UPPER TRACT UROTHELIAL CARCINOMA: MORPHOLOGY, DIAGNOSTICS AND TREATMENT

2018 ◽  
pp. 78-92
Author(s):  
Yu. A. Stepanova ◽  
A. V. Prokofieva ◽  
S. A. Dunaev ◽  
A. V. Glotov ◽  
M. V. Morozovz ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Malignant Tumor ◽  
Urothelial Cancer ◽  
New Technologies ◽  
Clinical Manifestations ◽  
Upper Urinary Tract ◽  
Diagnostic Methods ◽  
Modern Methods ◽  
Methods Of Treatment

Urothelial carcinoma is a malignant tumor that develops from the cells of the urothelium mucosa and can be detected both in the upper parts of the urinary tract (renal and pelvic system and ureter) and in the lower parts (bladder and urethra). Urothelial cancer of the upper urinary tract (UCUUT) is quite rare and accounts for 5–10% of all cases of urothelial cancer. UCUUT remains completely unexplored, having to date two equal theories of origin. Despite the modern radiology and endoscopic equipment, in view of the meager and sufficiently generalized  clinical manifestations (similar to other diseases), especially at the initial stages of the disease, it is necessary to constantly improve diagnostic methods for detecting the disease as early as possible. Already today, thanks to new technologies for diagnosis and treatment, it is possible to identify the disease at different stages and extend life to patients with UCUUT. The article presents data on morphology, clinic, diagnostics and modern methods of treatment of this pathology.

scholarly journals Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shangqing Ren ◽  
Hualin Feng ◽  
Yige Bao ◽  
Yi Wei ◽  
Yong Ou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standard Treatment ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Upper Urinary Tract ◽  
Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

403: Desmoplasia is an Independent Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2007 ◽  
Vol 177 (4S) ◽  
pp. 134-134
Author(s):  
Richard E. Zigeuner ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
Cord Langner
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

1093: Tumor Necrosis as Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2006 ◽  
Vol 175 (4S) ◽  
pp. 351-352
Author(s):  
Richard E. Zigeuner ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Tumor Necrosis ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

405: Alpha-Methylacyl-CoA Racemase (AMACR/P504S) Protein Expression in Urothelial Carcinoma of the Upper Urinary Tract Correlates with Tumour Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132
Author(s):  
Richard E. Zigeuner ◽  
Sebastian Leibl ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Protein Expression ◽  
Urothelial Carcinoma ◽  
Tumour Progression ◽  
Upper Urinary Tract

Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

Pathological significance and prognostic utility of KIBRA in upper urinary tract urothelial cancer

2021 ◽  
Vol 79 ◽  
pp. S1087
Author(s):  
T. Kondo ◽  
Y. Miyata ◽  
T. Matsuda ◽  
J. Harada ◽  
Y. Mukae ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Cancer ◽  
Upper Urinary Tract ◽  
Prognostic Utility

The Prognostic Value of E-Cadherin, α-, β-, and γ-Catenin in Urothelial Cancer of the Upper Urinary Tract

2006 ◽  
Vol 49 (5) ◽  
pp. 839-845 ◽  
Author(s):  
Keishi Kashibuchi ◽  
Kyoichi Tomita ◽  
Jack A. Schalken ◽  
Haruki Kume ◽  
Takuhiro Yamaguchi ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Prognostic Value ◽  
Urothelial Cancer ◽  
Upper Urinary Tract ◽  
E Cadherin

scholarly journals Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Heon Kim ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Functional Outcomes ◽  
Upper Urinary Tract ◽  
Rank Test ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Significant Difference ◽  
Segmental Ureterectomy ◽  
Urinary Tract Urothelial Carcinoma

AbstractThis study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan–Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), and intravesical recurrence-free survival (IVRFS) between the groups. We also compared the change in postoperative estimated glomerular filtration rate (eGFR). There was no significant difference in terms of CSS, PFS, and IVRFS between the RNU and SU groups, but the RNU group had a better OS than the SU group (p = 0.032). Postoperative eGFR was better preserved in the SU group than in the RNU group (p < 0.001). SU provides comparable CSS, PFS, and IVRFS for patients with UTUC compared to RNU, even in patients with advanced-stage and/or high-grade cancer. Further, SU achieves better preservation of renal function.

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