scholarly journals Standardization of the method of contrast-enhanced ultrasound of kidneys in patients with type 2 diabetes

2021 ◽  
Vol 25 (3) ◽  
pp. 50-65
Author(s):  
A. V. Borsukov ◽  
O. A. Gorbatenko
Keyword(s):  
Type 2 Diabetes ◽  
Ultrasound Examination ◽  
Diagnostic Methods ◽  
Contrast Enhanced Ultrasound ◽  
Quantitative Parameters ◽  
Contrast Enhanced ◽  
Standardized Method ◽  
The Right ◽  
Medical University

Aim of the research. Standardization of the quantitative assessment of the contrast-enhanced ultrasound examination of the kidneys in patients with type 2 diabetes.Materials and methods. On the basis of the Fundamental research laboratory “Diagnostic researches and minimally invasive technologies”, of the Federal State Budgetary Educational Institution of Higher Education “Smolensk State Medical University” of Smolensk State Medical University, the Ministry of Health of the Russian Federation, 12 patients with type 2 diabetes were examined in 2020. The age of the examined patients was 36–64 years old. Average age – 44 ± 1.8 years, of which 7 women (58.33%) and 5 men (41.67%). All patients were examined using a single diagnostic algorithm, which included 2 stages: 1 stage. Ultrasound examination of the kidneys (Aloka Hitachi Arietta 850 (Hitachi Medical Corporation, Japan) in B-mode; stage 2 – contrast-enhanced ultrasound examination (CEUS) of the kidneys. All patients were divided into 2 groups: the 1st group consisted of patients with type 2 diabetes type (n = 6), who underwent CEUS with subsequent assessment of the renal parenchyma in different areas of the cortex and medulla; group 2 consisted of patients with type 2 diabetes (n = 6) who underwent CEUS with subsequent standardized assessment in the indicated 5-th points of the arterial bed and 3 points of the venous bed.Results and discussions. Taking into account the current epidemiological situation in 2020, the number of performed radiation diagnostic methods, such as X-ray and computer examinations of the chest organs, significantly increased the overall background of radiation exposure on the bulk of patients. Taking into account the anxiety index of patients, ionizing research methods for the diagnosis of angionephrosclerosis are undesirable. The standardized method for quantitative parameters of CEUS showed good agreement (0.61–0.76). In turn, the assessment of the quantitative parameters of renal CEUS when using the routine technique showed low consistency (0.21–0.3). Cohen's kappa (CK) scores of 0 to 0.2 indicate a lack of agreement among clinicians; 0.21–0.4 – weak consistency; 0.41–0.6 – moderate agreement between doctors; 0.61–0.8 – good consistency; 0.81–1.0 – complete consistency.The circulatory system of the kidneys is characterized by the presence of a developed capillary network and, accordingly, low peripheral resistance, which confirms the importance of a standardized approach in conducting this study. In the context of the prevailing epidemiological circumstances, we understand that it is necessary to choose a reference research method that would allow us to accurately assess the characteristics of the experimental evaluation of this method. As a result of renal C EUS using a routine technique, hypoperfusion of the right kidney was revealed in 50% (n = 3) cases and the data were interpreted as normal in 50% (n = 3) cases. As a result of the renal CEUS using the proposed method, pronounced hypoperfusion of the right kidney was revealed in 100% (n = 6) cases. Dynamic nephroscintigraphy was used as a reference method to determine the functional work of the kidneys. According to the results of dynamic nephroscintigraphy of the kidneys, hypoperfusion of the right kidney was revealed in all cases in both groups of patients.Conclusion. 1. The standardized method for assessing the quantitative parameters of the kidney CEUS is more reproducible by the ultrasound doctors than the routine one. 2. Enhanced ultrasound can be used to assess the efficacy of hypoperfusion with the maximum efficacy of an equivalent dose per patient.

Drug for contrast-enhanced ultrasound examination: new dimension in early diagnosis of angionephrosclerosis in patients with type 2 diabetes on non-alcoholic fatty liver disease background

2020 ◽  
Vol 1 (30) ◽  
pp. 37-41
Author(s):  
A. V. Borsukov ◽  
O. A. Gorbatenko ◽  
D. Yu. Venidiktova ◽  
I. Z. Pulatova
Keyword(s):  
Type 2 Diabetes ◽  
Liver Disease ◽  
Early Diagnosis ◽  
Fatty Liver Disease ◽  
Ultrasound Examination ◽  
Contrast Enhanced Ultrasound ◽  
Alcoholic Fatty Liver ◽  
Contrast Enhanced ◽  
Alcoholic Fatty Liver Disease

Objective. To evaluate the diagnostic efficiency of the contrast-enhanced third-generation agent in the detection of angionephrosclerosis in patients with type 2 diabetes and non-alcoholic fatty liver disease background.Materials and methods. 26 patients (9 men and 17 women; mean age 61.5 ± 4.3 years) with a confirmed diagnosis of type 2 diabetes mellitus and NAFLD were examined. All patients underwent complex diagnostics, including: quantitative ultrasound steatometry of the liver in the framework of combined elastography with visual and quantitative assessment of the attenuation coefficient of the ultrasonic wave; ultrasound examination of the kidneys in B-mode with vascular diagnostics in the Doppler mapping mode. Also, all patients underwent contrast-enhanced ultrasound examination of the kidneys with the contrast agent for the diagnosis of angionephrosclerosis.Results. The method of CEUS of the kidneys with patients with type 2 diabetes and NAFLD has sensitivity of 92.7 %, and accuracy of 90.4 %. Color Doppler mode has sensitivity of 66.5–81.4 %, and accuracy of 58.4–73.6 %.Conclusion. The ultrasound contrast agent may be used in the early diagnosis of angionephrosclerosis in patients with type 2 diabetes and NAFLD as a non-alternative imaging method with no radiation exposure and no nephrotoxicity.

scholarly journals Improved Method of Contrast-enhanced Ultrasound examination of the Kidneys in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 6 (1) ◽  
pp. 18-25
Author(s):  
A. V. Borsukov ◽  
O. A. Gorbatenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Contrast Agent ◽  
Ultrasound Examination ◽  
Bolus Administration ◽  
Intravenous Bolus ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Improved Technique

Aim of the research. Тo evaluate the diagnostic efficacy of the contrast-enhanced ultrasound examination of kidneys in patients with type 2 diabetes mellitus with a dose of 0.5 ml of contrast agent administered.Materials and methods. We examined 12 patients with a verified diagnosis of type 2 diabetes. The age of the examined patients was 31–59 years, the mean age was 49 ± 1.3 years. All patients underwent complex diagnostics, including ultrasound examination of the kidneys in B-mode with further renal vessels color Doppler imaging to assess vessels hemodynamics. A contrast-enhanced ultrasound examination of the kidneys was carried out using Sonovue contrast agent at the doses of 2.5 ml (according to the European Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound) and 0.5 ml (an improved technique of contrast agent intravenous bolus administration).Results. The improved technique (0.5 ml of contrast agent intravenous bolus administration) in comparison with the European Recommendations technique (2.5 ml of contrast agent intravenous bolus administration) used in patients with type 2 diabetes showed no or minor differences in the qualitative and quantitative indicators of contrast-enhanced ultrasound examination which did not affect the interpretation of the results.Conclusion. The improved contrast-enhanced ultrasound examination technique using 0.5 ml of a contrast agent showed its possibilities in diagnosing diabetic nephropathy in patients with type 2 diabetes, and also revealed the potential of an economically beneficial distribution of a contrast agent without losing the quality and information content of the study.

scholarly journals Contrast-enhanced ultrasound of kidneys in patients with type 2 diabetes and chronic pyelonephritis: a new dosage of the contrast-enhanced agent

2021 ◽  
Author(s):  
A.V. Borsukov ◽  
S.B. Krukovskiy ◽  
L.N. Markelova ◽  
O.A. Gorbatenko ◽  
D.Yu. Venidiktova
Keyword(s):  
Contrast Agent ◽  
Ultrasound Examination ◽  
Chronic Pyelonephritis ◽  
Contrast Enhanced Ultrasound ◽  
Diagnostic Efficacy ◽  
Contrast Enhanced ◽  
Group 2 ◽  
Improved Technique ◽  
Medical University ◽  
Group 1

Objective. To evaluate the diagnostic efficacy of the contrast-enhanced ultrasound examination of kidneys in patients with chronic pyelonephritis with a dose of injected contrast agent – 1.0 ml. Materials and methods. In 2020, 20 patients with chronic pyelonephritis were examined on the basis of the Fundamental research laboratory “Diagnostic Researches and Minimally Invasive Technologies”, Smolensk State Medical University. All patients underwent ultrasound examination Doppler mapping mode of the kidneys and the. Also, all patients underwent contrast-enhanced ultrasound examination of the kidneys for the diagnosis of angionephrosclerosis. Results. Using the improved technique in patients of group 2 compared with patients in group 1, the quality of the images obtained was preserved. In patients of group 1 with chronic pyelonephritis, the quantitative indicators correspond to the initial manifestations of angionephrosclerosis. Conclusion. Thus, the improved CEUS technique with the use of 1.0 ml of contrast agent showed good possibilities in the diagnosis of angionephrosclerosis in patients with chronic pyelonephritis.

scholarly journals Ultrasound methods of imaging atherosclerotic plaque in carotid arteries: examinations using contrast agents

2020 ◽  
Vol 20 (82) ◽  
pp. 191-200
Author(s):  
Andrzej Fedak ◽  
◽  
Robert Chrzan ◽  
Ositadima Chukwu ◽  
Andrzej Urbanik ◽  
...  
Keyword(s):  
Blood Flow ◽  
Atherosclerotic Plaque ◽  
Ultrasound Examination ◽  
Contrast Enhanced Ultrasound ◽  
Plaque Stability ◽  
Examination Method ◽  
Inherent Feature ◽  
Contrast Enhanced ◽  
The Right ◽  
Physical Phenomena

The primary technique for detecting the presence and monitoring the development of carotid atherosclerotic plaque is ultrasound. The development of ultrasound techniques has made it possible to precisely visualise not only blood flow, but also vessel walls, including atherosclerotic plaque. Contrast-enhanced ultrasound examination enables one to make an objective observation of atherosclerotic plaque neovascularisation, clearly indicating active inflammation, which is an inherent feature of vulnerable (unstable) plaque. Depending on the examination method used, it is possible to precisely visualise different components of the plaque and its behaviour during blood flow through the vessel lumen or through the neovessels of the plaque, and, consequently, determine the possible presence of inflammation, which is a defining feature of plaque stability. The full utilisation of physical phenomena that underlie contrast-enhanced ultrasound will bring further enormous progress of diagnostic and probably also therapeutic methods for carotid atherosclerosis. The selection of the right examination method significantly accelerates diagnosis and adequate classification of plaque, and makes it possible to monitor the progression of atherosclerosis. However, one needs to bear in mind that ultrasound remains a very subjective method. The success of contrast-enhanced ultrasound also depends on the skills and experience of the examiner. Current attempts at increasing the objectivity of contrast-enhanced ultrasound examination using artificial intelligence will make it possible in the future to make a definitive evaluation of atherosclerotic plaque stability. This will allow one to assess the risk of ischaemic stroke adequately.

STUDY OF RADIATION CHARACTERISTICS THE RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2014 ◽  
pp. 73-77
Author(s):  
Van Chuong Nguyen ◽  
Thi Kim Anh Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Disease Duration ◽  
Left Kidney ◽  
Cross Sectional ◽  
The Right

Background: A Research glomerular filtration rate (GFR) of 61 patients with type 2 diabetes mellitus with renal scanning 99mTc-DTPA glomerular filtration rate at the hospital 175. Objective: (1) To study characteristics of imaging of renal function. (2) Understanding the relationship between GFR with blood sugar, HbA1c, blood pressure and albuminuria in patients with type 2 diabetes. Methods: Descriptive, prospective, cross-sectional study. Clinical examination, Clinical tests and 99mTc-DTPA GFR gamma - camera renography for patients. Result: GFR of the study group was 75,4 ± 22,3 ml/phut/1,73m2, the left kidney was 35,0 ± 13,0 is lower than the right kidney and 39,8 ± 11,9; p <0,01. There is no correlation between GFR with blood glucose and HbA1c, the risk of reduced GFR in hypertensive group associated is OR = 6,5 with p<0,01; albuminuria (+) is OR = 4,2 with p <0,01; and disease duration > 10 years is OR = 3,5 with p <0.01. Conclusion: GFR of the left kidneys is lower than the right kidney; correlation decreased GFR associated with hypertension, albuminuria and disease duration. Keywords: GFR, diabetes, albuminuria

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