scholarly journals Conductometric determination of propranolol hydrochloride in pharmaceuticals

2017 ◽  
Vol 36 (1) ◽  
pp. 110
Author(s):  
Elen Romão Sartori ◽  
Nathália Vieira Barbosa ◽  
Ronaldo Censi Faria ◽  
Orlando Fatibello-Filho
Keyword(s):  
Silver Nitrate ◽  
Spectrophotometric Method ◽  
Confidence Level ◽  
Titration Curve ◽  
Close Agreement ◽  
Conductometric Titration ◽  
Pharmaceutical Formulations ◽  
Propranolol Hydrochloride ◽  
Insoluble Salt

In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.

scholarly journals Conductometric determination of propranolol hydrochloride in pharmaceuticals

2011 ◽  
Vol 36 (1) ◽  
pp. 110-122 ◽  
Author(s):  
Elen Romão Sartori ◽  
Nathália Vieira Barbosa ◽  
Ronaldo Censi Faria ◽  
Orlando Fatibello-Filho
Keyword(s):  
Silver Nitrate ◽  
Spectrophotometric Method ◽  
Confidence Level ◽  
Titration Curve ◽  
Close Agreement ◽  
Conductometric Titration ◽  
Pharmaceutical Formulations ◽  
Propranolol Hydrochloride ◽  
Insoluble Salt

In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.

scholarly journals CONDUCTOMETRIC DETERMINATION OF LOSARTAN POTASSIUM USING PHOSPHOTUNGSTIC ACID, BROMOCRESOL PURPLE, MERCURY (II) CHLORIDE, AND CUPRIC CHLORIDE AS REAGENTS

2019 ◽  
pp. 6-10
Author(s):  
AFAF ABOUL-KHIER ABDEL-MONEM ◽  
EMAN AHMED BAHGAT
Keyword(s):  
Standard Deviation ◽  
Spectrophotometric Method ◽  
Confidence Level ◽  
Close Agreement ◽  
Phosphotungstic Acid ◽  
Cupric Chloride ◽  
Losartan Potassium ◽  
Bromocresol Purple ◽  
Relative Standard

Objectives: In the current study a simple and precise four conductometric methods were introduced for determination of Losartan Potassium (LK) in pure form and tablets. Methods: Method A is based on titration of LK using phosphotungstic acid, method B is based on titration of LK using bromocresol purple dye, method C is based on titration of LK using mercury (II) chloride, and method D is based on titration of LK using cupric chloride. Results: LK was found to be linear in the concentration range of 3–20 mg/mL for all methods except for method C, the concentration range was 1–12 mg/mL. The obtained percentage recoveries for the four methods ranged from 99.69% to 100.53%; the relative standard deviation values were not exceeding two for all methods. Conclusion: The suggested methods were successfully applied for the determination of LK in tablets, with results in close agreement at 95% confidence level with those obtained using the reference spectrophotometric method.  

scholarly journals Spectrophotometric determination of methyldopa in pharmaceutical formulations

2005 ◽  
Vol 30 (3) ◽  
pp. 23-28 ◽  
Author(s):  
P. R. S. Ribeiro ◽  
L. Pezza ◽  
H. R. Pezza
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Confidence Level ◽  
Low Cost ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Complexation Reaction ◽  
Excellent Correlation

A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 µg ml-1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.

scholarly journals A simple spectrophotometric method for the determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T

2010 ◽  
Vol 35 (4) ◽  
pp. 139-146 ◽  
Author(s):  
José L. Rufino ◽  
Flávio C. B. Fernandes ◽  
Mayara S. Ruy ◽  
Helena R. Pezza ◽  
Leonardo Pezza
Keyword(s):  
Spectrophotometric Method ◽  
Confidence Level ◽  
Comparative Method ◽  
Pharmaceutical Formulations ◽  
Multivariate Method ◽  
Absorbance Maximum ◽  
Red Color ◽  
Chloramine T ◽  
Good Agreement

A simple, rapid, accurate and inexpensive spectrophotometric method for the determination of tetracycline and doxycycline has been developed. The method is based on the reaction between these drugs and chloramine-T in alkaline medium producing red color products with absorbance maximum at the Λ = 535 and 525 nm for the tetracycline and doxycycline, respectively. The best conditions for the reactions have been found using multivariate method. Beer´s law is obeyed in a concentration ranges 1.03 x 10-5 to 3.61 x 10-4 mol L-1 and 1.75 x 10-5 to 3.48 x 10-4 mol L-1 for the tetracycline and doxycycline, respectively. The quantification limits were 5.63 x 10-6 mol L-1 and 7.12 x 10-7 mol L-1 for the tetracycline and doxycycline, respectively. The proposed method was successfully applied to the determination of these drugs in pharmaceutical formulations and the results obtained were in good agreement with those obtained by the comparative method at the 95% confidence level.

scholarly journals A SIMPLE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TETRACYCLINE AND DOXYCYCLINE IN PHARMACEUTICAL FORMULATIONS USING CHLORAMINE-T

2018 ◽  
Vol 35 (4) ◽  
pp. 139
Author(s):  
José Luiz Rufino ◽  
Flávio Cesar Bedatty Fernandes ◽  
Mayara S. Ruy ◽  
Helena Redigolo Pezza ◽  
Leonardo Pezza
Keyword(s):  
Spectrophotometric Method ◽  
Confidence Level ◽  
Comparative Method ◽  
Pharmaceutical Formulations ◽  
Multivariate Method ◽  
Absorbance Maximum ◽  
Red Color ◽  
Chloramine T ◽  
Good Agreement

A simple, rapid, accurate and inexpensive spectrophotometric method for the determination of tetracycline and doxycycline has been developed. The method is based on the reaction between these drugs and chloramine-T in alkaline medium producing red color products with absorbance maximum at the ë = 535 and 525 nm for the tetracycline and doxycycline, respectively. The best conditions for the reactions have been found using multivariate method. Beer´s law is obeyed in a concentration ranges 1.03 x 10-5 to 3.61 x 10–4 mol L-1 and 1.75 x 10-5 to 3.48 x 10–4 mol L-1 for the tetracycline and doxycycline, respectively. The quantification limits were 5.63 x 10-6 mol L-1 and 7.12 x 10-7 mol L-1 for the tetracycline and doxycycline, respectively. The proposed method was successfully applied to the determination of these drugs in pharmaceutical formulations and the results obtained were in good agreement with those obtained by the comparative method at the 95% confidence level.

scholarly journals New Kinetic Spectrophotometric Method for Determination of Folic Acid in Pharmaceutical Formulations

2015 ◽  
Vol 50 ◽  
pp. 169-178
Author(s):  
Mouhammed Khateeb ◽  
Basheer Elias ◽  
Fatema Al Rahal
Keyword(s):  
Folic Acid ◽  
Spectrophotometric Method ◽  
Pharmaceutical Formulations ◽  
Fixed Time ◽  
Rate Data ◽  
Sulfuric Acid Medium ◽  
Significant Difference ◽  
Kinetic Spectrophotometric ◽  
Comparison Of The Results

A simple and sensitive kinetic spectrophotometric method has been developed for the determination of folic acid (FA) in bulk and pharmaceutical Formulations. The method is based on the oxidation of FA by Fe (III) in sulfuric acid medium. Fe (III) subsequently reduces to Fe (II) which is coupled with potassium ferricyanide to form Prussian blue. The reaction is followed spectrophotometrically by measuring the increase in absorbance at λmax 725 nm. The rate data and fixed time methods were adopted for constructing the calibration curves. The linearity range was found to be 1–20 μg mL-1 for each method. The correlation coefficient was 0.9978 and 0.9993, and LOD was found to be 0.91 and 0.09 μg mL-1 for rate data and fixed time methods, respectively. The proposed method has been successfully applied to the determination of FA in formulations with no interference from the excipients. Statical comparison of the results shows that there is no significant difference between the proposed and pharmacopoeial methods

scholarly journals DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF HYDROQUINONE IN BULK, MARKETED CREAM AND PREAPARED NLC FORMULATION

2017 ◽  
Vol 9 (5) ◽  
pp. 102
Author(s):  
Sukhjinder Kaur ◽  
Taranjit Kaur ◽  
Gurdeep Kaur ◽  
Shivani Verma
Keyword(s):  
Spectrophotometric Method ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Pure Form ◽  
Nanostructured Lipid Carrier ◽  
Limit Of Quantification ◽  
Double Beam ◽  
Uv Visible ◽  
Development And Validation

Objective: The aim of the present work was to develop a simple, rapid, accurate and economical UV-visible spectrophotometric method for the determination of hydroquinone (HQ) in its pure form, marketed formulation as well as in the prepared nanostructured lipid carrier (NLC) systems and to validate the developed method.Methods: HQ was estimated at UV maxima of 289.6 nm in pH 5.5 phosphate buffer using UV-Visible double beam spectrophotometer. Following the guidelines of the International Conference on Harmonization (ICH), the method was validated for various analytical parameters like linearity, precision, and accuracy robustness, ruggedness, limit of detection, quantification limit, and formulation analysis.Results: The obtained results of the analysis were validated statistically. Recovery studies were performed to confirm the accuracy of the proposed method. In the developed method, linearity over the concentration range of 5-40 μg/ml of HQ was observed with the correlation coefficient of 0.998 and found in good agreement with Beer Lambert’s law. The precision (intra-day and inter-day) of the method was found within official RCD limits (RSD<2%).Conclusion: The sensitivity of the method was assessed by determining the limit of detection and limit of quantification. It could be concluded from the results obtained that the purposed method for estimation of HQ in pure form, in the marketed ointment and in the prepared NLC-formulation was simple, rapid, accurate, precise and economical. It can be used successfully in the quality control of pharmaceutical formulations and for the routine laboratory analysis.

scholarly journals Spectrophotometric method for the determination of Captopril in pharmaceutical formulations

2013 ◽  
Vol 10 (3) ◽  
pp. 965-970
Author(s):  
Baghdad Science Journal
Keyword(s):  
Aqueous Solution ◽  
Spectrophotometric Method ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Maximum Absorption ◽  
Neutral Medium ◽  
Pharmaceutical Tablets ◽  
Colored Product ◽  
Sensitive Spectrophotometric Method

A simple, rapid and sensitive spectrophotometric method has been developed for the determination of captopril in aqueous solution. The method is based on reaction of captopril with 2,3-dichloro 1,4- naphthoquinon(Dichlone) in neutral medium to form a stable yellow colored product which shows maximum absorption at 347 nm with molar absorptivity of 5.6 ×103 L.mole-1. cm-1. The proposed method is applied successfully for determination of captopril in commercial pharmaceutical tablets.

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