In vitro antiproliferative activity of some fluoro-substituted benzimidazole-based scaffolds
2021 ◽
Vol 4
(1)
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pp. 10-17
Keyword(s):
In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidazole derivatives showed significant antiproliferative activity against all the tested cancer cell lines. All the derivatives were found to be less toxic as compared to methotrexate (positive control) in human cells, indicating selective and efficient antiproliferative activity of these benzimidazole derivatives. These findings suggest that compounds ORT14 and ORT15 among this series are most effective and have potential for detailed investigations.
Keyword(s):
Keyword(s):
2019 ◽
Vol 53
(5)
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pp. 392-410
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Keyword(s):
In Vitro Antiproliferative Activity of Fresh Pineapple Juices on Ovarian and Colon Cancer Cell Lines
2015 ◽
Vol 21
(3)
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pp. 353-364
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Keyword(s):
2013 ◽
Vol 21
(7)
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pp. 2001-2006
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2018 ◽
Vol 5
(3)
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pp. 1-11
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