scholarly journals Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Ekstrak Biji Ramania (Bouea macrophylla Griff) dengan Asam Oleat (Oleic Acid) sebagai Minyak Pembawa

2018 ◽  
Vol 8 ◽  
pp. 276-284
Author(s):  
Vinny Indriani ◽  
Novita Eka Kartab Putri Tobing ◽  
Laode Rijai
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tween 20

Ekstrak biji B.macrophylla memiliki aktivitas antioksidan yang kuat namun memiliki kelarutan dan bioavailabilitas yang rendah. Meningkatkan efektivitas ekstrak biji B.macrophylla dilakukan dengan memformulasikan ke dalam sistem SNEDDS menggunakan Asam Oleat sebagai minyak pembawa. Hasil penelitian menunjukkan bahwa komposisi formula SNEDDS ekstrak biji B.macrophylla yang paling optimal terdiri dari kombinasi tween 20 : propilenglikol : asam oleat (0,5 : 3 : 1,5 dan 0,5 : 3,38 : 1,12) dalam 5 mL yang memiliki emulsification time  dengan rerata waktu 19,03 detik dan 15,2 detik; nilai transmitansi 92,8% dan 94,2%; ukuran tetesan 176,8 nm dan 161,1 nm; polidisperse index 0,357 dan 0,364; serta nilai nilai IC50 ektrak biji B.macrophylla 1,757 μg/mL.

scholarly journals SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM OF EFAVIRENZ: FORMULATION, IN VITRO EVALUATION AND CHARACTERIZATION

2019 ◽  
pp. 217-226
Author(s):  
PAMU SANDHYA
Keyword(s):  
Drug Delivery ◽  
Dissolution Rate ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Visual Observation ◽  
Stability Study ◽  
In Vitro Dissolution ◽  
Tween 20

Objective: The main objective of this study was to preparation and evaluation of efavirenz (EFV) to enhance its solubility and dissolution rate by self-emulsifying drug delivery system. Methods: EFV self-emulsifying drug delivery systems (SNEDDS) were formulated using different oils, surfactant, and co-surfactant. Peceol, Tween 20, and Capmul MCM were used as oil, surfactant, and co-surfactant, respectively, followed by the evaluation by the performance of different tests such as visual observation, solubility studies, thermodynamic stability study, transmittance studies, drug content, and in-vitro release study. Results: Fourier-transform infrared studies revealed negligible drug and polymer interaction. From the phase diagram, it was observed that self-emulsifying region was enhanced with increasing surfactant and co-surfactant concentrations with oil. F13 was selected as optimized formulation on the basis of physicochemical parameters, particle size, and in-vitro dissolution studies with the release of 98.39±5.10% drug in 1 hour. The optimized formulation size was found to be 156.7 nm as mean droplet size and Z-Average of 808.6 nm with -18.3 mV as zeta potential. Conclusion: The study demonstrated that SNEDDS was a promising strategy to enhance the dissolution rate of EFV by improving solubility.

A TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DEFERIOXAMINE MESYLATE FOR THE TREATMENT OF BETA-THALASSAEMIA MAJOR

2011 ◽  
Vol 23 (01) ◽  
pp. 29-35
Author(s):  
Chin-Hsiung Hsieh ◽  
Yuan-An Ku ◽  
Lien-Hua Chiu ◽  
Tai-Horng Young ◽  
Yi-You Huang
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Iron Overload ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Polysorbate 80 ◽  
Thalassaemia Major ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive

Patients with beta-thalassaemia major need blood transfusion frequently during their whole life. However, frequent transfusions will eventually lead to the accumulation of trivalent iron, resulting in iron overload. To reduce iron overload, patients are administered regularly with intravenous or subcutaneous infusion of deferioxamine mesylate (DFO). Nevertheless, high costs of medication, poor patient compliance, and side effects limit its use and patient's acceptance. To overcome such drawbacks, we developed a novel transdermal delivery system to administer the DFO instead of traditional injections. We assayed the feasibility of fabricating a transdermal DFO patch using the single-layer drug-in-adhesive drug delivery system. We used the pressure-sensitive adhesives and hydrogels as the drug reservoirs and studied the release profile of DFO from the transdermal patches in vitro. In order to enhance the transdermal delivery rate, chemical enhancers, polysorbate 80 and oleic acid, and physical enhancer, ultrasound, were incorporated into the monolith DFO patches. Experimental results showed that the combination of polysorbate 80 and oleic acid in the pressure-sensitive adhesives enhanced the penetration efficiency through nude mice skin. The pretreatment of nude mice skin with ultrasound temporally changed the diffusional resistance and facilitated DFO penetration through the skin. We expect that the new delivery system can enable the drug to penetrate through skin at a stable rate and reach the circulation system successfully, thus allowing the concentration of drug to achieve the therapeutic effect.

scholarly journals Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

2020 ◽  
Vol 10 (02) ◽  
pp. 210-216
Author(s):  
Esti Hendradi ◽  
Rahmi Annisa ◽  
Mochammad Yuwono
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Olive Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Palm Oil ◽  
Tween 20 ◽  
Hydrophilic Lipophilic Balance ◽  
Selection Of ◽  
Optimal Formula

Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

scholarly journals Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase

Pharmaciana ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 267 ◽  
Author(s):  
Sani Ega Priani ◽  
Nurrayyan Nurrayyan ◽  
Fitrianti Darusman
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Delivery System ◽  
Delivery System

FORMULATION AND EVALUATION OF LIPID BASED SELF EMULSIFYING DRUG DELIVERY SYSTEM OF GLIMEPIRIDE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (11) ◽  
pp. 48-51
Author(s):  
K Sneha Latha ◽  
◽  
G. B Kiran Kumar ◽  
G. A Mohammed ◽  
S.K Chowdary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Release ◽  
Dissolution Rate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Classification System ◽  
Tween 80 ◽  
Low Solubility ◽  
Biopharmaceutical Classification System

Aim of the present investigation was to develop lipid based self-emulsifying drug delivery system (SEDDS) to improve bioavailability of glimepiride. Glimepiride is a class II molecule according to BCS (Biopharmaceutical Classification System), having low solubility. Optimized self-emulsifying drug delivery system of glimepiride comprising oil (oleic acid), surfactant (Tween 80®) and co-surfactant (PEG 200®) was prepared. Optimized SEDDS of glimepiride showed increase in dissolution rate. It was concluded that the formulation was found to be showing significant improvement in terms of the drug release with complete release of drug within 18 minutes. Thus, self-emulsifying formulation of glimepiride was successfully developed.

Formulation and In Vitro Evaluation of Self Microemulsifying Drug Delivery System Containing Atorvastatin Calcium

2019 ◽  
Vol 16 (8) ◽  
pp. 768-779
Author(s):  
Mine Diril ◽  
Gülbeyaz Yıldız Türkyılmaz ◽  
H. Yeşim Karasulu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Droplet Size ◽  
Delivery System ◽  
Tablet Formulation ◽  
Tween 20 ◽  
Kinetic Evaluation ◽  
Atorvastatin Calcium ◽  
Solubility Studies

Objective: The aim of this study was to develop a new dosage form as an alternative to the classical tablet forms of atorvastatin calcium (AtrCa). The formulation strategy was to prepare an optimum self micro emulsifying drug delivery system (SMEDDS) to overcome the problem of low solubility of the active substance. Methods: In this study, pseudo ternary phase diagrams were plotted determined by the solubility studies. According to the solubility studies; oleic acid was used as the oil phase, Tween 20 and Span 80 were used as the surfactants and ethanol was used as the co-surfactant. SMEDDS formulations were characterized according to pH, electrical conductivity, density, refractive index, viscosity, emulsification time, dispersibility, robustness of dilution stability, droplet size, polidispersity index, zeta potential, transmittance %, cloud point, content quantification %, chemical and physical stability. The lipolysis study was conducted under fed and fasted conditions. In vitro release studies and kinetic evaluation were carried out. Permeability studies were also examined with Caco-2 cell culture. Results: The droplet size of the optimized formulation did not change significantly in different medias over the test time period. Improved SMEDDS formulation will progress steadily without precipitating along the gastrointestinal tract. Lipolysis studies showed that the oil solution had been exposed to high amount of lipolysis compared to the SMEDDS formulation. The release rate of AtrCa from AtrCa- SMEDDS formulation (93.8%, at 15 minutes) was found as increased when the results were compared with commercial tablet formulation and pure drug. The permeability value of AtrCa from AtrCa- SMEDDS formulation was found higher than pure AtrCa and commercial tablet formulation, approximately 9.94 and 1.64 times, respectively. Conclusion: Thus, lipid-based SMEDDS formulation is a potential formulation candidate for lymphatic route in terms of the increased solubility of AtrCa.

scholarly journals Formulasi Sediaan Nano Herbal Tempuyung (Sonchus arvensis L.) dalam Bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS)

2016 ◽  
Vol 3 (1) ◽  
pp. 50
Author(s):  
Budy Wijiyanto ◽  
Primadara Damayanti ◽  
Mira Amaliasari Sitorus ◽  
Ratih Dyah Listianingrum ◽  
Arifa Caryn Dea ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tween 20 ◽  
Peg 400 ◽  
Sonchus Arvensis

Tempuyung (Sonchus arvensis L.) merupakan tanaman asli Indonesia yang berhkasiat sebagai diuretik dan antioksidan. Untuk mendapatkan efek terapi yang optimal perlu inovasi untuk membuatnya menjadi sediaan nano herbal. Penelitian ini bertujuan  membuat sediaan nano herbal tempuyung dalam bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS).  Kandungan zat aktif tempuyung diekstraksi dengan etanol dan berikut diuapkan pelarutnya untuk mendapatkan ekstrak kental. Ekstrak yang diperoleh distandarisasi menurut Farmakope Herbal Indonesia. Berikutnya dibuat SNEDDS tempuyung dengan menggunakan minyak Capryol-90, surfaktan tween 20 dan ko-surfaktan PEG 400. SNEDDS yang diperoleh dikarakterisasi meliputi ukuran partikel dan zeta potensial. Dari ekstraksi diperoleh ekstrak kental sebanyak 77,52 g. Hasil ini telah memenuhi syarat jika dibandingkan dengan Farmakope Herbal yang menyebutkan perolehan rendemen ekstrak kental daun tempuyung adalah tidak kurang dari 7,5%.  Formulasi tempuyung dalam bentuk sediaan SNEDDS diperoleh suatu nanoemulsi yang jernih dengan ukuran partikel 16,2 ± 1,06 nm dan nilai zeta potensial -37,48±0,74 mV. Dapat disimpulkan bahwa ekstrak tempuyung menghasilkan suatu nano herbal dalam bentuk sediaan SNEDDS.

scholarly journals OPTIMASI PEMBUATAN NANOEMULSI VIRGIN COCONUT OIL

Jurnal Kimia ◽  
2018 ◽  
pp. 8
Author(s):  
N. M. D. Listyorini ◽  
N. L. P. D. Wijayanti ◽  
K. Widnyani Astuti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Coconut Oil ◽  
Tween 20 ◽  
Virgin Coconut Oil ◽  
Spontaneous Emulsification ◽  
Peg 400

Penelitian ini mempelajari optimasi pembuatan nanoemulsi menggunakan virgin coconut oil (VCO) yang bertujuan untuk memperoleh perbandingan minyak (VCO), surfaktan dan kosurfaktan yang dapat membentuk nanoemulsi yang memenuhi persyaratan menggunakan Self Nano-Emulsifying Drug Delivery System (SNEDDS). Metode yang digunakan adalah Spontaneous Emulsification yang termasuk ke dalam SNEDDS. Perbandingan yang digunakan dalam nanoemulsi yaitu minyak (VCO): surfaktan (Cremophor RH40 atau Tween 20): kosurfaktan (PEG 400 atau etanol): fase air (akua deion) dengan perbandingan (1:8:1):5, (1:7:2):5 dan (2:7:1):5 yang menghasilkan 12 buah formula. Dilakukan uji evaluasi berupa uji stabilitas isik dan persen transmitan ke-12 formula. Diperoleh 2 formula yang dilanjutkan untuk uji zeta potensial dan ukuran partikel yaitu F2 dan F7. Uji zeta potensial F2 (0,14 mV) dan F7 (0,48 mV) serta uji ukuran partikel F2 (20,8 nm) dan F7 (20,6 nm). Berdasarkan hasil uji evaluasi yang dilakukan maka diperoleh dua formula yaitu F2 (VCO: Cremophor RH40: PEG 400 (1: 8:1)) dan F7 (VCO: Cremophor RH40: Etanol (1: 7: 2)) yang sesuai persyaratan untuk menghasilkan nanoemulsi yang baik.

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