scholarly journals The insights on Oro-dispersible tablet

2020 ◽  
Vol 11 (1) ◽  
pp. 260-273
Author(s):  
Akshay Kumar S ◽  
Gowda D V ◽  
Sharadha M ◽  
Akhila A R
Keyword(s):  
Life Cycle ◽  
Buccal Mucosa ◽  
Dosage Form ◽  
Review Paper ◽  
Control Release ◽  
Complete Information ◽  
Fluid Consumption ◽  
Orodispersible Tablets ◽  
Orodispersible Tablet ◽  
Dispersible Tablet

Orodispersible tablets (ODTs) were the conventional product that disintegrates or dissolves into the buccal mucosa in less than 1mins in the absence of water and without chewing. They were first acquainted with the market during the 1980s, and end up one of the quickest developing subdivisions of the oral medication conveyance industry and their items are creating at an extraordinary rate. New orodispersible tablet innovations address numerous pharmaceutical and need of patients, extending from upgraded life-cycle the executives for reasonable medicating for pediatric, aged, and mental patients with trouble in swallowing. These supposedly affect about 35% of the all-inclusive community and related to various ailments like Parkinsonism, mental incapacity, motion sickness, obviousness, water inaccessibility, and so on. Other individuals possibly will face difficulties by utilizing control release solid oral product comprise the psychologically ill, partially developed patients, and rare patients those are unco-operative, on taking place diminished fluid consumption and are nauseated. To defeat such troubles, orodispersible tablets have been formulated. In this dosage form, the property of ODTs can be reached by the expansion of various additives such are super- the disintegrating agent is the main excipient. This has been motivated by both industry and academia to develop advanced orally dispersible products and advanced methodologies in the market. The ODTs are the most extensively implemented marketable products than others. The main purpose of this review paper is to provide the complete information of ODTs formulation

scholarly journals Orodispersible Tablet in Treatment of Migraine: Opportunities, Challenges and Recent Advancements

2021 ◽  
Vol 11 (4) ◽  
pp. 149-156
Author(s):  
Suhasis Bhattacharya ◽  
Tanmay Mohanta ◽  
Sujit Das ◽  
Rumpa Basak
Keyword(s):  
Drug Administration ◽  
Half Life ◽  
Dosage Form ◽  
Oral Route ◽  
Onset Of Action ◽  
Emergency Condition ◽  
Orodispersible Tablets ◽  
Orodispersible Tablet ◽  
Important Solution ◽  
Routes Of Drug Administration

The most comfortable and choicely path of drug administration is oral route. Orodispersible tablets bring a revolution among all routes of drug administration as well as oral route of drug administration also. Orodispersible tablets are unit dosage form but it has unique characteristics. It disintegrates in the mouth within a minute for the presence of saliva where the presence of super disintegrates in the preparation. Especially, old and child have no chance to swallow as a result it is very acceptable for them. Migraine is a very well-known irritating condition for adult and female. Migraine is a debilitating and common neurovascular illness associated with symptoms of one-sided headache, nausea with or without vomiting, photophobia and/or phonophobia. But these symptoms are subjective and vary from patient to patient. Orodispersible tablets are most important solution of migraine like emergency condition and helping human by transferring from hell to heaven. Very short half-life, quick disintegration, quick onset of action and better bioavailability brings the orodispersible tablets into the top position of the management of migraine. Sumatriptan, zolmitriptan like drugs are helping their hands to reduce migraine. Lastly, there are lots of drugs are investigating for this purpose and our hope that the orodispersible tablet can give the pioneer and will give the migraine free era to us and our futures. Keywords: Orodispersible tablet, migraine, sumatriptan, super disintegrate, fast dissolving

Research into the Building Information Model during the Whole Building Life-Cycle

2011 ◽  
Vol 368-373 ◽  
pp. 3797-3800
Author(s):  
Xu Dong Zeng ◽  
Wei Qiang Zhou
Keyword(s):  
Life Cycle ◽  
Information Integration ◽  
Architectural Design ◽  
Complete Information ◽  
Life Cycle Management ◽  
Information Model ◽  
Building Information Model ◽  
Building Information ◽  
Building Life Cycle ◽  
Project Life

Construction project life-cycle management should be based on the visualization of a virtual building, through the establishment of a Building Information Model in the phase of architectural design as a life-cycle information carrier to realize complete information integration. This enables all phases and territories of the whole building life-cycle to achieve in-time information-sharing so as to overcome traditional territory management pattern. This also improves the running mode and information management during the phases of design, costing, construction and operation.

scholarly journals Formulation and Evaluation of Orodispersible Tablet of Atorvastatin Calcium by Using Hibiscus rosa sinesis Mucilage as Natural Superdisintegrant

2019 ◽  
Vol 9 (6) ◽  
pp. 90-94
Author(s):  
Ashish Gupta ◽  
Juhi Bhadoria ◽  
G.N. Darwhekar
Keyword(s):  
Lipid Lowering ◽  
Content Uniformity ◽  
Atorvastatin Calcium ◽  
Drug Content ◽  
Orodispersible Tablets ◽  
Orodispersible Tablet ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Oral bioavailability of Atorvastatin Calcium is low (14%) and shows extensive intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. In the present work, orodispersible tablets of Atorvastatin calcium were prepared by direct compression method using Hibiscus rosa sinesis mucilage as natural superdisintegrant with a view to enhance patient compliance and to avoid hepatic first pass metabolism and to improve its bioavailability. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water-absorption ratio and in-vitro dispersion time. Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dispersion time. Keywords: Orodispersible tablet, Atorvastatin Calcium, lipid-lowering agent, Superdisintegrant, Hibiscus Rosa Sinensis, Bioavailability, solubility. 

scholarly journals Review Paper on Various Software Testing Techniques & Strategies

2019 ◽  
pp. 43-49
Author(s):  
Nahid Anwar ◽  
Susmita Kar
Keyword(s):  
Quality Assurance ◽  
Life Cycle ◽  
Software Testing ◽  
Review Paper ◽  
Critical Stage ◽  
Software Bugs ◽  
Software Applications ◽  
Development Life Cycle ◽  
Testing Techniques ◽  
Software Development Life Cycle

Software testing is the process of running an application with the intent of finding software bugs (errors or other defects). Software applications demand has pushed the quality assurance of developed software towards new heights. It has been considered as the most critical stage of the software development life cycle. Testing can analyze the software item to identify the disparity between actual and prescribed conditions and to assess the characteristics of the software. Software testing leads to minimizing errors and cut down software costs. For this purpose, we discuss various software testing techniques and strategies. This paper aims to study diverse as well as improved software testing techniques for better quality assurance purposes.

scholarly journals ORODISPERSIBLE TABLET: A Patient Friendly Dosage Form (a Review)

2015 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
C. K. Rameesa ◽  
M. K. Drisya
Keyword(s):  
Dosage Form ◽  
Orodispersible Tablet

scholarly journals REVIEW ON THE DEVELOPMENT OF FUEL CELLS AND ITS FUTURE PROSPECTS

2021 ◽  
Vol 83 (3) ◽  
pp. 75-84
Author(s):  
Thareny Ravichandran ◽  
Juhana Jaafar ◽  
Hamid Ilbeygi ◽  
Mochammad Purwanto
Keyword(s):  
Fuel Cells ◽  
Fuel Cell ◽  
Fossil Fuels ◽  
Review Paper ◽  
Complete Information ◽  
Current Status ◽  
Future Prospects ◽  
Storage Medium ◽  
Future Direction ◽  
Competing Technologies

Fossil fuels are unsustainable energy storage medium with pollution problems. With the limitation of fossil fuels, fuel cells, which are known as effective electrochemical converters, has attracted much attention. Present review paper provides a complete information on fuel cell technology and history which includes competing technologies, current status of research-and-development and its future direction. Fuel cell plays an important role in stationary applications from 1990s till now due to its efficiency upon reducing emissions.

scholarly journals Nifedipine Oral Disintegration Tablet: Design, Optimization, Invivo-pharmacokinetic and Stability Studies

2020 ◽  
Vol 11 (4) ◽  
pp. 8101-8107
Author(s):  
Arindam Chatterjee ◽  
Shaik Mohammad Abdulla ◽  
Nagarajan G ◽  
Birendra Shrivastava
Keyword(s):  
Optimization Design ◽  
Dosage Form ◽  
Excretion Rate ◽  
Cost Effective ◽  
Pharmacokinetic Studies ◽  
Disintegration Time ◽  
Elimination Half ◽  
Dispersible Tablet ◽  
Factorial Optimization ◽  
Bile Excretion

Nifedipine has a bioavailability of 45-56 percent and a 2-hour elimination half-life. It has a 50 percent kidney excretion rate and a 5-15 percent bile excretion rate. The intention of this research is to invent and evaluate Nifedipine loaded ODT and to prove the enhancement of bioavailability. The 23 factorial optimization design exposed about the outcome of independent variable on dependent variable throughout the formulation of Nifedipine ODT. From the records, it was accomplished that there was a good correlation between Disintegration time, Dissolution rate and super disintegration concentration. The formulation F4 (Nifedipine ODT) has achieve the goal of ODT drug delivery with desired release characteristics, cost-effective, decreased dose, effective administration and hence improved patient compliance. The invivo pharmacokinetic studies reveals that increase in AUC0-∞; decrease in Tmax; increase in Cmax in Nifedipine ODT shows better bioavailability and faster duration of therapeutic action than marketed Nifilat® dosage form. Nifedipine ODT was stable at various temperature, humidity conditions and there was no drastic change in evaluation parameters. That it was concluded that Oral dispersible tablet (ODT) was a suitable dosage form to enhance the solubility at the same time the bioavailability of BCS class II drugs like Nifedipine.

Development of Pediatric Orodispersible Tablets Based on Efavirenz as a New Therapeutic Alternative

2020 ◽  
Vol 18 (5) ◽  
pp. 342-353
Author(s):  
José Lourenço de Freitas Neto ◽  
Ilka do Nascimento Gomes Barbosa ◽  
Camila Gomes de Melo ◽  
Matheus Alves Ângelos ◽  
Larissa Morgana dos Santos Mendes ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Aqueous Solubility ◽  
Dissolution Profile ◽  
Multicomponent Systems ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orodispersible Tablet ◽  
Immunodeficiency Syndrome

Background: Efavirenz is the most used medication in the treatment of Acquired Immunodeficiency Syndrome (AIDS). The limited number of pediatric antiretroviral formulations approved by regulatory agencies is the most significant obstacle to adequate and efficient pharmacotherapy for this group of patients. The efavirenz has excellent therapeutic potential, but has low aqueous solubility/bioavailability. Methods: To minimize these limitations, multicomponent systems with β-cyclodextrin and polyvinylpyrrolidone K-30 were obtained. Due to the limited number of pediatric antiretroviral formulations, the development of a pediatric orodispersible tablet is an alternative that is thought easy to administer, since it disintegrates rapidly in the oral cavity. The multicomponent systems were obtained by the method of kneading and characterized by solubility test, X-ray diffraction, differential scanning calorimetry and infrared absorption spectroscopy by Fourier transform. The orodispersible tablets were prepared by direct compression. The quality control of hardness, friability, disintegration, and dissolution was performed. The influence of the components of the formulation on the characteristics of the tablets was evaluated through a 22 factorial design added with three central points, to compare the effect of the dependent variables on the responses. Results: An increase in drug solubility was observed, with a decrease in crystallinity. Besides that, an excellent dissolution profile presented with more than 83% of the drug's content dissolved in less than 15 minutes. Satisfactory disintegration time and friability were observed. Conclusion: It was observed that reduced concentrations of mannitol decreased the hardness and disintegration time of the formulations. The orodispersible tablet composed of efavirenz: β- cyclodextrin: polyvinylpyrrolidone, favors greater absorption and bioavailability. It has several advantages for pediatric patients, as the dosage form disintegrates quickly in the mouth and does not require water for administration, thereby improving patient compliance with the treatment.

Sign in / Sign up

Export Citation Format

Share Document