scholarly journals Modification of the clastogenic effects of cadmium in rat bone marrow with the melaxen

2020 ◽  
pp. 103-104
Author(s):  
Ф.Т. Чшиева ◽  
Т.В. Чшиев ◽  
Р.И. Кокаев
Keyword(s):  
Bone Marrow ◽  
Genotoxic Effects ◽  
Protective Properties ◽  
Cadmium Salt ◽  
Rat Bone

При хроническом применении мелаксена в дозе 10 мг/кг индукции генотоксических эффектов в костном мозге крыс не выявлено. Метафазный анализ после хронического совместного внутрижелудочного введения соли кадмия 0,3 мг/кг (в пересчете на металл) и мелаксена показал протекторные свойства последнего (р<0,01). There was no reveled induction of genotoxic effects in rat bone marrow at the constant use of “melaxen” at a dose of 10 mg/kg. The chronic joint intragastric injection of a cadmium salt of 0.3 mg / kg (in terms of metal) and “melaxen “ showed the protective properties of the remedy (p<0.01) after metaphase analysis.

Evaluation of genotoxic effects of semicarbazide on cultured human lymphocytes and rat bone marrow

2010 ◽  
Vol 48 (1) ◽  
pp. 209-214 ◽  
Author(s):  
Dimitris Vlastos ◽  
Hariklia Moshou ◽  
Klimentini Epeoglou
Keyword(s):  
Bone Marrow ◽  
Human Lymphocytes ◽  
Genotoxic Effects ◽  
Rat Bone

Combined Genotoxic Effects of Aflatoxin B1, Ochratoxin A and Zearalenone in Rat Bone Marrow and Blood Leukocytes

2013 ◽  
Vol 31 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Harutyunyan Tigran ◽  
◽  
Karapetyan Anna ◽  
Hovhannisyan Galina ◽  
Aroutiounian Rouben
Keyword(s):  
Bone Marrow ◽  
Ochratoxin A ◽  
Aflatoxin B1 ◽  
Genotoxic Effects ◽  
Blood Leukocytes ◽  
Rat Bone

scholarly journals Effect of 910-MHz Electromagnetic Field on Rat Bone Marrow

2004 ◽  
Vol 4 ◽  
pp. 48-54 ◽  
Author(s):  
George Demsia ◽  
Dimitris Vlastos ◽  
Demetrios P. Matthopoulos
Keyword(s):  
Bone Marrow ◽  
Electromagnetic Field ◽  
Female Rats ◽  
Male Rats ◽  
Polymorphonuclear Cells ◽  
Genotoxic Effects ◽  
Threefold Increase ◽  
Polychromatic Erythrocytes ◽  
Nonionizing Radiation ◽  
Rat Bone

Aiming to investigate the possibility of electromagnetic fields (EMF) developed by nonionizing radiation to be a noxious agent capable of inducing genotoxicity to humans, in the current study we have investigated the effect of 910-MHz EMF in rat bone marrow. Rats were exposed daily for 2 h over a period of 30 consecutive days. Studying bone marrow smears from EMF-exposed and sham-exposed animals, we observed an almost threefold increase of micronuclei (MN) in polychromatic erythrocytes (PCEs) after EMF exposure. An induction of MN was also observed in polymorphonuclear cells. The induction of MN in female rats was less than that in male rats. The results indicate that 910-MHz EMF could be considered as a noxious agent capable of producing genotoxic effects.

Evaluation of genotoxic effects of oral exposure to Aluminum oxide nanomaterials in rat bone marrow

2009 ◽  
Vol 676 (1-2) ◽  
pp. 41-47 ◽  
Author(s):  
A. Balasubramanyam ◽  
N. Sailaja ◽  
M. Mahboob ◽  
M.F. Rahman ◽  
S. Misra ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aluminum Oxide ◽  
Oral Exposure ◽  
Genotoxic Effects ◽  
Rat Bone

scholarly journals In Vivo Genotoxic Effects of Spiramycin in Rat Bone Marrow Cells.

CYTOLOGIA ◽  
1999 ◽  
Vol 64 (3) ◽  
pp. 277-283 ◽  
Author(s):  
H. B. Ila ◽  
M. Topaktas
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Genotoxic Effects ◽  
Rat Bone ◽  
Marrow Cells

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis

2018 ◽  
Vol 18 ◽  
Author(s):  
Chaitra Venugopal ◽  
Christopher Shamir ◽  
Sivapriya Senthilkumar ◽  
Janitri Venkatachala Babu ◽  
Peedikayil Kurien Sonu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neuroprotective Effects ◽  
Marrow Mesenchymal Stem Cells ◽  
Vitro Analysis ◽  
In Vitro Analysis ◽  
Rat Bone

Glucosamine Protects Rat Bone Marrow Cells Against Cisplatin-induced Genotoxicity and Cytotoxicity

2019 ◽  
Vol 19 (14) ◽  
pp. 1695-1702 ◽  
Author(s):  
Mohsen Cheki ◽  
Salman Jafari ◽  
Masoud Najafi ◽  
Aziz Mahmoudzadeh
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Micronucleus Assay ◽  
Ros Generation ◽  
Polychromatic Erythrocytes ◽  
Hematological Analysis ◽  
Antagonistic Potential ◽  
Harmful Effects ◽  
Rat Bone ◽  
Marrow Cells

Background and Objective: Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. Methods: Glucosamine was orally administrated to rats at doses of 75 and 150 mg/kg body weight for seven consecutive days. On the seventh day, the rats were treated with a single injection of cisplatin (5 mg/kg, i.p.) at 1h after the last oral administration. The cisplatin antagonistic potential of glucosamine was assessed by micronucleus assay, Reactive Oxygen Species (ROS) level analysis, hematological analysis, and flow cytometry. Results: Glucosamine administration to cisplatin-treated rats significantly decreased the frequencies of Micronucleated Polychromatic Erythrocytes (MnPCEs) and Micronucleated Normchromatic Erythrocytes (MnNCEs), and also increased PCE/(PCE+NCE) ratio in bone marrow cells. Furthermore, treatment of rats with glucosamine before cisplatin significantly inhibited apoptosis, necrosis and ROS generation in bone marrow cells, and also increased red blood cells count in peripheral blood. Conclusion: This study shows glucosamine to be a new effective chemoprotector against cisplatin-induced DNA damage and apoptosis in rat bone marrow cells. The results of this study may be helpful in reducing the harmful effects of cisplatin-based chemotherapy in the future.

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