scholarly journals Análise de coorte histórica de 10 anos de ambulatório especializado em doença inflamatória intestinal do Brasil / 10-year retrospective cohort analysis of inflammatory bowel disease in a specialized clinic of Brazil

2021 ◽  
Author(s):  
Jéssica Martins Torres ◽  
Gabriela Santos Silva ◽  
Felipe Bertollo Ferreira ◽  
Ana Paula Hamer Sousa Clara ◽  
Felipe Welling Lorentz ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Epidemiological Data ◽  
Espírito Santo ◽  
Retrospective Cohort Analysis ◽  
Inflammatory Bowel ◽  
Espirito Santo

Introdução: A doença inflamatória intestinal (DII) representa um grupo de afecções crônicas idiopáticas que levam à inflamação do intestino. As duas principais representantesdessa doença são a Doença de Crohn (DC) e a Retocolite Ulcerativa (RCU). A crescente incidência e prevalência das doenças inflamatórias intestinais em países em desenvolvimentocomo o Brasil torna cada vez mais necessário o entendimento do comportamento epidemiológico da doença. Objetivo: Este presente estudo tem como objetivo analisar o perfil clínico epidemiológico da doença inflamatória intestinal em hospital de referência para o tratamento dessa patologia. Métodos: Trata-se de um estudo tipo coorte histórica com abordagem quantitativa, realizado no Ambulatório de Gastroenterologia do Hospital Santa Casa de Misericórdia de Vitória (HSCMV) localizado no estado do Espírito Santo. A população estudada foi adquirida após busca no sistema informatizado dos atendimentos hospitalares e ambulatoriais sob o CID-10 K50 e K51 durante o período de 01/01/2010 até 31/12/2019 (N=300). Resultados: A média de idade no momento do diagnóstico da doença inflamatória intestinal foi de 35,1 anos. A análise comparativa das variáveis epidemiológicas mostra que no grupo de DC 67,5% dos participantes tiveram pelo menos uma internação por exacerbação da doença ao longo de seu acompanhamento, contrastando com 28,9% dos portadores de RCU. Em relação a classe de medicamentos, nota-se que o grupo de RCU teve 24,7% dos participantes usando imunobiológicos durante o período analisado, o uso dessemesmo medicamento no grupo de portadores de DC foi de 63,2%. Conclusão: Este trabalho assume sua importância ao trazer dados novos da epidemiologia da DII no estado do Espírito Santo e do comportamento da doença, além de apresentar diferenças importantes da  literatura mundial, se transformando, assim, em um documento de grande importância para o serviço. Palavras chave: Doença de Crohn, Colite ulcerativa, Epidemiologia AbstractIntroduction: Inflammatory bowel disease it’s an idiopathic disorder that leads to inflammation of the gastroenteric tissue. The two main representatitves of this condition areCrohn’s Disease and Ulcerative Colitis. The increasing incidence of this disorder in developing countries such as Brazil makes the understanding of epidemiological aspects increasingly important. Objective: This article aimed to explore the clinical-epidemiological aspects of patients diagnosed with inflammatory bowel disease. Method: It’s a retrospective cohort study. The study design includes the patients diagnosed with inflammatory bowel disease seen at the gastroenterology clinic of the Hospital Santa Casa de Misericórdia de Vitória during January, 2010 to December 2019. Results: The average age at the time of the diagnosis was 35,1 years old. The analysis shows that 67,5% of the patients with Crohn’s Disease (CD) was hospitalized at least one time due to descompensation compared to 28,9% of Ulcerative Colitis (UC) patients. 24,7% of the UC participants made use of immunobiological therapy contrasted with 63,2% of CD patients. Conclusion: This article brings to light new epidemiological data and disease’s behavior regarding inflammatory bowel disease in the state of Espírito Santo besides uncovers important divergences between this study and other articles. This way, it becomes an important tool to the Gastroenterology clinic.   Keyword: Crohn disease, Colitis ulcerative, Epidemiology

scholarly journals INFLAMMATORY BOWEL DISEASE: OUTPATIENT TREATMENT PROFILE

2017 ◽  
Vol 54 (2) ◽  
pp. 96-100 ◽  
Author(s):  
Rachael Miranda dos SANTOS ◽  
Ana Teresa Pugas CARVALHO ◽  
Kelly dos Santos SILVA ◽  
Selma Petra Chaves SÁ ◽  
Aparecida Helena dos SANTOS ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Outpatient Treatment ◽  
Outpatient Service ◽  
Epidemiological Data ◽  
White Female ◽  
Inflammatory Bowel

ABSTRACT BACKGROUND Crohn’s disease and ulcerative colitis are the two major forms of inflammatory bowel disease. The incidence and prevalence of both conditions have increased and are progressively increasing. These diseases are frequently recurrent and clinically highly severe. In Brazil, the lack of epidemiological data related to such diseases has left these patients in a vulnerable state and contributed to increased morbidity. OBJECTIVE To describe the profiles of patients with inflammatory bowel disease treated in an outpatient service in Brazil. METHODS This descriptive, exploratory, and retrospective documentary study with a quantitative approach was performed in an outpatient treatment service for inflammatory bowel disease, at a university polyclinic located in Rio de Janeiro, Brazil, from May to July 2016. The study included 556 patients and was approved by the research ethics committee of the institution (CAAE no. 55179316.6.0000.5259/2016). RESULTS The data showed a high prevalence of inflammatory bowel disease in white female patients. Crohn’s disease was diagnosed in more patients than was ulcerative colitis; the ileocolon was the most commonly affected location in patients with Crohn’s disease. The stenotic phenotype was prevalent in patients with Crohn’s disease. CONCLUSION The prevalence of the stenotic phenotype in Crohn’s disease in relation to others demonstrates the need for further investigations in this field of study in Brazil. In conclusion, the data showed that the epidemiologic profile of the study population is similar to that published in the national and international literature.

scholarly journals Risk Factors for and Frequency of CT Scans, Steroid Use, and Repeat Visits in Inflammatory Bowel Disease Patients Seen at a Single-Center Emergency Department: A Retrospective Cohort Study

2021 ◽  
Vol 10 (12) ◽  
pp. 2679
Author(s):  
Lindsay Euers ◽  
Shaadi Abughazaleh ◽  
Kerri Glassner ◽  
Prianka Gajula ◽  
Michelle Jones-Pauley ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Emergency Department ◽  
Ct Scan ◽  
Bowel Disease ◽  
Retrospective Cohort ◽  
Ct Scans ◽  
Steroid Use ◽  
Increased Risk ◽  
Inflammatory Bowel

Patients with inflammatory bowel disease often present to the emergency department due to the chronic relapsing nature of the disease. Previous studies have shown younger patients to have an increased frequency of emergency department visits, resulting in repeated exposure to imaging studies and steroids, both of which are associated with risks. We performed a retrospective cohort analysis of inflammatory bowel disease patients seen at Houston Methodist Hospital’s emergency department from January 2014 to December 2017 using ICD codes to identify patients with Crohn’s disease, ulcerative colitis, or indeterminate colitis from the electronic medical record. Data were collected on demographics, medications, and imaging. Five hundred and fifty-nine patients were randomly selected for inclusion. Older age was associated with decreased risk of CT scan or steroid use. Patients with ulcerative colitis compared to Crohn’s had decreased risk of CT scan, while there was an increased risk of CT in patients on a biologic, immunomodulator, or when steroids were given. Steroid use was also more common in those with inflammatory bowel disease as the primary reason for the visit. Patients in our study frequently received steroids and had CT scans performed. The increased risk of CT in those on a biologic, immunomodulator, or steroids suggests more severe disease may contribute. Guidelines are needed to reduce any unnecessary corticosteroid use and limit repeat CT scans in young inflammatory bowel disease patients to decrease the risk of radiation-associated malignancy over their lifetime.

Prebiotics and Probiotics in Inflammatory Bowel Disease: Where are we now and where are we going?

2020 ◽  
Vol 15 (3) ◽  
pp. 216-233 ◽  
Author(s):  
Maliha Naseer ◽  
Shiva Poola ◽  
Syed Ali ◽  
Sami Samiullah ◽  
Veysel Tahan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adverse Effects ◽  
Bowel Disease ◽  
Relapse Prevention ◽  
Remission Induction ◽  
Inflammatory Bowel

The incidence, prevalence, and cost of care associated with diagnosis and management of inflammatory bowel disease are on the rise. The role of gut microbiota in the causation of Crohn's disease and ulcerative colitis has not been established yet. Nevertheless, several animal models and human studies point towards the association. Targeting intestinal dysbiosis for remission induction, maintenance, and relapse prevention is an attractive treatment approach with minimal adverse effects. However, the data is still conflicting. The purpose of this article is to provide the most comprehensive and updated review on the utility of prebiotics and probiotics in the management of active Crohn’s disease and ulcerative colitis/pouchitis and their role in the remission induction, maintenance, and relapse prevention. A thorough literature review was performed on PubMed, Ovid Medline, and EMBASE using the terms “prebiotics AND ulcerative colitis”, “probiotics AND ulcerative colitis”, “prebiotics AND Crohn's disease”, “probiotics AND Crohn's disease”, “probiotics AND acute pouchitis”, “probiotics AND chronic pouchitis” and “prebiotics AND pouchitis”. Observational studies and clinical trials conducted on humans and published in the English language were included. A total of 71 clinical trials evaluating the utility of prebiotics and probiotics in the management of inflammatory bowel disease were reviewed and the findings were summarized. Most of these studies on probiotics evaluated lactobacillus, De Simone Formulation or Escherichia coli Nissle 1917 and there is some evidence supporting these agents for induction and maintenance of remission in ulcerative colitis and prevention of pouchitis relapse with minimal adverse effects. The efficacy of prebiotics such as fructooligosaccharides and Plantago ovata seeds in ulcerative colitis are inconclusive and the data regarding the utility of prebiotics in pouchitis is limited. The results of the clinical trials for remission induction and maintenance in active Crohn's disease or post-operative relapse with probiotics and prebiotics are inadequate and not very convincing. Prebiotics and probiotics are safe, effective and have great therapeutic potential. However, better designed clinical trials in the multicenter setting with a large sample and long duration of intervention are needed to identify the specific strain or combination of probiotics and prebiotics which will be more beneficial and effective in patients with inflammatory bowel disease.

scholarly journals The Changing Prognosis of Ulcerative Colitis and Crohn’s Disease by Decades

2021 ◽  
Author(s):  
Burton I Korelitz ◽  
Judy Schneider
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Medical Therapy ◽  
Bowel Disease ◽  
Surgical Intervention ◽  
Inflammatory Bowel

Abstract We present a bird’s eye view of the prognosis for both ulcerative colitis and Crohn’s disease as contained in the database of an Inflammatory Bowel Disease gastroenterologist covering the period from 1950 until the present utilizing the variables of medical therapy, surgical intervention, complications and deaths by decades.

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