scholarly journals The role of risk factors and endothelium dysfunction in the pathogenesis of the high normal arterial preassure and clinical signs of the vegetative disturbances in children

2015 ◽  
Vol 12 (4) ◽  
pp. 6-10
Author(s):  
N A Maksimovich

As a result of investigation of the children the dysfunction of endothelium at high normal arterial pressure is the cause of the hemodynamic disturbances of children, equal of the arterial hypertension. As a result the children with high normal arterial pressure are the groups of the risk for arterial hypertension wich need the complex of correction of theses disturbances, early diagnostics of the arterial hypertension and its profylaxis. AT high level risk factors and vasoconstrictive properties at children with high normal arterial pressure the more high frequency of headache, the heart pain, both pains and the episodes of high normal pressure.

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E Zuffa ◽  
F Dardi ◽  
M Palazzini ◽  
E Gotti ◽  
A Rinaldi ◽  
...  

Abstract Background Current pulmonary hypertension (PH) guidelines stratify the risk of patients with pulmonary arterial hypertension (PAH) using a multiparametric approach. Anyway, the role of unmodifiable risk factors is not taken into account. Purpose The aim of this study was to evaluate the role of unmodifiable risk factors (age, gender, PAH aetiology) in PAH risk stratification using the recently proposed simplified risk table and to test if these factors influence the response to PAH-specific treatment. Methods All patients with PAH referred to a single centre were included from 2003 to 2017. We applied a simplified risk assessment strategy using the following criteria: WHO functional class, 6-min walking distance, right atrial pressure or brain natriuretic peptide plasma levels and cardiac index (CI) or mixed venous oxygen saturation (SvO2). The last 2 criteria were based on which parameter was available; if both were available the worst was chosen. Risk strata were defined as: Low risk= at least 3 low risk and no high-risk criteria; High risk= at least 2 high risk criteria including CI or SvO2; Intermediate risk= definitions of low or high risk not fulfilled. Then we performed multivariate Cox analysis to evaluate what are the independent predictors of survival (age, gender, PAH aetiology together with the recently proposed simplified PAH risk table) and we tested if these factors influence the response to PAH specific therapy comparing the % improvement of hemodynamic parameters from baseline to 3–4 months after starting treatment. Wilcoxon-Mann-Whitney test was used for comparisons. Results Six hundreds and twenty-one treatment-naïve patients were enrolled. Age [HR (95% CI) = 1.022 (1.014–1.030); p-value <0.001], male gender [HR (95% CI) = 1.881 (1.479–2.392); p-value <0.001] and connective tissue disease (CTD)-PAH aetiology [HR (95% CI)= 2.278 (1.733–2.995); p-value <0.001] were all independent predictors of prognosis in patients with PAH together with the recently validated simplified PAH risk table [HR (95% CI) = 2.161 (1.783–2.618); p-value <0.001] but they didn't significantly influence the response to PAH specific treatment as shown in the Figure. Figure 1 Conclusions Age, gender and CTD-PAH aetiology significantly influence prognosis together with the recently validated simplified PAH risk table but don't significantly influence the response to PAH-specific treatment. Acknowledgement/Funding None


2004 ◽  
Vol 50 (12) ◽  
pp. 3804-3812 ◽  
Author(s):  
Dorothy J. Pattison ◽  
Deborah P. M. Symmons ◽  
Mark Lunt ◽  
Ailsa Welch ◽  
Robert Luben ◽  
...  

2007 ◽  
Vol 22 (4) ◽  
pp. 171-178 ◽  
Author(s):  
J-C Schoevaerdts ◽  
I Staelens

Objective: Epidemiological study related to the detection of chronic venous disease (CVD) in a Belgian population and gathering of a maximum amount of epidemiological data on CVD. Method: Survey based on a questionnaire completed by a general practitioner during consultation. Results: In total 3813 files of patients with CVD were completed and analysed. Of these patients suffering from CVD, 70% were women with a mean body mass index of 26.2 and a clinical, aetiological, anatomical and pathological elements classification as follows: C0 = 14; 10%; C1 = 14; 19%; C2 = 14; 29%; C3 = 14; 19%; C4 = 14; 16%; C5 = 14; 4%; C6 = 14; 3%. Risk factors, clinical signs, complications and therapeutic approach are analysed and described. Conclusion: High level of statistically analysable data could be obtained within a reasonable period. The study confirms the socioeconomic importance of CVD. For example, an industrial disablement of an average duration of 23.6 days is found in 6% of patients.


2013 ◽  
Vol 4 (2) ◽  
pp. 11-15
Author(s):  
I. M Davidovich ◽  
O. V Afonaskov

The authors have studied heart rhythm variability at rest and with cognitive loading, types of coronary behavior and reactive and personal anxiety in 86 men of young age, officers of the land forces. 52 of them had hypertensive disease (HD) of I–II stage. 34 men had normal arterial blood pressure. Patients with HD in comparison with normotensive men turned out to have additional risk factors accompanied arterial hypertension. They were hypersympaticotonia, high level of personal anxiety and coronary behavior type A.


2017 ◽  
Vol 95 (6) ◽  
pp. 535-544
Author(s):  
A. I. Telegina ◽  
R. A. Liferov ◽  
A. Ya. Fisun ◽  
R. G. Makiev ◽  
V. V. Gornov ◽  
...  

Based on the literature data and the results of their own research, the authors emphasize the importance of studying adverse effects of high emotional load during stress-induced hypertension and draw attention to the high prevalence of modifiable risk factors of cardiovascular disease among servicemen exposed to occupational stress. It has been shown that lifestyle of hypertensive subjects under heavy stress is characterized by irrational changes in eating behavior, high prevalence of smoking, increased alcohol consumption, and low physical activity. The leading role of long-term emotional stress was demonstrated as an independent risk factor of hypertension in servicemen exposed to long-term occupational psycho-emotional stress. Analysis of the intima-media complex thickness in brachiocephalic arteries, depending on the level of psychosocial stress demonstrated that the group of the examined servicemen with hypertension showed changes that might be due to the development of atherosclerotic process, the response to increased flow, and arterial wall tension at a high level of stress. These changes are unidirectional regardless of the duration of hypertension history. Results of evaluation of the overall risk of developing cardiovascular complications based on the SCORE scale in the servicemen with established and newly diagnosed hypertension under heavy stress suggest its enhancement in the next 10 years which makes necessary implementation of a system of measures for preventing and correcting pathological conditions caused by stressful loads. Stratification of risk factors is essential for early diagnosis of hypertension and the choice of adequate therapy in subjects undergoing high psycho-emotional stress.


2017 ◽  
Vol 23 (2) ◽  
pp. 60-63
Author(s):  
Arzu F. Mekhtieva

The purpose of study. To investigate characteristics of family environment as risk factors of development of arterial hypertension and high normal arterial pressure in school children.The methods. The thrice-repeated measurement of arterial pressure was implemented among 662 schoolchildren and questionnaire survey of their parents as well. The questionnaire included issues related to conditions of living, dimensions of housing area, material well-being and effect of passive tobacco smoking. The schoolchildren with arterial hypertension resided in 107 families, schoolchildren with high normal arterial pressure - in 78 families and other schoolchildren without arterial hypertension and high normal arterial pressure - in 477 families (control group).The results. The most exposure of arterial hypertension in schoolchildren was observed in families with unsatisfactory hygienic conditions of residence - 47.7±4.9% of cases; with housing, less than 4.0 m2 per one schoolchild - 27,1±4,3% of cases; and also in families with unfavorable material conditions - 62,6±4,7% of cases. The exposure of high normal arterial pressure is analogous. At strong intensity of tobacco smoking of parents’ exposure of arterial hypertension among schoolchildren made up to 45,8±4,8% of cases; at medium intensity - 33,6±4,6% of cases; at weak intensity - 12,1±3,2% of cases and in absence of passive tobacco smoking - 8,4±2,7% of cases. The similar picture is observed and at exposure of high normal arterial pressure.The conclusion. As far as positive social economic transformations are occurring and well-being of population is ameliorating, with time the impact of the first three noted risk factors of family environment of schoolchildren will become weaker. Yet, the impact of passive tobacco smoking on organisms of children can be minimized by force of available controlled explanatory work with parents.


2018 ◽  
Vol 90 (9) ◽  
pp. 138-143
Author(s):  
L A Strizhakov ◽  
S A Babanov ◽  
M V Lebedeva ◽  
S V Moiseev ◽  
V V Fomin

The article presents data of domestic and foreign authors on the relationship between occupational factors and arterial hypertension. The role of latent arterial hypertension, its frequency in the population, the lesion of the target organs and the prognosis in comparison with normotensive individuals, arterial hypertension of the "white coat" and stable arterial hypertension have been analyzed. Arterial hypertension in the workplace is a form of latent arterial hypertension. The authors review the influence of harmful production factors (physical, chemical), as well as psychosocial stress on the risk of developing arterial hypertension.The risk of developing hypertension in specified groups of workers has been analyzed separately. The place of production-related diseases in modern occupational pathology in the Russian Federation. A wider implementation of measures aimed at early diagnosis and prevention of arterial hypertension in workers is proposed.


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