The Effect of Nose Drops on an Acute Sinusitis: An Experimental Study in the Rabbit

1992 ◽  
Vol 6 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Mats Bende ◽  
Anders ÅKerlund ◽  
Marcos Intaglietta ◽  
Karl E. Arfors
Keyword(s):  
Experimental Study ◽  
Animal Model ◽  
Light Microscopy ◽  
Polymorphonuclear Leukocytes ◽  
Contralateral Side ◽  
Acute Sinusitis ◽  
Intracellular Enzyme ◽  
Sinus Mucosa ◽  
Maxillary Sinuses

An animal model was developed to study the effect of nose drops on an acute sinusitis. Leukocyte-stimulating n-formylmethionyl-leucyl-phenylalanine (FMLP) was added to polyvinyl sponges and placed bilaterally into the maxillary sinuses of the rabbit. Oxymetazoline nose drops were applied in one nasal cavity, on the contralateral side, using the application of saline as control. After 2 hours, the animals were killed, and the sponges were removed for analysis of leukocyte content by light microscopy and determination of myeloperoxidase (MPO), an intracellular enzyme in polymorphonuclear leukocytes. The sinus mucosa was dissected bilaterally and prepared for whole-amount light microscopy. There was a reduced number of leukocytes in the sinus mucosa on the side treated with oxymetazoline nose drops compared with the contralateral side. No significant differences were found in the number of leukocytes or MPO in the sponges. The effect of oxymetazoline may be due to its blood-flow-reducing effect or an effect on the endothelium in the microvascular bed.

scholarly journals Appearance and characteristics of the gunshot wounds caused by different fire weapons - animal model

2020 ◽  
Vol 148 (5-6) ◽  
pp. 350-356
Author(s):  
Anisa Gradascevic ◽  
Ivan Soldatovic ◽  
Anes Joguncic ◽  
Miroslav Milosevic ◽  
Nermin Sarajlic
Keyword(s):  
Experimental Study ◽  
Animal Model ◽  
Gunshot Wounds ◽  
Gunshot Residue ◽  
Forensic Investigation ◽  
Significant Difference ◽  
Different Types ◽  
Important Evidence ◽  
Gunpowder Residue

Introduction/Objective. Gunshot residue (GSR) on the skin of a victim are important evidence, with far better precision, for reconstructive questions in the forensic investigation of cases involving gunshot wounds. The aim of this experimental study was to analyze if there was any significant difference in macroscopic characteristics of wounds that were caused with different types of weapons from three different distances. Methods. This study was conducted at the Department of Ballistic and Mechanoscopic Expertise, Federal Police Directorate. Experiments were done on pigskin and 55 samples were made. Shooting was conducted using a system for safe firing. Samples of the pigskin were shot by firing projectiles from four different weapons and from three different distances, (contact wound, five centimetres and 10 centimetres). Results. At the contact range, wounds caused by automatic rifle had horizontal, vertical diameters larger than those made by pistols. Diameters on the wounds that were caused with different pistols, were similar. At the range of five centimetres, the narrowest part of contusion ring significantly differs even through pistol wounds. Diameters at the range of 10 centimetres are in favor of these results. Gunpowder residue scattering area was statistically different depending of type of weapon (p = 0.004). Conclusion. Wound diameters and surface area are useful for differentiation between pistol and rifle caused wounds. It is unsecure method for determination of pistol caliber or fire range. GSR have much greater potential for future analyses, but even GSR cannot be used to determine pistol caliber.

scholarly journals Influence of Anatomical Parameters on the Dimensions of the Subantral Space and Sinus Mucosa Thickening after Sinus Floor Elevation. A Retrospective Cone Beam Computed Tomography Study

2021 ◽  
Vol 9 (7) ◽  
pp. 76
Author(s):  
Yuki Omori ◽  
Yasushi Nakajima ◽  
Hideki Imai ◽  
Daichi Yonezawa ◽  
Mauro Ferri ◽  
...  
Keyword(s):  
Cone Beam ◽  
Sinus Floor Elevation ◽  
Axis Parallel ◽  
Height Gain ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation ◽  
Sinus Mucosa ◽  
Anatomical Parameters ◽  
Maxillary Sinuses

Background: Various anatomical parameters might influence the surgical approach for maxillary sinus floor elevation. The objective of the present study was to retrospectively evaluate the influence of anatomical parameters on the dimensions of the subantral space and of the sinus mucosa thickening after sinus floor elevation. Material and Methods: Seventy-eight maxillary sinuses in sixty-five patients were evaluated on cone beam computed tomographies taken before surgery and after one week (t1w) and nine months (t9m). Several parameters such as the distance XF between an axis parallel to the base of the nose (X-axes) and the sinus floor (F) were correlated with the height gain (IF) at t1w and t9m and the post-surgical edema. Results: A weak significant positive correlation was observed between height gain vs. sinus height of interest (XF), the balcony, and the sinus floor angle. The post-surgical edema was influenced by the initial mucosa thickness and the xenograft used. Conclusions: Various parameters might affect height gain and sinus mucosa thickening after sinus floor elevation. The height of interest, the balcony, and the sinus floor angle showed significant correlations with height gain. The initial thickness of the mucosa and the biomaterial used influenced the post-surgical edema.

scholarly journals Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Marc Bodenstein ◽  
Stefan Boehme ◽  
Stephan Bierschock ◽  
Andreas Vogt ◽  
Matthias David ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Animal Model ◽  
Electrical Impedance Tomography ◽  
Gas Flow ◽  
Electrical Impedance ◽  
Impedance Tomography

CT Findings in General Practice Patients with Suspected Acute Sinusitis

1996 ◽  
Vol 37 (3P2) ◽  
pp. 708-713 ◽  
Author(s):  
M. Lindbæk ◽  
U. L.-H. Johnsen ◽  
E. Kaastad ◽  
S. Dølvik ◽  
P. Møll ◽  
...  
Keyword(s):  
General Practice ◽  
Clinical Diagnosis ◽  
Interobserver Agreement ◽  
Acute Sinusitis ◽  
Fluid Level ◽  
Ct Findings ◽  
Kappa Value ◽  
Ct Evaluation ◽  
Common Combination ◽  
Maxillary Sinuses

Purpose: To study CT findings in general practice patients with a clinical diagnosis of acute sinusitis, and to examine the interobserver variation between 2 radiologists with regard to their CT evaluation. Material and Methods: Two hundred and one patients were examined with coronal CT images of the paranasal sinuses within 2 days of the clinical diagnosis. Patients with chronic sinusitis were excluded. Fluid level or total opacification of any sinus were used as evidence of sinusitis. Results: One hundred and twenty-seven (63%) patients had fluid level or total opacification in a sinus region, most in more than one region. One hundred and fifteen had CT signs of sinusitis in the ethmoid region, 84 in the maxillary, 18 in the frontal, and 10 in the sphenoid. Forty-nine patients had a negative CT. In the evaluation of interobserver agreement, the overall assessment of the CT yielded a kappa value of 0.70. Conclusion: The study demonstrated great variation in the CT findings in general practice patients with suspected acute sinusitis. More than one sinus region was affected in most patients in whom sinusitis was confirmed by CT imaging; the most common combination was ethmoid and maxillary sinuses. The interobserver agreement was substantial.

scholarly journals Determination of apoptosis through Bax expression in cryptorchid testis: an experimental study

2005 ◽  
Vol 11 (3) ◽  
pp. 170-173 ◽  
Author(s):  
Mehmet Dündar ◽  
Izzet Koçak ◽  
Nil Çulhaci ◽  
Haluk Erol
Keyword(s):  
Experimental Study ◽  
Cryptorchid Testis

Experimental Investigation of Microcutting Mechanisms in Marble Grinding

2009 ◽  
Vol 131 (6) ◽  
Author(s):  
LJ. Tanovic ◽  
P. Bojanic ◽  
R. Puzovic ◽  
S. Klimenko
Keyword(s):  
Experimental Study ◽  
Experimental Investigation ◽  
Cutting Force ◽  
Surface Finish ◽  
Normal Component ◽  
Natural Material ◽  
Grinding Process ◽  
Force Component ◽  
Diamond Grain

This paper offers an experimental study of the microcutting mechanisms in marble grinding to aid the optimization of the marble grinding process. The necessity for investigating these mechanisms is dictated by the increased use of marble in many applications and the fact that grinding and polishing processes are the dominant technologies used to meet surface finish requirements in this natural material. The experiments are aimed at the determination of the normal component of the cutting force and of the grain traces in microcutting with a single diamond grain. The investigations carried out make provisions for establishing critical grain penetration and cutting depths and allow the prediction of the normal cutting force component as a function of grain penetration speed and depth.

Determination of the L-ascorbic acid requirements in Wistar osteogenic disorder Shionogi rats for prolonged carcinogenesis experiments

1996 ◽  
Vol 30 (4) ◽  
pp. 337-346 ◽  
Author(s):  
S. W. Y. Chan ◽  
P. C. Reade
Keyword(s):  
Animal Model ◽  
Ascorbic Acid ◽  
Drinking Water ◽  
Normal Level ◽  
Physical Condition ◽  
Wistar Rats ◽  
Clinical Signs ◽  
Supplement Group ◽  
Palatal Mucosa

Wistar Shionogi rats of the ( od/od) substrain with the osteogenic disorder are unable to synthesize L-ascorbic acid ( L-AA) and appear to be an appropriate animal model for studying the effect of L-AA in carcinogenesis. To determine the minimal L-AA requirements of these animals for prolonged survival in a satisfactory physical condition during experimentation, four concentrations of L-AA (0.33 g/l, 0.67 g/l, 1.67 g/l and 3.33 g/l) were administered via drinking water to four groups of animals ( n=2). Their water intake per cage was recorded three times weekly and the plasma L-AA levels were determined at the start, after 2, 4, 8 and 12 weeks and at the termination of the experiment. To simulate the procedures to be undertaken in oral mucosal carcinogenesis experiments, the animals were gently restrained and a designated amount of sterile NaCl was applied to the palatal mucosa three times a week for 26 weeks. The L-AA supplement group with the lowest concentration (0.33 g/l L-AA) achieved mean plasma levels of 7 ± 1.38 μM, approximately one-eighth that of the normal level (mean plasma L-AA level in outbred Wistar rats was found to be 58 ± 3 μM) whilst those in the higher supplement group (3.33 g/l L-AA) achieved a mean of 18 ± 1.25 μM. All of the animals employed in the present study survived for 26 weeks and showed no clinical signs of L-AA deficiency during this period.

Sign in / Sign up

Export Citation Format

Share Document