scholarly journals Xp 11.2 translocation renal carcinoma in young adults; recently classified distinct subtype

2014 ◽  
Vol 48 (2) ◽  
pp. 197-202 ◽  
Author(s):  
Andrej Kmetec ◽  
Jera Jeruc
Keyword(s):  
Young Adults ◽  
Case Report ◽  
Young Adult ◽  
Lymph Nodes ◽  
Renal Carcinoma ◽  
Distant Metastases ◽  
Advanced Stage ◽  
Adult Males ◽  
Slow Growing ◽  
Distinct Subtype

Abstract Background. XP11.2 renal translocation carcinomas are often encountered in paediatric group of patients where they are believed to be rather indolent. They are rare but more aggressive in young adults. They are slow growing, sometimes without characteristic symptoms and their biologic behaviour is uncertain. Case report. We report two cases of this type of tumour in Slovenian young adult males with long and unusual history. Tumours were confirmed imunohistologically by positive reaction for CD10, P504S and TFE3. Conclusions. According to the indications in the literature prognosis of these tumours in young adults depends upon the stage. It seems that cysts, haematomas and necrosis around the kidney are often encountered in these tumours. In advanced stage with lymph nodes involvement or distant metastases, the prognosis is poor. Surgery seems to be basic mode of therapy

scholarly journals Peptic ulcer perforation in young Indians the causation and the trend

2017 ◽  
Vol 5 (1) ◽  
pp. 200
Author(s):  
Geeta Sabhnani ◽  
Akula Nyna Sindhu
Keyword(s):  
Young Adults ◽  
Peptic Ulcer ◽  
Young Adult ◽  
Duodenal Perforation ◽  
Peptic Ulcer Perforation ◽  
Adult Males ◽  
Ulcer Perforation ◽  
Surgical Emergencies ◽  
Causative Factors ◽  
History Of

Background: Peptic ulcer perforation is the commonest surgical emergencies in India. Recent emergency surgical procedures show an increasing trend in peptic ulcer perforation surgery in young adults. This study is carried out with an aim to understand the trend, causation and complications of peptic ulcer perforation in young Indians.Methods: A prospective observational study of young adult Indian patients operated for emergency peptic ulcer perforation for a 3 years period from January 2014 to January 2017 was carried out. The incidence, causative factors and the complications were analyzed.Results: In study of 150 patients, maximum incidence of 42.85% was seen in age group of 21 to 30 years that is young adults. 80% of them were males. 59% patients had blood group O. Association with smoking and alcoholism was seen in about 64% and 66.6% respectively. In about 13.33% there was an association seen with history of NSAID / steroid ingestion / treatment with proton pump inhibitors or H2antagonists.The duodenal perforation was found in 84.66%. In 90% the perforation was less than 1cm.Wound infection was the commonest complication among all patients. Mortality was seen in 3.33%.Conclusions: Peptic ulcer perforation shows increasing incidence in young adult males. The increased incidence shows association to smoking, alcoholism, irregular food habits, use of NSAIDS/steroids and overall stressed lifestyle. 

scholarly journals Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification

2011 ◽  
Vol 164 (6) ◽  
pp. 971-976 ◽  
Author(s):  
Caterina Mian ◽  
Gianmaria Pennelli ◽  
Susi Barollo ◽  
Elisabetta Cavedon ◽  
Davide Nacamulli ◽  
...  
Keyword(s):  
Overall Survival ◽  
Thyroid Carcinoma ◽  
Risk Stratification ◽  
Lymph Nodes ◽  
Distant Metastases ◽  
Advanced Stage ◽  
Primary Cancer ◽  
Ki 67 ◽  
Medullary Thyroid ◽  
Ret Mutation

ObjectiveMedullary thyroid carcinoma (MTC) derives from the parafollicular C cells, being sporadic in 75% of cases and familial in 25%, due to RET proto-oncogene germinal mutations. In sporadic forms, stage at diagnosis is the most important negative prognostic factor. The aim of this study was to evaluate the prognostic impact of molecular and immunohistochemical markers in sporadic MTC.Design and methodsWe studied 60 patients with sporadic MTC. For each case, we sought RET somatic mutations in the primary cancer and in lymph node metastases. The primary cancer also underwent immunohistochemical examination for Ki-67.ResultsA somatic RET mutation was found in 38% of patients, being M918T in 52% of them. We observed a statistically significant association between RET mutations and male gender (P<0.01), tumor size (P<0.05), lymph nodes (P<0.05) and distant metastases (P<0.001), advanced stage (P<0.05), increased risk of persistent disease (P=0.01), and low overall survival (P<0.01). High Ki-67 levels were similarly associated with extra-thyroid spread (P<0.05), lymph nodes (P<0.05) and distant metastases (P<0.001), advanced stage (P=0.01), and low overall survival (P=0.01).Combining somatic RET analysis with Ki-67 assessment seems to be useful for increasing the specificity of Ki-67 assessment alone and identifying patients with a more aggressive cancer: in our series, only the patients who died during the follow-up had both a somatic RET mutation and a Ki-67 expression level >50 cells/mm2.ConclusionsThe combined evaluation of RET and Ki-67 could act as an adjuvant prognostic marker useful for ameliorating the initial risk stratification of patients with sporadic MTC.

scholarly journals Effects of Citrulline Malate Supplementation on Aerobic and Muscular Endurance in Young Adults Men

2021 ◽  
Vol 23 (1) ◽  
pp. 72-78
Author(s):  
Alan Grala ◽  
Éderson Candellório ◽  
Paulo Sperandio ◽  
Emilly Maldonado ◽  
Bruno Dos Anjos ◽  
...  
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Perceived Exertion ◽  
Functional Performance ◽  
Muscular Endurance ◽  
Adult Males ◽  
Maximum Test ◽  
Endurance Tests ◽  
The Mean ◽  
Citrulline Malate

AbstractThe aim of this study was to evaluate the effects of citrulline malate (CIT) supplementation on aerobic and muscular endurance in young adult males. Eighteen young adult men (age: 21.5 ± 2.7 years) were randomized into two groups (Citrulline malate - CIT and Placebo - PLA; N = 9/group ) and received the respective supplements for 7 days. The CIT group was supplemented with 6 g CIT + 6 g dextrose (total: 12 g), while the PLA group received the same amount (12 g) of dextrose. At the pre- and post-supplementation, the following variables were analyzed: aerobic (maximal treadmill test, Tmax) and muscle (repetitions maximum test, Rmax) endurance tests, as well as mean and maximum heart rate (HR) in Tmax and ratings of perceived exertion (PSE) in Rmax. No significant (P > 0.05) differences were found between CIT and PLA groups in time until exhaustion in Tmax, total repetitions in Rmax, maximal HR and PSE from pre- to post-supplementation. The mean HR was statistically lower (P < 0.05) in the CIT group compared to the PLA in the Tmax. In conclusion, supplementation of CIT (6 g / day) does not improve aerobic and muscular endurance, as well as maximal HR or PSE in healthy young adults, despite reducing the mean HR during the maximal incremental test. Keywords: Endurance Training. Dietary Supplements. Physical Functional Performance. Citrulline. Nitric Oxide. ResumoO objetivo deste estudo foi avaliar os efeitos da suplementação de citrulina malato (CIT) sobre a resistência aeróbica e muscular em homens adultos jovens. Em um desenho experimental randomizado, duplo-cego e controlado com placebo, dezoito homens adultos jovens (idade: 21,5 ± 2,7 anos) foram randomizados em dois grupos (Citrulina malato – CIT e Placebo – PLA; N = 9/grupo) e receberam os respectivos suplementos por um período de 7 dias. O grupo CIT foi suplementado com 6 g de CIT + 6 g de dextrose (total: 12 g), enquanto o grupo PLA recebeu a mesma quantidade (12 g) de dextrose. Nos momentos pré e pós suplementação as seguintes variáveis foram analisadas: resistência aeróbia (teste incremental máximo em esteira rolante, Tmáx) e muscular (teste de repetições máximas, Rmáx), bem como a frequência cardíaca (FC) média e máxima no Tmáx e a análise da percepção subjetiva de esforço (PSE) no Rmáx. Nenhuma diferença significante (P > 0,05) foi encontrada entre os grupos CIT e PLA no tempo até a exaustão no Tmáx, total de repetições no Rmáx, FC máxima e PSE do momento pré para o pós suplementação. A FC média foi estatisticamente (P < 0,05) menor no grupo CIT comparado ao PLA no Tmáx. Em conclusão, a suplementação de CIT (6 g/dia) não melhora a resistência aeróbica e muscular, bem como a FC máxima ou PSE em adultos jovens saudáveis, apesar de reduzir a FC média durante o teste incremental máximo. Palavras-chave: Treino Aeróbico. Suplementos Nutricionais. Desempenho Físico Funcional. Citrulina. Óxido Nítrico.

scholarly journals Carcinoid tumour metastasis to the submandibular gland: a case report

2011 ◽  
Vol 93 (6) ◽  
pp. e67-e68 ◽  
Author(s):  
Aakshay Gulati ◽  
Parkash L Ramchandani ◽  
Emma Victoria King
Keyword(s):  
Case Report ◽  
Submandibular Gland ◽  
Rare Case ◽  
Carcinoid Tumour ◽  
Neck Region ◽  
Distant Metastases ◽  
Head And Neck Region ◽  
Tumour Metastasis ◽  
Pulmonary System ◽  
Slow Growing

Carcinoid tumours are slow growing tumours of neuroendocrine origin that primarily affect the gastrointestinal tract and pulmonary system. They can behave aggressively, with regional and distant metastases, although metastases to the head and neck region are uncommon. We present a rare case of carcinoid metastasis to the submandibular gland, which to the best of our knowledge has not been previously reported in the literature.

scholarly journals Occult primary breast cancer presenting with brachial plexopathy: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2098564
Author(s):  
Karen L Zhao ◽  
Yusha Liu ◽  
Kathryn P Scherpelz ◽  
Dennis S Kao ◽  
Jeffrey B Friedrich
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Unusual Case ◽  
Distant Metastases ◽  
Axillary Lymph Nodes ◽  
Brachial Plexopathy ◽  
Axillary Lymph ◽  
Occult Breast Cancer

Breast cancer affects about one in eight women over the course of her lifetime. Occult breast cancer, in which primary breast cancer is detected without evidence of disease in the breast itself, comprises up to 1% of new diagnoses; this is typically detected from abnormal axillary lymph nodes, and distant metastases are rare. Here, we present an unusual case of occult breast cancer presenting as upper extremity pain, edema, and weakness, with a metastatic mass to the brachial plexus being the only site of disease.

scholarly journals INVESTIGATION ON YOUNG ADULT HAND GRIP STRENGTH

2020 ◽  
Vol 20 (Special1) ◽  
pp. 45-50
Author(s):  
Nor Julahah J ◽  
Ummi Noor Nazahiah A ◽  
M. Asyraf CD ◽  
Norashiken O ◽  
Ahmad Faizal Salleh
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Grip Strength ◽  
Hand Grip Strength ◽  
Whole Body ◽  
Sitting Position ◽  
Adult Males ◽  
Hand Grip ◽  
The Difference ◽  
Hand Length

It is believed that exposure to whole-body vibration (WBV) may increase seated occupant drowsiness and seated. The purpose of this paper is to investigate the strength of the hand grip among the young adults in Malaysia. Also, to examine the correlation between anthropometry factors such as hand length (HL), hand breadth (HB), wrist circumference (WC) and body mass index (BMI) with average full hand grip strength of young adults. 40 Malaysian young adults with equal females and males and the range age of 23 to 28 years old voluntarily basis participated in this study. Three experiments were conducted in sitting position according to American Standard Hand Therapist (ASHT) with 45º, 90o and 135o of hand flexion using dynamometer. The results show the significant different full hand grip strength between Malaysian young adult females and females, the difference full hand grip strength for different hand flexion angles in sitting position and difference correlations between anthropometry factors and full hand grip strength for both young adult males and females.

Solitary Bladder Fibrous Tumor: A Case Report

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kessab A ◽  
◽  
EL Bahri A ◽  
Azakhmam M ◽  
Essaoudi MA ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Medical Staff ◽  
Immunohistochemical Study ◽  
Bladder Wall ◽  
Distant Metastases ◽  
Solitary Fibrous Tumors ◽  
Fibrous Tumor ◽  
Slow Growing ◽  
Acute Retention

The solitary fibrous tumor is an infrequent neoplasm of mesenchymal origin, mainly pleural, exceptionally urogenital. Our patient is 71 years old with no specific history who was presented to the emergency room for acute retention of urine relieved by a bladder catheter. An Uroscanner showed a thickening of the bladder wall which prompted the medical staff to perform a RTUV whose histological and immunohistochemical study confirmed the diagnosis of a solitary fibrous tumor of the bladder. Solitary fibrous tumors remain slow-growing neoplasms regardless of their site. The prognosis and aggressiveness are difficult to specify. Recurrences, locoregional extension and distant metastases can be seen in 10 to 20% of cases.

Sexual Dimorphism among the Kathmandu University Students Assessed by Anthropometric Studies

2018 ◽  
Vol 9 (05) ◽  
pp. 20469-20472
Author(s):  
Shakya R ◽  
Bhattacharya SC ◽  
Shrestha R
Keyword(s):  
Young Adults ◽  
Sexual Dimorphism ◽  
Young Adult ◽  
University Students ◽  
Plastic Surgery ◽  
Age Group ◽  
Adult Age ◽  
Clinically Normal ◽  
Crime Detection ◽  
Males And Females

Objectives: To observe the sexual dimorphism among the young adult age group ranging from 18-21 years, of Kathmandu University students by measuring craniofacial circumference and canthal distances. Rationale of the study: These data could be useful for establishing the craniofacial standards and adds an implementation on plastic surgery, crime detection as well as in the industrial field. Method: 300 clinically normal students of Kathmandu University aged between 18-21 years were examined for the study. Fronto-occipital circumference, outer and inner canthal distances were measured. All the parameters were compared between males and females. Result: The cranial circumference as well as the inner and outer canthal distance in males was found to be significantly higher as compared to the females. Conclusion: The results concluded that sexual dimorphism remarkably exists in young adults of Kathmandu University students.

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