Hypoxia-activated Probe for NIR Fluorescence and Photoacoustic Dual-mode Tumor Imaging
Keyword(s):
We rationally designed and synthesized a hypoxia-responsive probe TBTO featuring four diethylamino <i>N</i>-oxide groups that could undergo bioreduction in a hypoxic microenvironment, producing TBT with a typical D-A-D structure. It was demonstrated that TBT possesses NIR fluorescence emission and PA signal generation, benefiting from its both AIE property and a strong TICT effect. <i>In vitro</i> and <i>in vivo</i> assessments revealed the responsiveness of TBTO in a reductive environment and its NIR fluorescence and PA dual-mode imaging ability.
2021 ◽
Vol 22
(22)
◽
pp. 12214
Keyword(s):
2015 ◽
Vol 53
(10)
◽
pp. 6869-6881
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Keyword(s):