scholarly journals Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

2014 ◽  
Vol 12 (10) ◽  
pp. 1008-1015 ◽  
Author(s):  
Mariana Prodana ◽  
Adriana Voiculet ◽  
Sorina Garea ◽  
Mihaela Radu ◽  
Horia Iovu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Hybrid Material ◽  
Body Fluid ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Transmission Electronmicroscopy

AbstractThis paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.

Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

2020 ◽  
Vol 17 (10) ◽  
pp. 911-924
Author(s):  
Rohitas Deshmukh
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Target Tissue ◽  
Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

Geochemical Characterization of Lapita Pottery Via Inductively Coupled Plasma-mass Spectrometry (ICP-MS)

Archaeometry ◽  
2004 ◽  
Vol 46 (1) ◽  
pp. 35-46 ◽  
Author(s):  
D. J. Kennett ◽  
A. J. Anderson ◽  
M. J. Cruz ◽  
G. R. Clark ◽  
G. R. Summerhayes
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Geochemical Characterization ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Detection of microplastics using inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode

2020 ◽  
Vol 35 (3) ◽  
pp. 455-460 ◽  
Author(s):  
Eduardo Bolea-Fernandez ◽  
Ana Rua-Ibarz ◽  
Milica Velimirovic ◽  
Kristof Tirez ◽  
Frank Vanhaecke
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Single Event ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
First Time

The occurrence of microplastics (MPs) in the environment is a matter of increasing concern. In this work, it has been shown for the first time that ICP-MS operated in single-event mode can be used for the characterization of MPs relying on their C content.

scholarly journals Nanogels as nanocarriers for drug delivery: A review

ADMET & DMPK ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Rahul Rajput ◽  
Jitendra Narkhede ◽  
Jitendra B Naik
Keyword(s):  
Drug Delivery ◽  
Therapeutic Agent ◽  
Three Dimensional ◽  
Therapeutic Agents ◽  
Low Molecular Weight ◽  
Aqueous Dispersions ◽  
Pharmaceutical Agent ◽  
Recent Clinical Trial ◽  
Site Of Action ◽  
Biological Environment

Nanogels are submicron-size aqueous dispersions of water-swollen particles, composed of nano-sized three-dimensional highly cross-linked networks of hydrophilic polymers. An active pharmaceutical agent or therapeutic agent with high or low molecular weight can be easily encapsulated into nanogels that can be delivered to the site of action via various routes, including oral, pulmonary, nasal, parenteral and intraocular routes, among others. Therapeutic agents encapsulated into nanogels improve the therapeutic activity in the biological environment. The application of different nanogels in drug delivery and recent clinical trial studies has been described concisely in this review.

scholarly journals The Vesuvianite Gems of the Val d’Ala (Piedmont, Italy)

Minerals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 535
Author(s):  
Franca Piera Caucia ◽  
Luigi Marinoni ◽  
Maurizio Scacchetti ◽  
Maria Pia Riccardi ◽  
Omar Bartoli
Keyword(s):  
Inductively Coupled Plasma ◽  
Major Elements ◽  
Western Alps ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Gran Paradiso ◽  
Dark Green ◽  
Ree Patterns

In Val d’Ala (Western Alps in Piedmont, Italy), the most interesting rocks for mineralogical research are represented by rodingite (rich in mineralized veins and fractures) associated with serpentinite in the eclogitized oceanic crust of Piedmont Zone, south of Gran Paradiso Massif. Among the vein-filling minerals, vesuvianite is well appreciated for its potential as gem-quality materials, even though it has never been characterized in detail. This study provides a gemological characterization of eleven vesuvianite crystals from different localities of the Val d’Ala. The refractive index (1.717–1.708) and density (1.705–1.709) values of our vesuvianite are in the range of those in the literature. Scanning electron microscopy with energy-dispersive spectroscopy (SEM/EDS) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) established that the samples are pretty compositionally homogeneous in terms of major elements, while trace and rare earth elements (REE) contents are more variable. All REE patterns are characterized by pronounced positive Eu anomalies. The variations in color (from olive green to dark green with chocolate (reddish-brown color shades and polychrome bands) are due to the relevant presence of Fe and, to a lesser extent, Ti and Cr. The X-ray powder diffraction (XRPD) analyses and SEM/EDS quantitative study indicate that the other phases associated with vesuvianite are represented by diopside, garnet, clinochlore.

Pseudopolyrotaxane Structure Constructed by Polycaprolactone (PCL) Grafted on Multi-Walled Carbon Nanotubes and α-Cyclodextrins

2012 ◽  
Vol 487 ◽  
pp. 668-671 ◽  
Author(s):  
Shuai Hu ◽  
Mi Zhou ◽  
Song Hua Kong ◽  
Xin Qian
Keyword(s):  
Carbon Nanotubes ◽  
Supramolecular Chemistry ◽  
Hybrid Materials ◽  
Hybrid Material ◽  
New Approach ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Abstract The multi-walled carbon nanotubes (MWNTs) are modified through acidification, followed by the graft of polycaprolactone. The supramolecular forces of α-cyclodextrins (α-CDs) and PCL are used to produce MWNTs hybrid materials with pseudopolyrotaxane structure. XRD, FTIR, TGA, DSC are used for the characterization of its product. The preparation of this hybrid material provides a new approach for modifying carbon nanotubes in supramolecular chemistry with the expectation of applying this hybrid materials to the field of biomedicine.

scholarly journals Geochemical characterization of the Sutlegen bauxite deposit, SW Antalya

2021 ◽  
Vol 15 (3) ◽  
pp. 108-121
Author(s):  
Ozge Ozer Atakoglu ◽  
Mustafa Gurhan Yalcin
Keyword(s):  
Geochemical Characteristics ◽  
X Ray Diffraction ◽  
Bauxite Deposit ◽  
Multivariate Statistical Methods ◽  
Multivariate Statistical ◽  
X Ray ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Practical Implications

Purpose.The purpose is to determine geological and geochemical characteristics of the Sutlegen (Antalya, Turkey) bauxites, to identify the elements that played a major role in their formation. Methods. X-ray diffraction (XRD) mineral phase analysis, X-ray fluorescence (XRF) elemental analysis, plasma-mass spectrometry (ICP-MS), the petrographic and mineralogical analyses, and multivariate statistical methods were used. Findings. The major element content of the ore was determined as Al2O3 (60-35.2 wt%), SiO2 (39.5-0.2 wt%), Fe2O3 (48.4-19.5 wt%), TiO2 (36.9-16 wt%), and P2O5 (0.5-0.1 wt%). The Sutlegen region, which shows epirogenetic action with the uplift of the earth's crust, is generally rich in neritic carbonates. It was revealed that the bauxite ores have undergone moderate and strong laterization as a result of the deferruginization in the environment, and they were classified into four groups as lateritic, ferritic, kaolinitic, and bauxite. The increase in the aluminosilicate minerals, which were formed during the formation of bauxite in the environment was found to be directly proportional to the laterization processes. In this context, it was considered that the lateritic material that was firstly formed in the environment filled the cavities and pores of the karst-type limestones and sedimentary units in the region by superficial transfer phenomena. The bivariate diagrams of Log Cr vs. Log Ni revealed that the bauxite that formed in the region had an ultrabasic source. Originality. In literature, no scientific studies have been found on bauxite mineralization in the Sutlegen deposits that have been operated for a long period. Practical implications. In this context, the geochemical characteristics of bauxites revealed that the source of the laterization process in the region was the ultrabasic igneous rocks. The lateritic material moved by superficial transfer was accumulated on sandstone, claystone, siltstone, and limestone and in karstic cavities; then, it formed karstic bauxite (kaolinitic and bauxite) of different classifications due to the effect of metamorphism.

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