CONTINUOUS PNEUMOCOCCAL INVASIVE DISEASE REDUCTION, HIGH IMPACT ON PNEUMOCOCCAL MENINGITIS AND SEROTYPE 19A FOLLOWING PCV-13 IN CHILDREN: 10 YEARS ACTIVE SURVEILLANCE IN A MEXICAN HOSPITAL

2016 ◽  
Author(s):  
Enrique Chacon-Cruz
Keyword(s):  
Active Surveillance ◽  
Pneumococcal Meningitis ◽  
Invasive Disease ◽  
High Impact ◽  
Disease Reduction

scholarly journals Silent Mastoiditis Associated with Pneumococcal Meningitis

2021 ◽  
Vol 27 (2) ◽  
pp. 1-6
Author(s):  
Ashikin Mohd Nordin ◽  
Jean Jun Ong ◽  
Juriza Ismail ◽  
Norazlin Kamal Nor ◽  
Sau Wei Wong ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Pneumococcal Meningitis ◽  
Wide Spectrum ◽  
Clinical Signs ◽  
Invasive Disease ◽  
Upper Respiratory Tract ◽  
Slow Recovery ◽  
Acute Mastoiditis ◽  
Focus Of Infection ◽  
Upper Respiratory

Streptococcus pneumoniae (S pneumoniae) can cause a wide spectrum of diseases which includes upper respiratory tract infection as well as more severe invasive disease such as meningitis. Meningitis may be caused by invasion of the organism through the blood brain barrier, either via haematological spread or from an adjacent focus of infection such as the ears. We describe two infants with pneumococcal meningitis and silent mastoiditis. They both presented with a classical history to suggest meningitis with no apparent focus of infection. A brain imaging was done in the first infant to look for the underlying cause of his focal seizure and in the second infant, to assess for complications of meningitis, as he had a slow recovery. While they did not have any clinical signs to point towards the diagnosis, they were both diagnosed to have acute mastoiditis from brain imaging. We would like to highlight the importance of brain imaging in excluding silent mastoiditis in infants with meningitis, particularly in those whose clinical course appears atypical.

scholarly journals Use of 7-valent pneumococcal conjugate vaccine in EU

2006 ◽  
Vol 11 (49) ◽  
Author(s):  
P L Lopalco ◽  
Collective Editorial team
Keyword(s):  
Streptococcus Pneumoniae ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Meningitis ◽  
Invasive Disease ◽  
Morbidity And Mortality

Invasive disease due to Streptococcus pneumoniae is an important cause of morbidity and mortality in Europe as well as worldwide. Pneumococcal meningitis, septicaemia and pneumonia are particularly frequent in children

scholarly journals Resource requirements for national active surveillance programmes of high impact exotic pests in New Zealand

2003 ◽  
Vol 56 ◽  
pp. 10-15 ◽  
Author(s):  
S. Ganev ◽  
M. Braithwaite
Keyword(s):  
New Zealand ◽  
Active Surveillance ◽  
Fruit Fly ◽  
Diagnostic Techniques ◽  
High Impact ◽  
Reference Laboratory ◽  
Plant Pest ◽  
Exotic Pests ◽  
Resource Requirements ◽  
Pest Detection

Organisms that are new to New Zealand are detected every year These range from benign or saprophytic to significant pests Currently detection of exotic organisms relies on a combination of public submissions reporting from research scientists and limited planned surveillance programmes With the exception of the fruit fly surveillance programme the Ministry of Agriculture and Forestry Biosecurity Authority (MAFBA) does not undertake active surveillance programmes for high impact exotic pests of horticulture and agriculture This is seen as a potentially significant deficiency The National Plant Pest Reference Laboratory (NPPRL) was commissioned by MAFBA to conduct pilot surveys of twelve high impact exotic pests to determine the resources required to plan carry out field surveys and conduct laboratory identifications The surveys were statistically designed to enable early pest detection and hence maximise the probability of pest eradication Pest selection was based on pest reputation biology epidemiology and the use of various diagnostic techniques to provide a variety of potential scenarios This paper presents details of the sampling statistical methods and resources that were used to compile information on active surveillance programmes for each pest

Postmortem and in situ TEM methods to study the mechanism of failure in controlled-morphology high-impact polystrene resin

1996 ◽  
Vol 54 ◽  
pp. 178-179
Author(s):  
R. C. Cieslinski ◽  
M. T. Dineen ◽  
J. L. Hahnfeld
Keyword(s):  
Poisson Ratio ◽  
Acrylonitrile Butadiene Styrene ◽  
High Impact ◽  
In Situ Tem ◽  
Styrene Copolymers ◽  
Controlled Morphology ◽  
Point Bend ◽  
Mechanism Of Failure ◽  
Impact Energies

Advanced Styrenic resins are being developed throughout the industry to bridge the properties gap between traditional HIPS (High Impact Polystyrene) and ABS (Acrylonitrile-Butadiene-Styrene copolymers) resins. These new resins have an unprecedented balance of high gloss and high impact energies. Dow Chemical's contribution to this area is based on a unique combination of rubber morphologies including labyrinth, onion skin, and core-shell rubber particles. This new resin, referred as a controlled morphology resin (CMR), was investigated to determine the toughening mechanism of this unique rubber morphology. This poster will summarize the initial studies of these resins using the double-notch four-point bend test of Su and Yee, tensile stage electron microscopy, and Poisson Ratio analysis of the fracture mechanism.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

Pelvic Impairments

2018 ◽  
Vol 23 (4) ◽  
pp. 9-10
Author(s):  
James Talmage ◽  
Jay Blaisdell
Keyword(s):  
Pelvic Ring ◽  
Reproductive Organs ◽  
High Impact ◽  
Pelvic Fractures ◽  
Motor Dysfunction ◽  
Impact Event ◽  
Concomitant Injuries ◽  
Rating Process ◽  
Pass Through ◽  
A Minor

Abstract Pelvic fractures are relatively uncommon, and in workers’ compensation most pelvic fractures are the result of an acute, high-impact event such as a fall from a roof or an automobile collision. A person with osteoporosis may sustain a pelvic fracture from a lower-impact injury such as a minor fall. Further, major parts of the bladder, bowel, reproductive organs, nerves, and blood vessels pass through the pelvic ring, and traumatic pelvic fractures that result from a high-impact event often coincide with damaged organs, significant bleeding, and sensory and motor dysfunction. Following are the steps in the rating process: 1) assign the diagnosis and impairment class for the pelvis; 2) assign the functional history, physical examination, and clinical studies grade modifiers; and 3) apply the net adjustment formula. Because pelvic fractures are so uncommon, raters may be less familiar with the rating process for these types of injuries. The diagnosis-based methodology for rating pelvic fractures is consistent with the process used to rate other musculoskeletal impairments. Evaluators must base the rating on reliable data when the patient is at maximum medical impairment and must assess possible impairment from concomitant injuries.

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