronic microscopy (TEM) and in-vitro release rate. The formulae GLH1, GLX1 and GHX1 showed release of linagliptin more than 75% after 8 hrs. While the only formula among the three (GHX1) showed release of gliclazide more than 80% after 8 h. So, the formula GHX1 showed acceptable release of more than 80% of both gliclazide and linagliptin after 8 h. Conclusions: The formula GHX1 which containing (0.5:1 xanthan gum: drugs) was the best nanoparticles formula which released more than 80% of both drugs after 8 h and could achieve good extended release over 24 h.

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