scholarly journals Vitamin D Supplementation Replaced Catheter Ablation in a Patient with Frequent Premature Ventricular Contractions

2021 ◽  
Vol 7 (2) ◽  
pp. 57-61
Author(s):  
Gabriel Cismaru ◽  
Dana Pop ◽  
Dumitru Zdrenghea ◽  
Radu Rosu
Keyword(s):  
Vitamin D ◽  
Catheter Ablation ◽  
Antiarrhythmic Drugs ◽  
Beta Blockers ◽  
Vitamin D Supplementation ◽  
Slight Reduction ◽  
Safe Alternative ◽  
Premature Ventricular Contractions ◽  
Calcium Blockers ◽  
High Burden

Abstract A high premature ventricular contractions (PVC) burden can disturb the patient’s condition through fatigue during exercise or palpitations. Hence, researchers started to look for treatment options that decrease PVC burden without the side effects of antiarrhythmic drugs, and vitamin D could be a valuable solution and safe alternative to drugs or catheter ablation for high-burden PVCs. We present the case of a 24-year-old patient with high-burden PVC of >25,500/24 hours referred for urgent catheter ablation. Treatment with beta-blockers and calcium blockers did not reduce PVC burden. Under propafenone, there was a slight reduction in the number of PVCs to 21,200/24 hours, therefore the patient was referred for catheter ablation. As there was a vitamin D deficiency of 10.1 ng/mL, an attempt of vitamin D supplementation was done, with increase of vitamin D to 32.1 ng/mL and decrease of PVC burden to 9,600/24 hours. Further dietary supplementation increased 25-OH vitamin D to 50.2 ng/mL and decreased the PVC burden to 119/24 hours. Consequently, catheter ablation was canceled, and the patient remained free of antiarrhythmic drugs.

scholarly journals Symptomatic Premature Ventricular Contractions in Vasovagal Syncope Patients: Autonomic Modulation and Catheter Ablation

2021 ◽  
Vol 12 ◽  
Author(s):  
Lihui Zheng ◽  
Wei Sun ◽  
Yu Qiao ◽  
Bingbo Hou ◽  
Jinrui Guo ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Antiarrhythmic Drugs ◽  
Vasovagal Syncope ◽  
Ventricular Outflow Tract ◽  
Vagal Activity ◽  
Autonomic Modulation ◽  
Premature Ventricular Contractions ◽  
Before And After ◽  
The Impact

IntroductionThere has been limited reports about the comorbid premature ventricular contractions (PVCs) and vasovagal syncope (VVS). Deceleration capacity (DC) was demonstrated to be a quantitative evaluation to assess the cardiac vagal activity. This study sought to report the impact of autonomic modulation on symptomatic PVCs in VVS patients.Methods and ResultsTwenty-six VVS patients with symptomatic idiopathic PVCs were consecutively enrolled. Identification and catheter ablation of left atrial ganglionated plexi (GP) and PVCs were performed in 26 and 20 patients, respectively. Holter 24 h-electrocardiograms were performed before and after the procedure to evaluate DC and PVCs occurrence. Eighteen patients were subtyped as DC-dependent PVCs (D-PVCs) and eight as DC-independent PVCs groups (I-PVCs). In D-PVCs group, circadian rhythm of hourly PVCs was positively correlated with hourly DC (P < 0.05) while there was no correlation in I-PVCs group (P > 0.05). Fifty-three GPs with positive vagal response were successfully elicited (2.0 ± 0.8 per patient). PVCs failed to occur spontaneously nor to be induced in six patients. In the remaining 20 patients, PVCs foci identified were all located in the ventricular outflow tract region. Post-ablation DC decreased significantly from baseline (P < 0.05). During mean follow-up of 10.64 ± 6.84 months, syncope recurred in one patient and PVCs recurred in another. PVCs burden of the six patients in whom neither catheter ablation nor antiarrhythmic drugs were applied demonstrated a significant decrease during follow-up (P = 0.037).ConclusionAutonomic activities were involved in the occurrence of symptomatic idiopathic PVCs in some VVS patients. D-PVCs might be facilitated by increased vagal activities. Catheter ablation of GP and PVCs foci may be an effective, safe treatment in patients with concomitant VVS and idiopathic PVCs.

Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: A single-center retrospective study

Heart Rhythm ◽  
2014 ◽  
Vol 11 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Li Zhong ◽  
Ying-Hsiang Lee ◽  
Xin-Miao Huang ◽  
Samuel J. Asirvatham ◽  
Win-Kuang Shen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Catheter Ablation ◽  
Antiarrhythmic Drugs ◽  
Relative Efficacy ◽  
Single Center ◽  
Premature Ventricular Contractions

Effects of Vitamin D and Exercise on the Wellbeing of Older Community-Dwelling Women: A Randomized Controlled Trial

Gerontology ◽  
2015 ◽  
Vol 62 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Radhika Patil ◽  
Saija Karinkanta ◽  
Kari Tokola ◽  
Pekka Kannus ◽  
Harri Sievänen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
Mental Wellbeing ◽  
Slight Reduction ◽  
Group Exercise ◽  
Double Blind ◽  
Vitamin D Levels

Background: Evidence for the effects of exercise and vitamin D supplementation on quality of life (QoL), fear of falling (FoF) and mental wellbeing in older adults is conflicting. Objective: To study the effects of vitamin D supplementation and multimodal group exercise on psychosocial functions of wellbeing, including QoL, mental wellbeing and FoF. Method: This is a 2-year, double-blind, placebo-controlled vitamin D and open exercise intervention trial with 409 older Finnish women (70-80 years of age) randomized to 4 treatment arms: (1) placebo without exercise, (2) vitamin D (800 IU/day) without exercise, (3) placebo and exercise, and (4) vitamin D (800 IU/day) with exercise. Exercisers participated in group exercise twice per week for 12 months and once per week for the subsequent 12 months, plus home exercises. Results: When comparing with the placebo without exercise group, there were no statistically significant differences between groups receiving either vitamin D, exercise or both treatments for changes in QoL or mental wellbeing (although a slight decline was seen in mental wellbeing in those receiving vitamin D only, p = 0.044). The initial slight reduction in FoF was significant in all intervention groups compared with controls (p < 0.05), but this was only temporary. Conclusion: Neither vitamin D nor exercise contributes to better QoL, FoF or mental wellbeing in community-dwelling healthy older women with sufficient vitamin D levels.

scholarly journals Vitamin D Deficiency Manifested by Premature Ventricular Complexes from RVOT: A Report on Two Twins

2021 ◽  
Vol 11 (2) ◽  
pp. 220-223
Author(s):  
Gabriel Cismaru ◽  
Cecilia Lazea ◽  
Daniela Iacob ◽  
Simona Cainap
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Right Ventricular Outflow Tract ◽  
Structural Heart Disease ◽  
Vitamin D Supplementation ◽  
Normal Serum ◽  
The Body ◽  
Premature Ventricular Contractions ◽  
Serum Vitamin D

Vitamin D receptor is present in almost every cell of the body. Although some studies have suggested that values >30ng/ml would be sufficient, there is no consensus on the optimal values of serum vitamin D. Vitamin D deficiency can lead to “benign” manifestations, such as back pain, joint pain, fatigue, and heavy sweating. Premature ventricular contractions (PVCs) originating from the right ventricular outflow tract (RVOT) are considered “benign,” as they occur in patients without structural heart disease and their exact cause remains unknown. We describe the case of a 10-year-old boy with frequent PVCs and vitamin D deficiency that was corrected after vitamin D supplementation. On the contrary, his twin brother had normal serum vitamin D and no PVCs. The disappearance of PVCs occurred after treatment with vitamin D 2000 IU/day.

scholarly journals Are premature ventricular contractions in patients without apparent structural heart disease really safe?

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Charles Jazra ◽  
Oussma Wazni ◽  
Wael Jaroudi
Keyword(s):  
Heart Disease ◽  
Catheter Ablation ◽  
Beta Blockers ◽  
Structural Heart Disease ◽  
Arrhythmogenic Right Ventricular Dysplasia ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Channel Blockers ◽  
Premature Ventricular Contractions ◽  
Lv Dysfunction

<p>Premature ventricular complexes (PVC) are considered benign when they occur in patients without apparent structural heart disease. They usually originate from the right, or less commonly, left ventricular outflow tract. Their suppression was not beneficial in patients with heart disease like myocardial infarction and cardiomyopathies. Recently it has been shown that their suppression medically or by ablation, improved the left ventricular (LV) dysfunction. This led to the hypothesis that they may contribute to this LV dysfunction especially when they are particularly frequent (&gt; 20000 per day). Because of some overlap with arrhythmogenic right ventricular dysplasia, the evaluation in patients without apparent heart disease should consider an magnetic resonance imaging if the echocardiography was not able to help in diagnosis especially when there is a suspicion.</p><p>Patients without structural heart disease and low-to modest PVC burdens do not always require treatment.</p><p>When necessary, treatment for PVCs involves beta-blockers, calcium channel blockers, or other antiarrhythmic</p><p>drugs and catheter ablation in selected cases. Catheter ablation can be curative, but it is typically reserved</p><p>for drug-intolerant or medically refractory patients with a high PVC burden.</p>

scholarly journals Vitamin D as a Substitute of Catheter Ablation in a Paediatric Patient with High Burden Premature Ventricular Contractions: A Case Report

2021 ◽  
Author(s):  
Gabriel Cismaru ◽  
Cecilia Lazea ◽  
Simona Cainap ◽  
Daniela Iacob
Keyword(s):  
Vitamin D ◽  
Catheter Ablation ◽  
Vitamin D Deficiency ◽  
Right Ventricular Outflow Tract ◽  
Dietary Supplementation ◽  
Ventricular Outflow Tract ◽  
Premature Ventricular Contractions ◽  
Holter Ecg ◽  
Cardiology Department ◽  
Coronary Artery Injury

Catheter ablation is established as a treatment option for patients with high number Premature Ventricular Contractions (PVCs). However, complications can occur: cardiac tamponade, coronary artery injury or infectious endocarditis. Reversible causes such as hypocalcaemia, hypomagnesaemia and hypokalemia can be responsible for PVCs. Here, a case of nine years old boy, with vitamin D deficiency that presented high number PVCs which corrected using vitamin D dietary supplementation was described. A nine-year-old boy was hospitalised in the Cardiology Department for catheter ablation of PVCs. He presented short of breath during football matches and asthenia. Electrocardiography(ECG) and Holter ECG demonstrated high number PVCs with a morphology consistent of Right Ventricular Outflow Tract (RVOT) origin. Catheter ablation was postponed until Vitamin D came to normal values. Dietary supplementation was performed, together with Holter ECG monitoring. After vitamin D normalisation, PVC burden reduced significantly without the need of catheter ablation or anti-arrhythmic drugs. Catheter ablation and anti-arrhythmic drugs can be avoided in patients with frequent PVCs and vitamin D deficiency.

Profiling older community-dwellers with hypovitaminosis D: A classification tree analysis

2020 ◽  
Vol 90 (3-4) ◽  
pp. 195-199 ◽  
Author(s):  
Gaelle Chevallereau ◽  
Mathilde Legeay ◽  
Guillaume T. Duval ◽  
Spyridon N. Karras ◽  
Bruno Fantino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Classification Tree ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
Gait Disorders ◽  
Hydroxyvitamin D ◽  
Chaid Analysis ◽  
Clinical Profiles ◽  
Community Dwellers

Abstract. Despite the high prevalence of hypovitaminosis D in older adults, universal vitamin D supplementation is not recommended due to potential risk of intoxication. Our aim here was to determine the clinical profiles of older community-dwellers with hypovitaminosis D. The perspective is to build novel strategies to screen for and supplement those with hypovitaminosis D. A classification tree (CHAID analysis) was performed on multiple datasets standardizedly collected from 1991 older French community-dwelling volunteers ≥ 65 years in 2009–2012. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D ≤ 50 nmol/L. CHAID analysis retained 5 clinical profiles of older community-dwellers with different risks of hypovitaminosis D up to 87.3%, based on various combinations of the following characteristics: polymorbidity, obesity, sadness and gait disorders. For instance, the probability of hypovitaminosis D was 1.42-fold higher [95CI: 1.27–1.59] for those with polymorbidity and gait disorders compared to those with no polymorbidity, no obesity and no sadness. In conclusion, these easily-recordable measures may be used in clinical routine to identify older community-dwellers for whom vitamin D supplementation should be initiated.

No effect of vitamin D supplementation on metabolic parameters but on lipids in patients with type 2 diabetes and chronic kidney disease

2020 ◽  
pp. 1-10
Author(s):  
Jiwoon Kim ◽  
Ji Sun Nam ◽  
Heejung Kim ◽  
Hye Sun Lee ◽  
Jung Eun Lee
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Supplementation ◽  
Lipid Profiles ◽  
Metabolic Parameters ◽  
Injection Group ◽  
Different Doses

Abstract. Background/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n = 33), the oral cholecalciferol 1,000 IU/day group (B, n = 34), or the single 200,000 IU injection group (C, n = 25, equivalent to 2,000 IU/day). 52% of the patients had less than 60 mL/min/1.73m2 of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4 ± 1.2 ng/mL vs. B, 10.7 ± 1.2 ng/mL vs. C, 14.6 ± 1.7 ng/mL; p < 0.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters.

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