scholarly journals Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system

2013 ◽  
Vol 11 (2) ◽  
pp. 180-188 ◽  
Author(s):  
Nataša Pejić ◽  
Nataša Sarap ◽  
Jelena Maksimović ◽  
Slobodan Anić ◽  
Ljiljana Kolar-Anić
Keyword(s):  
Perturbation Technique ◽  
Kinetic Method ◽  
Reaction System ◽  
Direct Determination ◽  
Pharmaceutical Formulations ◽  
Oscillatory Reaction ◽  
Reaction Conditions ◽  
Good Sample ◽  
Pulse Perturbation

AbstractA simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0°C, [H2SO4]0 = 7.60×10−2 mol L−1, [KIO3]0 = 5.90×10−2 mol L−1, [H2O2]0 = 1.50×10−1 mol L−1 and j 0 = 2.95×10−2 min−1), the linear relationship between maximal potential shift ΔE m , and PX concentration was obtained in the concentration range 11.2–480.5 µg mL−1 with a detection limit of 9.9 µg mL−1. The method had a rather good sample throughput of 25 samples h−1 with a precision RSD = 4.7% as well as recoveries RCV ≤ 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.

Kinetic determination of morphine by means of Bray–Liebhafsky oscillatory reaction system using analyte pulse perturbation technique

2007 ◽  
Vol 582 (2) ◽  
pp. 367-374 ◽  
Author(s):  
Nataša D. Pejić ◽  
Slavica M. Blagojević ◽  
Slobodan R. Anić ◽  
Vladana B. Vukojević ◽  
Miroslav D. Mijatović ◽  
...  
Keyword(s):  
Perturbation Technique ◽  
Reaction System ◽  
Oscillatory Reaction ◽  
Kinetic Determination ◽  
Pulse Perturbation ◽  
Analyte Pulse Perturbation Technique

Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system

2005 ◽  
Vol 381 (3) ◽  
pp. 775-780 ◽  
Author(s):  
Nataša Pejić ◽  
Slavica Blagojević ◽  
Slobodan Anić ◽  
Vladana Vukojević ◽  
Ljiljana Kolar-Anić
Keyword(s):  
Reaction System ◽  
Oscillatory Reaction ◽  
Pulse Perturbation

scholarly journals Indirect spectrophotometric determination of gentamicin and vancomycin antibiotics based on their oxidation by potassium permanganate

2006 ◽  
Vol 4 (4) ◽  
pp. 708-722 ◽  
Author(s):  
Akram El-Didamony ◽  
Alaa Amin ◽  
Ahmed Ghoneim ◽  
Ayman Telebany
Keyword(s):  
Acid Medium ◽  
Potassium Permanganate ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Reaction Conditions ◽  
Subsequent Determination ◽  
Optimum Reaction ◽  
Acid Orange Ii ◽  
Sulphuric Acid Medium

AbstractFour simple, accurate, sensitive and economical procedures (A–D) for the estimation of gentamicin sulphate and vancomycin hydrochloride, both in pure form and in pharmaceutical formulations have been developed. The methods are based on the oxidation of the studied drugs by a known excess of potassium permanganate in sulphuric acid medium and subsequent determination of unreacted oxidant by reacting it with amaranth dye (method A), acid orange II (method B), indigocarmine (method C) and methylene blue (method D), in the same acid medium at a suitable λmax=521, 485, 610 and 664 nm, respectively. The reacted oxidant corresponds to the drug content. Regression analysis of Beer-Lambert plots showed good correlations in the concentration ranges 4–8, 3–8, 4–9 and 5–9 µg ml−1 with gentamicin and 4–8, 1.5–4, 1.5–4 and 3.5–5.5 µg ml−1 with vancomycin for methods A, B, C, and D, respectively. The molar absorptivity, sandell sensitivity, detection and quantification limits were calculated. The stoichiometric ratios for the cited drugs were studied. The optimum reaction conditions and other analytical parameters were evaluated. The influence of the substance commonly employed as excipients with these drugs were studied. The proposed methods were applied to the determination of these drugs in pharmaceutical formulations. The results have demonstrated that the methods are equally accurate and reproducible as the official methods.

Detection of L-Tert-Leucine in the Enzyme-Catalyzed Reaction System

2013 ◽  
Vol 641-642 ◽  
pp. 717-720
Author(s):  
Sheng Deng ◽  
Li Cui ◽  
Li Min Ma
Keyword(s):  
Quality Control ◽  
Correlation Coefficient ◽  
Flow Rate ◽  
Catalytic Reaction ◽  
Reaction System ◽  
Direct Determination ◽  
Average Recovery ◽  
Enzyme Catalytic Reaction

Direct Determination of L-Ter-Leucine in Enzyme Catalytic Reaction System by HPLC Was Studied. the Detection Were Performed on a Kromasil 700-5C18 Column Using a Eluant Containing 0.25% (NH4)H2PO4 and 100% Methanol (V((NH4)H2PO4):V(methanol)=100:5) with the Flow Rate of 0.8 Ml/min at,detection Wavelength of 205nm. there Was a Good Line Correlation between Peak Area and Contents in the Rang of 0.2-10 Mg/ml, the Correlation Coefficient Was 0.9986, the Average Recovery Was 98.88% with a Relative Stand Deviation of 0.78% (n=5). this Method Is Simple, Stable, Accurate and Reliable for the Quality Control of L–ter-Leucine.

Spectrophotometric Determination of Ephedrine Hydrochloride and Phenylephrine Hydrochloride

1982 ◽  
Vol 65 (4) ◽  
pp. 894-898
Author(s):  
Mohamed M Amer ◽  
Aly M Taha ◽  
Salwa R El-Shabouri ◽  
Pakinaz Y Khashaba
Keyword(s):  
Pharmaceutical Formulations ◽  
Eye Drops ◽  
Amine Group ◽  
Reaction Conditions ◽  
Phenylephrine Hydrochloride ◽  
Secondary Amine Group ◽  
Ephedrine Hydrochloride ◽  
Colored Product ◽  
The Relationship

Abstract A method is described for quantitative determination of the sympathomimetic amines ephedrine HCl and phenylephrine HCl. The method is based on the interaction of N-alkylvinylamine formed from the condensation of the free secondary amine group and acetaldehyde with chloranil to give a vinylaminosubstituted quinone. The colored product for ephedrine HCl and phenylephrine HCl exhibits 2 maximas at about 320 and 680 nm. All variables were studied to optimize reaction conditions. The relationship between absorbance and concentration was linear within 1-25 μg/mL under the conditions studied for both drugs at both wavelengths. The method has been applied to the analysis of some pharmaceutical formulations including tablets and eye drops with good recoveries (98.75-100.4%).

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