ERG1: Marker of lymph node sinus histiocytosis?

2017 ◽  
Author(s):  
Adriana Handra-Luca
Keyword(s):  
Lymph Node ◽  
Sinus Histiocytosis ◽  
Lymph Node Sinus

scholarly journals FTY720 Blocks Egress of T Cells in Part by Abrogation of Their Adhesion on the Lymph Node Sinus

2011 ◽  
Vol 187 (5) ◽  
pp. 2244-2251 ◽  
Author(s):  
Liang Zhi ◽  
Pilhan Kim ◽  
Brian D. Thompson ◽  
Costas Pitsillides ◽  
Alexander J. Bankovich ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Lymph Node Sinus

Primary Pancreatic Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease): An Unusual Extranodal Manifestation Clinically Simulating Malignancy

2010 ◽  
Vol 134 (2) ◽  
pp. 276-278 ◽  
Author(s):  
Mark Podberezin ◽  
Ronald Angeles ◽  
Grace Guzman ◽  
David Peace ◽  
Sujata Gaitonde
Keyword(s):  
Adipose Tissue ◽  
Lymph Node ◽  
Unusual Case ◽  
Sinus Histiocytosis ◽  
Gastrointestinal System ◽  
Rare Entity ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease

Abstract Sinus histiocytosis with massive lymphadenopathy (SHML), also called Rosai-Dorfman disease, is a rare entity. Its etiology and pathogenesis are still essentially unclear. The histologic hallmark of this disease is proliferation of distinctive histiocytes within lymph node sinuses and in extranodal sites. Approximately 23% of patients with SHML, documented in the SHML Registry, presented with disease primarily in extranodal sites, and very few cases of SHML (<1%) involving the gastrointestinal system have been described in the literature. We report an unusual case of primary pancreatic SHML with infiltration of the process into peripancreatic, perinephric, and perisplenic adipose tissue, simulating malignancy.

scholarly journals Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies

Immuno ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 223-230
Author(s):  
Yoshihiro Komohara ◽  
Toshiki Anami ◽  
Kenichi Asano ◽  
Yukio Fujiwara ◽  
Junji Yatsuda ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Animal Studies ◽  
Antigen Presenting Cells ◽  
Defense Responses ◽  
The Body ◽  
Novel Approach ◽  
Anti Cancer ◽  
Lymph Node Sinus ◽  
Antigen Presenting

Lymph nodes are secondary lymphoid organs that appear as bean-like nodules usually <1 cm in size, and they are localized throughout the body. Many antigen-presenting cells such as dendritic cells and macrophages reside in lymph nodes, where they mediate host defense responses against pathogens such as viruses and bacteria. In cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs) to react to cancer cell-derived antigens. Macrophages located in the lymph node sinus are of particular interest in relation to anti-cancer immune responses because many studies using both human specimens and animal models have suggested that lymph node macrophages expressing CD169 play a key role in activating anti-cancer CTLs. The regulation of lymph node macrophages therefore represents a potentially promising novel approach in anti-cancer therapy.

Sinus histiocytosis with massive lymphadenopathy: a case report and literature review

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Jianying Feng ◽  
Tiantian Han ◽  
Fuyong Jiao
Keyword(s):  
Lymph Node ◽  
Clinical Manifestations ◽  
Morphological Diversity ◽  
Lymph Node Involvement ◽  
Sinus Histiocytosis ◽  
Skin Damage ◽  
Neck Lymph Node ◽  
Massive Lymphadenopathy ◽  
High Gamma ◽  
Node Involvement

Sinus histiocytosis with with massive lymphadenopathy is a benign lymphoproliferative disorder.In 1969, Rosai and Dorfman[1] made detailed research on it, so it was also called Rosai DorfnlRn disease (rosai.dorfmandisease, RDD).The clinical manifestations were fever, neck lymph node enlargement, leukocytosis and high gamma globulin.Histopathological findings showed that lymph node involvement was present in group RDD, and the infiltration of the cells was predominant, especially the phagocytosis of the histiocytic cells.About 43% of RDD patients have lymph node involvement in [2], in which the skin is the most common extranodal organs involved.About 10% of patients with skin damage, skin rash and morphological diversity, is easy to be misdiagnosed.In this paper, through the analysis of a case of RDD and EB virus infection, in clinical in patients with special infection can be early detection and treatment.

Concomitant Occurrence of Sinus Histiocytosis With Massive Lymphadenopathy and Nodal Marginal Zone Lymphoma

2011 ◽  
Vol 135 (3) ◽  
pp. 390-393
Author(s):  
Changlee S Pang ◽  
David D Grier ◽  
Michael W Beaty
Keyword(s):  
Lymph Node ◽  
Marginal Zone ◽  
Lymphoproliferative Disorders ◽  
Marginal Zone Lymphoma ◽  
Sinus Histiocytosis ◽  
Unknown Etiology ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Children And Young Adults ◽  
Nodal Marginal Zone Lymphoma

Abstract Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a rare self-limiting disorder of histiocytes with unknown etiology. Sinus histiocytosis with massive lymphadenopathy is most common in children and young adults and is characterized by painless lymphadenopathy. Histologically there is a proliferation of sinus histiocytes with lymphophagocytosis or emperipolesis. On rare occasions, SHML has been associated with lymphoma, usually involving different anatomic sites and developing at different times. We report a case of concomitant SHML and nodal marginal zone lymphoma involving the same lymph node without involvement of other nodal or extranodal sites. The presence of concomitant SHML within the lymph node involved by nodal marginal zone lymphoma may represent the responsiveness of SHML histiocytes to B-cell–derived cytokines in lymphoproliferative disorders. To our knowledge, this is the first description of concomitant occurrence of SHML and nodal marginal zone lymphoma.

Uptake Mechanism of Interstitially Injected 99mTc-Labeled Antimony Trisulphide Colloid in the Popliteal Lymph Node of Rabbits

1985 ◽  
Vol 24 (01) ◽  
pp. 39-43
Author(s):  
R. Senekowitsch ◽  
J. M. Sessler ◽  
S. Möllenstädt ◽  
H. Kriegel ◽  
G. Hör ◽  
...  
Keyword(s):  
Lymph Node ◽  
Distribution Pattern ◽  
Polymorphonuclear Leukocytes ◽  
Popliteal Lymph Node ◽  
Uptake Mechanism ◽  
Draining Lymph Node ◽  
Lymph Node Sinus ◽  
The Right ◽  
Medullary Cords ◽  
Radioactivity Distribution

SummaryThe right popliteal lymph node was studied in rabbits by well counting, histoautoradiography and electron microscopy, after interstitial injection of 99mTc-labeled antimony trisulphide (Sb2S3) colloid into the right hind pad. The highest radioactivity concentration (96.8%/g) was measured 6 hr following injection. At 24 hr, the concentration had dropped to nearly half of the maximum (51.5%/g). At each time, only a single or a few lymph node sectors were found to contain 99mTc. Initially, the radioactivity distribution pattern in the draining lymph node was stripy. Beginning at 15 min p.i., there was a progressive change from stripy to focal radioactivity distribution pattern. Until 6 hr after injection, the bulk of radioactivity was trapped by macrophages in the lumen and wall of the lymph node sinus system, predominantly in medullary sinuses. Surprisingly, at 24 hr the majority of labeled cells were eosinophilic polymorphonuclear leukocytes located in medullary sinuses and medullary cords. Up to 24 hr p. i., no accumulation of radioactivity could be detected in the cortical and paracortical lymph node parenchyma. In conclusion, interstitially injected 99mTc-Sb2S3 colloid is not homogeneously draining lymph node. Moreover, both macrophages and eosinophilic polymorphonuclear leukocytes are involved in the filtration process

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