scholarly journals Recovery of serum metallothionein level after hemodialysis in patients with end stage renal failure

2020 ◽  
Vol 11 (2) ◽  
pp. 1748-1753
Author(s):  
Sazan D. Saeed ◽  
Ansam N. Al-Hasani ◽  
Marwan S. Al-Nimer
Keyword(s):  
Heavy Metals ◽  
Renal Failure ◽  
Serum Level ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
The Body ◽  
Cross Sectional ◽  
End Stage Renal Failure ◽  
Mdrd Equation ◽  
End Stage

Metallothioneins (MTs) are intracellular metal-protein which not alone have inactivated heavy metals but also have traced elements while improving the antioxidant status. Serum levels of some heavy metals and trace elements showed toxic levels in the end-stage renal failure. This study is aimed to determine the serum level of metallothionein in patients with chronic kidney disease (CKD) and to show the effects of hemodialysis on its level. This cross-sectional study included 125 patients with CKD managed with regular hemodialysis. Estimated glomerular filtration rate (eGFR) was calculated by using the Cockroft and Gault equation adjusted to the body surface area (ml/min/m2), and 4 variable modified diet in renal disease (4-v MDRD) equation (ml/min/1.73m2). The mean ± SD of serum metallothionein was significantly less than the corresponding level of healthy subjects (1113.4±289.5 pg/ml versus 1536.0±341.4 pg/ml). Hemodialysis improves the serum level of metallothionein to attain 1437.6±406.1 pg/ml. There is a non-significant correlation between serum metallothionein with the eGFR and hemodialysis did not produce a significant effect on the correlation between serum metallothionein with eGFR.  We conclude that serum metallothionein level is a useful prognostic marker for CKD and hemodialysis plays a role in the recovery of serum metallothionein level.

scholarly journals Acute Intradialytic Complications in End Stage Renal Disease on Maintenance Hemodialysis

2012 ◽  
Vol 52 (187) ◽  
Author(s):  
R K Agrawal ◽  
S Khakurel ◽  
R Hada ◽  
D Shrestha ◽  
A Baral
Keyword(s):  
Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Hemodialysis is the preferred method of treatment for Nepalese patients with End Stage Renal Disease. Despite the technological advances and better understanding of physiology associated with hemodialysis, a number of complications are known to be associated with hemodialysis. This study was undertaken to study the frequency of acute intradialytic complications in patients undergoing hemodialysis. Methods: A cross-sectional study was conducted at Nephrology unit of a tertiary care hospital from 15 June, 2007 to 15 December, 2007. A total of 28 patients were included in the study. Patients with acute renal failure and acute on chronic renal failure were excluded from the study. Results: Total sessions of hemodialysis during the period were 1455. Hypotensive episode were 66 (4.5%) and was the commonest complication and followed by hypertensive episodes were 58 (3.8%). Other problems encountered were transfusion reactions were 23 episodes (1.5%), rigors not related to transfusions were 13 episodes (0.8%), nausea/vomiting were 20 episodes (1.4%), muscle cramps were 12 episodes (0.8%), hypoglycemia were 6 episodes 5(0.4%). Conclusions: The frequency of intradialytic complications is low and many of them are not life threatening. Keywords: complications; end stage renal disease; hemodialysis; hypertension; hypotension.

Calcium and Strontium Metabolic Studies in Patients on Capd

1998 ◽  
Vol 18 (4) ◽  
pp. 410-414 ◽  
Author(s):  
Nicholas Apostolidis ◽  
Themis Paradellis ◽  
Andreas Karydas ◽  
Andreas Manouras ◽  
Nicholas Katirtzoglou ◽  
...  
Keyword(s):  
Renal Failure ◽  
Nuclear Physics ◽  
Healthy Subjects ◽  
Medical Center ◽  
The Body ◽  
Healthy Controls ◽  
Duration Of Treatment ◽  
Cross Sectional ◽  
Renal Bone Disease ◽  
End Stage

Background Strontium is known to affect calcium metabolism both experimentally and in clinical studies on conditions other than end-stage renal failure (ESRF) and continuous ambulatory peritoneal dialysis (CAPD). Objective To investigate Sr metabolism in relation to that of Ca in ESRF patients undergoing CAPD, and the possible influence of the duration of treatment. Design Cross-sectional observational study. Setting University medical center and Institute of Nuclear Physics. Patients Twenty-four patients on CAPD; 14 chronic renal failure (CRF) patients not on dialysis, and 52 healthy controls. Measurements Calcium and Sr content of serum, urine or dialysate effluent, and selected dietary products. Results Calcium and Sr are absorbed by the intestinal tract of healthy subjects with equal efficiency. Serum Ca levels were considerably lower in CRF patients than in healthy subjects and patients on CAPD (p < 0.001). Serum Sr was significantly higher in both CAPD and CRF patients than in healthy controls (p < 0.001). The Sr/Ca ratio in the sera of the healthy subjects was defined by the preferential excretion of Sr over Ca by the kidney. This preferential excretion was lost during renal failure. During treatment there was a tendency for the uptake of both Ca and Sr to increase. Conclusions Strontium is accumulated in the body during renal failure and CAPD cannot restore normal levels. Considering the varying effects of different doses of Sr on bone metabolism experimentally, it would be interesting to determine by further studies the possible significance of the observed Sr accumulation for renal bone disease.

scholarly journals Vitamin D Supplementation in Tuberculosis Patients: A Cross Sectional Study

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Dina Keumala Sari ◽  
Nurfida Khairina Arrasyid ◽  
Y. S. Harahap
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Previous studies have not been able to show with certainty the effect of vitamin D supplementation in tuberculosis patients. The objective of this study is to determine whether vitamin D supplementation to patients with tuberculosis could influence 25-hydroxyvitamin D (25(OH)D) and calcium serum levels. The results, after 28 days, the vitamin D supplementation showed significant increase of 25(OH)D serum level at the end point (p=0.001), but not for the calcium serum level (p=0.3). The Conclusions is supplementation with 1,000 IU vitamin D per day increased the 25(OH)D serum level but there was no association with the calcium serum level.

scholarly journals Serum electrolytes levels in patients with type 2 diabetes mellitus: a cross-sectional study

2020 ◽  
Vol 23 (3) ◽  
pp. 223-228
Author(s):  
Shridhar Reshma ◽  
Sushith Sushith ◽  
Mangalore Balakrishna Prathima ◽  
D'Sa Janice ◽  
Gopal R Madan ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
The Body ◽  
Serum Electrolytes ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Electrolyte Disturbances ◽  
Group 2 ◽  
Group 1

BACKGROUND:Diabetes Mellitus (DM) is a common metabolic disease worldwide. Electrolyte played significant roles in thenormal functioning of the body, and deregulation is indicative of different types of disease and electrolyte disturbances are often reported in type 2 DM (T2DM). AIM:The aim of the study was to estimate the levels of serum electrolytes in outpatients with T2DM and correlate serum electrolytes with random blood sugar (RBS). MATERIALS AND METHODS:Patients with T2DM visiting the outpatient Departments of Medicine, between April 2016 and March 2017 were included. Of 148 diagnosed T2DM cases, 74 were had RBS level 300mg/dL (group-1) and 74 had RBSlevel 300mg/dL (group-2). Serum sodium (Na+), potassium (K+), chloride (Cl-) levels were measured by using the Roche 9180electrolyte analyzer. RESULTS:In this study, there was a significant decrease in serum Na+levels in group 1 (131.834.36 mmol/L) compared to group 2(134.154.90mmol/L).The serum levels of K+was found to be increased in group 1 (4.510.61 mmol/L) in comparison with group 2 (4.260.52 mmol/L). In group-1, an inverse relationship was present between serum Na+(r=-0.342) and Cl-(r=-0.538) with RBS which was statistically significant. In group-2, a significant correlation was present between serum K+and RBS (r=0.356, p0.05). CONCLUSIONS:The study showed lower levels of Na+and higher K+levels in group-1 compared to group-2 subjects. This study showed that the distribution of serum Na+and K+levels is dependent on plasma glucose levels in patients with DM and also suggests that monitoring the electrolyte levels in hyperglycemia is pertinent in the management of diabetes.

Effect of haemodialysis on serum levels of tumour markers in patients with end-stage renal failure

Nephrology ◽  
1998 ◽  
Vol 4 (5-6) ◽  
pp. 403-406
Author(s):  
Alexandros GERAKIS ◽  
Angeliki BARBATSI ◽  
Sophia SARANTI ◽  
Theodora STROGYLOU ◽  
Dimitrios VALIS
Keyword(s):  
Renal Failure ◽  
Serum Levels ◽  
Tumour Markers ◽  
End Stage Renal Failure ◽  
End Stage

Increased serum levels of endopeptidase 24.11 (‘enkephalinase”) in patients with end-stage renal failure

Life Sciences ◽  
1989 ◽  
Vol 45 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Monique Deschodt-Lanckman ◽  
Françoise Michaux ◽  
Eric De Prez ◽  
Daniel Abramowicz ◽  
Jean-Louis Vanherweghem ◽  
...  
Keyword(s):  
Renal Failure ◽  
Serum Levels ◽  
End Stage Renal Failure ◽  
Endopeptidase 24.11 ◽  
End Stage

scholarly journals Serum Levels of Zinc and Copper in Cases of Juvenile Idiopathic Arthritis

2019 ◽  
pp. 1-8
Author(s):  
Hala Salah El Din Talaat ◽  
Mohamed Farouk Mohamed ◽  
Asmaa Ismael Ahmed ◽  
Eman Shafik Shafie
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Serum Level ◽  
Disease Activity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Copper Level ◽  
Cross Sectional ◽  
Female Ratio ◽  
Significant Difference

Background: Juvenile idiopathic arthritis (JIA) represents a heterogeneous group of autoimmune diseases that arises before the age of 16 years and lasts more than 6 months. During acute inflammation of the disease, serum copper concentration increases and zinc decreases, that could point to the possible pharmacological properties of these trace elements. Aim: To measure the serum level of zinc and copper in patients with juvenile idiopathic arthritis (JIA) with different subtypes and correlate the levels of zinc and copper with the disease activity. Methods: This cross-sectional study was done on 40 patients already diagnosed clinically with JIA; patients were followed-up at the Rheumatology Outpatient Clinic, Children's Hospital, Cairo University. Results: Out of forty patients, 16 were males (40%) and 24 were females (60%) with a male to female ratio (M: F) of 1:1.5. Out of the forty patients 17 were in activity and 23 were without activity. Thirty age and sex matched controls were included for comparison. Serum copper level was significantly higher in patients with JIA than those of the controls (P= 0.017) while there were no significant difference in serum level of zinc between JIA patients and that of the controls. Conclusion: Alteration of serum copper and zinc probably is a defense response against JIA; increased copper may be due to inflammation associated, these elements could serve as biomarkers for the disease activity.

DOMINAN FACTORS RELATED TO QUALITY OF LIFE OF PATIENTS WITH END STAGE RENAL FAILURE UNDERGOING HEMODIALYSIS AT TABANAN GENERAL HOSPITAL

2018 ◽  
Vol 2 (2) ◽  
pp. 195
Author(s):  
Anselmus Aristo Parut ◽  
I Gusti Ayu Puja Astuti Dewi
Keyword(s):  
Quality Of Life ◽  
Renal Failure ◽  
General Hospital ◽  
Hemodialysis Patients ◽  
The Body ◽  
Dominant Factor ◽  
Life Questionnaire ◽  
End Stage Renal Failure ◽  
End Stage

Background : Renal failure is a clinical condition which irreversible reduction in renal function and need hemodialysis as replacement for kidney function. Hemodialysis is a dialysis that perform outsite the body. Indonesian Association Of Nephrology (Pernerfi) stated that new hemodialysis and active hemodialysis patients in Indonesia since 2007-2018 increased, 14.644 new hemodialysis patients and 7.276 active hemodialysis patients.Method : This is a descriptive analysis study with cross-sectional design and multiple logistic regression to identify dominant factor related to quality of life hemodialysis patients. Location of this research was Tabanan General Hospital. The sampling technique was nonprability sampling with total population were 166 patients. Data collected using insomnia questionnaire, family support questionnaire, quality if life questionnaire and complication observation form. Result : The result showed that, higher OR found in intra hemodialysis variabel (OR:180,917), which mean that intra hemodialysis complication is a dominan factor related to quality of life hemodialysis patients. Patients who had complication were more likely to have low quality of life. Further study are needed to identify factors related to intra hemodialysis complications.  Keywords : Dominan factors, intra hemodialysis complications, quality if life, end stage renal failure, hemodialysis.  

Pharmacokinetics of Recombinant Hirudin in Hemodialyzed End-stage Renal Failure Patients

1997 ◽  
Vol 77 (04) ◽  
pp. 650-655 ◽  
Author(s):  
R Vanholder ◽  
A Camez ◽  
N Veys ◽  
A Van Loo ◽  
A M Dhondt ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Residual Renal Function ◽  
Hemodialysis Patients ◽  
The Body ◽  
Pharmacokinetic Data ◽  
High Flux ◽  
Recombinant Hirudin ◽  
End Stage Renal Failure ◽  
End Stage

SummaryRecently, hirudin was used for the first time as an anticoagulant during hemodialysis in men. Pharmacokinetic data of this compound in end-stage renal failure are however not available. In this study, the pharmacokinetics of recombinant hirudin (HBW 023) was evaluated in hemodialysis-treated end-stage renal failure patients. HBW 023 was administered as a bolus at the start of a single dialysis (0.02 to 0.08 mg/kg) in 20 patients, and plasma hirudin levels were followed during this and the 5 following dialyses, without additional hirudin administration. The initial dialysis (HDj) was performed with a low flux polysulfone dialyzer; the following dialyses (up to HD6) with a high flux polysulfone dialyzer and regular heparin. Hirudin levels averaged 504.0 ± 214.0 and 527.7 ± 217.1 ng/ml in the middle and at the end of HDj, and then gradually decreased to 15.2 ± 15.2 ng/ml at the end of HD6. Pharmacokinetic data were compared to those obtained in healthy controls (n = 5), receiving the same dose, and reaching the same peak hirudin level. Hirudin half-life was >30 times longer in hemodialysis patients (51.8 ± 15.6 vs. 1.7 ± 1.5 h, p <0.001), whereas area under the curve was >60 times higher (34,669 ± 14,898 vs. 545 ± 205 ng/ml X h, p <0.001). Distribution volume was lower in hemodialysis patients (11.0 ± 3.1 vs. 14.1 ± 2.0 1, p <0.05). Hirudin disappearance rate was the same during high flux polysulfone dialysis as during interdialytic periods. Hirudin removal was markedly higher in those patients still maintaining some residual renal function and parameters of hirudin removal were significantly correlated to residual creatinine clearance. It is concluded that hirudin removal from the body is markedly depressed in hemodialyzed end-stage renal failure patients and that even minor residual renal function may increase this removal rate.

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