Development of the method for quantitive determination of an active substance in “Tamsuloprost” suppositories

2014 ◽  
Vol 0 (3(79)) ◽  
pp. 46-50
Author(s):  
V. I. Grytsenko ◽  
O. A. Ruban ◽  
S. M. Gubar ◽  
V. I. Gusarov
Keyword(s):  
Active Substance

scholarly journals The Theory of Wetting, and the Determination of the Wetting Power of Dipping and Spraying Fluids containing a Soap Basis

1915 ◽  
Vol 7 (2) ◽  
pp. 219-239 ◽  
Author(s):  
W. F. Cooper ◽  
W. H. Nuttall
Keyword(s):  
United States ◽  
South Africa ◽  
Active Substance ◽  
Sodium Arsenite ◽  
The United States ◽  
Active Constituent ◽  
Wetting Power ◽  
The Government

The dipping of sheep and cattle, as a means of eradicating ‘scab,’ lice, ticks, etc., and the diseases which it is now known the latter may transmit, has met with such success, that compulsory dipping is now in vogue in most pastoral countries. Where compulsory dipping obtains, there must of necessity be some system of the standardisation of dips. In Queensland and South Africa, the respective Governments issue official formulae from which the stockbreeder can prepare his own dipping fluid. Only such proprietary dips, as are duly recognised by the Government, may be employed. In the United States, the regulations for the sale of proprietary dips are still more stringent. The quantity of active substance, usually sodium arsenite, nicotine or cresylic acid, is defined within very narrow limits. Further, no proprietary dip is now recognised, unless the manufacturer can furnish a ‘Field Tester,’ by means of which the stockbreeder can himself determine, in a simple and fairly trustworthy manner, the percentage of active constituent in his bath.

scholarly journals Development of UV-spectrophotometry Method of the Quantitative Determination of a New Substance Quinazoline-4(3h)-on Derivate

2020 ◽  
Vol 9 (1) ◽  
pp. 30-34
Author(s):  
E. S. Mishchenko ◽  
A. D. Lazaryan ◽  
T. T. Lihota
Keyword(s):  
Quantitative Determination ◽  
Active Substance ◽  
Research Work ◽  
Biologically Active ◽  
Uv Spectrophotometry ◽  
Pharmacological Effects ◽  
Specific Absorption ◽  
Biologically Active Substance ◽  
Effective Remedy

Introduction. The aim idea of this research article is a development of the quantitative determination of a biologically active substance quinazolin4(3H)-on derivate with laboratory cypher «VMA-10-182, by UV-spectrophotometry with followed validation. The substance is an effective remedy that combines several pharmacological effects, like an antidepressant, anxiolytic and nootropic. As a result of preclinical trials, the research compound has proven to be an effective remedy in the fight and prevention of acute cerebrovascular accident (stroke). The substance realized pharmacological effects by stimulating the production of nitric oxide by the endothelial cells of the brain. As aresult of stimulating is a vasodilation of the vessels and improvement of blood flow in the ischemic part of the vessels occur. Therefore, for introducing the biologically active substance into medical practice we need to develop ways to control the quality of substance.Aim. The objective of this research work is to develop a method of the quantitative determination of a biologically active substance, derivative quinazolin-4(3H)-on (laboratory sypher – VMA-10-18), by method of UV spectrophotometry. The results of the research work were validated.Materials and methods. In this research we used a substance VMA-10-18 wich was previously purified from the initial and intermediate products of the synthesis. This substance is a white crystalline powder, odorless, hygroscopic.Results and discussion. The quantitative content of the active substance derived quinazolin-4(3H)-on has been determined. The specific absorption rate was calculated, followed by statistical processing of the results. The validation was carried out according to the «Specificity», «Linearity», «Accuracy», «Repeatability». The results indicate the effectiveness of the developed methodology and experimental reproducibility.Conclusion. Researches of physicochemical properties show al us use 95 % ethanol as a solvent. As a result we developed a method for the quantitative determination of the substance which can be proposed for inclusion in the normative documents. The quantitative determination of the active substance in the test substance was established, and the specific absorption index was calculated. All information are statistically processed and meet the requirements of regulatory documentation.

scholarly journals Development of methods for standardization of the active substance, namely the model mixture based on decamethoxine and thiotriazoline

2021 ◽  
Vol 23 (5) ◽  
pp. 703-707
Author(s):  
L. I. Kucherenko ◽  
O. O. Chonka ◽  
O. O. Portna
Keyword(s):  
Hydrochloric Acid ◽  
Polyvinyl Alcohol ◽  
Quantitative Determination ◽  
Active Substance ◽  
Model Mixture ◽  
State Enterprise ◽  
Chemical Reagents ◽  
The Creation ◽  
Active Substances

Today, the important problem is the creation of new decamethoxine and thiotriazoline based drugs for the treatment of stomatitis. The aim of the work is to develop a method for quantitative determination of decamethoxine and thiotriazoline in the model mixture (1:25) by spectrophotometry. Materials and methods. Series 6 model mixtures were made at the ratio of decamethoxine and thiotriazoline 1:25. We used certified substances: thiotriazoline series GTT 3460911 (manufacturer: State Enterprise Chemical Reagents Plant, Kharkiv), decamethoxine series № 010915 (manufacturer: LLC “PHARMCHIM”). Optizen POP spectrophotometer, polyvinyl alcohol, hydrochloric acid, and eosin were used. Results. A method for quantitative determination of decamethoxine and thiotriazoline in MS was developed. It was established that the content of active substances in MS is thiotriazoline from 0.5021 to 0.5096, decamethoxine from 0.0207 to 0.0211. Conclusions. A method for quantitative determination of decamethoxine and thiotriazoline in MS has been developed. The method of quantitative determination of decamethoxine and thiotriazoline in MS is reproducible.

Determination of content of active substance in copolymeric pour-depressant additives

1987 ◽  
Vol 23 (3) ◽  
pp. 158-159
Author(s):  
A. A. Filippov ◽  
N. G. Pavlovskaya ◽  
L. B. Itsikson
Keyword(s):  
Active Substance

scholarly journals Determination of toxicity of various preparative forms of pesticidal fungicides for nodule bacteria inoculants

2020 ◽  
Vol 224 ◽  
pp. 04032
Author(s):  
Y V Laktionov ◽  
Y V Kosulnikov ◽  
V V Yachno ◽  
A P Kozhemyakov
Keyword(s):  
Temperature Regime ◽  
Active Substance ◽  
Bradyrhizobium Japonicum ◽  
Rhizobium Leguminosarum ◽  
Holding Time ◽  
Expert Group ◽  
Nodule Bacteria ◽  
Biological Products ◽  
Soybean Nodule

The aim of our study was to determine the effect of fungicide formulation, brand of fungicide, its concentration in the solution, holding time and temperature regime of the solution on the number of survivors of nodule bacteria of soybean, lupine, peas and lentils in a solution. Bacterial suspensions of soybean nodule bacteria (Bradyrhizobium japonicum 634b), lupine (Bradyrhizobium lupini 367a), pea (Rhizobium leguminosarum 261b), and lentils (Rhizobium leguminosarum 712) were studied. Wetting powders Benomil (active substance benomil 500 g/kg, LLC “Soyuzagrohim”, Russia), Benorad (active substance benomil 500 g/kg, JSC “August”, Russia) and Fundazol (active substance benomil 500 g/l, LLC “Agro-Kemi”, Russia) and concentrates of suspension Maxim KS (active substance fludioxonil, 25 g/l; “Syngenta International AG”, Switzerland), Protect KS (active substance fludioxonil, 25 g/l; LLC “Agro Expert Group”, Russia), Protect Forte VSK (active substance fludioxonil, 40 g/l + flutriafol, 30 g/l; LLC “Agro Expert Group”, Russia) were studied as fungicidal disinfectants. Compatibility was determined after the preparation of tank solutions of biological products and fungicides, followed by an assessment of the percentage of surviving rhizobia depending on the brand of fungicide, its concentration (10 and 20%), the holding time of the solution (2, 4, 8 h) and the temperature regime of the solution (2-5, 16-18, 27 °C).

Near-infrared determination of active substance content in intact low-dosage tablets

Talanta ◽  
2005 ◽  
Vol 66 (5) ◽  
pp. 1294-1302 ◽  
Author(s):  
P CHALUS ◽  
Y ROGGO ◽  
S WALTER ◽  
M ULMSCHNEIDER
Keyword(s):  
Active Substance ◽  
Near Infrared ◽  
Low Dosage
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