Chronic atypical respiratory infections (Mycoplasma pneumoniae, Chlamydophila pneumoniae) and asthma control in children

Nineteen patients aged 18–65 years with moderate and severe exacerbations of atopic asthma were examined for respiratory viruses, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. Interferon system, IL-4 and γ-IFN serum levels were also investigated. Viral infections (RS-virus, adenovirus, influenza types A (H1N1, H3N2) and B viruses, parainfluenza types 1 and 3 viruses) were diagnosed serologically or using PCR with direct detection of viral nucleic acids in 73.6 % of the patients. Diagnostic level of Mycoplasma pneumoniae antigen was found in 78.9 % of the patients, anti-Chlamydophila pneumoniae antibodies were detected in 31.6 %. Leukocyte interferon-producing function was decreased in all the patients.

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Atypical pathogen infection of respiratory system

Medycyna Faktów ◽

10.24292/01.mf.0121.10 ◽

2021 ◽

Vol 14 (1) ◽

pp. 78-81

Author(s):

Adam J. Sybilski

Keyword(s):

Mycoplasma Pneumoniae ◽

Respiratory Infections ◽

Chlamydophila Pneumoniae ◽

Medical Attention ◽

Intensive Care Treatment ◽

Atypical Pneumonia ◽

Upper Respiratory Tract ◽

Atypical Pathogen ◽

Upper Respiratory ◽

Atypical Bacteria

The frequency of respiratory infections, especially atypical pneumonia, is increasing significantly. Most often, atypical pneumonia is caused by Mycoplasma pneumoniae and Chlamydophila pneumoniae. Human is the only reservoir of these atypical bacteria. The infection occurs via droplets or direct contact with a sick person or convalescent. Pneumonia of the etiology of Mycoplasma pneumoniae and Chlamydophila pneumoniae most often affects children without comorbidities and is usually mild, while most patients with Legionella infection require intensive care treatment. Symptoms of mycoplasma infection can range from mild symptoms in the upper respiratory tract to pneumonia and extrapulmonary symptoms. The infection is often underdiagnosed, and patients usually do not seek medical attention and treatment. Chlamydial pneumonia is, in most cases, mild, similar to Mycoplasma pneumoniae, and tends to heal itself. The drugs of choice in the treatment of atypical pneumonia are macrolides, and because of the best compliance in children – azithromycin.

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Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza in children with respiratory infections in Alexandria, Egypt

The Journal of Infection in Developing Countries ◽

10.3855/jidc.4458 ◽

2014 ◽

Vol 8 (03) ◽

pp. 379-383 ◽

Cited By ~ 8

Author(s):

Tiziana Grassi ◽

Fabiola Mancini ◽

Alessandra Ciervo ◽

Maria Fenicia Vescio ◽

Abeer Ghazal ◽

...

Keyword(s):

Mycoplasma Pneumoniae ◽

Bacterial Infections ◽

Respiratory Infections ◽

Chlamydophila Pneumoniae ◽

Influenza Viruses ◽

Upper Respiratory Tract ◽

Mild Disease ◽

Etiological Agents ◽

Pediatric Morbidity

Introduction: Acute respiratory infections (ARI) are the leading cause of pediatric morbidity and mortality worldwide. Information about etiological agents of ARI in developing countries is still limited. Methodology: Throat swabs collected from children hospitalized with ARI between December 2009 and May 2010 were investigated for Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza viruses by molecular analyses. Results: This study conducted in Alexandria, Egypt, was designed to determine the prevalence of several microorganisms in 156 children hospitalized with ARI. Overall, samples from 76 individuals (49%) were found to be positive for at least one pathogen, and 10 of them were positive for two agents. C. pneumoniae was the most commonly detected agent, followed by M. pneumonia and H1N1 pandemic influenza virus. Positivity for C. pneumoniae was associated with colder months and mild disease of the upper respiratory tract such as laryngitis. Conclusions: Further studies are needed to identify other possible agents of ARI (e.g., RSV, adenoviruses, other bacterial infections) in this population and to better understand the causal role of atypical bacteria detected in respiratory samples.

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Diagnosis of Mycoplasma pneumoniae and Chlamydophila pneumoniae in pediatric cases of acute respiratory infections using IgM ELISA and Real time multiplex PCR

Indian Journal of Medical Microbiology ◽

10.1016/j.ijmmb.2021.08.163 ◽

2021 ◽

Vol 39 ◽

pp. S47-S48

Author(s):

C. Fathima Shereen ◽

Manoj B. Jais ◽

Ravinder Kaur

Keyword(s):

Multiplex Pcr ◽

Real Time ◽

Mycoplasma Pneumoniae ◽

Respiratory Infections ◽

Chlamydophila Pneumoniae ◽

Acute Respiratory Infections ◽

Igm Elisa

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Acute Respiratory Infection by Chlamydophila pneumoniae and Mycoplasma pneumoniae in a Population of Older Adults in Colombia

Universitas Médica ◽

10.11144/javeriana.umed58-4.pneu ◽

2017 ◽

Vol 58 (4) ◽

Author(s):

Nidi Lorena Corredor Cubides ◽

Karent Juileth Beltrán Suárez ◽

Juan Camilo Segura Salgero ◽

Laura Bettin Torres ◽

Jeanette Coriat Budik ◽

...

Keyword(s):

Older Adults ◽

Mycoplasma Pneumoniae ◽

Respiratory Infection ◽

Acute Respiratory Infection ◽

Respiratory Infections ◽

Age Groups ◽

Mortality Rates ◽

Chlamydophila Pneumoniae ◽

Upper Respiratory Infections ◽

Upper Respiratory

AbstractIntroduction: Acute Respiratory Infection (ARI) is a heterogeneous group of viral and bacterial respiratory pathologies including Chlamydophila pneumoniae (CP) and Mycoplasma pneumoniae (MP) that are not routinely identified; these infections in the older adults have mortality rates 3 to 5 times higher than that recorded in other age groups. Methods: this study was conducted prospectively to determine the proportion of atypical bacterial pathogens in older adults with ARI in Bogotá. Microbiological diagnosis was determined by real-time PCR (qPCR) in samples of respiratory origin and serology for antibodies IgG, IgA and IgM to MP and CP. Results: A total of 71 patients were enrolled from 2012 to 2013. Upper respiratory infections were diagnosed in the 69% of patients and lower respiratory infections in 31%. MP was identified in 9.8% and CP in 8.5%. Conclusions: these findings indicated that CP and MP must be viewed as a significant etiological agent of ARI in older adults in Bogotá.

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