scholarly journals Study on Enteric Vacant Capsules Based on Hydroxypropyl Methylcellulose Phthalate-55S

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Liping L ◽  
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Tween 80 ◽  
Ammonia Solution ◽  
Cellulose Solution ◽  
Preparation Process ◽  
Molding Process ◽  
Agar Solution ◽  
Enteric Coated ◽  
Hollow Capsule ◽  
Hydroxypropyl Methylcellulose Phthalate

The formulation and preparation technology of enteric cellulose hollow capsules were studied, and its properties were evaluated. The enteric cellulose hollow capsules were prepared with hydroxypropyl methylcellulose phthalate~55S (Hp55S) as film~forming material, agar as molding agent and hydroxypropyl methylcellulose (HPMC) as disintegration regulator. The preparation process was as follows: (1) At room temperature, 9~16 phr of Hp55S was dissolved in 30~50 phr of dilute ammonia solution with pH of 10~11 to obtain transparent Hp55S glue solution; (2) Put 1.2~1.6 parts of agar into 50~70 parts of water, heat and boil to obtain agar solution. 1~7 phr of HPMC, 0.12~0.16 phr of KCl and 0.1~0.2 phr of Tween~80 were poured into agar solution to disperse evenly, and then the temperature of gel solution was reduced to 50~55 oC to obtain agar/HPMC mixed gel solution; (3) The Hp55S solution was heated to 50~55 oC and then poured into agar/HPMC solution to obtain composite cellulose solution. The temperature of the solution was kept at 50~55 oC. (4) Enteric cellulose hollow capsules were prepared by dipping in glue, shaping, drying, trimming and assembling. The results showed that the enteric cellulose hollow capsules met the quality requirements of “enteric coated hollow capsules” in Chinese Pharmacopoeia. Compared with the traditional formula and preparation process of enteric coated hollow capsules, it avoids the use of organic solvents and multiple molding process. The enteric cellulose hollow capsule greatly reduces the preparation cost from the formula to the process, which is green, safe and environmental friendly, and has good application value.

scholarly journals Effects of pH and Electrolytes on Castor Oil Emulsions with Various Stabilisers Using Khaya senegalensis Gum as an Emulsifier

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Deryl Nii Okantey Kuevi ◽  
Noble Kuntworbe ◽  
Enoch Ayertey
Keyword(s):  
Castor Oil ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
Physical Stability ◽  
Tween 80 ◽  
Volume Data ◽  
Emulsifying Property ◽  
Khaya Senegalensis ◽  
Effects Of Ph ◽  
The Stability

Dispersed systems such as emulsions are easily destabilised during processing and storage since they are thermodynamically unstable systems. It is for this reason emulsifiers/stabilisers are frequently employed in pharmaceutical emulsion formulations to increase their short- and long-term kinetic stability. This current study seeks to investigate the potential emulsifying property of gums obtained from Khaya senegalensis (family: Meliaceae) trees. Gums were collected, authenticated, oven-dried, milled, filtered, and purified using 96% ethanol. The microbial quality of the gum was assessed following the BP (2013) specifications. The purified gum was free from some selected pathogenic microorganisms, rendering the gum safe for consumption. The emulsifying property was investigated by formulating emulsions using castor oil and employing the dry gum method. The ratios of oil-to-water-to-gum for the formulation of a stable emulsion were determined. The stability of the emulsion was evaluated, and an effort was made to improve the stability by incorporating Tween 80, hydroxypropyl methylcellulose, and xanthan gum. From the results, it can be inferred that Tween 80 (0.5%) was able to stabilise the emulsion. Addition of xanthan gum worsened the creaming. The effects of pH (4.0, 5.5, 7.2, 9.0, and 11.0) and electrolytes (0.1 M of NaCl, KCl, and CaCl2) on the physical stability of oil-in-water emulsions were studied during 12 weeks of storage. Percentage creaming volume and whether there was phase inversion were the criteria used as the evaluation parameter. From the percentage creaming volume data, emulsions formulated with both gums showed the lowest creaming volumes at pH of 7.2, followed by the acidic regions (pH 4.0, 5.5), with the basic regions (pH 9.0, 11.0) recording the highest creaming volumes. The effects of the various electrolytes at a constant concentration of 0.1 M on the o/w emulsions were found in this order NaCl < KCl < CaCl2. This study proves that Khaya senegalensis gum can successfully be employed as an emulsifying agent in pharmaceutical formulations.

scholarly journals THE INFLUENCE OF VARIATION OF HYDROXYPROPYL METHYLCELLULOSE AND TWEEN 80 CONCENTRATIONS ON PHYSICAL CHARACTERISTICS AND PHYSICAL STABILITIES GEL OF WATER DRY EXTRACT OF TEMULAWAK

2019 ◽  
pp. 44-48
Author(s):  
SEKAR AYU PAWESTRI ◽  
TEUKU NANDA SAIFULLAH SULAIMAN
Keyword(s):  
Wound Healing ◽  
Software Design ◽  
Hydroxypropyl Methylcellulose ◽  
Water Extract ◽  
Tween 80 ◽  
Physical Characteristics ◽  
Homogeneity Test ◽  
Dry Extract ◽  
Design Expert ◽  
Optimum Formula

Objective: Water extract of temulawak (Curcuma xanthorrhizaRoxb.) contains curcumin, which known has antibacterial, antiinflammation, and antifungal activity so that it has potential used as wound healing. The purpose of this study was formulating gel of water extract of temulawak made by variation of hydroxypropyl methylcellulose (HPMC) and tween 80 concentrations and investigating the influence of formulations on physical characteristics and physical stabilities gel. Methods: Gel was made by variation of HPMC and tween 80 concentrations (3,00%: 1,00%; 5,00%: 1,00%; 3,00%: 2,00%; 5,00%; 2,00%). Gel preparations was evaluated the physical characeristics by organoleptic test, homogeneity test, pH, viscosity, spreadability, adhesiveness, and stability. The physical properties were analyzed by software Design Expert 9. Results: The results showed that HPMC has dominant influenced on viscosity, spreadability, and adhesiveness. HPMC and tween 80 have not influence on organoleptic, homogeneity, and pH of the gel. Optimum formula is HPMC 5,00% and tween 80 1,00%. Optimum formula is stable on organoleptic, homogeneity, pH, viscosity, and adhesiveness; however spreadability of gel is not stable during 3 mo storage. Conclusion: Variation of HPMC and tween 80 concentrations influenced viscosity, spreadability, and adhesiveness, while they were not influenced on organoleptic, homogeneity, and pH of gel. HPMC had dominant influenced on viscosity, spreadability, and adhesiveness gel.

The Modification of VPO Catalyst Precursor and Characterization

2011 ◽  
Vol 335-336 ◽  
pp. 1485-1488
Author(s):  
Yan Lin Zhang ◽  
Dian Hui Hou ◽  
Yang Zhou ◽  
Xi Wu Fan ◽  
Nai Di Tan
Keyword(s):  
Surface Area ◽  
Crystalline Phase ◽  
Catalyst Surface ◽  
Tween 80 ◽  
Catalyst Precursor ◽  
Preparation Process ◽  
Vpo Catalysts ◽  
Tem Characterization ◽  
Vpo Catalyst ◽  
Tween 60

Tween 60 and Tween 80 as dispersant had been adding in the preparation process to increase the surface area of VPO catalysts. XRD、 XPS and TEM characterization tests show that the crystalline phase and the catalyst surface area of adding surfactant Tween 60 and Tween 80 are different from that did not. Although the two types of crystalline phase are to (VO)2P2O7but their microscopic structures are different and found that the surface area of the former is 35-40m2/ g, while the surface area without adding surfactants is only 19m2/ g.

scholarly journals QBD-BASED DEVELOPMENT AND EVALUATION OF ENTERIC COATED MUCOADHESIVE MICROCAPSULES OF AMOXICILLIN TRIHYDRATE AS A NOVEL CHRONOTHERAPEUTIC APPROACH FOR TREATMENT OF BACTERIAL INFECTIONS

2018 ◽  
Vol 10 (8) ◽  
pp. 90 ◽  
Author(s):  
Shyam Narayan Prasad ◽  
Hemant Kumar Patel ◽  
Abhijit V. Gothoskar
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Hydroxypropyl Methylcellulose ◽  
Entrapment Efficiency ◽  
Drug Content ◽  
Eudragit L100 ◽  
Significant Difference ◽  
Amoxicillin Trihydrate ◽  
Mucoadhesive Property ◽  
Enteric Coated

Objective: The present work entails design and characterization of enteric coated mucoadhesive microcapsules loaded with amoxicillin trihydrate as a novel chronotherapeutic approaches for the treatment and management of bacterial infection.Methods: The microcapsules were prepared by solvent evaporation technique using ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) as rate-controlling and mucoadhesive polymers, followed by a triple coating with Eudragit L100 as enteric coating polymer. Box-Behnken statistical design (BBD) was applied for optimization of formulations containing EC, HPMCK100M and Eudragit L100 as factors for selected responses like entrapment efficiency, mucoadhesive property and drug release in 24 h. The optimized microcapsules were also characterized for particle size, drug content, swelling index, mucoadhesive strength, and in vivo antiulcer activity.Results: The optimized microcapsules exhibited good entrapment efficiency, particle size and mucoadhesive property. FT-IR studies revealed that there was no drug-polymer interaction. SEM studies revealed that microcapsules were non-aggregated, spherical in shape and smooth appearance. In vitro drug release data from microcapsules was fitted to different kinetic models to explain release profiles. The correlation coefficient (r2) value indicated that drug release followed Higuchi model. Analysis of variance (ANOVA) showed significant difference in the release of drug from all the prepared formulations at P < 0.05 level. Accelerated stability study of optimized formulation (F4) upto 6 month showed there was no change in drug content and release characteristics during storage.

scholarly journals DEVELOPMENT AND CHARACTERIZATION OF ORAL SWELLABLE RAPID RELEASE FILM WITH SUPERDISINTEGRANT-SURFACTANT

2021 ◽  
pp. 75-80
Author(s):  
NEHA IMTIAZ ◽  
SUTAPA BISWAS MAJEE ◽  
GOPA ROY BISWAS
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Diclofenac Sodium ◽  
Hydroxypropyl Methylcellulose ◽  
Tween 80 ◽  
Fickian Diffusion ◽  
Disintegration Time ◽  
Rapid Release ◽  
Oral Films

Objective: Oral disintegrating films consisting of hydrophilic polymer are designed to be quickly hydrated by saliva, adhere to the mucosa and disintegrate rapidly to release the drug. The aim of the present study was to prepare stable, flexible swellable rapid release oral films with hydroxypropyl methylcellulose E15 LV (HPMC) and polyvinyl alcohol (PVA) in different ratios. Guar gum was incorporated as the mucoadhesive agent. In order to achieve rapid disintegration of the film cross carmellose sodium (superdisintegrant) and surfactant like Tween 80 were added. The model drug used in the study was diclofenac sodium. Methods: Films were developed using HPMC E15 LV and PVA by solvent casting method and characterized for thickness, swelling index, disintegration time, folding endurance, drug content, and in vitro drug release pattern and kinetics. Results: The prepared swellable rapid release oral films were quite flexible and transparent with a smooth texture. The swelling index study confirmed that the films possessed the desired swelling property. Fastest disintegration was observed with the oral film containing HPMC: PVA in the ratio of 2:1, guar gum at 120 mg, 20% w/w crosscarmellose sodium and 4%w/w Tween 80. The swellable rapid release oral films were found to follow either Higuchi or Korsmeyer-Peppas model with drug release following either Fickian or non-Fickian diffusion. Maximum drug release of around 70% was observed from the above-mentioned film in 1hr in simulated salivary fluid. Conclusion: Therefore, swellable rapid release oral films with HPMC E15 LV: PVA, guar gum, croscarmellose sodium and Tween 80 demonstrated satisfactory swelling, rapid disintegration and improved drug release for oromucosal absorption.

Study on the Preparation Process of Corn Straw-Pumice Composite Concrete

2013 ◽  
Vol 357-360 ◽  
pp. 955-958
Author(s):  
Jian Suo Ma ◽  
Jing Sun ◽  
Huan Qin Cai ◽  
Run Shan Bai
Keyword(s):  
Water Absorption ◽  
Building Materials ◽  
Raw Materials ◽  
Northern China ◽  
Preparation Process ◽  
Corn Straw ◽  
Molding Process ◽  
Main Crop ◽  
Large Water ◽  
Materials Used

In order to prepare energy saving and environmental protection building materials, a new kind of concrete was made by the combination of corn stalks which is the main crop in northern China, natural pumice resources and cement. Corn stalks and pumice are all lightweight material with open pores and large water absorption; therefore they must be pretreated before preparing concrete by blocking holes to reduce the amount of grout. The raw materials used in the experiments are lightweight materials; it is advisable to adopt the pressure vibration molding process to reduce aggregate stratification.

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