Characterization and Physicochemical Evaluation of Molecular Complexes Formed Between Umifenovir and Dicarboxylic Acids

2014 ◽  
Vol 52 (1-2) ◽  
pp. 28-40 ◽  
Author(s):  
A. Kons ◽  
A. Bērziņš ◽  
K. Krūkle-Bērziņa ◽  
A. Actiņš
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Thermal Properties ◽  
Infrared Spectroscopy ◽  
Solid State ◽  
Dicarboxylic Acids ◽  
Molecular Complexes ◽  
Resonance Spectroscopy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Physicochemical Evaluation

Abstract The paper reports the investigation of three umifenovir molecular complexes with dicarboxylic acids, prepared to improve the bioavailability of this drug. All three molecular complexes were investigated by powder X-ray diffraction, infrared spectroscopy, and solid-state nuclear magnetic resonance spectroscopy. The solubility and thermal properties were determined as well. Polymorph and solvate screening of umifenovir molecular complexes were performed by recrystallization from various solvents, as well as neat and solvent-drop grinding

3-[N-(4-Methoxybenzyl)amino]benzo[de]anthracen-7-one

Molbank ◽  
10.3390/m1287 ◽  
2021 ◽  
Vol 2021 (4) ◽  
pp. M1287
Author(s):  
Alise Kirilova ◽  
Aleksandrs Pučkins ◽  
Sergey Belyakov ◽  
Elena Kirilova
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Infrared Spectroscopy ◽  
Resonance Spectroscopy ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
X Ray Diffraction ◽  
X Ray ◽  
Step Procedure ◽  
Ft Ir

Herein, we describe the synthesis of 3-[N-(4-methoxybenzyl)amino]benzo[de]anthracen-7-one via a two-step procedure including 3-aminobenzanthrone condensation with anisaldehyde and following reduction of obtained imine to appropriate amine by sodium borohydride. The structure of the synthesized compounds was established by elemental analysis, nuclear magnetic resonance spectroscopy, mass spectrometry (EI-MS), and infrared spectroscopy (FT-IR) and confirmed by single-crystal X-ray diffraction. The title compound was analyzed by thermal gravimetric analysis, UV/vis, and fluorescence spectroscopy.

Étude structurale d'une imidazolylcétone l'isopropyl-1-phényl-2-diaza-1,3-one-6-bicyclo[3,3,0]octène-2

1990 ◽  
Vol 68 (12) ◽  
pp. 2192-2197
Author(s):  
Jean-Pierre Reboul ◽  
Pierre Brouant ◽  
Jacques Barbe ◽  
Claude Caranoni ◽  
Catherine Soula ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Structure In Solution ◽  
State Configuration

The solid state configuration of 1-isopropyl-2-phenyl-1,3-diaza-6-one-bicyclo[3.3.0]oct-2-ene was determined from X-ray diffraction data (a = 10.039(3) Å; b = 8.683(3) Å; c = 15.505(6) Å; β = 90.72(9)°; P21/c;R = 0.047). This structure is compared to those of three other related (Δ-2)-imidazolines. Molecular structure in solution was investigated by 1H nuclear magnetic resonance spectroscopy. Results clearly indicate that the title compound has the same structure in the solid state as in solution. On the contrary, this configuration differs appreciably from those of other (Δ-2)-imidazolines considered in this report. Keywords: (Δ-2)-imidazolines, crystal structure, NMR, conformations.

scholarly journals The protection of Nifedipin from photodegradation due to complex formation with β-cyclodextrin

2010 ◽  
Vol 8 (4) ◽  
pp. 744-749 ◽  
Author(s):  
Vesna Nikolić ◽  
Dušica Ilić ◽  
Ljubiša Nikolić ◽  
Mihajlo Stanković ◽  
Milorad Cakić ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Differential Scanning Calorimetry ◽  
Infrared Spectroscopy ◽  
Solid State ◽  
Inclusion Complex ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Time Intervals ◽  
X Ray ◽  
Photodegradation Products

AbstractThe inclusion complex β-cyclodextrin:nifedipin was prepared in solid state by coprecipitation with 1:1 mol ratio. The structure of the obtained complex and nifedipin was characterized by use of X-ray diffraction (XR), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and differential scanning calorimetry (DSC) methods. The photodegradation of nifedipin and the β-cyclodextrin:nifedipin inclusion complex in solid state was monitored under natural daylight by infrared spectroscopy, whereby the free nifedipin degraded four to five times faster than the complexed nifedipin. The photodegradation products of both free and complexed nifedipin, formed during irradiation at 350 nm (with corresponding energy flux of 18 W m−2) were monitored by liquid chromatography during various time intervals. The speed of formation of nitroso- and nitro-phenyl derivatives by nifedipin irradiation was significantly higher than those of complexed nifedipin irradiation, which indicates its increased photostability in the inclusion complex. The effect on this property is significant because it contributes both to the improvement of the therapeutic effect of nifedipin and to the safer application thereof.

Synthèse et caractérisation des oxypentafluorouranates(VI) NH4UOF5, KUOF5, RbUOF5 et CsUOF5

1978 ◽  
Vol 56 (14) ◽  
pp. 1874-1880 ◽  
Author(s):  
Philippe Joubert ◽  
Roland Bougon ◽  
Bernard Gaudreau
Keyword(s):  
Infrared Spectroscopy ◽  
Solid State ◽  
Alkali Metal ◽  
Vibrational Spectroscopy ◽  
Uranium Atom ◽  
The Other ◽  
Metal Fluoride ◽  
X Ray Diffraction ◽  
X Ray ◽  
Raman And Infrared Spectroscopy

The oxypentafluorouranates(VI) MUOF5, where M = NH4, K, Rb, Cs, have been synthetized from reaction of UOF4 with the ammonium or corresponding alkali metal fluoride in liquid SO2. According to X-ray diffraction, Raman and infrared spectroscopy, and from an isomorphism with the corresponding hexafluorouranates(V) MUF6, two different environments around the uranium atom are observed. In CsUOF5 the five fluorine atoms and the oxygen around the uranium result in a pseudo-octahedral surrounding whereas for the other complexes (M = NH4, K, Rb) each uranium is surrounded by eight light atoms forming a dodecahedron. In this structure the dodecahedra are linked together by fluorine atoms to form infinite chains. The UOF5− ion has been characterized by vibrational spectroscopy in the solid state. The proposed assignment, which was made with the assumption of a C4v symmetry of the UOF5− ion, was confirmed by a force constant calculation. From these data and contrary to the values reported for comparable oxypentafluoroanions, the axial fluorine is found to be less ionic than the equatorial ones.

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