Clinical and epidemiological characteristics of pediatric patients with positive serology for Mycoplasma pneumoniae, treated in the third level hospital from 2006 to 2008

Introduction: Infection by Mycoplasma pneumoniae is becoming more frequent at younger ages. It appears as a generally benign and unspecific clinical condition of respiratory symptoms and sometimes responsible for a broad spectrum of extrapulmonary manifestations. Objective: To describe demographic, clinical, laboratory, and treatment characteristics of pediatric-age patients with positive serology for M. pneumoniae diagnosed at the Pablo Tobón Uribe Hospital (HPTU) during the 2006-2008 period. Materials and methods: Observational, retrospective study, which describes the demographic, clinical, laboratory, and treatment characteristics of patients from 1 month to 14 years of age with positive IgM for M. pneumoniae seen at HPTU during September 2006 and November 2008. Results: We reviewed 305 clinical charts of patients with positive IgM for M. pneumoniae. The average age was 5.15 years ± 3.62 SD. Cough (87.5%), fever (65.9%), rhinorrea (39.3%), and respiratory difficulty (38%) were the most frequent clinical findings. Extrapulmonary compromise was mainly manifested in the skin (12.8%), the central nervous system (CNS) (3.6%), and osteomuscular system (3.9%). Auscultation and thoracic X-ray were normal in 33.1% and 30.8% of the patients, respectively. Episodes of asthma exacerbation were related to infection by Mycoplasma in 35% of the cases. A total of 51% of the patients required hospitalization with an average stay of seven days. All the patients received antibiotic treatment; clarithromycin (75.8%) was the antibiotic of choice. Conclusion: Infection by M. pneumoniae has a broad range of clinical manifestations, requiring a high index of clinical suspicion and an active search for extrapulmonary compromise given that in our realm there is no specific diagnostic method for the acute infection.

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Lyme borreliosis

Oxford Textbook of Rheumatology ◽

10.1093/med/9780199642489.003.0101_update_002 ◽

2013 ◽

pp. 772-777

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in late manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years or induce a persisting immunopathological response that may cause acrodermatitis chronica atrophicans, chronic neuroborreliosis of the central nervous system, or antibiotic resistant Lyme arthritis. However, even these chronic manifestations usually slowly regress after thorough antibiotic and symptomatic therapy, although in part with irreversible organ defects.

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Lyme borreliosis

10.1093/med/9780199642489.003.0101 ◽

2013 ◽

Cited By ~ 1

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

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Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital

Archives of Iranian Medicine ◽

10.34172/aim.2020.10 ◽

2020 ◽

Vol 23 (4) ◽

pp. 272-276 ◽

Cited By ~ 6

Author(s):

Ling Peng ◽

Kang-Yong Liu ◽

Fei Xue ◽

Ya-Fang Miao ◽

Ping-An Tu ◽

...

Keyword(s):

Nucleic Acid ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Early Recognition ◽

Case Reports ◽

Clinical Manifestations ◽

Nucleic Acid Testing ◽

Single Center ◽

Cross Sectional ◽

Epidemiological Characteristics

Background: In December 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was reported in Wuhan, Hubei province, China, which has subsequently affected more than 200 countries worldwide including Europe, North America, Oceania, Africa and other places. The number of infected people is rapidly increasing, while the diagnostic method of COVID-19 is only by nucleic acid testing. Objective: To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. To clarify the early epidemiology and clinical characteristics about COVID-19. Methods: Cross-sectional, single-center case reports of the 86 patients screened at Zhoupu Hospital in Pudong New District, Shanghai, China, from January 23 to February 16, 2020. Epidemiology, demography, clinical, laboratory and chest CTs were collected and analyzed. The screened patients were divided into COVID-19 and non-COVID-19 based on nucleic acid test results. Results: Of the 86 screened patients, 11 were confirmed (12.8%) by nucleic acid testing (mean age 40.73 ± 11.32, 5 males). No significant differences were found in clinical symptoms including fever, cough, dyspnea, sore throat, and fatigue (P > 0.05). No statistical difference was observed in plasma C-reactive protein (CRP) between the two groups (COVID-19 and non-COVID-19 ) of patients (P = 0.402), while the white blood cell count and lymphocyte count of the confirmed patients were slightly lower than those of the suspected patients (P < 0.05). Some non-COVID-19 chest CTs also showed subpleural lesions, such as ground-glass opacities (GGO) combined with bronchiectasis; or halo nodules distributed under the pleura with focal GGO; consolidation of subpleural distribution or combined with air bronchi sign and vascular bundle sign, etc. Conclusion: The early clinical manifestations and imaging findings of COVID-19 are not characteristic in non-outbreak areas. Etiological testing should be performed as early as possible for clinically suspected patients.

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Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles

Epidemiology and Infection ◽

10.1017/s0950268805005522 ◽

2005 ◽

Vol 134 (3) ◽

pp. 548-555 ◽

Cited By ~ 19

Author(s):

I. PULJIZ ◽

I. KUZMAN ◽

O. DAKOVIC-RODE ◽

N. SCHÖNWALD ◽

B. MISE

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Aspartate Aminotransferase ◽

Chlamydia Pneumoniae ◽

Clinical Findings ◽

Community Acquired Pneumonia ◽

C Reactive Protein ◽

Reactive Protein ◽

Epidemiological Characteristics ◽

Mycoplasma Pneumoniae Pneumonia

The purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae (87 patients) and Mycoplasma pneumoniae (147 patients). C. pneumoniae and M. pneumoniae infection was confirmed by serology. C. pneumoniae patients were older (42·12 vs. 24·64 years), and were less likely to have a cough, rhinitis, and hoarseness (P<0·001). C. pneumoniae patients had higher levels of C-reactive protein (CRP), and aspartate aminotransferase (AST) than M. pneumoniae patients (P<0·001). Pleural effusion was recorded more frequently in patients with M. pneumoniae (8·84 vs. 3·37%). There were no characteristic epidemiological and clinical findings that would distinguish CAP caused by M. pneumoniae from C. pneumoniae. However, some factors are indicative for C. pneumoniae such as older age, lack of cough, rhinitis, hoarseness, and higher value of CRP, and AST.

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Reporte de un probable caso de Hemoglobina S / Talasemia Beta.

Revista Medica Herediana ◽

10.20453/rmh.v15i3.788 ◽

2013 ◽

Vol 15 (3) ◽

pp. 173

Author(s):

John RAMÍREZ CUENTAS ◽

Olga LIZAMA OLAYA ◽

Josilú MARTÍNEZ LA ROSA ◽

Mercy JHONG OLIVERA ◽

Eduardo SALAZAR LINDO

Keyword(s):

Cell Morphology ◽

Clinical Presentation ◽

Clinical Laboratory ◽

Reticulocyte Count ◽

Clinical Manifestations ◽

Electrophoretic Analysis ◽

Clinical Findings ◽

Red Cell ◽

Careful Observation ◽

Hematological Evaluation

We report the case of a patient with Hemoglobin S / Thalassemia. It is feasible to recognize this infrequent disease by its clinical presentation and the aid of clinical laboratory . On this patient, the diagnosis was established based on the clinical findings, hematological evaluation (with careful observation of the red cell morphology and reticulocyte count) and electrophoretic analysis of hemoglobin. We discusse the physiopathology, clinical manifestations, treatment and alternative of prevention of this disease.

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Clinical-epidemiological and treatment characteristics of children with COVID-19 in a tertiary referral center in Perú

10.1101/2020.09.18.20186866 ◽

2020 ◽

Author(s):

Christian Chiara-Chilet ◽

Medalit Luna-Vilchez ◽

Julio Maquera-Afaray ◽

Blanca Salazar-Mesones ◽

Diana Portillo-Alvarez ◽

...

Keyword(s):

Clinical Laboratory ◽

Clinical Manifestations ◽

Bivariate Analysis ◽

Tertiary Referral Center ◽

Critical Care Units ◽

Treatment Information ◽

Treatment Characteristics ◽

Previous Contact ◽

Radiological Pattern ◽

General Wards

Introduction The COVID-19 pandemic has a great impact on children's health. This study describes the clinical, epidemiological and treatment characteristics of children presenting COVID-19 at the Instituto Nacional de Salud del Niño San Borja (INSN-SB) Methods This was a retrospective study of patients with a confirmed diagnosis of COVID-19 from March to July 2020. Demographic, clinical, laboratory, radiological, and treatment information were collected. Data analysis included descriptive statistics and bivariate analysis to determine differences between patients in general wards and the intensive care unit (ICU). Results We included 91 patients, 33 being females (36.3%). The most affected age group was children > 2 years of age (63 cases) with a median age of 6 years (IQR 3-10), and 61.5% were from Lima. The previous contact was determined in 30.8% of cases. A positive SARS CoV-2 PCR result was obtained in 50.6%. The presence of comorbidity was 53.8%. The most frequent symptoms were: fever (39.6%), general malaise (23.1%), cough (19.8%), and respiratory distress (14.3%). The presence of multisystem inflammatory syndrome in children (MIS-C) was confirmed in 6 patients. Antibiotics were administered in 76.9%. The most frequent radiological pattern was bilateral interstitial infiltrates (57.7%). Mortality was higher in patients in the ICU than in the hospitalization ward (27.3% vs. 4.3%, respectively; p = 0.02) Conclusions COVID-19 in children presents mild and moderate clinical manifestations. The presence of comorbidity is an important factor for hospitalization, and mortality is high upon admission to critical care units.

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Lyme borreliosis

Oxford Textbook of Rheumatology ◽

10.1093/med/9780199642489.003.0101_update_003 ◽

2013 ◽

pp. 772-777

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

Lyme borreliosis (LB) is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi. The most frequent clinical manifestations include erythema migrans, meningoplyneuritis, and arthritis. Diagnosis of LB is made on clinical grounds and usually supported by a positive serology. Early diagnosis and treatment almost always leads to a rapid healing of the disease. However, in disseminated manifestations gradual remission of symptoms may take several weeks to months. In rare cases, the pathogen can persist for many years, causing acrodermatitis chronica atrophicans, chronic neuroborreliosis of the central nervous system, or Lyme arthritis. Moreover, the infection may induce a persisting immunopathological response, resulting in ‘antibiotic-resistant’ Lyme arthritis. However, even these chronic manifestations usually slowly regress after thorough antibiotic and symptomatic therapy, although in part with irreversible organ defects.

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Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Current Issues in Pharmacy and Medical Sciences ◽

10.1515/cipms-2018-0022 ◽

2018 ◽

Vol 31 (3) ◽

pp. 113-116 ◽

Cited By ~ 1

Author(s):

Mostafa Javanian ◽

Arefeh Babazadeh ◽

Soheil Ebrahimpour ◽

Mehran Shokri ◽

Masomeh Bayani

Keyword(s):

Clinical Laboratory ◽

Clinical Symptoms ◽

Clinical Signs ◽

Clinical Manifestations ◽

Gastrointestinal Symptoms ◽

Medical Sciences ◽

Laboratory Findings ◽

Cross Sectional ◽

Number Of Patients ◽

Epidemiological Characteristics

Abstract The clinical and para clinical manifestations of influenza in various patients have range from an autoimmune disease to a life-threatening respiratory infection. In addition, the severity of the disease is influenced by factors such as demographic factors, underlying diseases, and immune response. Therefore, in this study, we evaluated the clinical, laboratory and epidemiological characteristics of patients with this type of influenza in Babol (north of Iran). This study was conducted as a descriptive cross-sectional study from October 2015 to March 2016. Subsequently, in this study, records of 123 patients with clinical signs of the influenza-like disease who have undergone the clinical sign in hospitals affiliated to Babol University of Medical Sciences were reviewed. Of 123 patients admitted to a possible diagnosis of influenza, 58 patients (47.2%) were PCR positive for H1N1, while seventy nine (64.2%) participants were women and 21 (17.1%) had diabetes or underlying lung disease. Most of the involved age groups were of individuals above the age of 50. These were followed by the 21-35 years-old. Fever (78%), cough (65.9%), shivering (58.5%) and myalgia (56.1%) were the most common clinical symptoms. Increased levels of transaminases (43.1%), leukocytosis (35.8%) and thrombocytopenia (34.2%) were as well reported in patients as the most frequently reported para clinical findings. In the present study, the most usual clinical symptoms were fever, cough, chill, and myalgia, while gastrointestinal symptoms were also noticeably observed in patients. In an experimental study, a significant number of patients showed leukocytosis and thrombocytopenia and increased transaminases.

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Lyme borreliosis

10.1093/med/9780199642489.003.0101_update_001 ◽

2016 ◽

Author(s):

Andreas Krause ◽

Volker Fingerle

Keyword(s):

Lyme Borreliosis ◽

Erythema Migrans ◽

Clinical Manifestations ◽

Lyme Arthritis ◽

Symptomatic Therapy ◽

Positive Serology ◽

Antibiotic Resistant ◽

Acrodermatitis Chronica Atrophicans ◽

Rapid Healing ◽

The Central Nervous System

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Nutritional B12 Deficiency in Infants of Vitamin B12-Deficient Mothers

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000080 ◽

2011 ◽

Vol 81 (5) ◽

pp. 328-334 ◽

Cited By ~ 6

Author(s):

Oya Halicioglu ◽

Sezin Asik Akman ◽

Sumer Sutcuoglu ◽

Berna Atabay ◽

Meral Turker ◽

...

Keyword(s):

Megaloblastic Anemia ◽

Maternal Diet ◽

Clinical Manifestations ◽

Serum Vitamin ◽

Failure To Thrive ◽

Clinical Findings ◽

Vitamin B ◽

Animal Products ◽

Hematological Evaluation ◽

Nutritional Vitamin

Aim: Nutritional vitamin B12 deficiency in infants may occur because the maternal diet contains inadequate animal products. Clinical presentations of the infants who had nutritional vitamin B12 deficiency were analyzed in this study. Subjects and Methods: Patients with nutritional vitamin B12 deficiency were enrolled in the study between 2003 and 2010. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. Results: Thirty children aged 1 - 21 months constituted the study group. Poverty was the main cause of inadequate consumption of animal products of the mothers. All infants had predominantly breastfed. The most common symptoms were developmental delay, paleness, apathy, lethargy, anorexia, and failure to thrive. Hematological findings were megaloblastic anemia (83.3 %), thrombocytopenia (30 %), and severe anemia (13.3 %). All of the mothers had low serum B12 levels; eight of them had megaloblastic anemia. Conclusion: The unusual clinical manifestations of vitamin B12 deficiency may also be seen apart from neurological and hematological findings. Nutritional vitamin B12 deficiency due to maternal deficiency might be a serious health problem in infants. Therefore, screening and supplementation of pregnant and lactating women to prevent infantile vitamin B12 deficiency should be considered.

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