Spectrophotometric determination of methyldopa in pharmaceutical preparation via ion pair formation
2019 ◽
Vol 10
(2)
◽
pp. 1367-1371
A simple, rapid and low-cost spectrophotometric method for determination of Methyldopa (MDA) based on ion-pair formation using Bromothymol blue (BTB) as a reagent in alkaline medium (pH 8.7). The absorbance of the green-blue-coloured product is measured at 616 nm. Beer's Law is obeyed at concentration range up to 5-20μg/ml with molar absorptivity 0.8279x104 L/mol.cm. The correlation coefficient, limit of detection and limit of quantification were 0.9982, 0.4318 μg/ml and 1.4393 μg/ml respectively. The method has been successfully applied to the determination of Methyldopa in pharmaceutical preparations.
2020 ◽
Vol 11
(4)
◽
pp. 291-297
1983 ◽
Vol 66
(6)
◽
pp. 1447-1449
◽
2010 ◽
Vol 3
(4)
◽
pp. 265-270
◽
2010 ◽
Vol 1
(3)
◽
pp. 215-220
◽
2019 ◽
Vol 13
(1)
◽
pp. 52-57