scholarly journals DEVELOPMENT OF GEL DOSAGE FORM OF ETHYL ACETATE EXTRACT OF MANGOSTEEN RIND

2017 ◽  
Vol 1 (1) ◽  
pp. 28 ◽  
Author(s):  
Ketut Widyani Astuti ◽  
Ni Putu Ayu Dewi Wijayanti ◽  
I Gusti Ngurah Jemmy Anton Prasetia
Keyword(s):  
Ethyl Acetate ◽  
Propylene Glycol ◽  
Dosage Form ◽  
Ethyl Acetate Extract ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Dispersive Power ◽  
Optimum Formula ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract Alpha-mangostin is a xanthonoid compound contained in mangosteen rind (Garcinia mangostana L.) and has an antibacterial effect against Staphylococcus aureus, the bacterium that causes acne. In this study, mangosteen rind extract is formulated in a gel dosage form. This study aimed to determine the optimum formula, the physical and chemical properties as well as the optimum formula release profile of the gel dosage form of mangosteen rind extract. The mangosteen rind extract gel formula consists of viscolam, propylene glycol, glycerin, microcare®, ethyl acetate extract of mangosteen rind, and distilled water. The formula was optimized by varying the concentrations of viscolam (2% and 5%), propylene glycol (5% and 20%) and glycerin (2% and 15%) using a factorial experimental design program called Design Expert 7.0.0. The 8 formulas were developed into gel dosage form and the physical and chemical properties were then evaluated. The evaluation tests include viscosity, dispersive power, and pH tests. The evaluation results were processed using the Design Expert 7.0.0 program to determine the optimum formula. The results of the analysis showed the optimum formula of gel dosage form of mangosteen rind extract with viscolam percentage of 4.97%, propylene glycol of 9.91%, glycerin of 12.23%, microcare® of 0.3%, TEA (q.s), ethyl acetate extract of mangosteen rind of 1%, and distilled water of 45%. The evaluation results of the physical and chemical properties of the gel optimum formula revealed the viscosity of 2,345 cps, dispersive power of 6.59 cm, and pH of 6.74. Alpha-mangostin release test on the optimum formula revealed a flux value of 41.327 ?g/cm2/t1/2. From these results, it is concluded that the optimum formula has met the physical and chemical characteristics of a good gel.

scholarly journals FORMULASI DAN UJI PELEPASAN KRIM EKSTRAK ETANOL DAUN JAMBU BIJI DENGAN POTENSI ANTIJERAWAT

Jurnal Kimia ◽  
2020 ◽  
pp. 119
Author(s):  
N. P. Y. A. Dewi ◽  
N. L. G. W. Pebriani ◽  
P. A. Duarsa ◽  
P. C. I. Warnaya ◽  
I. D. A. A. D. Candraningrat ◽  
...  
Keyword(s):  
Stearic Acid ◽  
Chemical Properties ◽  
Ethanol Extract ◽  
Physical And Chemical Properties ◽  
Guava Leaves ◽  
Guava Leaf ◽  
Optimum Formula ◽  
Physical And Chemical ◽  
Active Substances ◽  
And Chemical Properties

Guava leaves contain quercetin which can inhibit the growth of Propionibacterium acne. Thus, guava leaves have the potential to be anti-acne. Based on the benefits of guava leaves, it is necessary to formulate the ethanol extract of guava leaves in cream preparation and its characterization as well as to know the rate of releasing active substances. Preparation and standardization of guava leaf simplicia was carried out. After that, maceration, standardization and phytochemical screening of guava leaf ethanol extract were done. Positive extracts containing flavonoids were formulated into cream preparation. The concentration of stearic acid as emulgator of 14% and 18% was optimized. The formula was tested for physical and chemical properties such as organoleptic, spreadability, adhesion, viscosity and pH. The optimum formula was characterized using Franz diffusion test to determine the release of the active substance. The results showed that concentration of stearic acid as emulgator influenced the physical and chemical properties of the cream. Based on the results of this study it could be concluded that the optimum formula was stearic acid concentration of 14% with the release active substances for 3 hours of 2,5882 mg. Keywords: Guava leaves, acne, cream, stearic acid, diffusion

Physical and Chemical Properties and Subcutaneous Implantation of Mineral Trioxide Aggregate Mixed with Propylene Glycol

2016 ◽  
Vol 42 (3) ◽  
pp. 474-479 ◽  
Author(s):  
Marina Angélica Marciano ◽  
Bruno Martini Guimarães ◽  
Pablo Amoroso-Silva ◽  
Josette Camilleri ◽  
Marco Antonio Hungaro Duarte
Keyword(s):  
Propylene Glycol ◽  
Mineral Trioxide Aggregate ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Subcutaneous Implantation ◽  
Physical And Chemical ◽  
And Chemical Properties

scholarly journals Bioactivity, physical and chemical properties of MTA mixed with propylene glycol

2015 ◽  
Vol 23 (4) ◽  
pp. 405-411 ◽  
Author(s):  
Vaishali Prakash NATU ◽  
Nileshkumar DUBEY ◽  
Gerald Choon Leong LOKE ◽  
Teng Seng TAN ◽  
Wee Hsuan NG ◽  
...  
Keyword(s):  
Propylene Glycol ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

Statistical criteria of stellar population types

1966 ◽  
Vol 24 ◽  
pp. 101-110
Author(s):  
W. Iwanowska
Keyword(s):  
Stellar Population ◽  
Chemical Properties ◽  
Spectrophotometric Study ◽  
Physical And Chemical Properties ◽  
Population Type ◽  
The Galaxy ◽  
Distribution Parameters ◽  
Physical And Chemical ◽  
Statistical Criteria ◽  
And Chemical Properties

In connection with the spectrophotometric study of population-type characteristics of various kinds of stars, a statistical analysis of kinematical and distribution parameters of the same stars is performed at the Toruń Observatory. This has a twofold purpose: first, to provide a practical guide in selecting stars for observing programmes, second, to contribute to the understanding of relations existing between the physical and chemical properties of stars and their kinematics and distribution in the Galaxy.

Response of corn (Zea mays L.) to various organic-based fertilizers in marginal upland of Sta. Rita, Samar

2017 ◽  
pp. 31-43
Author(s):  
Berta Ratilla ◽  
Loreme Cagande ◽  
Othello Capuno
Keyword(s):  
Block Design ◽  
Management Strategies ◽  
Chemical Properties ◽  
Organic Fertilizers ◽  
Growth And Yield ◽  
Physical And Chemical Properties ◽  
Total N ◽  
Randomized Complete Block Design ◽  
Physical And Chemical ◽  
And Chemical Properties

Organic farming is one of the management strategies that improve productivity of marginal uplands. The study aimed to: (1) evaluate effects of various organic-based fertilizers on the growth and yield of corn; (2) determine the appropriate combination for optimum yield; and (3) assess changes on the soil physical and chemical properties. Experiment was laid out in Randomized Complete Block Design, with 3 replications and 7 treatments, namely; T0=(0-0-0); T1=1t ha-1 Evans + 45-30-30kg N, P2O5, K2O ha-1; T2=t ha-1 Wellgrow + 45-30-30kg N, P2O5, K2O ha-1; T3=15t ha-1 chicken dung; T4=10t ha-1 chicken dung + 45-30-30kg N, P2O5, K2O ha-1; T5=15t ha-1 Vermicast; and T6=10t ha-1 Vermicast + 45-30-30kg N, P2O5, K2O ha-1. Application of organic-based fertilizers with or without inorganic fertilizers promoted growth of corn than the control. But due to high infestation of corn silk beetle(Monolepta bifasciata Horns), its grain yield was greatly affected. In the second cropping, except for Evans, any of these fertilizers applied alone or combined with 45-30-30kg N, P2O5, K2O ha-1 appeared appropriate in increasing corn earyield. Soil physical and chemical properties changed with addition of organic fertilizers. While bulk density decreased irrespective of treatments, pH, total N, available P and exchangeable K generally increased more with chicken dung application.

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