scholarly journals Comprehending the role of Homeopathic Preparations of Rauwolfia serpentina on oxidative stress parameters of cardiac tissue of DOCA-salt induced hypertensive male rats: An Experimental approach

2021 ◽  
pp. 100115
Author(s):  
Sandeep Kumar ◽  
Gagan Bihari Nityananda Chainy ◽  
Jagneshwar Dandapat ◽  
Akshaya Kumar Hati ◽  
Laxmikanta Nanda
Keyword(s):  
Oxidative Stress ◽  
Cardiac Tissue ◽  
Experimental Approach ◽  
Male Rats ◽  
Oxidative Stress Parameters ◽  
Rauwolfia Serpentina ◽  
Stress Parameters

Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Jennifer Chidera Awurum ◽  
Sunday Amos Onikanni ◽  
Adedotun Adefolalu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Role ◽  
Diabetic Rats ◽  
Gene Expressions ◽  
Ki 67 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

scholarly journals Clinical Significance of ROMs, OXY, SHp and HMGB-1 in Canine Leishmaniosis

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 754
Author(s):  
Michela Pugliese ◽  
Alessandra Sfacteria ◽  
Gaetano Oliva ◽  
Annastella Falcone ◽  
Manuela Gizzarelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lymph Nodes ◽  
Clinical Signs ◽  
Biological Tissues ◽  
Stress Index ◽  
Control Group ◽  
Canine Leishmaniosis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

This study aimed to investigate the role of oxidative stress parameters (ROMs, OXY, SHp), the Oxidative Stress index (OSi), and High Mobility Group Box-1 protein (HMGB-1) in canine leishmaniosis (CanL). For this study, thirty dogs, naturally infected with Leishmania spp. (Leishmania Group, LEISH) and ten healthy adult dogs (control group, CTR) were included. The diagnosis of CanL was performed by a cytological examination of lymph nodes, real time polymerase chain reaction on biological tissues (lymph nodes and whole blood), and an immunofluorescence antibody test (IFAT) for the detection of anti-Leishmania antibodies associated with clinical signs such as dermatitis, lymphadenopathy, onychogryphosis, weight loss, cachexia, lameness, conjunctivitis, epistaxis, and hepatosplenomegaly. The HMGB-1 and oxidative stress parameters of the LEISH Group were compared with the values recorded in the CTR group (Mann Whitney Test, p < 0.05). Spearman rank correlation was applied to evaluate the correlation between the HMGB-1, oxidative stress biomarkers, hematological and biochemical parameters in the LEISH Group. Results showed statistically significant higher values of SHp in the LEISH Group. Specific correlation between the ROMs and the number of red blood cells, and between HGMB-1 and SHp were recorded. These preliminary data may suggest the potential role of oxidative stress in the pathogenesis of CanL. Further studies are undoubtedly required to evaluate the direct correlation between inflammation parameters with the different stages of CanL. Similarly, further research should investigate the role of ROMs in the onset of anemia.

Effects of combined exposure to heat and psychological stress on oxidative stress parameters of adult male rats

2021 ◽  
Author(s):  
Faezeh Abbasi Balochkhaneh ◽  
Somayeh Farhang Dehghan ◽  
Abbas Haghparast ◽  
Mohammad Hossein Vaziri ◽  
Mehrdad Helmi Kohanehshari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psychological Stress ◽  
Adult Male ◽  
Male Rats ◽  
Combined Exposure ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Chemoprotective Potential of Helianthemum confertum Against the Loss of Molecular and Functional Integrity of the Liver Cell in Doxorubicin-Treated Rats

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Radja Djebbari ◽  
Yasmine Chemam ◽  
Nassima Boubekri ◽  
Zohra Lakroun ◽  
Mohammed Kebieche ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Function ◽  
Histological Study ◽  
Antioxidant Properties ◽  
Liver Cells ◽  
Male Rats ◽  
Protective Effects ◽  
Butanol Extract ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemum confertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of liver cells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 days and/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histological study were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemical parameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters described by an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicited histopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout the DOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity. The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost all adverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipid peroxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowed the normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanol extract of H. confertum exerted antioxidant properties.

scholarly journals Role of vitamin C against bifenthrin induced oxidative damage in lungs of Wistar rats

2016 ◽  
Vol 8 (1) ◽  
pp. 346-349
Author(s):  
Muneer Ahmad Dar ◽  
Rajinder Raina ◽  
Arshad Hussain Mir ◽  
Pawan Kumar Verma ◽  
Mahrukh Ahmad
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Protective Role ◽  
Group Iv ◽  
Control Value ◽  
Oxidative Stress Parameters ◽  
Group I ◽  
Stress Parameters

The aim of present study was to unravel the protective role of vitamin C on oxidative stress parameters in lung homogenates of bifenthrin intoxicated rats. Rats were divided into four groups. Group I served as control while group II animals were treated with bifenthrin @ 5.8mg/Kg/day. In group III, vitamin C was orally administered @ 60mg/Kg/day where as group IV received both vitamin C and bifenthrin @ 60mg/Kg/day and 5.8mg/Kg/day respectively. After 30th day of treatment, lung samples were taken and analysed for oxidative stress parameters. Significant (P<0.05) increase in lipid peroxidation was observed from control value of 4.80±0.39 to 7.90±0.50 in bifenthrin treated animals. Mean control values of SOD, GSH-Px and CAT were 0.55±0.05, 0.98±0.03 and 138.70±6.01 which were significantly (P<0.05) decreased to values of 0.27±0.0, 0.53±0.05 and 91.10±9.70 respectively in bifenthrin treated animals. The value of GST increased significantly (p<0.05) to 1.05±0.06 in bifenthrin administered animals from control value of 0.70±0.08. Pre-treatment with vitamin C in ameliorative group IV significantly restored the normal values of lipid peroxidation, SOD, GST and CAT but could not reverse the decreased values of GSH-Px. The present research is first of its type where in free radical generation due to bifenthrin –a commonly used insecticide was evaluated in lung homogenates when given orally which might be due to residues present in the lung. Besides it will be helpful in better understanding of toxicological profile of pyrethoids, the most commonly used insecticides.

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