Role of brain serotonin in age-related decline in physical activity in mice

2021 ◽  
Author(s):  
Pablo Blanco Martinez de Morentin ◽  
Lora K Heisler ◽  
Matevz arcon ◽  
Alasdair Leeson-Payne ◽  
Yuliia Martynova
Keyword(s):  
Physical Activity ◽  
Brain Serotonin ◽  
Age Related

PHYSICAL ACTIVITY AS HEALTHY INTERVENTION AGAINST SEVERE OXIDATIVE STRESS IN ELDERLY POPULATION

2013 ◽  
pp. 1-9
Author(s):  
C. TOMAS-ZAPICO ◽  
E. IGLESIAS-GUTIERREZ ◽  
B. FERNANDEZ-GARCIA ◽  
D. DE GONZALO-CALVO
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Elderly Population ◽  
Physiological Basis ◽  
Related Disease ◽  
Age Related ◽  
Wide Range ◽  
Health Related ◽  
Relevant Risk Factor

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.

scholarly journals IMPACT OF PHYSICAL ACTIVITY OF PRESCHOOL CHILDREN ON THE DEVELOPMENT OF EXECUTIVE FUNCTIONS: THEORETICAL REVIEW OF STUDIES

2020 ◽  
pp. 214-238
Author(s):  
Alla A. Tvardovskaya ◽  
Valerian F. Gabdulkhakov ◽  
Natalya N. Novik ◽  
Almira M. Garifullina
Keyword(s):  
Physical Activity ◽  
Preschool Children ◽  
Research Problem ◽  
Age Related ◽  
Main Components ◽  
Regulatory Functions ◽  
Relationship Of ◽  
The Relationship ◽  
Positive Effect

Relevance. The increase of children interest in entertainment TV programs, mobile applications and video games available on the internet causes a significant decrease in their physical activity: children get used to a sedentary or lying down lifestyle. The research problem lies in the contradiction that arises due to understanding of the positive effect of physical activity on the development of the regulatory functions of a preschooler, and a significant decrease in this activity in the digital conditions of the modern educational environment. The relevance and prospects of the study of the relationship between regulatory functions and physical activity of preschool children in new digital environment are not yet fully realized. The objective of the paper is to review the studies by foreign scientists in order to identify and describe relevant indicators of physical activity in preschool children interrelated with the main components of regulatory functions (inhibitory control, working memory, cognitive flexibility). Method. A theoretical review of research papers published over the past ten years (2010–2020) on the subject of relationship of various physical activity indicators and regulatory functions in preschool children. Results. The paper provides a comparative analysis of studies conducted by foreign authors. It allows to reveal basic indicators of physical activity in children which are essential for the development of regulatory functions (sufficiency of physical activity; age-related appropriateness; the nature of physical activity; the form of physical activity arrangement), and particular indicators (the relationship of physical activity and regulatory functions in various sports, duration and intensity of physical activity, the availability of software for the development of physical activity in preschool children) as well. Conclusions. The review showed that the majority of the authors emphasized the significant role of basic physical activity indicators and their influence on regulatory functions. Aerobic exercises are the most effective in the development of regulatory functions in preschool children. Particular indicators are selected from the studies of the development of regulatory functions in specific sports (football, karate, yoga, mini-trampoline), and additional research on the duration and intensity of physical activity is needed.

scholarly journals Age-related changes in microcirculation: the role of regular physical activity

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Pavel V. Mikhailov ◽  
◽  
Alexey V. Muravyov ◽  
Igor A. Osetrov ◽  
Anton A. Muravev ◽  
...  
Keyword(s):  
Physical Activity ◽  
Regular Physical Activity ◽  
Age Related ◽  
Age Related Changes

The role of a Mediterranean diet and physical activity in decreasing age-related inflammation through modulation of the gut microbiota composition

2021 ◽  
pp. 1-16
Author(s):  
Jessie S. Clark ◽  
Bradley S. Simpson ◽  
Karen J. Murphy
Keyword(s):  
Physical Activity ◽  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Potential Method ◽  
Current Evidence ◽  
Older Individuals ◽  
Age Related ◽  
Predominant Factor ◽  
Study Designs

Abstract Chronic inflammation is known to be a predominant factor in the development of many age-related conditions including CVD, type II diabetes and neurodegenerative diseases. Previous studies have demonstrated that during the ageing process there is an increase in inflammatory biomarkers, which may be partially brought about by detrimental changes in the gut microbiota. The Mediterranean diet (MedDiet) and physical activity (PA) are protective against inflammation and chronic disease, and emerging evidence has shown that these effects may be partially mediated through favourable changes in the gut microbiota. In this review, we have evaluated the published literature on the effect of a MedDiet and PA on the gut microbiota. We also discuss the relationship between the gut microbiota and inflammation with a focus on healthy ageing. While inconsistent study designs make forming definitive conclusions challenging, the current evidence suggests that both a MedDiet and PA are capable of modifying the gut microbiota in a way that is beneficial to host health. For example, the increases in the relative abundance of SCFA producing bacteria that are considered to possess anti-inflammatory properties. Modification of the gut microbiota through a MedDiet and PA presents as a potential method to attenuate age-related increases in inflammation, and additional studies utilising older individuals are needed to fill the knowledge gaps existing in current literature.

scholarly journals Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4080
Author(s):  
Ligia J. Dominguez ◽  
Nicola Veronese ◽  
Laura Vernuccio ◽  
Giuseppina Catanese ◽  
Flora Inzerillo ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Dietary Patterns ◽  
Social Engagement ◽  
Lifestyle Factors ◽  
Current Evidence ◽  
World Population ◽  
Age Related

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for cognitive impairment and dementia is advanced age followed by other determinants such as genetic, socioeconomic, and environmental factors, including nutrition and physical activity. In the next decades, a rise in dementia cases is expected due largely to the aging of the world population. There are no hitherto effective pharmaceutical therapies to treat age-associated cognitive impairment and dementia, which underscores the crucial role of prevention. A relationship among diet, physical activity, and other lifestyle factors with cognitive function has been intensively studied with mounting evidence supporting the role of these determinants in the development of cognitive decline and dementia, which is a chief cause of disability globally. Several dietary patterns, foods, and nutrients have been investigated in this regard, with some encouraging and other disappointing results. This review presents the current evidence for the effects of dietary patterns, dietary components, some supplements, physical activity, sleep patterns, and social engagement on the prevention or delay of the onset of age-related cognitive decline and dementia.

718 THE ROLE OF BODY COMPOSITION AND PHYSICAL ACTIVITY ON THE AGE-RELATED DECLINE IN VO2max IN WOMEN (AGES 21???63)

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S130
Author(s):  
L. T. WIER ◽  
A. S. JACKSON ◽  
G. W. AYERS ◽  
J. E. STUTEVILLE
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Age Related

Protective Role of Recent and Past Long-Term Physical Activity on Age-Related Cognitive Decline: The Moderating Effect of Sex

2018 ◽  
Vol 26 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Iréné Lopez-Fontana ◽  
Carole Castanier ◽  
Christine Le Scanff ◽  
Alexandra Perrot
Keyword(s):  
Physical Activity ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Moderating Effect ◽  
Age Related ◽  
Age Related Cognitive Decline ◽  
The Impact ◽  
Activity Questionnaire

This study aimed to investigate if the impact of both recent and long-term physical activity on age-related cognitive decline would be modified by sex. One-hundred thirty-five men (N = 67) and women (N = 68) aged 18 to 80 years completed the Modifiable Activity Questionnaire and the Historical Leisure Activity Questionnaire. A composite score of cognitive functions was computed from five experimental tasks. Hierarchical regression analyses performed to test the moderating effect of recent physical activity on age-cognition relationship had not revealed significant result regardless of sex. Conversely, past long-term physical activity was found to slow down the age-related cognitive decline among women (β = 0.22,p = .03), but not men. The findings support a lifecourse approach in identifying determinants of cognitive aging and the importance of taking into account the moderating role of sex. This article presented potential explanations for these moderators and future avenues to explore.

Age-related memory deficit: Role of study time and encoding strategies

2010 ◽  
Author(s):  
Charlotte Froger ◽  
Badiaa Bouazzaoui ◽  
Laurence Taconnat
Keyword(s):  
Memory Deficit ◽  
Study Time ◽  
Age Related ◽  
Encoding Strategies
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