scholarly journals Alpha Lipoic Acid Influence in the Attenuation of Oxidative Stress and of Clinical Manifestations of Neuropathy in Diabetes Mellitus Patients

2018 ◽  
Vol 15 (4) ◽  
pp. 15-26
Author(s):  
Bondar Andrei Cristian ◽  
Popa Amorin Remus
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Healthy Subjects ◽  
Microvascular Complications ◽  
Clinical Manifestations ◽  
Clinical Aspects ◽  
Alpha Lipoic Acid ◽  
Perception Threshold

AbstractAlpha lipoic acid is an antioxidant substance used for the pathogenic treatment of diabetic neuropathy, oxidative stress being a central mechanism in diabetic microvascular complications. Our study included 24 diabetes mellitus patients with diabetic neuropathy and 20 healthy subjects. Diabetes patients were given alpha lipoic acid 600 mg intravenously for 10 days and then per os for 30 days.Significant improvements were observed concerning oxidative stress evaluated by measuring serum malondyaldehide and ceruloplasmin. The clinical characteristic of neuropathy improved, both the level of pain decreased and the vibration perception threshold increased. Our study demonstrated a two times higher level of oxidative stress in patients with diabetes compared to healthy subjects, and that by influencing oxidative stress we could influence the clinical aspects of neuropathy. Further investigations need to be done to explore the pleiotropic effects of alpha lipoic acid on other mechanisms that are implicated in the pathogenies of diabetic neuropathy.

Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis

Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 101-110 ◽  
Author(s):  
Nasrin Sadeghiyan Galeshkalami ◽  
Mohammad Abdollahi ◽  
Rezvan Najafi ◽  
Maryam Baeeri ◽  
Akram Jamshidzade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Coenzyme Q10 ◽  
Alpha Lipoic Acid ◽  
Experimental Diabetic Neuropathy

Changes of oxidative stress markers after treatment of diabetic neuropathy with alpha-lipoic acid

2018 ◽  
Vol 275 ◽  
pp. e204-e205
Author(s):  
F.S. Ferenc sztanek ◽  
Hajnalka Lorincz ◽  
Dora Banyai ◽  
Petra Sandor ◽  
Agnes Molnar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Víctor Manuel Mendoza-Núñez ◽  
Beatriz Isabel García-Martínez ◽  
Juana Rosado-Pérez ◽  
Edelmiro Santiago-Osorio ◽  
José Pedraza-Chaverri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Older Adults ◽  
Lipoic Acid ◽  
Glycosylated Hemoglobin ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Alpha Lipoic Acid ◽  
Markers Of Inflammation

Alpha-lipoic acid (ALA) has been used as a dietary supplement at different doses in patients with diabetes mellitus type 2 (T2DM) due to its antioxidant, anti-inflammatory, and hypoglycemic effects. However, the reports on the effects of ALA are controversial. For this reason, the purpose of the present study was to determine the effect of 600 mg/day of ALA on the markers of oxidative stress (OxS) and inflammation and RAGE in older adults with T2DM. A quasiexperimental study was carried out with a sample of 135 sedentary subjects (98 women and 37 men) with a mean age of64±1years, who all had T2DM. The sample was divided into three groups: (i) experimental group (EG) with 50 subjects, (ii) placebo group (PG) with 50 subjects, and control group (CG) with 35 subjects. We obtained the following measurements in all subjects (pre- and posttreatment): glycosylated hemoglobin (HbA1c), receptor for advanced glycation end products (RAGE), 8-isoprostane, superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant status (TAS), and inflammatory (CRP, TNF-α, IL-6, IL-8, and IL-10) markers. Regarding the effect of ALA on HbA1c, a decrease was observed in the EG (baseline8.9±0.2vs. posttreatment8.6±0.3) and the PG (baseline8.8±0.2vs. posttreatment8.4±0.3) compared to the CG (baseline8.8±0.3vs. six months9.1±0.3) although the difference was not statistically significant (p<0.05). There was a statistically significant decrease (p<0.05) in the blood concentration of 8-isoprostane in the EG and PG with respect to the CG (EG: baseline100±3vs. posttreatment57±3, PG: baseline106±7vs. posttreatment77±5, and CG: baseline94±10vs. six months107±11pg/mL). Likewise, a statistically significant decrease (p<0.05) in the concentration of the RAGE was found in the EG (baseline1636±88vs. posttreatment1144±68) and the PG (baseline1506±97vs. posttreatment1016±82) compared to CG (baseline1407±112vs. six months1506±128). A statistically significant decrease was also observed in all markers of inflammation and in the activity of SOD and GPx in the CG with respect to the EG and PG. Our findings suggest that the administration of ALA at a dose of 600 mg/day for six months has a similar effect to that of placebo on oxidative stress, inflammation, and RAGE in older adults with T2DM. Therefore, higher doses of ALA should be tried to have this effect. This trial is registered with trial registration numberISRCTN13159380.

scholarly journals Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3254
Author(s):  
Triantafyllos Didangelos ◽  
Eleni Karlafti ◽  
Evangelia Kotzakioulafi ◽  
Zisis Kontoninas ◽  
Charalampos Margaritidis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Superoxide Dismutase ◽  
Diabetic Neuropathy ◽  
Vitamin B12 ◽  
Lipoic Acid ◽  
Controlled Study ◽  
Alpha Lipoic Acid ◽  
Double Blind ◽  
Perception Threshold

Aim: To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN). Patients–methods: In this prospective, double-blind, placebo-controlled study, 85 patients with Diabetes Mellitus Type 2 (DMT2) were randomly assigned, either to receive the combination of four elements (active group, n = 43), or placebo (n = 42) for 12 months. We used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measured the vibration perception threshold (BIO), and Cardiovascular Autonomic Reflex Tests (CARTs). Nerve function was assessed by DPN Check [sural nerve conduction velocity (SNCV) and amplitude (SNAP)]. Pain (PS) and quality of life (QL) questionnaires were administered. Results: At follow-up, BIO, MNSIQ, QL, PAIN, and SNCV, SNAP, and B12 levels had significantly improved inactive group (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.027, p = 0.031, and p < 0.001 respectively), whereas the inplacebo group MCR (mean circular resultant) and PAIN deteriorated (p < 0.001, p < 0.001). The changes in MNSIQ, QL, SNCV, BIO, and PAIN differed significantly between groups (p < 0.001, p < 0.001, p = 0.031, p < 0.001, and p < 0.001 respectively). Conclusions: The combination of the four elements in one tablet for 12 months in patients with DMT2 improved all indices of peripheral neuropathy, including SNAP and SNCV, pain, and Quality of Life perception, except CARTs and MNSIE.

scholarly journals Az oxidatív stressz szerepe a diabeteses neuropathia kialakulásában

2016 ◽  
Vol 157 (49) ◽  
pp. 1939-1946 ◽  
Author(s):  
Ferenc Sztanek ◽  
Ágnes Molnárné Molnár ◽  
Zoltán Balogh
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Microvascular Complications ◽  
Advanced Glycation ◽  
Complications Of Diabetes ◽  
Kinase C ◽  
Glycation End Products ◽  
Comparative Trials

Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress. The development of modern medicines to treat diabetic neuropathy needs intensive long-term comparative trials in the future. Orv. Hetil., 2016, 157(49), 1939–1946.

scholarly journals Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110122
Author(s):  
Bíborka Nádró ◽  
Hajnalka Lőrincz ◽  
Ágnes Molnár ◽  
Anita Szentpéteri ◽  
Eszter Zöld ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Sensory Neuropathy ◽  
Significant Negative Correlation ◽  
Alpha Lipoic Acid ◽  
Perception Threshold ◽  
Necrosis Factor Alpha ◽  
Beneficial Effects ◽  
Before And After ◽  
Patients With Diabetes

Objectives Progranulin (PGRN) is a secreted growth factor that helps to regulate neuronal survival by blocking tumor necrosis factor-alpha (TNFα) receptors. The antioxidant alpha-lipoic acid (ALA) is used in diabetic neuropathy to improve nerve conduction and relieve neuropathic pain, but its effects on PGRN levels have not yet been elucidated. Methods In this prospective study, 54 patients with type 2 diabetes and peripheral neuropathy received 600 mg of ALA daily for 6 months. Twenty-four patients with diabetes without neuropathy were also included in the study. Serum PGRN and TNFα levels were determined using enzyme-linked immunosorbent assays. In addition, current perception threshold (CPT) testing was used to assess sensory neuropathy. Results After ALA treatment, serum PGRN levels were significantly increased and CPT values were significantly improved. Furthermore, there were significant positive correlations among TNFα, ICAM-1, and PGRN levels both before and after ALA treatment. A significant negative correlation was observed between the improvements in CPT and the PGRN levels. Furthermore, ICAM-1 levels were an independent predictor of PGRN levels. Conclusions Changes in serum PGRN levels indicate that ALA treatment may have beneficial effects on endothelial function and neuronal inflammation.

scholarly journals Association of Oxidative Stress Markers with Vascular Stiffness Parameters in Patients with Diabetic Neuropathy

BioMed ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 1-12
Author(s):  
Dominika Mačáková ◽  
Markéta Plchová ◽  
Lubica Cibičková ◽  
Ondřej Krystyník ◽  
David Karásek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Vascular Stiffness ◽  
Infusion Therapy ◽  
Control Group ◽  
Alpha Lipoic Acid ◽  
Complications Of Diabetes ◽  
Oxidative Markers ◽  
Wall Stiffness

Introduction: One of the most common chronic complications of diabetes mellitus is diabetic neuropathy. The aim of the study was to elucidate the association between selected markers of oxidative stress and markers of vascular stiffness and to contribute to the understanding of the pathophysiological links between oxidative stress and micro- and macrovascular complications of diabetes. Methods: We enrolled patients with type 2 DM (n = 49), with moderate to severe diabetic polyneuropathy of lower extremities, and a control group without microvascular complications (n = 29). The neuropathy group received alpha-lipoic acid infusion therapy. Sampling was performed before and after treatment to determine the level of oxidative markers (advanced glycation end-products—AGEs, glycation products of AOPP proteins, MDA malondialdehyde and oxidized LDL), parameters of metabolic control and parameters of vascular wall stiffness were measured by sphygmomanometry. Results: After the administration of alpha-lipoic acid, we demonstrated a significant reduction in the level of three selected oxidation markers (AOPP: p < 0.001, AGE: p < 0.001, oxLDL: p < 0.05). In contrast, the level of MDA did not change significantly (p = 0.83). Throughout the group, oxLDL was significantly correlated with central BP (SBP and DBP in the aorta, p < 0.05 and <0.01) and with the augmentation index (AiX/75 bpm, p < 0.01). AOPP significantly correlated with systolic BP in the aorta (p < 0.05). We did not find significant associations in the remaining oxidation markers. Conclusion: In our study, we demonstrated a reduction in the level of oxidative markers after alpha-lipoic acid administration and also an association between markers of oxidative damage to lipids and proteins (oxLDL and AOPP) and some parameters of vascular stiffness.

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