Profil pacjenta diagnozowanego w kierunku boreliozy na przykładzie pacjentów szpitala pediatrycznego Warszawskiego Uniwersytetu Medycznego w latach 2013-2015

2018 ◽  
Vol 22 (1) ◽  
Author(s):  
Małgorzata Badełek-Izdebska ◽  
Małgorzata Dębska ◽  
Lidia Zawadzka-Głos
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Clinical Symptoms ◽  
Elisa Test ◽  
Facial Nerve Paralysis ◽  
Pediatric Hospital ◽  
Serological Tests ◽  
Nerve Paralysis ◽  
History Of ◽  
Medical University

Introduction. Lyme borreliosis is the most frequent tick-borne disease in Europe and North America. It is a chronic, multi-organ disease, with phasic course. The diagnosis is based on clinical symptoms and serologic findings at the patient bitten by the tick. Aim. Aim of this study was to analyze the recommendations for the tests towards the Lyme disease at patients of the Pediatric Hospital of Medical University of Warsaw. Material and methods. We conducted a retrospective analysis of medical data of children hospitalized at the Pediatric Hospital in the period from January 2013 to the end of February 2015, who had performed diagnostic tests for Borrelia burgdorferi infection. Results. In the period from 1st January 2013 to 28th February 2015 tests forantibodies to Borrelia burgdorferi were ordered in 226 patients, including 119 girls and 107 boys. The ELISA test was performed in 219 patients, Western blot test was performed in 25 patients, and the presence of antibodies in the cerebrospinal fluid was examined in 2 patients. Diagnosed patients presented various symptoms. Patients from the two largest groups reported with articular complaints and heart symptoms. The group of patients diagnosed with fever, headache and facial nerve paralysis was less numerous. A small group of patients had a history of tick bite and presented with erythema. Conclusions. Patients of the Pediatric Hospital of the Medical University of Warsaw, who were ordered to perform tests for Lyme disease, presented symptoms from various organs and systems. These symptoms overlap with ailments and symptoms described in people who have been diagnosed with Lyme disease in both the early and late stages of the disease. The serological tests in connection with the medical history and physical examination are an important element in the diagnostics of Lyme disease in children.

Morphea after Borrelia-induced facial nerve palsy

2020 ◽  
pp. 239719832095689
Author(s):  
Catherine B Xie ◽  
Shawn Cowper ◽  
Ian D Odell
Keyword(s):  
Borrelia Burgdorferi ◽  
Facial Nerve ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Localized Scleroderma ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
Common Cause ◽  
Autoimmune Phenomenon ◽  
History Of

Morphea, also known as localized scleroderma, is characterized by inflammation and fibrosis of the skin. The exact pathogenesis of morphea is unknown, but generally includes genetic predisposition to autoimmunity combined with an environmental insult. Previous cases have been associated with active Borrelia infection; however, Borrelia infection as a direct cause of morphea was not generalizable to most patients. Within endemic areas, Borrelia burgdorferi is the most common cause of facial nerve paralysis, another autoimmune phenomenon. We report a case of facial morphea in a young man with family history of autoimmune disease who developed morphea in the same location as two previous episodes of Borrelia-induced facial nerve palsy. This case is remarkable because it suggests Borrelia burgdorferi induced loss of local immune tolerance to host antigens, first with facial nerve palsy and followed years later by development of morphea.

Etiology and clinical features of epididymo-orchitis: A single-center study in Tehran, Iran

2020 ◽  
Vol 20 ◽  
Author(s):  
Sara Abolghasemi ◽  
Mohammad Alizadeh ◽  
Ali Hashemi ◽  
Shabnam Tehrani
Keyword(s):  
Chlamydia Trachomatis ◽  
Clinical Symptoms ◽  
Urine Culture ◽  
Clinical Manifestations ◽  
Urinary Frequency ◽  
Serological Tests ◽  
Duration Of Symptoms ◽  
Two Samples ◽  
History Of ◽  
Tract Infections

Introduction: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed to investigate the etiology, clinical sequelae and risk factors of patients with epididymo-orchitis in Tehran, Iran. Materials and Methods: Patients presenting with epididymo-orchitis were prospectively analyzed in order to study the etiology and pattern of the disease. Bacteriological, molecular and serological tests were undertaken to look for Chlamydia trachomatis, Neisseria gonorrhoeae, Brucella spp., Mycoplasma spp, and other bacteria. Results: Fifty patients with epididymo-orchitis were evaluated according to their clinical symptoms, duration of symptoms, physical examination, and laboratory studies. The mean age of the patients was 53 years. Fever, dysuria, pain in the flanks, urinary frequency and discharges occurred in 58.0%, 50.0%, 50.0%, 28.0% and 6.0%, respectively. Bacterial pathogen was identified in 26% (13/50) of patients by urine culture. Escherichia coli was the etiological agent in 11/13 patients (84.6%). Two out of 50 patients (4.0%) were also positive for Chlamydia trachomatis. Two samples were serologically positive for Brucella spp. High Mean age, fever, urinary frequency, history of the underlying disease and history of urinary tract infections were found to have a significant association with the positive bacteriologic urine culture (P<0.05). Conclusions: The most common clinical manifestations were fever, dysuria, and abdominal pain. E. coli and C. trachomatis were the major causative agents. Use of a set of diagnostic approaches including clinical symptoms, urine culture and more precise techniques such as PCR should be taken into consideration for the definitive diagnosis.

Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?

2019 ◽  
Vol 51 (05) ◽  
pp. 326-329 ◽  
Author(s):  
Richard Straube ◽  
Karin Voit-Bak ◽  
A. Gor ◽  
Til Steinmeier ◽  
George P. Chrousos ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Membrane Filtration ◽  
Clinical Symptoms ◽  
Causal Relation ◽  
Pilot Trial ◽  
Lipid Profiles ◽  
Common Causes ◽  
Before And After ◽  
History Of ◽  
Lipids And Lipoproteins

AbstractDyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies.

scholarly journals Familial Bell’s Palsy: A Case Report and Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Mark Kubik ◽  
Liliana Robles ◽  
Doris Kung
Keyword(s):  
Case Report ◽  
Bell’S Palsy ◽  
Facial Nerve Paralysis ◽  
Bell's Palsy ◽  
Unique Case ◽  
Nerve Paralysis ◽  
Csf Analysis ◽  
History Of ◽  
Sheer Number ◽  
Rule Out

Objective. To describe a unique case of familial Bell’s palsy and summarize the current literature regarding possible hereditary influences.Design. Case report.Main Outcome Measures. Clinical exam, CSF analysis, and family history provided per the patient.Results. We report the case of a 58-year-old female who presented with recurrent and bilateral episodes of facial palsy. The patient underwent multiple CSF investigations to rule out a possible infectious and rheumatologic etiology that were all negative. Further questioning revealed she was one of seven family members with a history of unilateral facial nerve paralysis.Conclusion. The sheer number of similar case studies to date suggests that familial clustering of Bell’s palsy is a real, noncoincidental phenomenon. Our case represents a unique and perplexing example of one such family. Familial Bell’s palsy may represent an autoimmune disease secondary to inherited HLA alloantigens or a structural predisposition to disease based on the dimensions of the facial canal.

scholarly journals Lyme disease, An Emerging Infection in Nepal: A Case Report

2020 ◽  
Vol 8 (02) ◽  
pp. 90-92
Author(s):  
Prabin Khatri ◽  
Chandra Mohan Sah ◽  
Rano Mal Piryani ◽  
Shatdal Chaudhary ◽  
Puspa Raj Dhakal ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Joint Pain ◽  
Histological Findings ◽  
Multisystemic Disease ◽  
Tingling Sensation ◽  
History Of ◽  
The Given

ABSTRACT Lyme disease, an infectious multisystemic disease is caused by "Borrelia burgdorferi". It is a spirochete transmitted by the Ixodes tick. Until today, only one case has been reported from Nepal. Here we report case of a 50-year female from Gulmi, who presented with a history of fever, multiple joint pain, tiredness, tingling sensation, and a painful brownish raised lesion over the neck and anterior chest. The clinical diagnosis was confirmed by histological findings typical of erythema chronicum migrans and by serology. The patient was treated successfully with doxycycline. This is the second case report of Lyme disease from Nepal and the first documented case who presented with typical erythema chronicum migrans. We suspect that Lyme disease might not have been considered in the differential diagnosis of fever with rash and joint pain in Nepal and suggest that it is to be kept as a differential in the given scenario.  

scholarly journals Lyme disease: New knowledge regarding its physiopathology, diagnosis, therapy and prevention

2002 ◽  
Vol 55 (5-6) ◽  
pp. 207-212
Author(s):  
Jovan Vukadinov ◽  
Sinisa Sevic ◽  
Grozdana Canak ◽  
Nadezda Madle-Samardzija ◽  
Vesna Turkulov ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Antigenic Variation ◽  
Clinical Symptoms ◽  
Epidemiological Studies ◽  
Lyme Arthritis ◽  
Major Protein ◽  
Selective Treatment ◽  
Multisystem Disease ◽  
New Guidelines

Introduction Lyme disease is a tick-borne disease caused by a spirochete Borrelia burgdorferi, which manifests as a multisystem disease of the skin nervous system, heart and joints. Recently it is the most common vector-borne disease in Yugoslavia. New epidemiological studies New epidemiological studies revealed that ticks can occasionally be infected not only by Borrelia burgdorferi, but also by some other microbes that can cause diseases in humans. Recently discovered the variable major protein-like sequence, antigenic variation of B. burgdorferi B 31 partly explains the ability of this organism to evade an active immune response. A key role in development of clinical symptoms associated with lyme disease belongs to the connection with ability of B. burgdorferi to induce and activate metallopeptidases and fibrinolytic enzymes, leading to extracellular matrix destruction. Diagnosis and treatment Diagnosis of Lyme borreliosis is made on the basis of clinical picture, exposure to ticks in endemic areas and serologic confirmation. It seems that polymerase chain reaction has little role in detection of B. burgdorferi in urine, blood, and spinal fluid samples, but it is most useful in evaluating the effectiveness of antibiotic therapy of Lyme arthritis. Infectious Diseases Society of America had prepared new guidelines for selective treatment of Lyme disease. Vaccination is still the best way of prevention for people living in high-risk areas.

scholarly journals AWARENESS OF LYME BORRELIOSIS OF THE PATIENTS OF TERNOPIL REGIONAL TB DISPENSARY

2017 ◽  
Author(s):  
L. P. Melnyk ◽  
L. A. Hryshchuk ◽  
M. Koziol–Montewka ◽  
P. S. Tabas ◽  
R. O. Klos
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Preventive Measures ◽  
Epidemiological Data ◽  
Sufficient Information ◽  
Tick Bites ◽  
The World ◽  
History Of

Background. Lyme disease has many clinical features similar tothose in sarcoidosis and tuberculosis. Epidemiological data in the world, in particular in Ukraine, proves the increase in Lyme borreliosis incidence. Ternopil region is endemic with Lyme borreliosis.Objective. The research was aimed to investigate the prevalence of infection with Borrelia burgdorferi and epidemiology features of borreliosis among the patients of Ternopil Regional TB Dispensary.Methods. In total, 29 patients were admitted to Departments of Differential Diagnostic, TB Therapy and TB Surgery of Ternopil Regional TB Dispensary in October 2016-January 2017. All the surveyed answered the questions of an integrated international questionnaire, where they noted the area and a number of tick bites, described the removal method, noted the survey for borreliosis pathogen and complaints after tick bites.Results. It was established that 5 respondents had a history of tick bites episodes, but only in one case the patient was examined of borreliosis. Tick bites were noticed in 3 patients with sarcoidosis and 1 with tuberculosis (TB) and exudative pleurisy, respectively.Conclusions. The absence of appeals for medical care, lack of sufficient information on Lyme borreliosis and disuse of preventive measures for tick bites by the interviewed patients of Ternopil regional TB dispensary departments proves the need of improvement of health education on Lyme borreliosis (LB) among this category of population. 24 (82.7%) of 29 respondents did not remember the tick bite. The symptoms of (LB) are similar to those in sarcoidosis and tuberculosis (pleural lesions, heart, joints, nervous system, skin), and the presence of tick bites gives the reasons to examine these patients of Borrelia burgdorferi senso lato.

Facial Nerve Paralysis, Associated with Fits

2016 ◽  
pp. 113-114
Author(s):  
Donald W. Winnicott
Keyword(s):  
Family History ◽  
Facial Nerve ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
The Family ◽  
History Of

In this case, Winnicott presents the family history of a seven-year-old, one of twins suffering from facial nerve paralysis associated with fits.

Facial Nerve Paralysis

2016 ◽  
pp. 111-112
Author(s):  
Donald W. Winnicott
Keyword(s):  
Young Child ◽  
Facial Nerve ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
History Of

In this case, Winnicott presents the history of facial nerve paralysis in a very young child. In this case, the symptoms gradually fade and appear not to return.

scholarly journals Multiple sclerosis and positive lyme serology

1994 ◽  
Vol 52 (4) ◽  
pp. 566-571 ◽  
Author(s):  
Marco Aurélio Lana-Peixoto
Keyword(s):  
Multiple Sclerosis ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Erythema Migrans ◽  
White Matter Lesions ◽  
White Female ◽  
Periventricular White Matter ◽  
Positive Serology ◽  
History Of ◽  
Relationship Of

As Lyme neuroborreliosis (LNB) may clinically mimick multiple sclerosis (MS) the presence of antibodies to Borrelia burgdorferi in serum of patients with a MS-like disease in non-edemic areas for Lyme disease may be troublesome. We report the case of a 45-year-old white female with the diagnosis of relapsing/ remitting form of MS due to a 15-year history of optic neuritis and recurrent episodes of motor and sensation disturbance in the upper right limb and in both lower extremites associated with bladder dysfunction. A magnetic resonance imaging of the brain revealed multiple high intensity periventricular white matter lesions. The patient had been exposed to ticks but did not recall the presence of erythema migrans. ELISA for Lyme disease was positive in two different laboratories and the positive serology was confirmed by Western blotting. No convincing reponse followed treatment with ceftriaxone. Although it is clear that the patient had been infect by Borrelia burgdorferi the relationship of this spirochetal infection with the neurological disease could not be ascertained.

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