The Use of Psychotropic Medication for People with Severe Disabilities and Challenging Behavior: Current Status and Future Directions

1998 ◽  
Vol 23 (2) ◽  
pp. 83-97 ◽  
Author(s):  
Craig H. Kennedy ◽  
Kim A. Meyer

People with severe disabilities who engage in challenging behavior are often prescribed psychotropic medication as a form of intervention. Although the goal of the medication is to reduce challenging behavior, limited empirical evidence is available to support the use of psychotropic intervention for people with severe disabilities. However, across a range of drug classes basic research suggests that many psychotropic medications selectively affect dimensions of behavior that could be of benefit in reducing challenging behavior. Currently, researchers cannot demonstrate whether most drugs prescribed to reduce challenging behavior are effective or predict when adverse side effects will emerge from their use. In this article we review the basic literature on behavioral pharmacology and integrate those findings with existing applied research to update JASH readers regarding the status of psychotropic medication. From this review, we present a set of suggestions that include: (a) improving research practices, (b) increasing the diversity of individuals involved in decision-making processes regarding medication use, and (c) developing consumer-friendly strategies for monitoring drug effects.

OSEANA ◽  
2020 ◽  
Vol 45 (2) ◽  
pp. 1-12
Author(s):  
Ita Wulandari ◽  
Dede Falahudin

Persistent organic pollutants (POPs) have been identified as representing a serious threat to the marine environment and received formal attention by nations worldwide including Indonesia as one of the signatories and ratified countries for the Stockholm Convention.  Due to their emerging issues, the study of POPs at all aspects is needed. Therefore, this paper attempts to review characteristics and toxicological properties of POPs, the current status of POPs National Implementation Plans (NIPs) in Indonesia, and propose future directions of POPs study in Indonesia from basic research such as monitoring of POPs distribution in Indonesian seas to applied research for example study of POPs alternative compounds.


Buildings ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 567
Author(s):  
Hongping Yuan ◽  
Wenbo Du ◽  
Zeyu Wang ◽  
Xiangnan Song

Megaproject practices worldwide have triggered increasing research in megaproject management issues and led to an increasing number of papers being published during the last decade. However, it is demonstrated by the literature that there is no systematic examination on research development in the discipline of megaproject management, and consequently it is very difficult for scholars to quickly understand and grasp the research trend. Therefore, a research question naturally comes out, i.e., what is the status quo of megaproject management research and what are the research directions worthy of further investigation? This study aims to answer the question by conducting a systematic examination of the research development in the discipline of megaproject management. A total of 117 relevant articles, identified from six major international journals between 2009 and 2021, were analyzed based on the number of papers published annually, main author contributions, citations, categorization of the research methods and data analysis methods adopted, and research topics covered. The results indicated that developed countries, such as Australia, Canada, the United States, and the United Kingdom, have enjoyed significant advantages in terms of megaproject management research. It also revealed that more sophisticated views and theory have been used effectively, rather than only basic qualitative methods, in a number of studies on megaproject management. Future studies on megaproject management will be led globally, where megaprojects will remain designed and built to better built environments. In addition, continuous in-depth research on related topics can promote innovation in megaproject management to achieve sustainable megaproject development. Megaproject management will continue to be a hot research topic in the future; in particular, megaproject investment and finance management have emerged as new challenging topics. The findings can be valuable for both industry practitioners and researchers to gain deeper understanding of the current status and future directions of megaproject management research.


Author(s):  
Christopher D. Wickens ◽  
Robert S. Gutzwiller

A model for task switching which focuses on the decision making of operators in overloaded multitask conditions is reviewed and new research presented. The STOM model is an ongoing effort and as such, work is now accumulating, which serves to validate the model as a useful predictive method, but also is uncovering uncertainties that require further investigation. Here we summarize the origins of the model, which was informed by past modeling efforts, a literature review and a meta-analysis. We then describe in detail the basic parameters of STOM and the current status of each, before discussing future directions and six uncertainties uncovered when building our understanding of task switching choice.


2021 ◽  
Author(s):  
Marília B Visacri ◽  
Aline de S Nicoletti ◽  
Eder de C Pincinato ◽  
Pía Loren ◽  
Nicolás Saavedra ◽  
...  

Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.


2016 ◽  
Vol 17 (8) ◽  
pp. 755-762 ◽  
Author(s):  
Xu Zhou ◽  
Renhe Liu ◽  
Shuo Qin ◽  
Ruilian Yu ◽  
Yao Fu

2020 ◽  
Vol 11 ◽  
Author(s):  
Nathaniel Edward Bennett Saidu ◽  
Chiara Bonini ◽  
Anne Dickinson ◽  
Magdalena Grce ◽  
Marit Inngjerdingen ◽  
...  

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