COMPARATIVE HISTOMORPHOMETRIC STUDY REGARDING THE IN VIVO BONE HEALING EFFICACY OF ANORGANIC BOVINE BONE, Β-TRICALCIUM PHOSPHATE AND BIOACTIVE GLASSES ON RABBIT TIBIA MODEL

2016 ◽  
Author(s):  
Vlad Marian Anghelescu
Keyword(s):  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Bovine Bone ◽  
Bioactive Glasses ◽  
Histomorphometric Study ◽  
Rabbit Tibia

scholarly journals In vivo biodegradation of magnesium alloys screws in rabbit tibia: influence on bone healing

2017 ◽  
Vol 46 ◽  
pp. 347
Author(s):  
J. Levorova ◽  
L. Dugova ◽  
D. Ulmann ◽  
R. Vrbova ◽  
J. Duskova ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Bone Healing ◽  
Rabbit Tibia

Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin

2005 ◽  
Vol 284-286 ◽  
pp. 329-332 ◽  
Author(s):  
Akari Takeuchi ◽  
Chikara Ohtsuki ◽  
Masanobu Kamitakahara ◽  
Shinichi Ogata ◽  
Masao Tanihara ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Porous Body ◽  
Bone Repair ◽  
Organic Polymer ◽  
Silk Sericin ◽  
Rabbit Tibia ◽  
Conventional Sintering ◽  
Bioresorbable Material ◽  
Made In

Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for a-TCP coated with sericin than for mere a-TCP. The a-TCP porous body coated with sericin is expected as a material that show less degradation than mere a-TCP, and may result in suitable bone repair.

scholarly journals Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration

2018 ◽  
Vol 4 (1) ◽  
pp. 108-122 ◽  
Author(s):  
Cédric Bossard ◽  
Henri Granel ◽  
Yohann Wittrant ◽  
Édouard Jallot ◽  
Jonathan Lao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Degradation Rate ◽  
Sol Gel ◽  
Bone Substitutes ◽  
Porous Scaffolds ◽  
Apatite Formation ◽  
Bovine Bone ◽  
Bioactive Glasses ◽  
Hybrid Scaffolds

Abstract Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes.

scholarly journals Histologic and histomorphometric study of bone repair around short dental implants inserted in rabbit tibia, associated with tricalcium phosphate graft bone

2014 ◽  
Vol 36 (2) ◽  
pp. 257 ◽  
Author(s):  
Marlice Azoia Lukiantchuki Barbosa ◽  
Liogi Iwaki Filho ◽  
Lilian Cristina Vessoni Iwaki ◽  
Maria Raquel Marçal Natali ◽  
Wilton Mitsunari Takeshita ◽  
...  
Keyword(s):  
Dental Implants ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Histomorphometric Study ◽  
Rabbit Tibia

Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia

2017 ◽  
Vol 80 (9) ◽  
pp. 1000-1008 ◽  
Author(s):  
Rafael Scaf de Molon ◽  
Celso Eduardo Sakakura ◽  
Rafael Silveira Faeda ◽  
Rafael Sartori ◽  
Daniel Palhares ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Bone Healing ◽  
Titanium Implants ◽  
Histomorphometric Study ◽  
Rabbit Tibia ◽  
Term Administration

scholarly journals Nanostructured Zn-Substituted Monetite Based Material Induces Higher Bone Regeneration Than Anorganic Bovine Bone and β-Tricalcium Phosphate in Vertical Augmentation Model in Rabbit Calvaria

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 143
Author(s):  
Lorena Benito-Garzón ◽  
Yasmina Guadilla ◽  
Idoia Díaz-Güemes ◽  
Iván Valdivia-Gandur ◽  
María-Cristina Manzanares ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Biological Behavior ◽  
Bovine Bone ◽  
Bone Augmentation ◽  
Osteogenic Activity ◽  
Over Time ◽  
Multicomponent Material

The capacity of a nanostructured multicomponent material composed of Zn-substituted monetite, amorphous calcium phosphate, hydroxyapatite and silica gel (MSi) to promote vertical bone augmentation was compared with anorganic bovine bone (ABB) and synthetic β-tricalcium phosphate (β-TCP). The relation between biological behavior and physicochemical properties of the materials was also studied. The in vivo study was conducted in a vertical bone augmentation model in rabbit calvaria for 10 weeks. Significant differences in the biological behavior of the materials were observed. MSi showed significantly higher bone regeneration (39%) than ABB and β-TCP (24%). The filled cylinder volume was similar in MSi (92%) and ABB (91%) and significantly lower in β-TCP (81%) implants. In addition, β-TCP showed the highest amount of non-osteointegrated particles (17%). MSi was superior to the control materials because it maintains the volume of the defect almost full, with the highest bone formation, the lowest number of remaining particles, which are almost fully osteointegrated and having the lowest amount of connective tissue. Besides, the bone formed was mature, with broad trabeculae, high vascularization and osteogenic activity. MSi resorbs gradually over time with an evident increment of the porosity and simultaneous colonization for vascularized new bone. In addition, the osteoinductive behavior of MSi material was evidenced.

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