scholarly journals Serum electrolytes levels in patients with type 2 diabetes mellitus: a cross-sectional study

2020 ◽  
Vol 23 (3) ◽  
pp. 223-228
Author(s):  
Shridhar Reshma ◽  
Sushith Sushith ◽  
Mangalore Balakrishna Prathima ◽  
D'Sa Janice ◽  
Gopal R Madan ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
The Body ◽  
Serum Electrolytes ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Electrolyte Disturbances ◽  
Group 2 ◽  
Group 1

BACKGROUND:Diabetes Mellitus (DM) is a common metabolic disease worldwide. Electrolyte played significant roles in thenormal functioning of the body, and deregulation is indicative of different types of disease and electrolyte disturbances are often reported in type 2 DM (T2DM). AIM:The aim of the study was to estimate the levels of serum electrolytes in outpatients with T2DM and correlate serum electrolytes with random blood sugar (RBS). MATERIALS AND METHODS:Patients with T2DM visiting the outpatient Departments of Medicine, between April 2016 and March 2017 were included. Of 148 diagnosed T2DM cases, 74 were had RBS level 300mg/dL (group-1) and 74 had RBSlevel 300mg/dL (group-2). Serum sodium (Na+), potassium (K+), chloride (Cl-) levels were measured by using the Roche 9180electrolyte analyzer. RESULTS:In this study, there was a significant decrease in serum Na+levels in group 1 (131.834.36 mmol/L) compared to group 2(134.154.90mmol/L).The serum levels of K+was found to be increased in group 1 (4.510.61 mmol/L) in comparison with group 2 (4.260.52 mmol/L). In group-1, an inverse relationship was present between serum Na+(r=-0.342) and Cl-(r=-0.538) with RBS which was statistically significant. In group-2, a significant correlation was present between serum K+and RBS (r=0.356, p0.05). CONCLUSIONS:The study showed lower levels of Na+and higher K+levels in group-1 compared to group-2 subjects. This study showed that the distribution of serum Na+and K+levels is dependent on plasma glucose levels in patients with DM and also suggests that monitoring the electrolyte levels in hyperglycemia is pertinent in the management of diabetes.

scholarly journals Study of body mass index (BMI) and serum lipid profile of patients at a tertiary hospital: a cross sectional study

2018 ◽  
Vol 6 (6) ◽  
pp. 2060
Author(s):  
Archana . ◽  
Vibhuti Agarwal ◽  
Naved Ahmad ◽  
Akash Gupta
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Study Data ◽  
Cross Sectional ◽  
Group 2 ◽  
Group 1

Background: Sedentary lifestyle have an impact on the prevalence and incidence of obesity related disorders and leads to the development of type 2 diabetes mellitus, dyslipidemias and metabolic disorders that aggravate the risk in the development of cardiovascular diseases (CVD).Methods: In our study, data of 220 subjects belonging to age group of 25 to 55 years were collected. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters. Subjects were categorized into two groups (BMI <25 and BMI ≥25). Serum was separated by centrifuging blood at 3000 rpm for 10 min and analyzed for lipid profile on Erba Chem 7 semi-auto analyzer.Results: In our present hospital based study we estimated the Lipid Profile in individuals categorized into two groups. (Group 1 BMI <25) and (Group 2 BMI ≥25), We found the values of Triglycerides, LDL and VLDL in Group 1 are lower as compared to Group 2.Conclusions: Our study showed positive correlation between lipid profile and obesity. Obesity is said to predispose individuals to metabolic syndrome associated diseases.

Evaluation of anthropometric results after acupuncture and diet applications in obesity patients:an experimental-control study

2021 ◽  
Vol 45 (2) ◽  
pp. 97-106
Author(s):  
Hayriye Alp
Keyword(s):  
Cross Sectional Study ◽  
Ear Acupuncture ◽  
The Body ◽  
Cross Sectional ◽  
Coronary Insufficiency ◽  
Acute Coronary Insufficiency ◽  
Liver And Kidney ◽  
Group 2 ◽  
Control Study ◽  
Group 1

Obesity is a disease defined by excessive fat storage in the body. It is an energy balance problem; the increase in body fat is caused by an imbalance between energy intake and energy expenditure. This study aimed to determinate the changes in the anthropometric measurements of patients after acupuncture treatment used in obesity treatment. The present study was a cross-sectional study conducted in 2019 in xxx University's GETAT Center). Patients aged between 18–65 years with a BMI > 25 were included in the study. The participants were divided into two groups: Group 1 (acupuncture and diet) and Group 2 (diet only). Exclusion criteria: Pregnant women, breastfeeding patients , susceptible demographics (acute coronary insufficiency, immunodeficiency, severe psychotic disorder, liver and kidney failure), and those who could not give consent were not included in the study. Weight, BMI, and metabolic age values were measured with a Tanita device; the same diagnostic device was used for all patients. Both body and ear acupuncture were performed. In patients with all acupuncture, the yuan points of abnormal meridians were used for pulse diagnosis. ST 24, 25, and 36 (ZuSanLi); GV 20, 21, 5, 5, and LR 3 (Taichong); SP 6 and 9, GB 34, UB 62, HT 7, LU 9, and PC 6 (Nei Guan); and SI 3 and EXT-HN 3 (Yin-Tang) points were dewed. For ear acupuncture, hunger, kidney, larynx, stomach, jerome, and shen-men points were taken. A t-test was applied to pre- and post-acupuncture measurement values. After acupuncture, the waist circumference of the participants decreased significantly (p < 0.005). The BMI of the participants also decreased significantly after acupuncture (p < 0.005). In these studies, LU 6, ST 40, ST 21, K 4, ST 36 and 25, and LI 11 body points were used, while hunger, stomach, and shen-men points were commonly used as ear points.

scholarly journals Leptin, ghrelin and calprotectin: inflammatory markers in childhood asthma?

2013 ◽  
Vol 8 ◽  
Author(s):  
Nazan Cobanoglu ◽  
Nilufer Galip ◽  
Ceyhun Dalkan ◽  
Nerin Nadir Bahceciler
Keyword(s):  
Skin Prick Test ◽  
Vital Capacity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Prick Test ◽  
Previous Diagnosis ◽  
Group 2 ◽  
Group 1

Background: Appetite-modulating hormones ghrelin and leptin might be relevant to asthma with their pro-inflammatory effects, and calprotectin has been recognized as a promising marker of inflammation. The purpose of this study was to explore whether asthma, atopy and lung functions has a relation with serum levels of leptin, ghrelin and calprotectin as inflammatory markers in children. Methods: A cross-sectional study was performed by searching the doctor diagnosed asthma through questionnaires filled in by parents who were phoned, and children were invited to supply fasting blood samples in order to measure serum levels of leptin, ghrelin and calprotectin, and to perform skin prick test and spirometry. Participants were divided into Group 1, children with previous diagnosis of asthma, and Group 2, children without previous diagnosis of asthma. Results: One thousand and two hundred questionnaires were distributed and 589 of them were returned filled in. Out of 74 children whose parents accepted to participate in the study, 23 were in Group 1 and 51 were in Group 2. There was no statistical difference in serum levels of leptin, ghrelin, calprotectin, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) , forced expiratory flow between 25 and 75% of vital capacity (FEF25-75) values , and skin prick test results between the two groups (p values are 0.39, 0.72, 0.5, 0.17, 0.5, 0.27, 0.18, and 0.81 respectively). Conclusion: In this study the inflammation in asthmatic children could not be shown by using serum leptin, ghrelin and calprotectin levels and this is possibly due to the low number of children with ever asthma and equal skin prick test positivity in both groups. This study is the first study aimed to show the relation between serum calprotectin levels and inflammation in asthma. As this study was a cross-sectional study, further prospectively designed randomized controlled studies are necessary to show the association of these markers and inflammation in asthma.

scholarly journals Effect of the Cut-Off Level for Thyroid-Stimulating Hormone on the Prevalence of Subclinical Hypothyroidism among Infertile Mexican Women

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 417
Author(s):  
Lidia Arce-Sánchez ◽  
Salvatore Giovanni Vitale ◽  
Claudia Montserrat Flores-Robles ◽  
Myrna Souraye Godines-Enriquez ◽  
Marco Noventa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Subclinical Hypothyroidism ◽  
Thyroid Autoimmunity ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Mexican Women ◽  
Cross Sectional ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The primary aim of this study was to compare the prevalence of subclinical hypothyroidism (SCH) using two different cut-off levels for TSH values (≥2.5 mIU/L versus ≥4.1 mIU/L). The secondary objective was to analyze the clinical-biochemical characteristics in women with and without SCH. This was a retrospective cross-sectional study. In total, 1496 Mexican women with infertility were included: Group 1, women with TSH levels ranging between 0.3 and 2.49 mIU/L, n = 886; Group 2, women with TSH between 2.5 and 4.09 mIU/L, n = 390; and Group 3, women with TSH ≥4.1 mIU/L n = 220. SCH prevalence was 40.7% (CI 95%: 38.3–43.3%) with TSH cut-off ≥ 2.5 mIU/L, and 14.7% (CI 95%: 12.7–16.5%) with TSH cut-off ≥ 4.1 mIU/L, (p = 0.0001). The prevalence of overweight was higher in Group 2 than in Groups 1 and 3. Thyroid autoimmunity, obesity and insulin resistance were higher in Group 3 than in Group 1 (p < 0.05). No other differences were observed between groups. Conclusions: The prevalence of SCH in our selected patients increased almost three times using a TSH cut-off ≥ 2.5 mIU/L compared with a TSH cut-off ≥ 4.1 mIU/L. Women with TSH ≥4.1 mIU/L compared with TSH cut-off ≤ 2.5 mIU/L more often presented with obesity, thyroid autoimmunity and insulin resistance.

scholarly journals Role of feasibility and pilot studies in randomised controlled trials: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e022233 ◽  
Author(s):  
Amanda Jane Blatch-Jones ◽  
Wei Pek ◽  
Emma Kirkpatrick ◽  
Martin Ashton-Key
Keyword(s):  
Feasibility Study ◽  
Randomised Controlled Trials ◽  
Feasibility Studies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group 2 ◽  
Randomised Controlled ◽  
Pilot Feasibility Study ◽  
Group 1

ObjectivesTo assess the value of pilot and feasibility studies to randomised controlled trials (RCTs) funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme. To explore the methodological components of pilot/feasibility studies and how they inform full RCTs.Study designCross-sectional study.SettingBoth groups included NIHR HTA programme funded studies in the period 1 January 2010–31 December 2014 (decision date). Group 1: stand-alone pilot/feasibility studies published in the HTA Journal or accepted for publication. Group 2: all funded RCT applications funded by the HTA programme, including reference to an internal and/or external pilot/feasibility study. The methodological components were assessed using an adapted framework from a previous study.Main outcome measuresThe proportion of stand-alone pilot and feasibility studies which recommended proceeding to full trial and what study elements were assessed. The proportion of ‘HTA funded’ trials which used internal and external pilot and feasibility studies to inform the design of the trial.ResultsGroup 1 identified 15 stand-alone pilot/feasibility studies. Study elements most commonly assessed weretesting recruitment(100% in both groups),feasibility(83%, 100%) andsuggestions for further study/investigation(83%, 100%). Group 2 identified 161 ‘HTA funded’ applications: 59 cited an external pilot/feasibility study wheretesting recruitment(50%, 73%) andfeasibility(42%, 73%) were the most commonly reported study elements: 92 reported an internal pilot/feasibility study wheretesting recruitment(93%, 100%) andfeasibility(44%, 92%) were the most common study elements reported.Conclusions‘HTA funded’ research which includes pilot and feasibility studies assesses a variety of study elements. Pilot and feasibility studies serve an important role when determining the most appropriate trial design. However, how they are reported and in what context requires caution when interpreting the findings and delivering a definitive trial.

scholarly journals Pre-teens, Audio Analgesia and Dental Care: A Cross-Sectional Study

2020 ◽  
Vol 4 (4) ◽  
pp. 98-101
Author(s):  
Akshaye Kumar ◽  
Priyanka Sharma ◽  
Arjun Malhotra
Keyword(s):  
Cross Sectional Study ◽  
Pain Tolerance ◽  
Control Group ◽  
Cross Sectional ◽  
Pearson’S Correlation ◽  
Promising Alternative ◽  
Pearson's Correlation ◽  
Group 2 ◽  
Fear And Anxiety ◽  
Group 1

INTRODUCTION: Research has proven that music plays an important role in alleviating fear and anxiety among patients.AIM: To assess the effect of audio analgesia in pre-teen children aged 8-12 years undergoing dental restorations. MATERIALS AND METHOD: Data was collected using a pre-tested and pre-validated proforma filled by the child prior to start of the treatment by circling the number corresponding to the expected pain during the procedure [Ranged 0 (No pain) -10 (Maximum pain)]. Children who reported their expected pain above 5, were enrolled in group 1 (The ones receiving audio analgesia) while the remaining were assigned group 2 (controls). Children in group 1 were asked to put on their favourite song using noise cancellation headphones and the procedure was commenced. After completion of the treatment, the VAS scale was re-introduced and the children were asked to re-circle the actual pain experienced during the procedure. Data was analyzed using SPSS version 20.0 using the chi-squared test and Pearson’s correlation coefficient. A significant value was obtained when p was≤ 0.05. RESULTS: Of the total 80 children enrolled in the present study, there were an equal number of males and females (40 each). It was observed that 70.3% of children in group 1 had an increased pain tolerance as compared to only 37.2% of children in the control group(p=0.01). Pearson’s Correlation revealed a positive and linear association (r: +0.721) and a significant relationship (p = 0.03) between both groups. CONCLUSION: Audio analgesia has been proven to a promising alternative to distract the patient from the anxiety faced in the dental setting and is recommended for nervous and anxious patients.

Possibilities of pulse oscillometry in the diagnosis of small airway dysfunction in patients with bronchial asthma

MedAlliance ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 72-78
Keyword(s):  
Vital Capacity ◽  
Cross Sectional Study ◽  
Functional Method ◽  
Small Airway ◽  
Entire Group ◽  
Body Plethysmography ◽  
Air Trapping ◽  
Cross Sectional ◽  
Group 2 ◽  
Group 1

Small airway dysfunction (SAD) is associated with poorly controlled asthma and frequent exacerbations. Objective: To assess the prevalence of SAD in asthmatics using spirometry, body plethysmography, and impulse oscillometry (IOS). Materials and methods: The observational cross-sectional study of 61 patients with asthma was performed. Conclusion available SAD was made on the basis of identifying one of the criteria or their combination: 1) slow vital capacity (SVC) - forced vital capacity (FVC) >10% according spirometry; 2) "air trapping" according body plethysmography; 3) presence of pathological frequency dependence of the resistance (R) at 5 and 20 Hz (R5-R20 > 0,07 kPa•sec/l) according IOS. Results: The analysis was performed for the entire group as well as for patients with FEV1 > 80 %pred. and FEV1/SVC < 0,7 (group 1) and patients with FEV1 > 80 %pred. and normal FEV1/SVC (group 2). SAD was most often diagnosed using IOS and the selected criterion R5-R20>0,07 kPa •sec/l since 75% of patients had this deviation in the entire group, 65% of patients in group 1 and 55% of patients in group 2 whereas only in 48% and 24% of cases in the entire group according body plethysmography and spirometry, respectively. Conclusion: SAD is definitely observed in patients with asthma. IOS is a more effective method of diagnosing SAD compared to spirometry and body plethysmography and can serve as a supplement functional method, especially in cases of normal parameters of spirometry and body plethysmography in asthmatics.

EVALUATION OF THE ORAL SYMPTOMS IN COVID 19 PATIENTS IN KAMRUP METRO- A CROSS-SECTIONAL STUDY

2021 ◽  
pp. 58-61
Author(s):  
Rubi Kataki ◽  
Pranamee Barua ◽  
Debosmita Roy ◽  
Prasanta Kumar Rabha
Keyword(s):  
Cross Sectional Study ◽  
Burning Sensation ◽  
Taste Sensation ◽  
Cross Sectional ◽  
Live Virus ◽  
Oral Manifestation ◽  
Oral Symptoms ◽  
Group 2 ◽  
Novel Coronavirus ◽  
Group 1

The novel coronavirus are found to affect the ACE2 receptors in the epithelial cells of the lining of the respiratory tract. Since live virus have been found in the saliva of infected patients, and ACE2 receptors are present in epithelial lining of salivary glands and tongue, there are chances that the virus might affect the oral cavity and hence might have oral manifestation. The aim of the study was to determine and evaluate the presence of oral symptoms in the patients infected with the 2019 Novel Coronavirus (Covid 19). In this cross sectional descriptive study, a set of questionnaires was MATERIALS AND METHODS: formulated and the patients who have come to covid screening centers in Kamrup Metro region were interviewed for both oral symptoms and general symptoms. A total of 467 patients were evaluated. The samples were divided according to covid positive or negative. Group 1: Covid positive (+ve); Group 2: Covid negative (- ve). Out of which Group 1 had 287 patients whereas Group 2 had 180 patients. Upon statist RESULTS: ical analysis, signicant differences were found with respect to fever, cough, breathing difficulty, sore throat, arthralgia, and asthenia where covid positive patients found to have a high prevalence of these symptoms. On evaluation of the of the oral symptoms in both covid positive and negative patients signicant differences were found viz., burning sensation, swollen gums , changes in taste sensation, pain in the TMJ and bleeding gums with covid positive patients having more predilection of having all these symptoms. On evaluation of the gender predilection between positive patients with symptoms, positive patients without symptoms and negative patients with symptoms , there found to be no signicant difference. oral CONCLUSION symptoms of burning sensation, changes in taste sensation , bleeding gums and pain in the TMJ are found to be more prevalent with patients having corona virus infection.

Influence of Metabolic Syndrome on Factors Associated with Chronic Kidney Disease: A Cross-Sectional Study

2021 ◽  
Vol 17 ◽  
Author(s):  
Camila Santos Marreiros ◽  
Thaís Rodrigues Nogueira ◽  
Paulo Pedro do Nascimento ◽  
Diana Stefany Cardoso de Araújo ◽  
Nayara Vieira do Nascimento Monteiro ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Glucose ◽  
Cross Sectional ◽  
Significance Level ◽  
Glucose Levels ◽  
Progression Of Kidney Disease

Background: Metabolic Syndrome (MetS) is defined by the presence of three or more of the following components: inadequate fasting serum glucose levels and elevated waist circumference, hypertension and dyslipidemia, which represent a potential risk for the development and/or worsening of Chronic Kidney Disease. Objective: This research aimed to investigate the presence of MetS and its influence on associated factors in patients with Chronic Kidney Disease undergoing hemodialysis. Methods: This is an evaluation of a cross-sectional multicenter research project, carried out with 95 patients with Chronic Kidney Disease, seen at outpatient clinics in the state capital Piaui. Anthropometric, biochemical and hemodynamic parameters were determined. The data were analyzed using the Stata® v.12 software (Statacorp, College Station, Texas, USA), adopting a significance level of p < 0,05. The survey received ethical approval (nº 2.527.329). Results: It was observed that individuals with elevated BMI, WC, NC, SBP, DBP were more likely to develop MetS, with significant differences (p <0.001). In addition, it was found that serum levels of glucose, insulin, HOMA-IR, TC, LDL, TG and blood pressure were higher in the group with MetS. Conclusion: It was concluded that changes in the parameters analyzed in patients with CKD reinforce MetS as a predictive condition for worsening nutritional status and a factor for the progression of kidney disease.

Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients

2018 ◽  
Vol 128 (08) ◽  
pp. 520-527
Author(s):  
Daniël H. van Raalte ◽  
Eva van der Palen ◽  
Pauline Idema ◽  
Liza Wong ◽  
Sander W. M. Keet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Circulation ◽  
Cross Sectional Study ◽  
Capillary Endothelium ◽  
Cross Sectional ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Novel Target ◽  
Insulin Uptake

Abstract Background Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients. Methods Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Thirty-six participants were studied in the fasted state (22 ND subjects and 14 T2D patients termed NDF and T2DF) and 34 participants 1-h following a glucose challenge (18 ND subjects and 16 T2D patients indicated as NDG and T2DG). Main outcome measure was fractional extraction (FE) of insulin (FEins) and glucose using the forearm balance method. Results In NDF, FEins was 18 (10–26) % at lower insulin levels (63 51–80] pmol/l), while in NDG at higher insulin levels (776 [543–1176] pmol/l), FEins was 9 (4–16) % (p = 0.01 vs. NDF). In NDF only, a negative correlation was observed between FEins and arterial plasma insulin load (rho = − 0.575;p = 0.006) and fasting plasma glucose levels (rho = − 0.551;p = 0.01). In T2DF FEins was 6 (1–19) % and not different from FEins in T2DG (10 2–14) %), and was not associated to fasting glucose. FEins tended to be higher in NDF compared to T2DF (p = 0.07). Discussion We propose that in ND individuals, besides passive diffusion, an active high-affinity pathway with limited capacity around lower physiologic insulin levels exists for insulin transendothelial transport, contributing to glycemic control. In T2D patients, this mechanism of peripheral insulin uptake is diminished or even absent. Modulation of insulin extraction from the circulation may be a novel target to improve glucose metabolism in T2D.

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