Predictors of Changes in Physical Properties of Skin in Patients with Diabetes Mellitus

2012 ◽  
Vol 19 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Anca-Elena Crăciun ◽  
Mirela Moldovan ◽  
Adriana Rusu ◽  
Cristina Niţă ◽  
C. Crăciun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Physical Properties ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Entire Group ◽  
Skin Elasticity ◽  
Human Organ ◽  
Negatively Associated ◽  
Patients With Diabetes ◽  
Age And Sex

Predictors of Changes in Physical Properties of Skin in Patients with Diabetes MellitusIntroduction: The skin, the largest human organ, is often affected by diabetes mellitus (DM). We know that DM affects the hydration of stratum corneum (SC), the sebum content of the skin and to some extent, the barrier function of the epidermis and elasticity, but we do not know the factors leading to these changes. Objectives: The objectives of this study were to determine the factors associated with changes in physical properties of the skin (skin hydration degree, sebumetry, transepidermal water loss and skin elasticity) in patients with diabetes. Materials and methods: The physical properties of the skin were assessed using the Multi Probe Adapter Systems MPA ® (Courage-Khazaka, Germany) in 57 patients with diabetes and 46 non-diabetic. Results: Statistical analysis of the entire group of 103 subjects showed a significant association between female gender and decreased SC hydration (p<0.05 in all cases), decreased values of transepidermal water loss (TEWL) (β=-0.282, p=0.006) and decreased elasticity of the skin in forearm (β=-0.216, p=0.043). Also, the presence of DM was negatively associated with levels of SC hydration measured on the forearm (β=-0.281, p=0.005). Furthermore, in patients with diabetes, the presence of diabetic neuropathy (DNP) was negatively associated with the hydration of SC measured at all levels (forearm: β=-0.465, p<0.001; leg: β=-0.590, p<0.001; tight: β=-0.198, p<0.001). The observed relationship was independent of age and sex of the participants (p<0.05 after adjustment for age and sex). Regarding skin elasticity, increasing age was associated with lower levels of skin elasticity both in entire group and in patients with DM, at all sites of measurements (p<0.05 in all cases). Additionally, in patients with diabetes, elasticity of the skin measured at forearm and tight was negativelly associated with type of DM (forearm: β=-0.335, p=0.023; tight: β=-0.522, p<0.001). In our study, nor diabetes neither DNP were not associated with TEWL values. Conclusions: The presence of DNP seems to be the main predictor of decreased SC hydration in all measuring points and skin elasticity is significantly associated with age. There are some gender-related modification in physical properties of the skin. Surprisingly, type 2 DM was associated with reduced elasticity in the thigh, and this association was independent of age and sex.

scholarly journals Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2021
Author(s):  
Aneta Prokopová ◽  
Jana Pavlačková ◽  
Pavel Mokrejš ◽  
Robert Gál
Keyword(s):  
Water Loss ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Elasticity ◽  
Cosmetic Products ◽  
Collagen Hydrolysate ◽  
Carbopol Gel ◽  
Cosmetic Formulation ◽  
The Right ◽  
Positive Effect

Chicken stomachs can be processed into collagen hydrolysate usable in cosmetic products. The aim of the study was to verify the effects of a carbopol gel formulation enriched with 1.0% (w/w) chicken hydrolysate on the properties of the skin in the periorbital area after regular application twice a day for eight weeks in volunteers ageed 50 ± 9 years. Skin hydration, transepidermal water loss (TEWL), skin elasticity and skin relief were evaluated. Overall, skin hydration increased by 11.82% and 9.45%, TEWL decreased by 25.70% and 17.80% (always reported for the right and left area). Generally, there was an increase in skin elasticity, a decrease in skin roughness, as the resonance times decreased by 85%. The average reduction of wrinkles was 35.40% on the right and 41.20% on the left. For all results, it can be seen that the longer the cosmetic gel formulation is applied, the better the results. Due to the positive effect on the quality and functionality of the skin, it is possible to apply the cosmetic gel formulation in the periorbital area. The advantage of the product with chicken collagen hydrolysate is also the biocompatibility with the skin and the biodegradability of the formulation.

Effect of sock type on foot health

2019 ◽  
Vol 89 (18) ◽  
pp. 3871-3881 ◽  
Author(s):  
Rebecca Van Amber ◽  
Raechel M Laing ◽  
Cheryl A Wilson ◽  
Linda A Dunn ◽  
Tim Jowett
Keyword(s):  
Diabetes Mellitus ◽  
Stratum Corneum ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Fiber Content ◽  
Foot Health ◽  
Merino Wool ◽  
Stratum Corneum Hydration ◽  
Structure Changes ◽  
Over Time

The objective was to determine whether changes in indicators of skin health among participants suffering from diabetes mellitus could be attributable to the type of sock worn (fiber content, structure). Changes in skin health over time (e.g. temperature, skin hardness, transepidermal water loss, stratum corneum hydration) can indicate improvement or deterioration, and these may be related to socks worn. Socks of different structure (single jersey, terry), and of fiber content (merino wool, cotton) were worn over a period of 22 weeks by participants suffering from diabetes mellitus. Each participant was their own control: change over time in skin hardness, stratum corneum hydration, transepidermal water loss and temperatures were monitored. Properties of the sock fabrics were measured as new and after use to determine effects of wear. Limited evidence of improved skin health was attributable to socks composed primarily of wool.

scholarly journals The Addition of Tissue Stromal Vascular Fraction To Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial

2021 ◽  
Author(s):  
Joris A van Dongen ◽  
Joeri v Boxtel ◽  
Joep C Willemsen ◽  
Linda A Brouwer ◽  
Karin M Vermeulen ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Therapeutic Effect ◽  
Water Loss ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Transepidermal Water Loss ◽  
Skin Aging ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Quality

Abstract Background Lipofilling has become popular as a treatment to improve aging related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) have been added to lipofilling to increase the therapeutic effect of adipose derived stromal cells (ASCs). Objectives In this study, we hypothesized that mechanical isolated SVF augments the therapeutic effect of PRP supplemented lipofilling to improve facial skin quality. Methods This prospective, double-blinded, placebo-controlled, randomized trial was conducted between 2016 and 2019. In total, 28 female subjects were enrolled with 25 completing the follow-up. All patients received PRP supplemented lipofilling with either mechanical isolated SVF or saline. SVF was isolated by means of the fractionation of adipose tissue (FAT) procedure (tissue-SVF). Results were evaluated by changes in skin elasticity and transepidermal water loss, changes in skin aging related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation as well as patient satisfaction (FACE-Q), recovery, and number of complications up to 1 year postoperative. Results The addition of tSVF to PRP supplemented lipofilling did not improve skin elasticity, transepidermal water loss nor skin aging related features. No improvement in patient satisfaction with overall facial appearance nor facial skin quality was seen when tSVF was added to PRP supplemented lipofilling. Conclusions PRP supplemented lipofilling with tSVF compared to PRP supplemented lipofilling alone does not improve facial skin quality nor patient satisfaction in a healthy population. PRP supplemented lipofilling with tSVF can be considered a safe procedure.

scholarly journals Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Osman Evliyaoğlu ◽  
Nilgün Başaran ◽  
Veysel Sucu ◽  
Leyla Bulut ◽  
Okan Dikker ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Patients With Diabetes ◽  
Age And Sex

scholarly journals Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Nilgün Basaran ◽  
Osman Evliyaoglu ◽  
Veysel Sucu ◽  
Okan Dikker ◽  
Leyla Bulut ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Patients With Diabetes ◽  
Age And Sex

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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