The clinical application of the novel diagnosis and treatment flowchart for peri-implantitis: Part 3 clinical application on severe case

Abstract Purpose To test a stent-graft specifically designed for the ascending aorta in phantom, cadaver, and clinical application, and to measure deployment accuracy to overcome limitations of existing devices. Methods A stent-graft has been designed with support wires to fixate the apices toward the inner curvature, thereby eliminating the forward movement of the proximal end which can happen with circumferential tip capture systems. The device was deployed in three aortic phantoms, and in four cadavers, deployment precision was measured. Subsequently, the device was implanted in a patient to exclude a pseudoaneurysm originating from the distal anastomosis after ascending aortic replacement. Results The stent-grafts were successfully deployed in all phantoms and cadavers. Deployment accuracy of the proximal end of the stent-graft was within 1 mm proximally and 14 mm distally to the intended landing zone on the inner curvature, and 2–8 mm distal to the intended landing zone on the outer curvature. In clinical application, the pseudoaneurysm could be successfully excluded without complications. Conclusion The novel stent-graft design promises accurate placement in the ascending aorta. The differential deployment of the apices at the inner and outer curvatures allows deployment perpendicular to the aortic axis. Level of Evidence No level of evidence.

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Severe case of intestinal vasculitis: knife's edge diagnosis and treatment

Endoscopy ◽

10.1055/s-0032-1306789 ◽

2012 ◽

Vol 44 (S 02) ◽

pp. E128-E128

Author(s):

P. Lenz ◽

J. Dominick ◽

P. Barth ◽

M. Köhler ◽

D. Domagk ◽

...

Keyword(s):

Severe Case ◽

Diagnosis And Treatment

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Promising Applications of Nanoparticles in the Treatment of Hearing Loss

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.750185 ◽

2021 ◽

Vol 9 ◽

Author(s):

Zilin Huang ◽

Qiang Xie ◽

Shuang Li ◽

Yuhao Zhou ◽

Zuhong He ◽

...

Keyword(s):

Drug Delivery ◽

Hearing Loss ◽

Inner Ear ◽

Drug Delivery System ◽

Clinical Application ◽

Delivery System ◽

Diagnosis And Treatment ◽

Biological Research ◽

Medical Applications ◽

Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

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APASL practical recommendations for the management of hepatocellular carcinoma in the era of COVID-19

Hepatology International ◽

10.1007/s12072-020-10103-4 ◽

2020 ◽

Author(s):

Shuichiro Shiina ◽

Rino A. Gani ◽

Osamu Yokosuka ◽

Hitoshi Maruyama ◽

Hiroaki Nagamatsu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Medical Staff ◽

Close Contact ◽

Diagnosis And Treatment ◽

Asia Pacific ◽

Curative Treatment ◽

The Novel ◽

Medical Care System ◽

Hygiene Measures ◽

Novel Coronavirus

Abstract Background COVID-19 has been giving the devastating impact on the current medical care system. There are quite many guidelines on COVID-19, but only a few on the management of hepatocellular carcinoma (HCC) during COVID-19 pandemic. Aims We develop these recommendations to preserve adequate clinical practice for the management of HCC. Methods Experts of HCC in the Asia–Pacific region exchanged opinions via webinar, and these recommendations were formed. Results Close contact should be minimized to reduce possible exposure of both medical staff and patients to the novel coronavirus. To prevent transmission of the virus, meticulous hygiene measures are important. With the decrease in regular medical service, the medical staff may be mobilized to provide COVID-19-related patient care. However, diagnosis and treatment of HCC should not be delayed because of COVID-19 pandemic. The management of HCC should be the same as in non-pandemic circumstances. HCC is highly malignant, thus it is recommended not to delay curative treatment such as surgery and ablation. However, a kind of triage is necessary even among patients with HCC when resources are insufficient for all to be treated. Curative treatments should be periodized and cytoreductive or non-curative treatment such as vascular interventions and systemic therapy may be postponed until it can be performed safely with sufficient resources. For patients with confirmed or suspected to be infected with the novel coronavirus, diagnosis and treatment should be postponed until the virus is eliminated or they are confirmed as not being infected with it. Conclusions These are collection of measures implemented by front-line medical professionals. We would evolve these recommendations over time as more real-world data becomes available.

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Clinical diagnosis and treatment of throat foreign bodies under video laryngoscopy

Journal of International Medical Research ◽

10.1177/0300060520940494 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094049

Author(s):

Chuanyao Lin ◽

Dingding Liu ◽

Han Zhou ◽

Xiaoli Zhang ◽

Ling Lu ◽

...

Keyword(s):

Clinical Diagnosis ◽

Clinical Application ◽

Foreign Bodies ◽

Diagnosis And Treatment ◽

Video Laryngoscopy ◽

Fish Bones ◽

Drum Tower Hospital

Objective This study was designed to explore the clinical application of video laryngoscopy in the diagnosis and treatment of throat foreign bodies (FBs). Method In total, 1572 patients diagnosed with throat FBs at the Department of Otolaryngology of Nanjing Drum Tower Hospital were retrospectively analysed. The covariables collected were the time from FB ingestion to admission, age, sex, duration of admission, and site of impaction. Result The most common FBs were fish bones, which accounted for 1446 (91.98%) of 1572 FBs. Among all 1572 FBs, 1004 (63.87%) were successfully removed by video laryngoscopy without complications. A shorter duration of admission was associated with a higher diagnostic rate under video laryngoscopy. The diagnostic rate of sharp FBs was significantly higher than that of non-sharp FBs. The most common sites of throat FBs were the tongue root (42.29%), epiglottic vallecula (19.40%), tonsil (18.21%), and piriform fossa (10.65%). Conclusion Video laryngoscopy is a powerful tool for the diagnosis and treatment of throat FBs, allowing for identification of rare locations of FBs as well as refractory FBs.

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Emerging Novel GII.P16 Noroviruses Associated with Multiple Capsid Genotypes

Viruses ◽

10.3390/v11060535 ◽

2019 ◽

Vol 11 (6) ◽

pp. 535 ◽

Cited By ~ 10

Author(s):

Leslie Barclay ◽

Jennifer L. Cannon ◽

Mary E. Wikswo ◽

Annie R. Phillips ◽

Hannah Browne ◽

...

Keyword(s):

Amino Acid ◽

Severe Case ◽

Molecular Data ◽

Antigenic Drift ◽

The Novel ◽

Structural Protein ◽

Protein Coding ◽

Recombinant Viruses ◽

The Us ◽

Genomic Regions

Noroviruses evolve by antigenic drift and recombination, which occurs most frequently at the junction between the non-structural and structural protein coding genomic regions. In 2015, a novel GII.P16-GII.4 Sydney recombinant strain emerged, replacing the predominance of GII.Pe-GII.4 Sydney among US outbreaks. Distinct from GII.P16 polymerases detected since 2010, this novel GII.P16 was subsequently detected among GII.1, GII.2, GII.3, GII.10 and GII.12 viruses, prompting an investigation on the unique characteristics of these viruses. Norovirus positive samples (n = 1807) were dual-typed, of which a subset (n = 124) was sequenced to yield near-complete genomes. CaliciNet and National Outbreak Reporting System (NORS) records were matched to link outbreak characteristics and case outcomes to molecular data and GenBank was mined for contextualization. Recombination with the novel GII.P16 polymerase extended GII.4 Sydney predominance and increased the number of GII.2 outbreaks in the US. Introduction of the novel GII.P16 noroviruses occurred without unique amino acid changes in VP1, more severe case outcomes, or differences in affected population. However, unique changes were found among NS1/2, NS4 and VP2 proteins, which have immune antagonistic functions, and the RdRp. Multiple polymerase-capsid combinations were detected among GII viruses including 11 involving GII.P16. Molecular surveillance of protein sequences from norovirus genomes can inform the functional importance of amino acid changes in emerging recombinant viruses and aid in vaccine and antiviral formulation.

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