scholarly journals The Addition of Tissue Stromal Vascular Fraction To Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial

2021 ◽  
Author(s):  
Joris A van Dongen ◽  
Joeri v Boxtel ◽  
Joep C Willemsen ◽  
Linda A Brouwer ◽  
Karin M Vermeulen ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Therapeutic Effect ◽  
Water Loss ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Transepidermal Water Loss ◽  
Skin Aging ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Quality

Abstract Background Lipofilling has become popular as a treatment to improve aging related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) have been added to lipofilling to increase the therapeutic effect of adipose derived stromal cells (ASCs). Objectives In this study, we hypothesized that mechanical isolated SVF augments the therapeutic effect of PRP supplemented lipofilling to improve facial skin quality. Methods This prospective, double-blinded, placebo-controlled, randomized trial was conducted between 2016 and 2019. In total, 28 female subjects were enrolled with 25 completing the follow-up. All patients received PRP supplemented lipofilling with either mechanical isolated SVF or saline. SVF was isolated by means of the fractionation of adipose tissue (FAT) procedure (tissue-SVF). Results were evaluated by changes in skin elasticity and transepidermal water loss, changes in skin aging related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation as well as patient satisfaction (FACE-Q), recovery, and number of complications up to 1 year postoperative. Results The addition of tSVF to PRP supplemented lipofilling did not improve skin elasticity, transepidermal water loss nor skin aging related features. No improvement in patient satisfaction with overall facial appearance nor facial skin quality was seen when tSVF was added to PRP supplemented lipofilling. Conclusions PRP supplemented lipofilling with tSVF compared to PRP supplemented lipofilling alone does not improve facial skin quality nor patient satisfaction in a healthy population. PRP supplemented lipofilling with tSVF can be considered a safe procedure.

Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation

2021 ◽  
Author(s):  
Barbara Hersant ◽  
Mounia SidAhmed-Mezi ◽  
Celine Aboud ◽  
Jeremy Niddam ◽  
Samuel Levy ◽  
...  
Keyword(s):  
Synergistic Effects ◽  
Platelet Rich Plasma ◽  
Post Treatment ◽  
Facial Appearance ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Rejuvenation ◽  
Serious Adverse Events ◽  
Autologous Platelet Rich Plasma ◽  
Cellular Matrix

Abstract Background Many therapeutic options are currently available for facial skin rejuvenation, but little evidence exists about the efficacy of combining such procedures. Objectives To assess and investigate the synergic effect of HA and a-PRP injections on facial skin rejuvenation. Methods For this randomized controlled prospective study, 93 eligible patients were enrolled and randomized into three intervention groups to undergo a series of three treatments sessions with either a-PRP, HA or Cellular Matrix-BCT-HA (PRP-HA) injected on facial cheeks. Results A total of 93 patients were included. Treatment with Cellular Matrix BCT-HA led to a very significant improvement in the overall facial appearance compared to groups treated with a-PRP and HA alone (p<0.0001). Participants treated with Cellular Matrix showed a 20%, 24% and 17% increase in FACE-Q score at 1 month, 3 months and 6 months post-treatment, respectively. For the HA group, the improvement of FACE-Q score was 12%, 11% and 6% at 1, 3- and 6-months post-treatment, respectively, while the a-PRP group showed a 9% improvement in FACE-Q score at 1 month and 11% and 8% improvement at 3- and 6-months post-treatment, respectively.Biophysical measurements showed significantly improved skin elasticity for the group Cellular BCT-HA compared to a-PRP and HA alone. No serious adverse events were reported. Conclusions Combining a-PRP and HA seems to be a promising treatment for facial rejuvenation with a very significant improvement in facial appearance and skin elasticity compared to a-PRP or HA alone.

scholarly journals Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2021
Author(s):  
Aneta Prokopová ◽  
Jana Pavlačková ◽  
Pavel Mokrejš ◽  
Robert Gál
Keyword(s):  
Water Loss ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Elasticity ◽  
Cosmetic Products ◽  
Collagen Hydrolysate ◽  
Carbopol Gel ◽  
Cosmetic Formulation ◽  
The Right ◽  
Positive Effect

Chicken stomachs can be processed into collagen hydrolysate usable in cosmetic products. The aim of the study was to verify the effects of a carbopol gel formulation enriched with 1.0% (w/w) chicken hydrolysate on the properties of the skin in the periorbital area after regular application twice a day for eight weeks in volunteers ageed 50 ± 9 years. Skin hydration, transepidermal water loss (TEWL), skin elasticity and skin relief were evaluated. Overall, skin hydration increased by 11.82% and 9.45%, TEWL decreased by 25.70% and 17.80% (always reported for the right and left area). Generally, there was an increase in skin elasticity, a decrease in skin roughness, as the resonance times decreased by 85%. The average reduction of wrinkles was 35.40% on the right and 41.20% on the left. For all results, it can be seen that the longer the cosmetic gel formulation is applied, the better the results. Due to the positive effect on the quality and functionality of the skin, it is possible to apply the cosmetic gel formulation in the periorbital area. The advantage of the product with chicken collagen hydrolysate is also the biocompatibility with the skin and the biodegradability of the formulation.

Transepidermal water loss, temperature and sebum levels on women's facial skin follow characteristic patterns

2000 ◽  
Vol 6 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Sabine Lopez ◽  
Isabelle Le Fur ◽  
Frédérique Morizot ◽  
Guylaine Heuvin ◽  
Christiane Guinot ◽  
...  
Keyword(s):  
Water Loss ◽  
Transepidermal Water Loss ◽  
Facial Skin

Predictors of Changes in Physical Properties of Skin in Patients with Diabetes Mellitus

2012 ◽  
Vol 19 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Anca-Elena Crăciun ◽  
Mirela Moldovan ◽  
Adriana Rusu ◽  
Cristina Niţă ◽  
C. Crăciun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Physical Properties ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Entire Group ◽  
Skin Elasticity ◽  
Human Organ ◽  
Negatively Associated ◽  
Patients With Diabetes ◽  
Age And Sex

Predictors of Changes in Physical Properties of Skin in Patients with Diabetes MellitusIntroduction: The skin, the largest human organ, is often affected by diabetes mellitus (DM). We know that DM affects the hydration of stratum corneum (SC), the sebum content of the skin and to some extent, the barrier function of the epidermis and elasticity, but we do not know the factors leading to these changes. Objectives: The objectives of this study were to determine the factors associated with changes in physical properties of the skin (skin hydration degree, sebumetry, transepidermal water loss and skin elasticity) in patients with diabetes. Materials and methods: The physical properties of the skin were assessed using the Multi Probe Adapter Systems MPA ® (Courage-Khazaka, Germany) in 57 patients with diabetes and 46 non-diabetic. Results: Statistical analysis of the entire group of 103 subjects showed a significant association between female gender and decreased SC hydration (p<0.05 in all cases), decreased values of transepidermal water loss (TEWL) (β=-0.282, p=0.006) and decreased elasticity of the skin in forearm (β=-0.216, p=0.043). Also, the presence of DM was negatively associated with levels of SC hydration measured on the forearm (β=-0.281, p=0.005). Furthermore, in patients with diabetes, the presence of diabetic neuropathy (DNP) was negatively associated with the hydration of SC measured at all levels (forearm: β=-0.465, p<0.001; leg: β=-0.590, p<0.001; tight: β=-0.198, p<0.001). The observed relationship was independent of age and sex of the participants (p<0.05 after adjustment for age and sex). Regarding skin elasticity, increasing age was associated with lower levels of skin elasticity both in entire group and in patients with DM, at all sites of measurements (p<0.05 in all cases). Additionally, in patients with diabetes, elasticity of the skin measured at forearm and tight was negativelly associated with type of DM (forearm: β=-0.335, p=0.023; tight: β=-0.522, p<0.001). In our study, nor diabetes neither DNP were not associated with TEWL values. Conclusions: The presence of DNP seems to be the main predictor of decreased SC hydration in all measuring points and skin elasticity is significantly associated with age. There are some gender-related modification in physical properties of the skin. Surprisingly, type 2 DM was associated with reduced elasticity in the thigh, and this association was independent of age and sex.

scholarly journals Oryza Ceramide®, a rice-derived extract consisting of glucosylceramides and β-sitosterol glucoside, improves facial skin dehydration in Japanese subjects

2021 ◽  
Vol 11 (8) ◽  
pp. 385
Author(s):  
Tsuyoshi Takara ◽  
Kazuo Yamamoto ◽  
Naoko Suzuki ◽  
Shinichiro Yamashita ◽  
Shin-ichiro Iio ◽  
...  
Keyword(s):  
Water Loss ◽  
Random Number Generator ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Controlled Study ◽  
Skin Barrier Function ◽  
Facial Skin ◽  
Double Blind ◽  
Hydrophobic Fraction

Background and objective: The ingestion of plant-derived glucosylceramides (GlcCer) has been reported to contribute to skin barrier function and hydration of the epidermis. b-sitosterol glucoside (BSG) colocalized with GlcCer in the rice hydrophobic fraction has been shown to increase ceramides in the stratum corneum in vitro. Although clinical studies demonstrated that GlcCer reduced transepidermal water loss (TEWL), the contribution of BSG to epidermal dehydration when applied with GlcCer remains unknown. Therefore, we herein conducted a clinical trial on the effects of a rice-derived mixed fraction of GlcCer and BSG (Oryza Ceramide®) on TEWL and other skin parameters. Methods: A randomized, double-blind, placebo-controlled study design was used. Oryza Ceramide® (type PCD, 40 mg daily) containing 1.2 mg of GlcCer and 40 mg of BSG was used as the active sample. We enrolled 44 healthy Japanese women with epidermal dehydration. All subjects were randomly allocated to an active group (n=22) or placebo group (n=22) using a computerized random number generator. Capsules containing the active sample or placebo were administered for 12 weeks between August and December 2020. Cheek TEWL after 12 weeks was assessed as the primary outcome, and TEWL on a different part of the skin and various skin parameters, including epidermal moisture, pigmentation, pores, and elasticity, were measured before and after 4, 8, and 12 weeks of the intervention. Blood, urine, and body parameters were also examined to evaluate safety.Results: Forty-four subjects completed the trial, and the per protocol set comprised 22 each in the active and placebo groups. Cheek TEWL significantly reduced after the Oryza Ceramide® intervention for 4 and 12 weeks. Among the secondary outcomes examined, lip moisture (12 weeks) and visible pore number (4 weeks) were improved by Oryza Ceramide®. Laboratory tests revealed no abnormalities to suggest any adverse effects of Oryza Ceramide®.Conclusions: Oryza Ceramide® (40 mg/day) consisting of GlcCer and BSG improved facial TEWL, lip moisture, and visible pores, and these effects may be attributed to increases in epidermal ceramides. The combination of rice GlcCer and BSG appears to be beneficial for improving facial skin conditions.Trial Registration: UMIN-CTR: UMIN000041295Foundation: The study was funded by Oryza Oil & Fat Chemical Co., Ltd. and Aichi Prefectural Subsidies for Research and Development of Creative Products in 2020.Keywords: rice; glucosylceramide; β-sitosterol glucoside; trans epidermal water loss; pore 

scholarly journals COMPARATIVE ANALYSIS OF THE FACE AND NECK SKIN ELASTICITY IN 20-30 YEARS WOMEN

2017 ◽  
Vol 20 (4) ◽  
pp. 252-256
Author(s):  
Tatiyana N. Korolkova ◽  
L. L Ambartsumyan ◽  
I. A Shepilova ◽  
A. V Maslova
Keyword(s):  
Comparative Analysis ◽  
Skin Aging ◽  
Main Direction ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Initial State ◽  
Aging Material ◽  
The Third ◽  
Comparison Groups ◽  
The Face

Prevention and correction of external signs of the face and neck aging are the main direction of modern cosmetology. The study of the skin functions of various zones of face and neck will allow to carry out more effectively cosmetic effects. The aim is to study the features of the elasticity of facial skin (forehead, skin around the eyes, cheeks) and neck in patients without external signs of skin aging. Material and methods. Elasticity of the face and neck skin was determined in 63 women aged 20-30 years, who made up four comparison groups: in the 1st group (22 women) the elasticity of the forehead skin was studied, in the 2nd group (43 women) - around eye, in the third group (49 women) - cheeks, in the 4th group (24 women) - the neck. To measure the elasticity of the skin the Cutometer MPA 580 (“Courage Khazaka”, Germany) was used. Results. The comparative analysis was performed with the forehead skin. The skin around the eyes was 61-68% more stretchy (R0, R8), 65% worse returned to the initial state (R1), including 26-62% with repeated suction cycles sensor (R3, R4, R9), by 1-11% less elastic (R2, R5, R7), by elastic-viscous properties (R6) is 26% better, but overall its elasticity is lower by 35-53% (F0, F1). The cheek skin is 91- 104% more stretchy (R0, R8), worse returns to the initial state (R1) by 22%, including by 10-82% with repeated suction cycles by the sensor (R3, R4, R9),13% more elastic (R2) and 15% less elastic (R5, R7), the elastic-viscous properties (R6) 41% better, but overall its elasticity is lower by 31-100% (F0, F1) . The neck skin is 186-257% more stretchable (R0, R8), 6% worse returns to the initial state (R1), including 13-164% with repeated suction cycles by the sensor (R3, R4, R9), by 11-28% more elastic (R2, R5, R7), by elastic-viscous properties (R6) 50% better, but overall its elasticity is lower by 88-153% (F0, F1). Conclusion. The skin of the forehead, around the eyes, cheeks and neck, according to the elasticity indices, has significant differences. The obtained data should be taken into account when carrying out various cosmetology techniques, further study are needed.

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