scholarly journals Association of a combination of alleles and genotypes of polymorphic variants of matrix metalloproteinase genes and their tissue inhibitors genes with a risk of developing of gastric cancer

2020 ◽  
pp. 70-72
Author(s):  
Л.Ф. Галлямова ◽  
А.Х. Нургалиева ◽  
Ш.М. Хуснутдинов ◽  
Д.Д. Сакаева ◽  
Э.К. Хуснутдинова
Keyword(s):  
Gastric Cancer ◽  
Matrix Metalloproteinase ◽  
Frequency Distribution ◽  
Healthy Individuals ◽  
Polymorphic Loci ◽  
Republic Of Bashkortostan ◽  
Polymorphic Variants ◽  
The Republic ◽  
Mmp9 Gene ◽  
Reduced Risk

Проведен анализ распределения частот аллелей/генотипов полиморфных локусов rs1799750 и rs494379 гена MMP1, rs2285053 гена MMP2, rs3025058 гена MMP3, rs3918242 и rs17576 гена MMP9, rs2276109 гена MMP12, rs8179090 гена TIMP2 и rs9619311 гена TIMP3 у 314 пациентов с раком желудка, а также у 339 здоровых индивидов из Республики Башкортостан. С помощью алгоритма APSampler выявлены сочетания аллелей/генотипов, ассоциированные как с повышенным, так и с пониженным риском развития заболевания. The analysis of the frequency distribution of alleles/genotypes of polymorphic loci rs1799750 and rs494379 of the MMP1 gene, rs2285053 of the MMP2 gene, rs3025058 of the MMP3 gene, rs3918242 and rs17576 of the MMP9 gene, rs2276109 of the MMP12 gene, rs8179090 of the TIMP2 gene and rs9619311 of the TIMP3 gene in 314 patients with gastric cancer, as well as in 339 healthy individuals from the Republic of Bashkortostan. Using the APSampler algorithm were identified combinations of alleles/genotypes associated with increased and reduced risk of developing the disease.

scholarly journals The role of the immune response mediator genes polymorphism in the predisposition to juvenile idiopathic arthritis

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Liliia Sh. Nazarova ◽  
Ksenia V. Danilko ◽  
Viktor A. Malievsky ◽  
Akhat B. Bakirov ◽  
Tatiana V. Viktorova
Keyword(s):  
Immune Response ◽  
Juvenile Idiopathic Arthritis ◽  
Control Group ◽  
Polymorphic Loci ◽  
Republic Of Bashkortostan ◽  
Clinical Variants ◽  
The Republic ◽  
Relationship Of ◽  
The Relationship

Objective ― The aim of the work was to study the contribution of the immune response mediator genes polymorphism (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) to the formation of the predisposition to juvenile idiopathic arthritis (JIA) and its clinical variants. Material and Methods ― The JIA group included 330 patients and the control group – 342 volunteers without autoimmune diseases from the Republic of Bashkortostan, Russia. Genotyping was conducted by the real-time polymerase chain reaction. Results ― Taking into account the differences by sex, it was established, that the alleles/genotypes of the TNFA rs1800629, LTA rs909253, IL2-IL21 rs6822844, PTPN22 rs2476601 polymorphic loci and the TNFA rs1800629*G – LTA rs909253*G haplotype are associated with the development of JIA as a whole (p<0.05); alleles/genotypes of the LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601 polymorphic loci and the TNFA rs1800629*G – LTA rs909253*G haplotype – with some of JIA clinical variants (p<0.05). Conclusion ― In this work, the relationship of the alleles, genotypes and haplotypes of a number of the immune response mediator genes polymorphic loci with the risk of the development of JIA and its clinical variants was established. Specific associations were observed for girls and boys, which indicates the existence of sexual dimorphism in the JIA pathogenesis.

The dynamics of demographic indices in the Republic of Bashkortostan

2020 ◽  
Vol 28 (4) ◽  
Author(s):  
Victorov V. V. ◽  
◽  
Sharafutdinov M. A. ◽  
Mukhamadeeva O. R. ◽  
Pavlova M. Yu. ◽  
...  
Keyword(s):  
Republic Of Bashkortostan ◽  
Demographic Indices ◽  
The Republic

Irrigation regime and water consumption of potatoes in the Republic of Bashkortostan, depending on the reclamation condition of lands

2020 ◽  
Vol 0 (6) ◽  
pp. 13-19
Author(s):  
Guzel Gumerova ◽  
Georgiy Gulyuk ◽  
Dmitry Kucher ◽  
Anatoly Shuravilin ◽  
Elena Piven
Keyword(s):  
Water Consumption ◽  
Weather Conditions ◽  
Growing Season ◽  
Vegetation Period ◽  
Forest Steppe ◽  
Total Water ◽  
Total Water Consumption ◽  
Republic Of Bashkortostan ◽  
Irrigated Lands ◽  
The Republic

Data of long-term researches (2015–2018) in southern forest-steppe zone of the Republic of Bashkortostan, is justified theoretically and experimentally the mode of irrigation of potatoes on leached chernozems of unsatisfactory, satisfactory and good ameliorative condition of irrigated lands. For the growing periods of potatoes with different heat and moisture supply, the number of watering, the timing of their implementation, irrigation and irrigation norms are established. On lands with unsatisfactory meliorative state the number of irrigation depending on weather conditions of potato vegetation period varied from 0 to 3 (1.5 on average) with average irrigation norm – 990 m3/ha. With satisfactory meliorative state of lands the number of irrigation on average increased from 0 to 4 (2.3 on average) with irrigation norm – 1305 m3/ha. On lands with good meliorative state the number of irrigation was the highest – from 1 to 5 (3 on average) with average irrigation irrigation norm is 1653 m3/ha. It was noted that in the dry periods of potato vegetation the greatest number of watering was carried out (3–5 watering), and in the wet periods (2017) watering was not carried out except for the area with a good reclamation state, where only one irrigation was carried out by the norm of 550 m3/ha. Water consumption of potato was studied in dynamics as a whole during the growing season and the months of the growing season depending on weather conditions of vegetation period and land reclamation condition of irrigated lands, as well as in the control (without irrigation). The lowest total water consumption was in the area without irrigation and averaged 226.8 mm. In irrigated areas, its values increased to 319-353.4 mm. The average daily water consumption varied from 2.12 to 3.3 mm. The highest rates of potato water consumption were observed in June and July, and the lowest – in May and August. In the total water consumption of potatoes on the site without irrigation, the largest share was occupied by atmospheric precipitation and in addition to them the arrival of moisture from the soil. Irrigation water was used in irrigated areas along with precipitation, the share of which was 30.2–46.1 %.

Hygienic assessment of learning environment conditions (by the example of higher educational institutions of the city of Ufa)

2020 ◽  
Vol 99 (4) ◽  
pp. 405-411
Author(s):  
Elena Ju. Gorbatkova
Keyword(s):  
Ionizing Radiation ◽  
Educational Institutions ◽  
Higher Educational Institutions ◽  
Factors Affecting ◽  
Republic Of Bashkortostan ◽  
Average Relative Humidity ◽  
Higher Educational ◽  
The Republic ◽  
And Performance ◽  
The City

Introduction. The important factors affecting health and performance of young people are the conditions of education, in particular, a comfortable microclimate in the classrooms of higher educational institutions. Materials and methods. In view of the urgency of this problem, an analysis was made of the microclimate parameters of educational organizations of different profiles (Ufa city, the Republic of Bashkortostan). 294 classrooms were studied in 22 buildings of 4 leading universities in Ufa. A total of 3,822 measurements were taken to determine the parameters of the microclimate. The analysis of ionizing radiation in the aerial environment of classrooms. There was performed determination of radon and its affiliated products content. In order to assess the conditions and lifestyle of students of 4 higher educational institutions of the city of Ufa, we conducted an anonymous survey of 1,820 students of I and IV years of education. Results. The average temperature in the classrooms of all universities studied was 23.9±0.09 C. The average relative humidity in all classrooms was 34.2 ± 0.42%. Analysis of ionizing radiation (radon and its daughter products decay) in the aerial environment of the classrooms and sports halls located in the basement determined that the average annual equivalent equilibrium volumetric activity of the radon daughter products (EROA ± Δ222Rn) ranged from 28 ± 14 to 69 ± 34.5 meter, which meets the requirements established by SanPiN. Conclusion. The hygienic assessment of the microclimate parameters of educational institutions of various profile revealed a number of deviations from the regulated norms. The results indicate the need to control the parameters of the microclimate, both from the administration of universities, and from the professors. According to the results of the study, recommendations were prepared for the management of higher educational institutions in Ufa.

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