Cardiovascular and Metabolic Comorbidities in Patients with Plaque-Type Psoriasis Never Treated with Systemic Antipsoriatic Drugs: a Case-Control Study

Abstract Previous studies have shown a higher prevalence of cardiometabolic diseases among patients with psoriasis compared to non-psoriatics. However, little attention has been paid to the effects of systemic antipsoriatic drugs. The aim of this study was to investigate the association between psoriasis and these comorbidities, comparing untreated patients with psoriasis and population-based control non-psoriatic patients. A hospital-based case-control study included 122 patients with plaque-type psoriasis and 122 age- and gender-matched controls. Patients who ever received systemic antipsoriatic drugs were excluded. There were no significant differences between psoriatic patients and controls regarding the prevalence of hypertension (p=0.311), coronary heart disease (p=0.480), diabetes (p=0.641), myocardial infarction (p=0.71), stroke (2.4% vs. 2.4%, p=1.00) and metabolic syndrome (p=0.764). The prevalence of hypertriglyceridemia in patients with psoriasis and controls was 41.8% and 28.7%, respectively (OR 1.78, 95% CI 1.04-3.04, p=0.032). Furthermore, significant differences were observed in mean triglyceride levels (p=0.013). Smoking was significantly more often reported in psoriatic patients compared to controls. Patients with psoriasis also had a higher mean BMI (26.24, SD 4.42) compared with controls (24.73, SD 3.86), p=0.005. Psoriasis showed a statistically significant association with BMI obesity classification [χ2(4)=11.560, p=0.02]. The prevalence of cardiovascular and metabolic comorbidities was not significantly higher in patients with plaquetype psoriasis who were never treated with systemic antipsoriatic drugs, compared to population-based non-psoriatic controls. Our data suggest that systemic antipsoriatic drugs may play an important role in the development of these comorbidities. However, this study confirms that untreated psoriasis patients have three major modifiable increased cardiovascular risk factors, such as smoking, obesity and hypertriglyceridemia.

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First Age- and Gender-Matched Case-Control Study in Australia Examining the Possible Association between Toxoplasma gondii Infection and Type 2 Diabetes Mellitus: The Busselton Health Study

Journal of Parasitology Research ◽

10.1155/2020/3142918 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Aus Molan ◽

Kazunori Nosaka ◽

Michael Hunter ◽

Jinxia Zhang ◽

Xiaoni Meng ◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Health Study ◽

Age And Gender ◽

Matched Case ◽

And Gender ◽

Matched Case Control Study ◽

Control Study

An emerging field of research is starting to examine the association of infectious pathogens with type 2 diabetes mellitus (T2DM). An understudied parasite of interest is Toxoplasma gondii. Globally, very few studies have been conducted to investigate this association. Additionally, very little data exists on the prevalence of T. gondii in the general Australian population. Our group sought to determine the prevalence, association, and risk factors between T. gondii infection and T2DM from a representative Australian human population. Through a cross-sectional, age- and gender-matched case-control study, 150 subjects with T2DM together with 150 control subjects from the Busselton Health Study cohort were investigated. Sera samples were tested for the presence of anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assays. Survey-derived data were also analyzed to evaluate associated risk factors. The IgG seroprevalence was found to be 62% and 66% for the T2DM and control groups, respectively (OR:0.84; p=0.471). IgM antibodies were detected in 5% of the T2DM patients and in 10% of the controls (OR=0.51; p=0.135). There were no significant differences between male and female IgG seroprevalence rates for both groups (OR:0.88, 0.80; p=0.723). The IgG seropositivity rate increased significantly in T2DM patients aged 45-84 years in comparison to those aged 18-44 years (p<0.05), but this was not observed in the control subjects. No risk factors were associated with T. gondii seropositivity in both groups. The first Australian study of its kind found T. gondii infection in Western Australia to be highly prevalent. The results also showed that there is no serological evidence of an association between T. gondii infection and T2DM in the studied subjects. Australian health authorities should focus on raising awareness of toxoplasma infection and target T. gondii transmission control. Further studies are needed to clarify the role of T. gondii in T2DM.

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Body size and risk of Hodgkin’s lymphoma by age and gender: a population-based case–control study in Connecticut and Massachusetts

Cancer Causes & Control ◽

10.1007/s10552-012-0100-1 ◽

2012 ◽

Vol 24 (2) ◽

pp. 287-295 ◽

Cited By ~ 10

Author(s):

Qian Li ◽

Ellen T. Chang ◽

Bryan A. Bassig ◽

Min Dai ◽

Qin Qin ◽

...

Keyword(s):

Body Size ◽

Hodgkin’S Lymphoma ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Hodgkin's Lymphoma ◽

Age And Gender ◽

And Gender ◽

Control Study

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Effect of socioeconomic status on risk of COVID-19: a population-based case-control study

10.21203/rs.3.rs-195468/v2 ◽

2021 ◽

Author(s):

Hüseyin Küçükali ◽

Osman Hayran ◽

Şeyda İleri ◽

Berkay Kurt ◽

Fatmanur Kuru ◽

...

Keyword(s):

Socioeconomic Status ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Age And Gender ◽

Individual Level ◽

Significant Difference ◽

And Gender ◽

The Relationship ◽

Control Study

Abstract Most of the studies investigating the relationship between socioeconomic status and the occurrence of COVID-19 have limitations due to their ecological design. To investigate the relationship between socioeconomic status and individual-level risk of developing COVID-19, we conducted a population-based, age and gender matched, case-control study in a district of Istanbul. The case group was defined as all confirmed COVID-19 cases (n=232) in the district in a week of August 2020. The control group was matched with cases in terms of age and gender and selected randomly from the directory of the same primary care provider in the district in a 1:1 ratio. The socioeconomic status was measured by the Turkish Socioeconomic Status Index which considers its three dimensions: education, occupation, and income. 168 cases (72.4% response) and 168 controls are included in the study. The mean socioeconomic status score is 70.28±7.09 for cases and 69.25±7.46 for controls (p=0.201). 15.2% (n=25) of cases and 22.4% (n=37) of controls is in lower socioeconomic status group (p=0.091). The analysis did not reveal a statistically significant difference between study groups. Socioeconomic status may not a significant predictor of COVID-19 occurrence at the individual-level. The disease seems to be a common threat to all individuals.

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