scholarly journals Relation between nailfold capillaroscopic pattern (assessed using a dermoscope) and organ involvement in systemic sclerosis

2021 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Ruovinuo Theunuo ◽  
Sarita Sasidharanpillai ◽  
Neeraj Manikath ◽  
Keerankulangara Devi ◽  
Koyakutty Abdul Samad ◽  
...  

Objectives: The objectives of the study were: (1) To document the nailfold capillary changes (using a dermoscope) in patients with systemic sclerosis attending a tertiary care center, (2) to study the relation between nailfold capillaroscopic pattern and skin sclerosis assessed by modified Rodnan skin score (mRSS), and (3) to study the relation between nailfold capillaroscopic pattern and organ involvement in systemic sclerosis. Materials and Methods: A cross-sectional study was conducted among 40 patients with systemic sclerosis who attended the dermatology outpatient department of a tertiary care center from January 1, 2018, to December 31, 2018. Nailfold capillaries were examined with the help of dinolite dermoscope AM4113ZT at 50× and 200× magnification, under polarized light. Results: Study participants included 34 (85%) females and 6 males (15%). The nailfold capillaroscopy showed “early scleroderma pattern” in 3 (7.5%) “active pattern” in 28 (70%) and “late pattern” in 9 (22.5%) patients. “Late scleroderma pattern” showed a significant association with disease duration, mRSS, and mean number of organs affected. Limitations: The study participants may be over-representing advanced cases since the study was conducted among patients attending a tertiary referral center. Conclusion: We found dermoscope to be a useful tool to study the nailfold capillary changes in patients with systemic sclerosis as reported by others. Late scleroderma pattern may serve as an indicator of high mRSS and involvement of more number of organs in systemic sclerosis.


2020 ◽  
Vol 6 (6) ◽  
pp. 114-119
Author(s):  
Dr. Dhwani Mehta ◽  
◽  
Dr. Charmi Pawani ◽  
Dr. Snehal B Kukadiya ◽  
Dr. Nimish Pandya ◽  
...  

Background and Aim: Quantifying birth defects in a population is felt as a need as it helpsinappropriate allocation of the health budget to tackle and reduce perinatal, neonatal, and infantmortality rates. Hence a study on congenital anomalies was undertaken in the region of Kachchhdistrict. Material and Methods: Present cross-sectional study was performed on 10 patientsdiagnosed with having congenital malformed fetuses at tertiary care center- G.K. General Hospital,Bhuj, Kachchh district, Gujarat, India over three months – January, February, March 2019. Results:Mean age of the study participants were 22.3 years, most (70%) of the study participants wereprimigravida. Hydrocephalus was the most common birth defect among study participants. Eightypercentages (80%) of study participants had gross anomalies. Sixty percentages (60%) ofparticipants had the outcome of termination. Conclusion: Congenital anomalies were in babies tomothers between 20-30 years of age. Once an anomaly is detected, various management optionsare to be discussed with the patients in consultation with a neonatologist, pediatric surgeon, andneurosurgeon when necessary.







Author(s):  
Subrata Kumar Das ◽  
Saptadipa Das

<p class="abstract"><strong>Background:</strong> The aim was to evaluate the parameters of metabolic syndrome (MS) in patients of alopecia areata and to investigate the possibility of an existing relationship between MS and alopecia areata (AA).</p><p class="abstract"><strong>Methods:</strong> This cross-sectional observational study included 50 patients with AA who attended OPD of department of dermatology at a tertiary care center during a period of 1 year. Clinical and laboratory parameters were noted in each patient.<strong></strong></p><p class="abstract"><strong>Results:</strong> This study included 50 patients with AA (33 males and 17 females). In the present study maximum number of patients belonged to the age group 20-30 years with 23 patients, followed by 30-40 years with 17  patients. Most of the study subjects, 17 were college students and number of employees were 15. Out of 50 patients 44  had patch(es) and 2 patient had alopecia totalis. In this study out of 50 patients, 38 had mild AA, 7 had AA and 5 patients had severe AA. No significant derangement of clinical and laboratory parameters of MS observed in patients of AA.</p><p class="abstract"><strong>Conclusions:</strong> In the present study we did not observe any significant derangement of clinical and laboratory parameters of  MS  in patients of alopecia areata.</p>



2021 ◽  
Vol 12 (2) ◽  
pp. 120-129
Author(s):  
Romita Bachaspatimayum ◽  
Zamzachin Guite ◽  
Thangjam Bijayanti Devi

Background: Genital ulcers are defined as breaches in the continuity of the genital mucosa and/or skin. Sexually transmitted infections (STIs) that cause genital ulcer disease (GUD) are syphilis, chancroid, donovanosis, lymphogranuloma venereum (LGV), and herpes genitalis. This study aimed to investigate the clinical and laboratory profiles of STI-related genital ulcers. Materials and Methods: A cross-sectional two-year study was conducted on patients attending the Outpatient Department of Dermatology, Venereology and Leprosy in a tertiary care center in northeastern India. Selected were 95 patients who presented themselves with STI-related genital ulcers. Detailed history taking and examination were conducted with basic tests to assist the diagnosis. Results: The male-to-female ratio was 3.32:1, and the most common site was the glans and prepuce in males (28.77%) and the labia majora and minora in females (36.36%). 96.84% of patients had superficial ulcers. The KOH mount was positive in 26 patients. The Tzanck smear was positive in 31 patients. RPR was positive in four. HIV was positive in eleven. Herpes genitalis (96.84%) was the most common GUD. Mixed STIs were attested in 41.05% of patients. Conclusion: GUD can take various forms of presentation. The available laboratory tests should be utilized. The possibility of mixed infections should always be kept in mind.



2018 ◽  
Vol 21 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Annemarie Bösch ◽  
Julia Wager ◽  
Boris Zernikow ◽  
Ralf Thalemann ◽  
Heidi Frenzel ◽  
...  


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