scholarly journals Varicella gangrenosa: A rare chickenpox complication

2021 ◽  
Vol 0 ◽  
pp. 1-3
Author(s):  
Athira Mohan ◽  
Anjana Suresh ◽  
Athira Sudhesan ◽  
Sobhanakumari Kunjumani ◽  
M. I. Celine
Keyword(s):  
Subcutaneous Tissue ◽  
Rare Complication ◽  
Skin Lesions ◽  
Lower Limbs ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Varicella Zoster ◽  
Wound Culture ◽  
Multiple Round ◽  
Life Threatening

Varicella gangrenosa is a rare but life-threatening dermatological complication of infection with varicella-zoster virus. A healthy 37-year-old male who had been diagnosed with varicella 20 days back was admitted to our hospital with complaints of fever and painful necrotic skin lesions. Physical examination revealed multiple round to oval ulcers covered with eschar predominantly over arms, lower limbs, back of trunk and flanks. Streptococcus pyogenes and Staphylococcus aureus grew in wound culture. Biopsy revealed ulceration and necrosis of epidermis, and edema, hemorrhage and granulation tissue formation involving the dermis and subcutaneous tissue. The patient was treated with acyclovir - parenteral followed by oral, antibiotics and supportive measures. The lesions healed and he was discharged after 20 days. We report this case to draw attention to the fact that varicella gangrenosum, even though a rare complication, may occur in the lesions of chicken pox and that the survival of patient depends on early diagnosis and aggressive treatment.

VZV myelitis with secondary HIV CSF escape

2021 ◽  
Vol 14 (6) ◽  
pp. e241738
Author(s):  
Julian J Weiss ◽  
Serena Spudich ◽  
Lydia Barakat
Keyword(s):  
Rare Complication ◽  
Fluorescent Antibody ◽  
Central Nervous System Infection ◽  
Skin Lesions ◽  
Antibody Testing ◽  
Hiv Viral Load ◽  
Varicella Zoster ◽  
Intravenous Acyclovir ◽  
Immunosuppressed Patients ◽  
Csf Escape

A 52-year-old woman with HIV and recent antiretroviral therapy non-adherence presented with a 5-day history of widespread painful vesicular skin lesions. Direct fluorescent antibody testing of the skin lesions was positive for varicella zoster virus (VZV). On day 3, she developed profound right upper extremity weakness. MRI of the brain and cervical spine was suggestive of VZV myelitis. Lumbar puncture was positive for VZV PCR in the cerebrospinal fluid (CSF) and CSF HIV viral load was detected at 1030 copies/mL, indicating ‘secondary’ HIV CSF escape. She was treated with intravenous acyclovir for 4 weeks and subsequent oral therapy with famciclovir then valacyclovir for 6 weeks. She also received dexamethasone. The patient had an almost full recovery at 6 months. Myelitis is a rare complication of reactivated VZV infection that can have atypical presentation in immunocompromised patients. Such ‘secondary’ HIV CSF escape should be considered in immunosuppressed patients with concomitant central nervous system infection.

Varicella-Zoster Virus

2018 ◽  
Author(s):  
Olivier Picone ◽  
Christelle Vauloup-Fellous ◽  
Laurent Mandelbrot
Keyword(s):  
Varicella Zoster Virus ◽  
Early Recognition ◽  
Varicella Vaccine ◽  
Skin Lesions ◽  
Varicella Infection ◽  
Varicella Zoster ◽  
Mother And Child ◽  
Life Threatening ◽  
Peripartum Period ◽  
The Impact

Chickenpox in a pregnant woman is uncommon, but it is a major concern for patients and their families, as well as for clinicians caring for pregnant women. Varicella infection during pregnancy is usually benign, but there can be serious consequences for both mother and child. Notably, fetal varicella syndrome (FVS) can happen when infection occurs before 21 weeks of gestation. It can present with serious neurological anomalies and unusual cicatricial skin lesions. Later in pregnancy, primary neonatal varicella may occur when the mother is infected in the peripartum period, and it can be life-threatening. The complications of varicella during pregnancy are reviewed, with an emphasis on early recognition, accurate timing of infection, and risk to the developing fetus and newborn infant. The impact of varicella vaccine on the epidemiology of these infections is reviewed, as well as indications for varicella-zoster virus (VZV)–specific immune globulin and antiviral therapy with acyclovir.

scholarly journals Hydroxyapatite coating of cellulose sponges attracts bone-marrow-derived stem cells in rat subcutaneous tissue

2009 ◽  
Vol 6 (39) ◽  
pp. 873-880 ◽  
Author(s):  
Miretta Tommila ◽  
Anne Jokilammi ◽  
Perttu Terho ◽  
Timothy Wilson ◽  
Risto Penttinen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Granulation Tissue ◽  
Wound Repair ◽  
Subcutaneous Tissue ◽  
Giant Cells ◽  
Tissue Formation ◽  
Mesenchymal Progenitor Cells ◽  
Granulation Tissue Formation ◽  
Calcium Sensing

The presence of bone-marrow-derived stem cells was investigated in a wound-healing model where subcutaneously implanted cellulose sponges were used to induce granulation tissue formation. When cellulose was coated with hydroxyapatite (HA), the sponges attracted circulating haemopoietic and mesenchymal progenitor cells more efficiently than uncoated cellulose. We hypothesized that the giant cells/macrophages of HA-coated sponges recognize HA as foreign material, phagocyte or hydrolyse it and release calcium ions, which are recognized by the calcium-sensing receptors (CaRs) expressed on many cells including haemopoietic progenitors. Our results showed, indeed, that the HA-coated sponges contained more CaR-positive cells than untreated sponges. The stem cells are, most probably, responsible for the richly vascularized granulation tissue formed in HA-coated sponges. This cell-guiding property of HA-coated cellulose might be useful in clinical situations involving impaired wound repair.

scholarly journals Paraplegia as a rare complication of tracheal resection anastomosis

2018 ◽  
Vol 4 (3) ◽  
pp. 823
Author(s):  
Khairul Bariah Noh ◽  
Irfan Mohamad ◽  
Thevagi Maruthamuthu ◽  
Sanjeevan Nadarajah ◽  
Nik Fariza Husna Nik Hassan
Keyword(s):  
Surgical Treatment ◽  
Granulation Tissue ◽  
Tracheoesophageal Fistula ◽  
Rare Complication ◽  
Laryngeal Edema ◽  
Tracheal Resection ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Acute Paraplegia ◽  
Stenotic Segment

<p class="abstract">Tracheal resection is the definitive surgical treatment whereby resection of stenotic segment with end-to-end anastomosis is performed. The procedure is indicated in a case of grade IV tracheal stenosis. Known complications include granulation tissue formation, restenosis of the trachea, anastomotic separation, tracheoesophageal fistula (TEF) and tracheoinnominate fistula (TIF), wound infection, laryngeal edema and laryngeal dysfunction. We present an 18- year-old gentleman whom previously ambulating, developed acute paraplegia following this surgery. In this report we discuss the possible causes that may lead to paraplegia in our case.</p>

scholarly journals Acute cerebellar ataxia associated with varicella zoster virus encephalitis

2021 ◽  
Author(s):  
Madson Caio dos Santos Dantas ◽  
João Pedro Cardoso Prudêncio
Keyword(s):  
Varicella Zoster Virus ◽  
Cerebellar Ataxia ◽  
Rare Complication ◽  
Skin Lesions ◽  
Pupillary Response ◽  
University Hospital ◽  
Varicella Zoster ◽  
Csf Analysis ◽  
Acute Cerebellar Ataxia ◽  
Vesicular Rash

Context: Varicella-zoster virus (VZV) primary infection causes a diffuse vesicular rash and affects mainly young people. VZV-associated encephalitis is a rare complication since the advent of vaccination, and can present as different neurological syndromes. This report aims to describe a case of acute cerebellar ataxia after VZV-associated encephalitis in a child, admitted to the Onofre Lopes University Hospital (HUOL) in Natal, Brazil. Case report: We present the case of a 9-year-old girl referred to HUOL with polymorphic skin lesions for 8 days. She evolved with headache, vomiting, drowsiness and confusion. Upon admission, she was pale (+/4+), anicteric, confused (GCS=14), hemodynamically stable, SaO2=99%, with pupillary response and no meningism. Laboratory tests showed Hb 11.7g/dl, leukocytes 7,200/mm³ (93% segmented, 1% eosinophils, 5% lymphocytes and 2% monocytes), AST 38U/ml and ALT 46U/ml. Once clinical diagnosis of VZVencephalitis was made, the patient was admitted to the ICU for monitoring and treatment. Cranial CT showed hypodensities on the frontal and occipital lobes; CSF analysis: glucose=76mg/dl, proteins=24mg/dl, leukocytes=9/mm3 (monocytes 78%). She improved progressively and was transferred to the ward, evolving with ataxia, suggesting cerebellitis. Conclusions: This case describes a chickenpox rare complication nowadays: encephalitis. Along evolution, the patient presented acute cerebellar ataxia, a more prevalent condition in children, usually having a limited course.

Difficult airway in a child with severe dystonia

2013 ◽  
Vol 127 (4) ◽  
pp. 438-439
Author(s):  
N Eze ◽  
G A Morrison
Keyword(s):  
Airway Management ◽  
Difficult Airway ◽  
Granulation Tissue ◽  
Tracheostomy Tube ◽  
Tissue Formation ◽  
Case Review ◽  
Retrospective Case ◽  
Granulation Tissue Formation ◽  
Systemic Steroids ◽  
Life Threatening

AbstractObjective:To describe the management of a 15-year-old girl with repeated life-threatening complications of her tracheostomy secondary to muscle dystonia and thoracolumbocervical lordosis.Method:This paper reports a retrospective case review.Results:Regular microlaryngoscopy and bronchoscopy, treatment with systemic steroids and a soft tracheostomy tube, in addition to better control of the dystonia, resulted in control of the patient's airway. This minimised tracheal inflammation and granulation tissue formation.Conclusion:The need for a tracheostomy in patients with thoracolumbocervical lordosis and severe dystonia should be considered only after all other options of airway management have been explored. Every attempt should be made to minimise tracheal trauma caused by excessive movement of a tracheostomy tube.

scholarly journals Parainfectious Transverse Myelitis secondary to Varicella Zoster Virus

2018 ◽  
Vol 1 (01) ◽  
pp. 69-73
Author(s):  
Nirmal Ghimire ◽  
Sanjib Dhungel ◽  
Krishna Dhungana ◽  
Srijana Pradhananga ◽  
Sushma Thapa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Varicella Zoster Virus ◽  
Transverse Myelitis ◽  
Skin Lesions ◽  
Sensory Function ◽  
Lower Limbs ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Resource Limited ◽  
Early Use

Varicella zoster virus is a human herpes virus that causes chickenpox and herpes zoster. Varicella zoster virus leads to numerous complications of the central and peripheral nervous systems. Transverse myelitis is a disorder characterized by focal inflammation of the spinal cord and results in loss of motor and sensory function below the level of injury. Transverse myelitis caused by Varicella zoster virus reactivation is rare in immunocompetent patients. Herein, we report a case of transverse myelitis caused by Varicella zoster virus in an immunocompetent young patient. A 33 years gentleman was admitted to our hospital with complaints of multiple pleomorphic skin lesions and fever for 10 days, unable to pass urine on his will for four days and weakness of bilateral lower limbs for three days. MRI spine showed long segment ill-defined mild T2 hyper intensity noted in the spinal cord along the visible portion of lower thoracic vertebra. The patient was treated with steroids and Acyclovir.He recovered completely in one month after discharge. Prompt clinical diagnosis with early use of antiviral and anti-inflammatory treatment is important for good outcome of disease in resource limited country like Nepal.

Proximal deep venous thrombosis following PTA of the superficial femoral artery – an obligation to disclose a complication that is rarely taken into account

VASA ◽  
2006 ◽  
Vol 35 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Klein-Weigel ◽  
Pillokat ◽  
Klemens ◽  
Köning ◽  
Wolbergs ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Femoral Artery ◽  
Superficial Femoral Artery ◽  
Rare Complication ◽  
Femoral Vein ◽  
Vein Thrombosis ◽  
Explicit Information ◽  
Life Threatening ◽  
Legal Consequences

We report two cases of femoral vein thrombosis after arterial PTA and subsequent pressure stasis. We discuss the legal consequences of these complications for information policies. Because venous thrombembolism following an arterial PTA might cause serious sequel or life threatening complications, there is a clear obligation for explicit information of the patients about this rare complication.

scholarly journals Case Series of Three Patients with Rifampicin-Induced Thrombocytopenia

2020 ◽  
Author(s):  
Chandramouli M.T
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adverse Reactions ◽  
Rare Complication ◽  
Case Series ◽  
Tuberculosis Treatment ◽  
Effective Drug ◽  
Antitubercular Drugs ◽  
Short Course ◽  
Life Threatening

AbstractLife-threatening adverse reactions of antitubercular drugs are uncommon; however, thrombocytopenia is one such rare complication encountered with rifampicin, isoniazid, ethambutol, and pyrazinamide. Rifampicin is the most effective drug and its use in the tuberculosis treatment led to the emergence of modern and effective short-course regimens. I am reporting case series of three patients with pulmonary tuberculosis presented with rifampicin-induced thrombocytopenia.

Intraorbital Abscess: A Rare Cause of Orbit Compression

FACE ◽  
2021 ◽  
pp. 273250162110050
Author(s):  
Samuel Ruiz ◽  
Rizal Lim
Keyword(s):  
Pediatric Population ◽  
Rare Complication ◽  
Disease Process ◽  
Rare Condition ◽  
External Drainage ◽  
Direct Extension ◽  
Life Threatening ◽  
History Of ◽  
High Index Of Suspicion ◽  
Prompt Diagnosis

Introduction: Intraorbital abscess is a rare complication of rhinosinusitis that affects most commonly the pediatric population. It is thought to be caused by direct extension or venous spread of infections from contiguous sites and can lead to life-threatening complications, like permanent visual loss and cerebral abscesses. Objectives: Intraorbital abscess is a rare condition that requires prompt diagnosis and treatment to avoid serious complications. Our objectives are to provide an overview of this rare disease process and its management including our successful treatment experience. Case Description: We present a 2 case report of a 13-year-old pediatric male and a 66-year-old male with history of chronic sinusitis who presented with a right intraorbital abscess successfully treated with external drainage with decompression of the orbit. Conclusion: When intraorbital abscess is encountered, a high index of suspicion is needed to allow prompt and accurate diagnosis for this infrequent condition. Timely surgical drainage of the abscess is needed to prevent the development of fatal complications.

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