Pregnant with COVID-19 and Rubella: Impact in the Maternal and Newborn Health

Author(s):  
Dias VC ◽  
◽  
Silva VL ◽  
Diniz CG ◽  
Ferreira-Machado AB ◽  
...  

Since December 2019, COVID-19 has become major global public health problem. The understanding of SARS-CoV-2, especially the effect on pregnant women and neonates, is still not fully elucidated. This report case describes a pregnant with COVID-19 and rubella. SARS-CoV-2 nucleic acid was not detected in the neonate just after birth, indicating that there was not vertical transmission. Although anti-SARS-CoV-2 Immunoglobulin G (IgG) antibody and anti-Rubella Virus IgG antibody were detected in the newborn serum, anti-SARS-CoV-2 (Immunoglobulin M) IgM and anti-Rubella Virus IgM were not detected. The observations may suggest transplacental transmission of coronavirus and rubella antibodies, ensuring immediate immunity against these pathogens to newborn.

2019 ◽  
Vol 19 (8) ◽  
pp. 567-578 ◽  
Author(s):  
Marcus Vinicius Nora de Souza ◽  
Thais Cristina Mendonça Nogueira

Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of Mycobacterium tuberculosis to all drugs used for the treatment of this disease, we desperately need new drugs and strategies that could reduce treatment time with fewer side effects, reduced cost and highly active drugs against resistant strains and latent disease. Considering that, 4H-1,3-benzothiazin-4-one is a promising class of antimycobacterial agents in special against TB-resistant strains being the aim of this review the discussion of different aspects of this chemical class such as synthesis, mechanism of action, medicinal chemistry and combination with other drugs.


Author(s):  
Nathalie Roos ◽  
Sari Kovats ◽  
Shakoor Hajat ◽  
Veronique Filippi ◽  
Matthew Chersich ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Resham B. Khatri ◽  
Yibeltal Alemu ◽  
Melinda M. Protani ◽  
Rajendra Karkee ◽  
Jo Durham

Abstract Background Persistent inequities in coverage of maternal and newborn health (MNH) services continue to pose a major challenge to the health-care system in Nepal. This paper uses a novel composite indicator of intersectional (dis) advantages to examine how different (in) equity markers intersect to create (in) equities in contact coverage of MNH services across the continuum of care (CoC) in Nepal. Methods A secondary analysis was conducted among 1978 women aged 15–49 years who had a live birth in the two years preceding the survey. Data were derived from the Nepal Demographic and Health Survey (NDHS) 2016. The three outcome variables included were 1) at least four antenatal care (4ANC) visits, 2) institutional delivery, and 3) postnatal care (PNC) consult for newborns and mothers within 48 h of childbirth. Independent variables were wealth status, education, ethnicity, languages, residence, and marginalisation status. Intersectional (dis) advantages were created using three socioeconomic variables (wealth status, level of education and ethnicity of women). Binomial logistic regression analysis was employed to identify the patterns of (in) equities in contact coverage of MNH services across the CoC. Results The contact coverage of 4ANC visits, institutional delivery, and PNC visit was 72, 64, and 51% respectively. Relative to women with triple disadvantage, the odds of contact coverage of 4ANC visits was more than five-fold higher (Adjusted Odds Ratio (aOR) = 5.51; 95% CI: 2.85, 10.64) among women with triple forms of advantages (literate and advantaged ethnicity and higher wealth status). Women with triple advantages were seven-fold more likely to give birth in a health institution (aOR = 7.32; 95% CI: 3.66, 14.63). They were also four times more likely (aOR = 4.18; 95% CI: 2.40, 7.28) to receive PNC visit compared to their triple disadvantaged counterparts. Conclusions The contact coverage of routine MNH visits was low among women with social disadvantages and lowest among women with multiple forms of socioeconomic disadvantages. Tracking health service coverage among women with multiple forms of (dis) advantage can provide crucial information for designing contextual and targeted approaches to actions towards universal coverage of MNH services and improving health equity.


Author(s):  
VEERENDRA UPPARA ◽  
SAISEKHAR KODIVANDLA ◽  
ASHIK ALI SHAIK

Heart failure (HF) is a major global public health problem irrespective of its causes. It generates an enormous clinical, societal, and economic, health loss burden with an increase in its prevalence reaching an epidemic proportion. The morbidity and mortality associated with heart failure are increasing the health-related burdens worldwide, especially in low- and middle-income countries. This review highlights the trends in HF burden, the clinical spectrum of HF, and the importance of neurohormonal pathways and the evolution of angiotensin receptor neprilysin inhibition in HF with updated clinical practice guidelines.


2015 ◽  
Vol 5 (2) ◽  
pp. 68-73
Author(s):  
Janet Perkins ◽  
Cecilia Capello ◽  
Aminata Bargo ◽  
Carlo Santarelli

Community participation in decision-making within the health sector is an essential component in advancing efforts toward primary health care (PHC). Since 2006, Enfants du Monde, a Swiss non-governmental organization (NGO), in collaboration with the local NGO Fondation pour le Développement Communautaire/Burkina Faso (FDC/BF), has been supporting the Ministry of Health (MoH) to include communities in decision-making related to maternal and newborn health (MNH) services. Notably, participatory community assessments (PCA) are conducted to provide a platform for community members to discuss MNH needs and be involved in the decision-making within the health sector. During the PCAs, participants identify and prioritize needs and propose solutions to improve MNH, solutions which are then integrated in the annual district health action plan. Integrated interventions include: promotion of birth preparedness and complication readiness; training health care providers in counselling skills; building awareness of men on MNH issues and their capacity to support women; and strengthening community bodies to manage obstetrical and neonatal complications. The inclusion of these interventions has contributed to the advancement of PHC in three regions in Burkina Faso.     


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